48 Matching Annotations
  1. Jul 2025
  2. www.sciencedirect.com www.sciencedirect.com
    Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication
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    sciencedirect.com/science/article/pii/S1550413125003043
  3. Dec 2024
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC5517315/
  5. Aug 2024
  6. www.sciencedirect.com www.sciencedirect.com
    CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes
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    sciencedirect.com/science/article/pii/S107476132400373X
  7. www.science.org www.science.org
    Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8+ T cell responses
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    science.org/doi/10.1126/sciadv.adl1122
  8. Jul 2024
  9. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
    1
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16487
  10. Jun 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gαz-independent and -dependent Improvements With EPA Supplementation on the Early Type 1 Diabetes Phenotype of NOD Mice
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11146416/
  12. Apr 2024
  13. 52.53.155.43 52.53.155.43
    Impact of ghrelin on islet size in non-pregnant and pregnant female mice
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    52.53.155.43/4f7c7de9c202a8cd4d6a0ae417dda113dd85bf07/bqae048-html.html
  14. Mar 2024
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8+ T cell responses
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10917340/
  16. Dec 2023
  17. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial aldehyde dehydrogenase-2 coordinates the hydrogen sulfide - AMPK axis to attenuate high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system
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    sciencedirect.com/science/article/pii/S2213231723003956
  18. www.sciencedirect.com www.sciencedirect.com
    Immunotherapy targeting B cells and long-lived plasma cells effectively eliminates pre-existing donor-specific allo-antibodies
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    sciencedirect.com/science/article/pii/S2666379123005530
  19. Oct 2023
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optimal temperature for the long-term culture of adult porcine islets for xenotransplantation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10611499/
  21. 52.53.155.43 52.53.155.43
    Real time quantification of apical polarity protein reveals novel dynamic processes in lumenal network establishment and remodeling in the pancreas
    1
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    52.53.155.43/0f0c4ae0aee27ebce60b7f3eb3f3d73940a644d7/2023.08.18.552936v1.full-html.html
  22. Aug 2023
  23. www.biorxiv.org www.biorxiv.org
    Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses
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    biorxiv.org/content/10.1101/2023.08.19.553954v1
  24. www.sciencedirect.com www.sciencedirect.com
    FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress
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    sciencedirect.com/science/article/pii/S221112472300997X
  25. Apr 2022
  26. www.sciencedirect.com www.sciencedirect.com
    Inducing and measuring apoptotic cell death in mouse pancreatic β-cells and in isolated islets
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    sciencedirect.com/science/article/pii/S2666166722001678
  27. Feb 2022
  28. academic.oup.com academic.oup.com
    Maternal hypothyroidism in rats reduces placental lactogen, lowers insulin levels and causes glucose intolerance
    1
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    academic.oup.com/endo/article/163/2/bqab231/6429715
  29. Aug 2021
  30. www.sciencedirect.com www.sciencedirect.com
    Localization of enteroviral RNA within the pancreas in donors with T1D and T1D-associated autoantibodies
    1
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    sciencedirect.com/science/article/pii/S2666379121002251
  31. www.sciencedirect.com www.sciencedirect.com
    The role of mitochondrial apoptotic pathway in islet amyloid-induced β-cell death
    1
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    sciencedirect.com/science/article/pii/S0303720721002689
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC5989056/
  33. academic.oup.com academic.oup.com
    β-Catenin Directs Long-Chain Fatty Acid Catabolism in the Osteoblasts of Male Mice
    1
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    academic.oup.com/endo/article/159/1/272/4565485
  34. academic.oup.com academic.oup.com
    Untitled document
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    academic.oup.com/endo/article/158/6/1645/3611548
  35. www.sciencedirect.com www.sciencedirect.com
    Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes
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    sciencedirect.com/science/article/pii/S2211124721009177
  36. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1550413118306399
  37. Jul 2021
  38. academic.oup.com academic.oup.com
    Lack of Lrp5 Signaling in Osteoblasts Sensitizes Male Mice to Diet-Induced Disturbances in Glucose Metabolism
    2
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    academic.oup.com/endo/article/158/11/3805/4117224
  39. academic.oup.com academic.oup.com
