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Cullin-3 adaptor SHKBP1 inhibits SQSTM1/p62 oligomerization and Keap1 sequestration

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  DOI: 10.1083/jcb.202501207
  
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Jan 2026
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FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion

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Limiting ER-associated degradation capacity triggers acute and chronic effects on insulin biosynthesis

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Cysteine allostery and autoinhibition govern human STING oligomer functionality

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Calcium overload induced mitochondrial and lysosomal dysfunction is regulated by Tousled-like kinase in a-synucleinopathy

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EBV infection and HLA-DR15 jointly drive multiple sclerosis by myelin peptide presentation

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  DOI: 10.1016/j.cell.2025.12.046
  
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Dec 2025
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Akt2 regulates autophagy and osteogenesis in diabetic osteoporosis via PI3K/AKT/mTOR signaling axis

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misra-et-al-2025-fam134b-controls-collagen-i-dynamics-in-hepatic-stellate-cell-driven-fibrosis-html.html

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Nov 2025
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Delivering Progranulin to Astrocytic Lysosomes Promotes Growth of Co‐Cultured Neurons

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Stra8 links neuronal activity to inhibitory circuit protection in the adult mouse brain

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Identification of ATG7 as a protein ATG8ylation substrate

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Sep 2025
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Pharmacological and toxicological profiling of JAMC-4/108: targeted induction of apoptosis in human colorectal cancer cells

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Targeting AQP5-mediated arginine deprivation in gastric cancer stem cells restores NK cell anti-tumor immunity

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Aug 2025
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PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer

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TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation

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Microcystin-LR hijacks mitochondrial bioenergetics and Wnt crosstalk: Unveiling a novel dual-pathway mechanism for adipogenesis dysregulation in environmental toxicology

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1. scibot 19 Aug 2025
  
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52.53.155.43/3af1c841c2bdd5eb801f1e97e5d21ecf6662ffe6/1-s2.0-S1532045625002108-main-html.html
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1-s2.0-S1532045625002108-main-html.html

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52.53.155.43/4ad8b2adc564ab28a95d5ab5cbd57c41c85e5f0e/1-s2.0-S1532045625002108-main-html.html
Jul 2025
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Lactoferrin attenuates renal fibrosis and uremic sarcopenia in a mouse model of adenine-induced chronic kidney disease

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May 2025
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Tomatidine Ameliorates Diabetes-Induced Cognitive Impairment and Tau Hyperphosphorylation Through the AMPK-TFEB Pathway

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1. scibot 29 May 2025
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.70087
Apr 2025
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Inflammation-responsive biomimetic nanoparticles with epigallocatechin-3-gallate for acute lung injury therapy via autophagy enhancement

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Mar 2025
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PDF-html.html

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Induction of MASH-like pathogenesis in the Nwd1−/− mouse liver

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A highland-adaptation variant near MCUR1 reduces its transcription and attenuates erythrogenesis in Tibetans

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  DOI: 10.1016/j.xgen.2025.100782
  
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Feb 2025
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1-s2.0-S2589004225003785-main-html.html

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1-s2.0-S2589004225002731-main-html.html

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Jan 2025
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Biotransformation of Ganoderma lucidum and Hericium erinaceus for ex vivo gut-brain axis modulation and mood-related outcomes in humans: CREB/BDNF signaling and microbiota-driven synergies

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sciencedirect.com/science/article/pii/S0378874125000765
Dec 2024
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Mechanism of enhancing chemotherapy efficacy in pancreatic ductal adenocarcinoma with paricalcitol and hydroxychloroquine

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cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00652-9
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MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics

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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury: PERK as a potential target for intervention

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  DOI: 10.4103/NRR.NRR-D-23-00794
  
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Nucleo-cytosolic acetyl-CoA drives tumor immune evasion by regulating PD-L1 in melanoma

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DEP-1 is a brain insulin receptor phosphatase that prevents the simultaneous activation of counteracting metabolic pathways

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Nov 2024
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Acidic Nanoparticles Restore Lysosomal Acidification and Rescue Metabolic Dysfunction in Pancreatic β-Cells under Lipotoxic Conditions

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  DOI: 10.1021/acsnano.3c09206
  
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  DOI: 10.1021/acsnano.3c09206
  
