46 Matching Annotations
  1. Aug 2024
  2. www.sciencedirect.com www.sciencedirect.com
    CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes
    1
    1. scibot 30 Aug 2024
      RRID:AB_2617169

      DOI: 10.1016/j.immuni.2024.07.024

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    sciencedirect.com/science/article/pii/S107476132400373X
  3. www.science.org www.science.org
    Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8+ T cell responses
    1
    1. scibot 02 Aug 2024
      RRID:AB_2617169

      DOI: 10.1126/sciadv.adl1122

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    science.org/doi/10.1126/sciadv.adl1122
  4. Jul 2024
  5. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
    1
    1. scibot 18 Jul 2024
      RRID:AB_2617169

      DOI: 10.1111/bph.16487

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16487
  6. Jun 2024
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gαz-independent and -dependent Improvements With EPA Supplementation on the Early Type 1 Diabetes Phenotype of NOD Mice
    1
    1. scibot 05 Jun 2024
      RRID:AB_2617169

      DOI: 10.1210/jendso/bvae100

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    ncbi.nlm.nih.gov/pmc/articles/PMC11146416/
  8. Apr 2024
  9. 52.53.155.43 52.53.155.43
    Impact of ghrelin on islet size in non-pregnant and pregnant female mice
    1
    1. scibot 24 Apr 2024
      RRID:AB_2617169

      DOI: 10.1210/endocr/bqae048

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    52.53.155.43/4f7c7de9c202a8cd4d6a0ae417dda113dd85bf07/bqae048-html.html
  10. Mar 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8+ T cell responses
    1
    1. scibot 09 Mar 2024
      RRID:AB_2617169

      DOI: 10.1126/sciadv.adl1122

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    ncbi.nlm.nih.gov/pmc/articles/PMC10917340/
  12. Dec 2023
  13. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial aldehyde dehydrogenase-2 coordinates the hydrogen sulfide - AMPK axis to attenuate high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system
    1
    1. scibot 20 Dec 2023
      RRID:AB_2617169

      DOI: 10.1016/j.redox.2023.102994

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    sciencedirect.com/science/article/pii/S2213231723003956
  14. www.sciencedirect.com www.sciencedirect.com
    Immunotherapy targeting B cells and long-lived plasma cells effectively eliminates pre-existing donor-specific allo-antibodies
    1
    1. scibot 20 Dec 2023
      RRID:AB_2617169

      DOI: 10.1016/j.xcrm.2023.101336

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    sciencedirect.com/science/article/pii/S2666379123005530
  15. Oct 2023
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optimal temperature for the long-term culture of adult porcine islets for xenotransplantation
    1
    1. scibot 31 Oct 2023
      AB_2617169

      DOI: 10.3389/fimmu.2023.1280668

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    ncbi.nlm.nih.gov/pmc/articles/PMC10611499/
  17. 52.53.155.43 52.53.155.43
    Real time quantification of apical polarity protein reveals novel dynamic processes in lumenal network establishment and remodeling in the pancreas
    1
    1. scibot 20 Oct 2023
      RRID:AB_2617169

      DOI: 10.1101/2023.08.18.552936

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    52.53.155.43/0f0c4ae0aee27ebce60b7f3eb3f3d73940a644d7/2023.08.18.552936v1.full-html.html
  18. Aug 2023
  19. www.biorxiv.org www.biorxiv.org
    Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses
    1
    1. scibot 28 Aug 2023
      RRID:AB_2617169

      DOI: 10.1101/2023.08.19.553954

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    biorxiv.org/content/10.1101/2023.08.19.553954v1
  20. www.sciencedirect.com www.sciencedirect.com
    FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress
    1
    1. scibot 18 Aug 2023
      RRID:AB_2617169

