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The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility

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  DOI: 10.1016/j.celrep.2025.116475
  
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sciencedirect.com/science/article/pii/S221112472501246X
Oct 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Antineoplastic Activity of a Novel Trispecific Single-Chain Antibody Targeting the hERG1/β1 Integrin Complex and TRAIL Receptors

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1. scibot 03 Oct 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0646
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12485380/
Sep 2025
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α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation

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  DOI: 10.1016/j.molcel.2025.08.022
  
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sciencedirect.com/science/article/pii/S1097276525007075
Aug 2025
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41594_2025_1631_MOESM4_ESM-html.html

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  DOI: 10.5281/zenodo.14243720
  
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52.53.155.43/2894f1585e3ca7aaaea575ab75ca401271c73618/41594_2025_1631_MOESM4_ESM-html.html
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p75NTR modulation prevents cellular, cortical activity and cognitive dysfunctions caused by perinatal hypoxia

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  DOI: 10.1093/brain/awaf084
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12316007/
Jul 2025
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Glucose-activated JMJD1A drives visceral adipogenesis via α-ketoglutarate-dependent chromatin remodeling

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  DOI: 10.1016/j.celrep.2025.116060
  
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Competence for transcellular infection in the root cortex involves a post-replicative, cell-cycle exit decision in Medicago truncatula

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1. scibot 08 Jul 2025
  
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  DOI: 10.7554/eLife.88588
  
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elifesciences.org/articles/88588
Jun 2025
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M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury

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  DOI: 10.4103/1673-5374.324858
  
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journals.lww.com/nrronline/fulltext/2022/05000/m1_type_microglia_can_induce_astrocytes_to_deposit.34.aspx
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MyD88 signalling in B cells and antibody responses during Oropouche virus-induced neurological disease in mice

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.ebiom.2025.105815
  
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thelancet.com/journals/ebiom/article/PIIS2352-3964(25)00259-2/abstract
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PDF-html.html

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  DOI: 10.1093/braincomms/fcaf224
  
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52.53.155.43/4a6a966e38c69c020e4968e09e6c8a3a036414fb/fcaf224-html.html
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Trametinib potentiates anti-PD-1 efficacy in tumors established from chemotherapy-primed pancreatic cancer cells

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  DOI: 10.1158/1535-7163.MCT-23-0833
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11614707/
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Development of Competitive ELISAs Suitable for Detection of Recombinant Human Growth Hormone in Illegal Nutritional Supplements

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1. scibot 11 Jun 2025
  
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  DOI: 10.1155/jamc/3021570
  
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onlinelibrary.wiley.com/doi/10.1155/jamc/3021570
May 2025
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1-s2.0-S2589004225009927-main-html.html

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.isci.2025.112731
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12172992/
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Increasing the developability of lambda chain antibodies: engineering to confer protein L binding activity and its consequences

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  DOI: 10.1016/j.ijbiomac.2025.144177
  
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sciencedirect.com/science/article/pii/S0141813025047294
Apr 2025
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Proton perception and activation of a proton-sensing GPCR

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1. scibot 11 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.02.030
  
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sciencedirect.com/science/article/pii/S1097276525001923
Jan 2025
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Histone-binding protein RBBP4 is necessary to promote neurogenesis in the developing mouse neocortical progenitors

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1. scibot 30 Jan 2025
  
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  DOI: 10.1523/ENEURO.0391-23.2024
  
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eneuro.org/content/11/12/ENEURO.0391-23.2024
Nov 2024
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Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer

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1. scibot 08 Nov 2024
  
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  DOI: 10.1158/0008-5472.CAN-23-3574
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11532783/
Oct 2024
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Inhibitors of the small membrane (M) protein viroporin prevent Zika virus infection

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1. scibot 06 Oct 2024
  
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  DOI: 10.7554/eLife.68404
  
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elifesciences.org/articles/68404
Sep 2024
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Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer

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  DOI: 10.1038/s41467-024-52523-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11410950/
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Adipose ADM2 ameliorates NAFLD via promotion of ceramide catabolism

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  DOI: 10.1016/j.apsb.2024.09.010
  
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sciencedirect.com/science/article/pii/S2211383524003733
Aug 2024
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Chronic Lithium Treatment Alters NMDA and AMPA Receptor Synaptic Availability and Dendritic Spine Organization in the Rat Hippocampus