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Reprogramming of fibroblasts into cancer-associated fibroblasts via IGF2-mediated autophagy promotes metastasis of lung cancer cells

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  DOI: 10.1016/j.isci.2024.111269
  
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Contactin -Associated protein1 Regulates Autophagy by Modulating the PI3K/AKT/mTOR Signaling Pathway and ATG4B Levels in Vitro and in Vivo

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Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy

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Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α–AKT–mTOR pathway in esophageal squamous cell carcinoma

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  12741
  
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Garcinia cambogia attenuates adipogenesis by affecting CEBPB and SQSTM1/p62-mediated selective autophagic degradation of KLF3 through RPS6KA1 and STAT3 suppression

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Cell-specific Nav1.6 knockdown reduced astrocyte-derived Aβ by reverse Na+-Ca2+ transporter-mediated autophagy in alzheimer-like mice

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BPS Publications

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  DOI: 10.1111/bph.16484
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16484
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Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance

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Induction of NASH in the Nwd1−/− mouse liver via SERCA2-dependent endoplasmic reticulum stress

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  DOI: 10.1101/2024.01.26.577307
  
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biorxiv.org/content/10.1101/2024.01.26.577307v2
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PRODH safeguards human naive pluripotency by limiting mitochondrial oxidative phosphorylation and reactive oxygen species production

2
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  Cell signalingCat#12741;RRID:AB_2617131
  
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PRODH safeguards human naive pluripotency by limiting mitochondrial oxidative phosphorylation and reactive oxygen species production

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HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression

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Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury

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Bacterial muropeptides promote OXPHOS and suppress mitochondrial stress in mammals

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Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability

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Feb 2024
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hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility

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HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance

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  DOI: 10.1101/2023.12.05.570182
  
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A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass

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Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease

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Nuclear localization of STING1 competes with canonical signaling to activate AHR for commensal and intestinal homeostasis

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E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC

1
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Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease

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Blocking AMPKαS496 phosphorylation improves mitochondrial dynamics and hyperglycemia in aging and obesity

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Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance

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S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy

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The heat shock protein Hsp27 controls mitochondrial function by modulating ceramide generation

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BPS Publications

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52.53.155.43/6079453bbbf12bd08872d5439d37d8b14bece994/British J Pharmacology - 2023 - Chen - DADLE promotes motor function recovery by inhibiting cytosolic phospholipase A2-html.html
Aug 2023
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Autophagy ablation in skeletal muscles worsens sepsis-induced muscle wasting, impairs whole-body metabolism, and decreases survival.

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  DOI: 10.1016/j.isci.2023.107475
  
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The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress

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Jul 2023
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SSRN-id4280868-html.html

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ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway

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Jun 2023
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SSRN-id4280868-html.html

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Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation

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Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer

1
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  DOI: 10.1158/0008-5472.CAN-22-2525
  
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Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion

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PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway

1
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  DOI: 10.1016/j.celrep.2023.112519
  
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Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease

1
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  DOI: 10.1038/s41467-023-38165-6
  
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Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity

1
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  DOI: 10.1016/j.celrep.2023.112447
  
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Determination of the autophagic flux in murine and human peripheral blood mononuclear cells

1
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  DOI: 10.3389/fcell.2023.1122998
  
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Myocardial structure and functional alterations in a preclinical model of exertional heat stroke

1
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Cold exposure alters lipid metabolism of skeletal muscle through HIF-1α-induced mitophagy

1
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  DOI: 10.1186/s12915-023-01514-4
  
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Dec 2022
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Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis

1
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USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction

1
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  DOI: 10.1016/j.celrep.2022.111653
  
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Nov 2022
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Liver autophagy-induced valine and leucine in plasma reflect the metabolic effect of sodium glucose co-transporter 2 inhibitor dapagliflozin

1
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  DOI: 10.1016/j.ebiom.2022.104342
  
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Oct 2022
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SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis

1
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Sox9 mediates Autophagy-dependent vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis

1
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  DOI: 10.1016/j.isci.2022.105161
  
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Sep 2022
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PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer

1
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  DOI: 10.1016/j.xcrm.2022.100741
  
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Aug 2022
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Glutamine metabolism modulates chondrocyte inflammatory response

1
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  DOI: 10.7554/eLife.80725
  
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Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance

2
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  DOI: 10.1126/sciadv.abo3610
  
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T cells mediate kidney tubular injury via impaired PDHA1 and Autophagy in type 1 diabetes

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  DOI: 10.1210/clinem/dgac378
  
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academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac378/6613175
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Upregulation of FOXO1 contributes to lipopolysaccharide-induced pulmonary endothelial injury by induction of autophagy

1
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  DOI: 10.21037/atm-21-5380
  
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Mar 2022
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Urolithin A alleviates blood-brain barrier disruption and... : Neural Regeneration Research

1
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  DOI: 10.4103/1673-5374.335163
  
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journals.lww.com/nrronline/Fulltext/2022/17090/Urolithin_A_alleviates_blood_brain_barrier.32.aspx
Feb 2022
onlinelibrary.wiley.com onlinelibrary.wiley.com

Autophagic and apoptotic cell death induced by the quinoline derivative 2-(6-methoxynaphthalen-2-yl)quinolin-4-amine in pancreatic cancer cells is via ER stress and inhibition of Akt/mTOR signaling pathway

1
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onlinelibrary.wiley.com/doi/10.1002/ddr.21916
Jan 2022
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Approaches and Protocols to Analyze Autophagy and Its Role in Death of Apoptosis-Resistant Senescent Tumor Cells

1
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  DOI: 10.1007/978-1-0716-2071-7_10
  
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Dec 2021
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Differential Autophagy Response in Men and Women After Muscle Damage

1
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  DOI: 10.3389/fphys.2021.752347
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8652069/
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Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells

1
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  DOI: 10.1158/0008-5472.CAN-20-3371
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8178204/
Oct 2021
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Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination

1
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  DOI: 10.7554/eLife.66278
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8478418/
Sep 2021
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Roles of autophagy in relation to mitochondrial stress responses of HeLa cells to lamellarin cytotoxicity

1
1. scibot 28 Sep 2021
  
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  DOI: 10.1016/j.tox.2021.152963
  
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Aug 2021
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Apocynin prevents cigarette smoking‐induced loss of skeletal muscle mass and function in mice by preserving proteostatic signalling

1
1. scibot 19 Aug 2021
  
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  DOI: 10.1111/bph.15482
  
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Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation

1
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  DOI: 10.1016/j.molcel.2019.03.021
  
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Genetically incorporated crosslinkers reveal NleE attenuates host autophagy dependent on PSMD10

1
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  DOI: 10.7554/eLife.69047
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8324295/
Jul 2021
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Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells

1
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  DOI: 10.1016/j.devcel.2021.06.011
  
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sciencedirect.com/science/article/pii/S1534580721005189
Feb 2021
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Hyperthermia Increases Neurotoxicity Associated with Novel Methcathinones

1
1. scibot 25 Feb 2021
  
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  RRID:AB_2617131
  
  DOI: 10.3390/cells9040965
  
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mdpi.com/2073-4409/9/4/965
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Pancreatic beta cell autophagy is impaired in type 1 diabetes

1
1. scibot 24 Feb 2021
  
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  rabbit anti-LC3A/B
  
  DOI: 10.1007/s00125-021-05387-6
  
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link.springer.com/article/10.1007/s00125-021-05387-6
Jan 2021
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Protective effect of hydrogen sulfide on endothelial cells through Sirt1-FoxO1-mediated autophagy

1
1. scibot 13 Jan 2021
  
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  AB_2617131
  
  DOI: 10.21037/atm-20-3647
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7791216/
Sep 2020
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A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity

1
1. scibot 23 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.01.042
  
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Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice

1
1. scibot 14 Sep 2020
  
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  RRID:AB_2617131
  
  DOI: 10.7554/eLife.56590
  
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Jan 2020
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Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5

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  DOI: 10.1016/j.celrep.2019.07.066
  
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RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres

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Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade

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  DOI: 10.3389/fncel.2019.00399
  
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Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

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p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

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Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models

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  DOI: 10.1016/j.cmet.2018.10.005
  
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Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles

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The cardioprotective effect of thymoquinone on ischemia‐reperfusion injury in isolated rat heart via regulation of apoptosis and autophagy

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Complement C3 Drives Autophagy-Dependent Restriction of Cyto-invasive Bacteria

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Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein

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A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader

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