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Jun 2026
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An orally active dual CBP/p300 degrader targets core dependencies of multiple myeloma

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1. scibot 04 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117464
  
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sciencedirect.com/science/article/pii/S2211124726005425
May 2026
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eIF4G2-mediated selective translation of chromatin regulators safeguards adult intestinal stem cell identity and differentiation

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1. scibot 01 May 2026
  
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  DOI: 10.1016/j.stem.2026.04.006
  
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sciencedirect.com/science/article/pii/S1934590926001463
Apr 2026
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Vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via N-bc2S1P synthesis on neonatal skin

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1. scibot 24 Apr 2026
  
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  DOI: 10.1016/j.chom.2026.03.023
  
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sciencedirect.com/science/article/pii/S1931312826001319
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Activation of T cell-intrinsic p53 by acetylation elicits antitumor immunity to boost cancer immunotherapy

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1. scibot 23 Apr 2026
  
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  DOI: 10.1158/2159-8290.CD-25-0649
  
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aacrjournals.org/cancerdiscovery/article/16/1/155/771238/Activation-of-T-Cell-Intrinsic-p53-by-Acetylation
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eIF4G2-dependent translation restrains pancreatic cancer progression

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1. scibot 16 Apr 2026
  
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  DOI: 10.64898/2026.03.14.711799
  
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biorxiv.org/content/10.64898/2026.03.14.711799v1
Mar 2026
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CBP-IDRs regulate acetylation and gene expression

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1. scibot 13 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117109
  
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sciencedirect.com/science/article/pii/S2211124726001877
Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

NAT10 promotes cancer metastasis by modulating p300/CBP activity through chromatin-associated tRNA

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1. scibot 04 Dec 2025
  
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  DOI: 10.1016/j.molcel.2025.11.010
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12709618/
Oct 2025
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A non-canonical immunometabolic function of BRD3 during sepsis

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1. scibot 22 Oct 2025
  
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  DOI: 10.1016/j.devcel.2025.09.016
  
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sciencedirect.com/science/article/pii/S153458072500601X
Aug 2025
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Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation

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1. scibot 07 Aug 2025
  
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  DOI: 10.1016/j.cell.2025.07.014
  
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sciencedirect.com/science/article/pii/S0092867425008037
May 2025
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Transcription factor cooperativity at a GATA3 tandem DNA sequence determines oncogenic enhancer-mediated activation

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115705
  
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sciencedirect.com/science/article/pii/S2211124725004760
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KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy

1
1. scibot 16 May 2025
  
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  DOI: 10.1016/j.ccell.2025.04.002
  
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sciencedirect.com/science/article/pii/S1535610825001394
Mar 2025
52.53.155.43 52.53.155.43

PDF-html.html

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1. scibot 26 Mar 2025
  
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  DOI: 10.1101/2025.03.14.643362
  
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52.53.155.43/4904a6ac570ee0a188db9dcfa738bde65420458f/PDF-html.html
Feb 2025
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H4K12 lactylation potentiates mitochondrial oxidative stress via the Foxo1 pathway in diabetes-induced cognitive impairment

1
1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.jare.2025.02.020
  
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sciencedirect.com/science/article/pii/S2090123225001183
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Proximity proteomic analysis of the NRF family reveals the Parkinson's disease protein ZNF746/PARIS as a co-complexed repressor of NRF2

1
1. scibot 13 Dec 2024
  
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  AB_2616020
  
  DOI: 10.1126/scisignal.adi9018
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10760916/
Nov 2024
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Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to modulate renal fibrosis through alternative splicing-mediated upregulation of CCN2

1
1. scibot 17 Nov 2024
  
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  DOI: 10.7554/eLife.98524
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11534337/
Sep 2024
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Global isonicotinylome analysis identified SMAD3 isonicotinylation promotes liver cancer cell epithelial–mesenchymal transition and invasion

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110775
  
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sciencedirect.com/science/article/pii/S2589004224020005
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TGF-β and RAS jointly unmask primed enhancers to drive metastasis

1
1. scibot 10 Sep 2024
  
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  AB_2616020
  
  DOI: 10.1016/j.cell.2024.08.014
  
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sciencedirect.com/science/article/pii/S009286742400905X
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread

1
1. scibot 21 Aug 2024
  
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  AB_2616020
  
  DOI: 10.1016/j.celrep.2024.114484
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11316253/
Jul 2024
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Discovery of a peptide proteolysis-targeting chimera (PROTAC) drug of p300 for prostate cancer therapy

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1. scibot 16 Jul 2024
  
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  DOI: 10.1016/j.ebiom.2024.105212
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11261775/
Jan 2024
www.science.org www.science.org

Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2

1
1. scibot 12 Jan 2024
  
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  AB_2616020
  
  DOI: 10.1126/scisignal.adi9018
  
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science.org/doi/10.1126/scisignal.adi9018
Dec 2023
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Metabolic regulation of homologous recombination repair by MRE11 lactylation

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1. scibot 22 Dec 2023
  
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  DOI: 10.1016/j.cell.2023.11.022
  
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sciencedirect.com/science/article/pii/S009286742301276X
Nov 2023
www.embopress.org www.embopress.org

SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1

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1. scibot 03 Nov 2023
  
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  RRID:AB_2616020
  
  DOI: 10.15252/embr.202357500
  
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embopress.org/doi/10.15252/embr.202357500
Sep 2023
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TGS1/PIMT knockdown reduces lipid accumulation in adipocytes, limits body weight gain and promotes insulin sensitivity in mice

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1. scibot 30 Sep 2023
  
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  DOI: 10.1016/j.bbadis.2023.166896
  
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sciencedirect.com/science/article/pii/S0925443923002624
Aug 2023
52.53.155.43 52.53.155.43