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1. scibot 23 Aug 2024
  
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  DOI: 10.2174/1570159X21666230913144420
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11333793/
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The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins

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sciencedirect.com/science/article/pii/S221112472400977X
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Sigma-1 receptor recruits LC3 mRNA to ER-associated omegasomes to promote localized LC3 translation enabling functional autophagy

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1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114619
  
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sciencedirect.com/science/article/pii/S2211124724009690
Jul 2024
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A methodology to globally assess ectodomain shedding using soluble fractions from the mouse brain

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  DOI: 10.3389/fpsyt.2024.1367526
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11219901/
Jun 2024
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The Exocyst Complex is Required for the Trafficking and Delivery of KCa3.1 to the Basolateral Membrane of Polarized Epithelia

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  DOI: 10.1152/ajpcell.00374.2022
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10243536/
May 2024
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Autophagy preferentially degrades non-fibrillar polyQ aggregates

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  DOI: 10.1016/j.molcel.2024.04.018
  
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sciencedirect.com/science/article/pii/S1097276524003836
www.biorxiv.org www.biorxiv.org

p75NTR upregulation following perinatal hypoxia leads to deficits in parvalbumin-expressing GABAergic cell maturation, cortical activity and cognitive abilities in adult mice

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1. scibot 03 May 2024
  
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  DOI: 10.1101/2024.01.16.574659
  
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biorxiv.org/content/10.1101/2024.01.16.574659v1
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A dynamin superfamily-like pseudoenzyme coordinates with MICOS to promote cristae architecture

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  DOI: 10.1016/j.cub.2024.04.028
  
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sciencedirect.com/science/article/pii/S0960982224004688
Apr 2024
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Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress

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  DOI: 10.1016/j.celrep.2024.114069
  
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sciencedirect.com/science/article/pii/S2211124724003978
Feb 2024
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A metabolically controlled contact site between vacuoles and lipid droplets in yeast

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  DOI: 10.1016/j.devcel.2024.01.016
  
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  DOI: 10.1016/j.devcel.2024.01.016
  
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sciencedirect.com/science/article/pii/S1534580724000364
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SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability

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  DOI: 10.1016/j.celrep.2024.113778
  
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sciencedirect.com/science/article/pii/S2211124724001062
Jan 2024
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Riboproteome remodelling during quiescence exit in Saccharomyces cerevisiae

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1. scibot 20 Jan 2024
  
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  DOI: 10.1016/j.isci.2023.108727
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10792236/
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Conformational transitions and activation of the adhesion receptor CD97

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  DOI: 10.1016/j.molcel.2023.12.020
  
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sciencedirect.com/science/article/pii/S1097276523010390
Dec 2023
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Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies

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  DOI: 10.1016/j.molcel.2023.11.027
  
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Apolipoprotein E (ApoE) orchestrates adipose tissue inflammation and metabolic disorders through NLRP3 inflammasome

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  RRID:AB_258167
  
  DOI: 10.1186/s43556-023-00158-8
  
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CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice

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  DOI: 10.1038/s41467-023-42595-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10684560/
Oct 2023
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Cerebral organoids derived from patients with Alzheimer’s disease with PSEN1/2 mutations have defective tissue patterning and altered development

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  DOI: 10.1016/j.celrep.2023.113310
  
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Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy

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Immune–epithelial cell cross-talk enhances antiviral responsiveness to SARS-CoV-2 in children

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  DOI: 10.15252/embr.202357912
  
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Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth

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  DOI: 10.15252/embj.2023114032
  
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The senescent secretome drives PLVAP expression in cultured human hepatic endothelial cells to promote monocyte transmigration

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  DOI: 10.1016/j.isci.2023.107966
  
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sciencedirect.com/science/article/pii/S2589004223020436
Sep 2023
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Signaling protein abundance modulates the strength of the spindle assembly checkpoint

1
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  DOI: 10.1016/j.cub.2023.08.074
  
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Lorazepam Stimulates IL6 Production and Is Associated with Poor Survival Outcomes in Pancreatic Cancer

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  DOI: 10.1158/1078-0432.CCR-23-0547
  
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Jul 2023
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Flat clathrin lattices are linked to metastatic potential in colorectal cancer