      DOI: 10.1016/j.celrep.2023.112986

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    sciencedirect.com/science/article/pii/S221112472300997X
  21. Apr 2022
  22. www.sciencedirect.com www.sciencedirect.com
    Inducing and measuring apoptotic cell death in mouse pancreatic β-cells and in isolated islets
    1
    1. scibot 15 Apr 2022
      RRID:AB_2617169

      DOI: 10.1016/j.xpro.2022.101287

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    sciencedirect.com/science/article/pii/S2666166722001678
  23. Feb 2022
  24. academic.oup.com academic.oup.com
    Maternal hypothyroidism in rats reduces placental lactogen, lowers insulin levels and causes glucose intolerance
    1
    1. scibot 01 Feb 2022
      RRID:AB_2617169

      DOI: 10.1210/endocr/bqab231

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    academic.oup.com/endo/article/163/2/bqab231/6429715
  25. Aug 2021
  26. www.sciencedirect.com www.sciencedirect.com
    Localization of enteroviral RNA within the pancreas in donors with T1D and T1D-associated autoantibodies
    1
    1. scibot 18 Aug 2021
      RRID:AB_2617169

      DOI: 10.1016/j.xcrm.2021.100371

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    sciencedirect.com/science/article/pii/S2666379121002251
  27. www.sciencedirect.com www.sciencedirect.com
    The role of mitochondrial apoptotic pathway in islet amyloid-induced β-cell death
    1
    1. scibot 17 Aug 2021
      RRID:AB_2617169

      DOI: 10.1016/j.mce.2021.111424

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    sciencedirect.com/science/article/pii/S0303720721002689
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes
    1
    1. scibot 12 Aug 2021
      AB_2617169

      DOI: 10.1016/j.cmet.2018.04.013

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    ncbi.nlm.nih.gov/pmc/articles/PMC5989056/
  29. academic.oup.com academic.oup.com
    β-Catenin Directs Long-Chain Fatty Acid Catabolism in the Osteoblasts of Male Mice
    1
    1. scibot 08 Aug 2021
      RRID:AB_2617169

      DOI: 10.1210/en.2017-00850

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    academic.oup.com/endo/article/159/1/272/4565485
  30. academic.oup.com academic.oup.com
    Untitled document
    1
    1. scibot 08 Aug 2021
      AB_2617169

      DOI: 10.1210/en.2016-1700

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    academic.oup.com/endo/article/158/6/1645/3611548
  31. www.sciencedirect.com www.sciencedirect.com
    Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes
    1
    1. scibot 04 Aug 2021
      RRID:AB_2617169

      DOI: 10.1016/j.celrep.2021.109490

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    sciencedirect.com/science/article/pii/S2211124721009177
  32. www.sciencedirect.com www.sciencedirect.com
    Untitled document
    1
    1. scibot 03 Aug 2021
      RRID:AB_2617169

      DOI: 10.1016/j.cmet.2018.10.007

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    sciencedirect.com/science/article/pii/S1550413118306399
  33. Jul 2021
  34. academic.oup.com academic.oup.com
    Lack of Lrp5 Signaling in Osteoblasts Sensitizes Male Mice to Diet-Induced Disturbances in Glucose Metabolism
    2
    1. scibot 28 Jul 2021
      AB_2617169

      DOI: 10.1210/en.2017-00657

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      Curator: @evieth

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      RRIDCUR:Duplicate RRID:AB_2617169 RRIDCUR:Validated
    2. scibot 28 Jul 2021
      RRID:AB_2617169

      DOI: 10.1210/en.2017-00657

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    academic.oup.com/endo/article/158/11/3805/4117224
  35. academic.oup.com academic.oup.com
    Glucose Transporter-4 Facilitates Insulin-Stimulated Glucose Uptake in Osteoblasts
    2
    1. scibot 27 Jul 2021
      AB_2617169u00a0

      DOI: 10.1210/en.2016-1583

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      Curator: @Jmenke

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      RRID:AB_2617169
    2. scibot 27 Jul 2021
      DAKO (A056401, AB_2617169)