NFYC-37 promotes tumor growth by activating the mevalonate pathway in bladder cancer

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1. scibot 17 Aug 2023
  
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  RRID:AB_2616020
  
  DOI: 10.1016/j.celrep.2023.112963
  
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2. scibot 10 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112963
  
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52.53.155.43/eb7aace05cf7a189f4453bfbeb3bcf344412f769/mmc4-html.html
Jul 2023
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A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression

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1. scibot 27 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112833
  
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sciencedirect.com/science/article/pii/S2211124723008446
May 2023
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Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells

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1. scibot 05 May 2023
  
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  DOI: 10.1002/cac2.12332
  
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onlinelibrary.wiley.com/doi/10.1002/cac2.12332
Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer

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1. scibot 16 Mar 2023
  
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  DOI: 10.1158/1078-0432.CCR-21-3603
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9481728/
Jan 2023
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EKLF/Klf1 regulates erythroid transcription by its pioneering activity and selective control of RNA Pol II pause-release

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1. scibot 28 Jan 2023
  
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  DOI: 10.1016/j.celrep.2022.111830
  
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sciencedirect.com/science/article/pii/S2211124722017223
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Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress

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1. scibot 28 Jan 2023
  
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  DOI: 10.1016/j.celrep.2023.112041
  
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sciencedirect.com/science/article/pii/S2211124723000529
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Cancer stem cells, not bulk tumor cells, determine mechanisms of resistance to SMO inhibitors

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1. scibot 25 Jan 2023
  
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  DOI: 10.1158/2767-9764.crc-22-0124
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9853917/
Aug 2022
52.53.155.43 52.53.155.43

ccr-21-3603-html.html

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1. scibot 27 Aug 2022
  
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  DOI: 10.1158/1078-0432.CCR-21-3603
  
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52.53.155.43/de81104a0064110ab6f8eb2e443412de8e9dbc9e/ccr-21-3603-html.html
Jul 2022
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Inhibition of SIRT2 promotes APP acetylation and ameliorates cognitive impairment in APP/PS1 transgenic mice

1
1. scibot 13 Jul 2022
  
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  DOI: 10.1016/j.celrep.2022.111062
  
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sciencedirect.com/science/article/pii/S2211124722008609
Jun 2022
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Cancer Stem Cells, not Bulk Tumor Cells, Determine Mechanisms of Resistance to SMO Inhibitors

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1. scibot 15 Jun 2022
  
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  DOI: 10.1158/2767-9764.CRC-22-0124
  
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aacrjournals.org/cancerrescommun/article/2/6/402/699311/Cancer-Stem-Cells-not-Bulk-Tumor-Cells-Determine
Apr 2022
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 05 Apr 2022
  
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  RRID:AB_2616020
  
  DOI: 10.1111/bph.15763
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15763
Jan 2022
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Histone Acetylation Defects in Brain Precursor Cells: A Potential Pathogenic Mechanism Causing Proliferation and Differentiation Dysfunctions in Mitochondrial Aspartate-Glutamate Carrier Isoform 1 Deficiency

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1. scibot 28 Jan 2022
  
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  DOI: 10.3389/fncel.2021.773709
  
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2. scibot 28 Jan 2022
  
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  DOI: 10.3389/fncel.2021.773709
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8790092/
Nov 2021
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Interplay between protein acetylation and ubiquitination controls MCL1 protein stability

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1. scibot 10 Nov 2021
  
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  DOI: 10.1016/j.celrep.2021.109988
  
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sciencedirect.com/science/article/pii/S2211124721014674
Oct 2021
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Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity

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1. scibot 29 Oct 2021
  
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  DOI: 10.1016/j.isci.2021.103177
  
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sciencedirect.com/science/article/pii/S2589004221011457
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NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain

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1. scibot 12 Oct 2021
  
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  DOI: 10.1016/j.molcel.2021.09.020
  
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Aug 2021
academic.oup.com academic.oup.com

Gestational Diabetes Epigenetically Reprograms the Cart Promoter in Fetal Ovary, Causing Subfertility in Adult Life

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1. scibot 04 Aug 2021
  
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  RRID:AB_2616020
  
  DOI: 10.1210/en.2019-00319
  
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academic.oup.com/endo/article/160/7/1684/5506444
Apr 2021
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SIRT6-CBP-dependent nuclear Tau accumulation and its role in protein synthesis

1
1. scibot 28 Apr 2021
  
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  RRID:AB_2616020
  
  DOI: 10.1016/j.celrep.2021.109035
  
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Reducing acetylated tau is neuroprotective in brain injury

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1. scibot 14 Apr 2021
  
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  DOI: 10.1016/j.cell.2021.03.032
  
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sciencedirect.com/science/article/pii/S0092867421003639
Feb 2021
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Targeted degradation of the enhancer lysine acetyltransferases CBP and p300

1
1. scibot 28 Feb 2021
  
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  RRID:AB_2616020
  
  DOI: 10.1016/j.chembiol.2020.12.004
  
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Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma

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1. scibot 28 Feb 2021
  
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  RRID:AB_2616020
  
  DOI: 10.1016/j.cmet.2020.12.011
  
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The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages

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1. scibot 25 Feb 2021
  
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  DOI: 10.1016/j.molcel.2020.12.040
  
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sciencedirect.com/science/article/pii/S1097276520309618
Jan 2020
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Untitled document

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.02.035
  
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sciencedirect.com/science/article/pii/S2211124719302062
Nov 2018
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Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors

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1. scibot 05 Nov 2018
  
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  Curator: @Jmenke
  
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cell.com/cell/fulltext/S0092-8674(18)31119-X