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ATM safeguards DNA replication by restraining pathological repriming at endogenous base lesions

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1. scibot 01 Oct 2026
  
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  RRID:AB_2572318
  
  DOI: 10.1016/j.molcel.2026.09.006
  
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sciencedirect.com/science/article/pii/S109727652600626X
Jul 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

αKG-mediated carnitine synthesis drives DNA repair via histone acetylation

1
1. scibot 18 Jul 2026
  
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  DOI: 10.1038/s41586-026-10584-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13307467/
Jun 2026
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PARP1 rewires neuroinflammatory and redox metabolism associated with reactive neuroglia in neuropathic pain

1
1. scibot 22 Jun 2026
  
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  DOI: 10.1016/j.redox.2026.104268
  
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sciencedirect.com/science/article/pii/S2213231726002673
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Deacetylated PCBP1 licenses PARP1 activity for DNA damage repair

1
1. scibot 04 Jun 2026
  
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  RRID:AB_2572318
  
  DOI: 10.1016/j.molcel.2026.05.008
  
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sciencedirect.com/science/article/pii/S109727652600314X
Feb 2025
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Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1/2-deficient tumors

1
1. scibot 27 Feb 2025
  
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  DOI: 10.1016/j.molcel.2025.01.031
  
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sciencedirect.com/science/article/pii/S109727652500098X
Aug 2024
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ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes

1
1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114626
  
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sciencedirect.com/science/article/pii/S2211124724009768
Jul 2024
www.cell.com www.cell.com

PARP1-driven repair of topoisomerase IIIα DNA-protein crosslinks by FEN1

1
1. scibot 23 Jul 2024
  
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  RRID:AB_2572318
  
  DOI: 10.1016/j.celrep.2024.114522
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00851-9
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The PP2A regulatory subunit PPP2R2A controls NAD+ biosynthesis to regulate T cell subset differentiation in systemic autoimmunity

1
1. scibot 18 Jul 2024
  
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  RRID:AB_2572318
  
  DOI: 10.1016/j.celrep.2024.114379
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00707-1
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

YZL-51N functions as a selective inhibitor of SIRT7 by NAD+ competition to impede DNA damage repair

1
1. scibot 01 Jul 2024
  
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  RRID:AB_2572318
  
  DOI: 10.1016/j.isci.2024.110014
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11214487/
Jan 2024
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PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis

1
1. scibot 25 Jan 2024
  
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  RRID:AB_2572318
  
  DOI: 10.1016/j.molcel.2023.12.041
  
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sciencedirect.com/science/article/pii/S1097276523011218
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A Bifunctional PARP-HDAC Inhibitor with Activity in Ewing Sarcoma

1
1. scibot 07 Sep 2023
  
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  RRID:AB_2572318
  
  DOI: 10.1158/1078-0432.CCR-22-3897
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10472104/
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice

1
1. scibot 10 Aug 2023
  
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  RRID:AB_2572318
  
  DOI: 10.1016/j.isci.2023.107375
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10433013/
Jul 2023
www.biorxiv.org www.biorxiv.org

Histone H1.2 Dependent Translocation of Poly (ADP-ribose) Initiates Parthanatos

1
1. scibot 07 Jul 2023
  
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  RRID:AB_2572318
  
  DOI: 10.1101/2023.06.18.545460
  
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biorxiv.org/content/10.1101/2023.06.18.545460v3
May 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Repurposing ceritinib induces DNA damage and enhances PARP inhibitor responses in high-grade serous ovarian carcinoma

1
1. scibot 05 May 2023
  
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  RRID:AB_2572318
  
  DOI: 10.1158/0008-5472.CAN-21-0732
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8770599/
Jan 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging

1
1. scibot 06 Jan 2023
  
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  RRID:AB_2572318
  
  DOI: 10.1016/j.isci.2022.105779
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9804145/
Dec 2022
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The ADP-ribose hydrolase NUDT5 is important for DNA repair

1
1. scibot 24 Dec 2022
  
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  RRID:AB_2572318
  
  DOI: 10.1016/j.celrep.2022.111866
  
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sciencedirect.com/science/article/pii/S2211124722017624
Oct 2022
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PARP-inhibition reprograms macrophages toward an anti-tumor phenotype

1
1. scibot 13 Oct 2022
  
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  RRID:AB_2572318
  
  DOI: 10.1016/j.celrep.2022.111462
  
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sciencedirect.com/science/article/pii/S2211124722013079
Aug 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PARP1 inhibition enhances reactive oxygen species on gut microbiota

1
1. scibot 24 Aug 2022
  
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  RRID:AB_2572318
  
  DOI: 10.1002/jcp.30861
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9805012/
May 2022
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A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination

1
1. scibot 25 May 2022
  
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  DOI: 10.1016/j.molcel.2022.04.031
  
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sciencedirect.com/science/article/pii/S109727652200394X
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The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62

1
1. scibot 11 May 2022
  
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  RRID:AB_2572318
  
  DOI: 10.1016/j.celrep.2022.110792
  
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sciencedirect.com/science/article/pii/S2211124722005599
Oct 2021
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PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination

1
1. scibot 06 Oct 2021
  
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  RRID:AB_2572318
  
  DOI: 10.1016/j.celrep.2021.109695
  
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sciencedirect.com/science/article/pii/S2211124721011426
Jul 2021
www.cell.com www.cell.com

Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency

1
1. scibot 03 Jul 2021
  
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  RRID:AB_2572318
  
  DOI: 10.1016/j.molcel.2021.06.011
  
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cell.com/molecular-cell/fulltext/S1097-2765(21)00458-5
May 2021
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Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability

1
1. scibot 07 May 2021
  
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  RRID:AB_2572318
  
  DOI: 10.1016/j.molcel.2020.06.028
  
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sciencedirect.com/science/article/pii/S1097276520304305
Sep 2020
elifesciences.org elifesciences.org

PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response

1
1. scibot 16 Sep 2020
  
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  RRID:AB_2572318
  
  DOI: 10.7554/eLife.60637
  
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  Curator: @evieth
  
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  RRIDCUR:Validated RRID:AB_2572318
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elifesciences.org/articles/60637
Jan 2020
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Poly(ADP-Ribose) Polymerase 2 Recruits Replication Protein A to Sites of LINE-1 Integration to Facilitate Retrotransposition

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2572318
  
  DOI: 10.1016/j.molcel.2019.07.018
  
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  Curator: @ethanbadger
  
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sciencedirect.com/science/article/pii/S1097276519305489
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Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2572318
  
  DOI: 10.1016/j.celrep.2019.05.058
  
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sciencedirect.com/science/article/pii/S2211124719306874
Nov 2017
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice

1
1. scibot 08 Nov 2017
  
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  AB_2572318
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5214542/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Inhibition of Poly-ADP-Ribosylation Fails to Increase Axonal Regeneration or Improve Functional Recovery after Adult Mammalian CNS Injury

1
1. scibot 08 Nov 2017
  
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  AB_2572318
  
  Curator: @gabimpine
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5187389/