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  DOI: 10.1016/j.isci.2023.107327
  
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Picolinic acid is a broad-spectrum inhibitor of enveloped virus entry that restricts SARS-CoV-2 and influenza A virus in vivo

1
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  DOI: 10.1016/j.xcrm.2023.101127
  
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Jun 2023
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Effects of Dietary Oleacein Treatment on Endothelial Dysfunction and Lupus Nephritis in Balb/C Pristane-Induced Mice

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  DOI: 10.3390/antiox12061303
  
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mdpi.com/2076-3921/12/6/1303
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Integrator facilitates RNAPII removal to prevent transcription-replication collisions and genome instability

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  DOI: 10.1016/j.molcel.2023.05.015
  
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Human Tim8a, Tim8b and Tim13 are auxiliary assembly factors of mature Complex IV

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  DOI: 10.15252/embr.202256430
  
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embopress.org/doi/10.15252/embr.202256430
Apr 2023
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Interaction between GPR110 (ADGRF1) and tight junction protein occludin implicated in blood-brain barrier permeability

1
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  DOI: 10.1016/j.isci.2023.106550
  
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Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation

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  DOI: 10.1016/j.cmet.2023.03.019
  
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Macrophage CD5L is a target for cancer immunotherapy

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  DOI: 10.1016/j.ebiom.2023.104555
  
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CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth

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  DOI: 10.1016/j.celrep.2023.112316
  
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sciencedirect.com/science/article/pii/S2211124723003273
Feb 2023
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DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops

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  DOI: 10.1016/j.celrep.2023.112148
  
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The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system

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  DOI: 10.1038/s41467-023-36058-2
  
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nature.com/articles/s41467-023-36058-2
Jan 2023
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SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum

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  DOI: 10.1016/j.celrep.2023.112028
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10010011/
Dec 2022
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Ring domains are essential for GATOR2-dependent mTORC1 activation

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  DOI: 10.1016/j.molcel.2022.11.021
  
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Sep 2022
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Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia

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Humanized zebrafish as a tractable tool for in vivo evaluation of pro-myelinating drugs

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  DOI: 10.1016/j.chembiol.2022.08.007
  
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sciencedirect.com/science/article/pii/S2451945622003154
Jul 2022
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A non-transcriptional function of Yap regulates the DNA replication program in Xenopus laevis

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  DOI: 10.7554/eLife.75741
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9328763/
Jun 2022
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The ER ladder is a unique morphological feature of developing mammalian axons

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  DOI: 10.1016/j.devcel.2022.05.002
  
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sciencedirect.com/science/article/pii/S1534580722003306
May 2022
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Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis

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sciencedirect.com/science/article/pii/S1534580722002866
Apr 2022
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Structural insights into cooperative DNA recognition by the CCAAT-binding complex and its bZIP transcription factor HapX

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  DOI: 10.1016/j.str.2022.04.001
  
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Regulation of Il6 expression by single CpG methylation in downstream of Il6 transcription initiation site

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  DOI: 10.1016/j.isci.2022.104118
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8983349/
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MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells

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  DOI: 10.1016/j.celrep.2022.110602
  
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Functional Assessment of Calcium-Sensing Receptor Variants Confirms Familial Hypocalciuric Hypercalcaemia

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  DOI: 10.1210/jendso/bvac025
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8962451/
Mar 2022
onlinelibrary.wiley.com onlinelibrary.wiley.com

Cortical reorganization of the glutamate synapse in the activity-based anorexia rat model: impact on cognition

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  DOI: 10.1111/jnc.15605
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15605
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Nitric oxide regulates adhesiveness, invasiveness, and migration of anoikis-resistant endothelial cells

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  DOI: 10.1590/1414-431X2021e11612
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8851903/
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BPS Publications

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  DOI: 10.1111/bph.15749
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15749
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Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin

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  DOI: 10.1016/j.celrep.2022.110441
  
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sciencedirect.com/science/article/pii/S2211124722001681
Feb 2022
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E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression

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  DOI: 10.1016/j.molcel.2022.01.002
  
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sciencedirect.com/science/article/pii/S1097276522000028
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Stabilization and structure determination of integral membrane proteins by termini restraining

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Acetylation-dependent regulation of BRAF oncogenic function

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An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance

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High-titer neutralization of Mu and C.1.2 SARS-CoV-2 variants by vaccine-elicited antibodies of previously infected individuals

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Aurora B phosphorylates Bub1 to promote spindle assembly checkpoint signaling

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Interplay between protein acetylation and ubiquitination controls MCL1 protein stability

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Partial resistance of SARS-CoV-2 Delta variants to vaccine-elicited antibodies and convalescent sera

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RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

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A Note of Caution: Gramicidin Affects Signaling Pathways Independently of Its Effects on Plasma Membrane Conductance

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Liquid culture system for efficient depletion of the endogenous nutrients in Arabidopsis seedlings

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Synthetic biosensor accelerates evolution by rewiring carbon metabolism toward a specific metabolite

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Untitled document

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Investigation of Ldb19/Art1 localization and function at the late Golgi

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Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation

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A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling

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Recruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein Biogenesis

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Quercetin Enhances the Anti-Tumor Effects of BET Inhibitors by Suppressing hnRNPA1

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  anti-mouse IgG
  
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Untitled document

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A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling

1
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Untitled document

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Development and Characterization of Novel Endoxifen-Resistant Breast Cancer Cell Lines Highlight Numerous Differences from Tamoxifen-Resistant Models

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Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G4C2 RNA in a cellular model

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Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs

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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

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Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells

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Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

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GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme

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Intein-mediated cytoplasmic reconstitution of a split toxin enables selective cell ablation in mixed populations and tumor xenografts

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Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites

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Calmodulin binds to Drosophila TRP with an unexpected mode

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cell.com/structure/abstract/S0969-2126(20)30463-9
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Parthenolide Destabilizes Microtubules by Covalently Modifying Tubulin

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cell.com/current-biology/fulltext/S0960-9822(20)31768-1
Dec 2020
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An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2

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Nov 2020
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Microtubule Attachment and Centromeric Tension Shape the Protein Architecture of the Human Kinetochore

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In utero exposure to maternal diabetes impairs nephron progenitor differentiation

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  DOI: 10.1152/ajprenal.00204.2019
  
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Oct 2020
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Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo

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Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner

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Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations

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Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding

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A Non-Replicative Role of the 3′ Terminal Sequence of the Dengue Virus Genome in Membranous Replication Organelle Formation

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Complementary α-arrestin-ubiquitin ligase complexes control nutrient transporter endocytosis in response to amino acids

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The YEATS Domain Histone Crotonylation Readers Control Virulence-Related Biology of a Major Human Pathogen

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Sleep deprivation regulates availability of PrPC and Aβ peptides which can impair interaction between PrPC and laminin and neuronal plasticity

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Chromatin Hyperacetylation Impacts Chromosome Folding by Forming a Nuclear Subcompartment

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Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1

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Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase

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Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability

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Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila

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Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction

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CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity

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p75 Neurotrophin Receptor Activation Regulates the Timing of the Maturation of Cortical Parvalbumin Interneuron Connectivity and Promotes Juvenile-like Plasticity in Adult Visual Cortex

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Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops

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ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12–ATG5-ATG16L1 complex assembly and autophagy

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Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly

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Signaling pathways in cytoskeletal responses to plasma membrane depolarization in corneal endothelial cells

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TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

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Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time

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Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila

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Arabidopsis ARGONAUTE 1 Binds Chromatin to Promote Gene Transcription in Response to Hormones and Stresses

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Actin Cross-Linking Toxin Is a Universal Inhibitor of Tandem-Organized and Oligomeric G-Actin Binding Proteins

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Repurposing HAMI3379 to Block GPR17 and Promote Rodent and Human Oligodendrocyte Differentiation

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Intrinsic Ribosome Destabilization Underlies Translation and Provides an Organism with a Strategy of Environmental Sensing

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NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis

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sciencedirect.com/science/article/pii/S1097276517307931
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Engineered Multivalent Sensors to Detect Coexisting Histone Modifications in Living Stem Cells

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Untitled document

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europepmc.org/articles/PMC5665648/
Nov 2017
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RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis

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f1000research.com f1000research.com

Reactivity of vertebrate-directed phospho-eEF2 antibody against the <i>Caenorhabditis elegans </i>orthologue phospho-EEF-2

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f1000research.com/articles/4-902/v1

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