      DOI: 10.1210/en.2016-1583

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      Curator: @Jmenke

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    academic.oup.com/endo/article/157/11/4094/2758329/Glucose-Transporter-4-Facilitates-Insulin
  36. May 2021
  37. academic.oup.com academic.oup.com
    Glucagon Receptor Inhibition Reduces Hyperammonemia and Lethality in Male Mice with Urea Cycle Disorder
    1
    1. scibot 10 May 2021
      RRID:AB_2617169

      DOI: 10.1210/endocr/bqaa211

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    academic.oup.com/endo/article/162/1/bqaa211/5988952
  38. Apr 2021
  39. www.sciencedirect.com www.sciencedirect.com
    Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes
    2
    1. scibot 20 Apr 2021
      RRID: AB_2617169

      DOI: 10.1016/j.devcel.2021.02.011

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      Curator: @bandrow

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      RRID:AB_2617169
    2. scibot 19 Apr 2021
      AB_2617169

      DOI: 10.1016/j.devcel.2021.02.011

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    sciencedirect.com/science/article/pii/S1534580721001222
  40. Jan 2021
  41. www.sciencedirect.com www.sciencedirect.com
    CDK2 limits the highly energetic secretory program of mature β cells by restricting PEP cycle-dependent KATP channel closure
    1
    1. scibot 27 Jan 2021
      RRID:AB_2617169

      DOI: 10.1016/j.celrep.2021.108690

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      Curator: @Naa003

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    sciencedirect.com/science/article/pii/S2211124721000036
  42. Nov 2020
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells
    1
    1. scibot 24 Nov 2020
      RRID:AB_2617169

      DOI: 10.1016/j.cmet.2020.11.006

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    ncbi.nlm.nih.gov/pmc/articles/PMC7664344/
  44. www.metabolismjournal.com www.metabolismjournal.com
    Noradrenergic fibers are associated with beta-cell dedifferentiation and impaired beta-cell function in humans
    1
    1. scibot 19 Nov 2020
      RRID:AB_2617169

      DOI: 10.1016/j.metabol.2020.154414

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    metabolismjournal.com/article/S0026-0495(20)30278-X/abstract
  45. Sep 2020
  46. www.sciencedirect.com www.sciencedirect.com
    The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress
    1
    1. scibot 26 Sep 2020
      RRID:AB_2617169

      DOI: 10.1016/j.celrep.2020.107846

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    sciencedirect.com/science/article/pii/S2211124720308275
  47. www.sciencedirect.com www.sciencedirect.com
    Islet O-GlcNAcylation Is Required for Lipid Potentiation of Insulin Secretion through SERCA2
    1
    1. scibot 17 Sep 2020
      RRID:AB_2617169

      DOI: 10.1016/j.celrep.2020.107609

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      Curator: @ethanbadger

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    sciencedirect.com/science/article/pii/S2211124720305581
  48. May 2020
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
    1
    1. nPOD_Curator 15 May 2020
      Initial screening for insulin, MHC class I, and CD8. For characterization of the sections before tetramer staining, staining for insulin, CD8, and HLA-ABC (all at room temperature) was performed using the antibodies listed in Table 3. Fixation was with acetone and sections were blocked with goat serum in a standard immunofluorescent staining protocol. An islet was determined as hyperexpressing MHC class I based on a threshold of three unequivocally positive cells, which was the maximum number found in all control islets examined.Table 3.Antibodies used for characterization of the sections prior to tetramer stainingAntigenPrimary antibodyDetection antibodyInsulinPolyclonal guinea pig anti-insulin (Dako; 1/140 dilution, 1-h incubation)Polyclonal goat anti–guinea pig IgG, highly cross-adsorbed, Alexa Fluor 488 (Invitrogen; 1/1000 dilution, 30-min incubation)HLA-ABCMouse monoclonal (clone W6/32) IgG2a against a monomorphic epitope on the 45 kD polypeptide products of the HLA-A, B and C loci (Dako; 1/100 dilution, 1 h incubation)Polyclonal goat anti–mouse IgG2a, isotype-specific, Alexa Fluor 594 (Invitrogen; 1/1000 dilution, 30-min incubation)CD8Mouse monoclonal (clone HIT8a) IgG1 against the CD8 alpha subunit (BD; 1/100 dilution, 1-h incubation)F(ab’)2 fragment of goat anti-mouse IgG, Alexa Fluor 594 (Invitrogen; 1/1000 dilution, 30-min incubation)

      Initial screening for insulin, MHC class I, and CD8

      obiwan:Method PMID:22213807 RRID:AB_2617169
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    ncbi.nlm.nih.gov/pmc/articles/PMC3260877/
  50. Jan 2020
  51. diabetes.diabetesjournals.org diabetes.diabetesjournals.org
    Differential effect of glucose on ER-mitochondria Ca2+ exchange participates to insulin secretion and to glucotoxicity-mediated dysfunction of β cells.
    1
    1. scibot 13 Jan 2020
      RRID:AB_2617169

      DOI: 10.2337/db18-1112

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    diabetes.diabetesjournals.org/content/68/9/1778
  52. www.sciencedirect.com www.sciencedirect.com
    CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells
    1
    1. scibot 13 Jan 2020
      RRID:AB_2617169

      DOI: 10.1016/j.celrep.2019.08.025

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      Curator: @ethanbadger

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      RRID:AB_2617169 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719310599
  53. www.sciencedirect.com www.sciencedirect.com
    Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA
    1
    1. scibot 13 Jan 2020
      RRID:AB_2617169

      DOI: 10.1016/j.celrep.2018.11.078

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      Curator: @evieth

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      RRID:AB_2617169 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124718318692
  54. Nov 2018
  55. www.sciencedirect.com www.sciencedirect.com
    Evidence for a Non-leptin System that Defends against Weight Gain in Overfeeding
    1
    1. scibot 05 Nov 2018
      RRID:AB_2617169

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    sciencedirect.com/science/article/pii/S1550413118303826
  56. academic.oup.com academic.oup.com
    Na+/Ca2+ Exchanger a Druggable Target to Promote β-Cell Proliferation and Function
    1
    1. scibot 05 Nov 2018
      RRID:AB_2617169

      Curator: @evieth

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      RRID:AB_2617169 RRIDCUR:Validated
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    academic.oup.com/jes/article/2/7/631/5003403
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes
    1
    1. scibot 05 Nov 2018
      AB_2617169

      Curator: @evieth

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    ncbi.nlm.nih.gov/pmc/articles/PMC5989056/
  58. Nov 2017
  59. www.sciencedirect.com www.sciencedirect.com
    Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata
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      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1550413117304989
  60. academic.oup.com academic.oup.com
    Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis
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    1. scibot 08 Nov 2017
      AB_2617169 

      Curator: @kaitlinsung

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      RRID:AB_2617169 RRIDCUR:Missing
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    academic.oup.com/endo/article/158/8/2503/3861370/Protective-Role-of-Complement-C3-Against-Cytokine
  61. academic.oup.com academic.oup.com
    The Inhibitory G Protein α-Subunit, Gαz, Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice
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      Curator: @bandrow

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    academic.oup.com/endo/article/158/6/1645/3611548/The-Inhibitory-G-Protein-Subunit-G-z-Promotes-Type
  62. www.sciencedirect.com www.sciencedirect.com
    Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors
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      Curator: @gabimpine

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    sciencedirect.com/science/article/pii/S1534580717300758
  63. www.sciencedirect.com www.sciencedirect.com
    Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes
    1
    1. scibot 08 Nov 2017
      AB_2617169

      Curator: @gabimpine

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  64. www.sciencedirect.com www.sciencedirect.com
    Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity
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      Curator: @gabimpine

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      RRID:AB_2617169 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0092867416315318