    Glucose Transporter-4 Facilitates Insulin-Stimulated Glucose Uptake in Osteoblasts
    2
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    academic.oup.com/endo/article/157/11/4094/2758329/Glucose-Transporter-4-Facilitates-Insulin
  40. May 2021
  41. academic.oup.com academic.oup.com
    Glucagon Receptor Inhibition Reduces Hyperammonemia and Lethality in Male Mice with Urea Cycle Disorder
    1
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    academic.oup.com/endo/article/162/1/bqaa211/5988952
  42. Apr 2021
  43. www.sciencedirect.com www.sciencedirect.com
    Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes
    2
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    sciencedirect.com/science/article/pii/S1534580721001222
  44. Jan 2021
  45. www.sciencedirect.com www.sciencedirect.com
    CDK2 limits the highly energetic secretory program of mature β cells by restricting PEP cycle-dependent KATP channel closure
    1
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    sciencedirect.com/science/article/pii/S2211124721000036
  46. Nov 2020
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC7664344/
  48. www.metabolismjournal.com www.metabolismjournal.com
    Noradrenergic fibers are associated with beta-cell dedifferentiation and impaired beta-cell function in humans
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    metabolismjournal.com/article/S0026-0495(20)30278-X/abstract
  49. Sep 2020
  50. www.sciencedirect.com www.sciencedirect.com
    The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress
    1
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    sciencedirect.com/science/article/pii/S2211124720308275
  51. www.sciencedirect.com www.sciencedirect.com
    Islet O-GlcNAcylation Is Required for Lipid Potentiation of Insulin Secretion through SERCA2
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    sciencedirect.com/science/article/pii/S2211124720305581
  52. May 2020
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
    1
    1. nPOD_Curator 15 May 2020
      Initial screening for insulin, MHC class I, and CD8. For characterization of the sections before tetramer staining, staining for insulin, CD8, and HLA-ABC (all at room temperature) was performed using the antibodies listed in Table 3. Fixation was with acetone and sections were blocked with goat serum in a standard immunofluorescent staining protocol. An islet was determined as hyperexpressing MHC class I based on a threshold of three unequivocally positive cells, which was the maximum number found in all control islets examined.Table 3.Antibodies used for characterization of the sections prior to tetramer stainingAntigenPrimary antibodyDetection antibodyInsulinPolyclonal guinea pig anti-insulin (Dako; 1/140 dilution, 1-h incubation)Polyclonal goat anti–guinea pig IgG, highly cross-adsorbed, Alexa Fluor 488 (Invitrogen; 1/1000 dilution, 30-min incubation)HLA-ABCMouse monoclonal (clone W6/32) IgG2a against a monomorphic epitope on the 45 kD polypeptide products of the HLA-A, B and C loci (Dako; 1/100 dilution, 1 h incubation)Polyclonal goat anti–mouse IgG2a, isotype-specific, Alexa Fluor 594 (Invitrogen; 1/1000 dilution, 30-min incubation)CD8Mouse monoclonal (clone HIT8a) IgG1 against the CD8 alpha subunit (BD; 1/100 dilution, 1-h incubation)F(ab’)2 fragment of goat anti-mouse IgG, Alexa Fluor 594 (Invitrogen; 1/1000 dilution, 30-min incubation)

      Initial screening for insulin, MHC class I, and CD8

      obiwan:Method PMID:22213807 RRID:AB_2617169
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    ncbi.nlm.nih.gov/pmc/articles/PMC3260877/
  54. Jan 2020
  55. diabetes.diabetesjournals.org diabetes.diabetesjournals.org
    Differential effect of glucose on ER-mitochondria Ca2+ exchange participates to insulin secretion and to glucotoxicity-mediated dysfunction of β cells.
    1
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    diabetes.diabetesjournals.org/content/68/9/1778
  56. www.sciencedirect.com www.sciencedirect.com
    CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells
    1
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    sciencedirect.com/science/article/pii/S2211124719310599
  57. www.sciencedirect.com www.sciencedirect.com
    Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA
    1
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    sciencedirect.com/science/article/pii/S2211124718318692
  58. Nov 2018
  59. www.sciencedirect.com www.sciencedirect.com
    Evidence for a Non-leptin System that Defends against Weight Gain in Overfeeding
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    sciencedirect.com/science/article/pii/S1550413118303826
  60. academic.oup.com academic.oup.com
    Na+/Ca2+ Exchanger a Druggable Target to Promote β-Cell Proliferation and Function
    1
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    academic.oup.com/jes/article/2/7/631/5003403
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC5989056/
  62. Nov 2017
  63. www.sciencedirect.com www.sciencedirect.com
    Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata
    1
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    sciencedirect.com/science/article/pii/S1550413117304989
  64. academic.oup.com academic.oup.com
    Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis
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    academic.oup.com/endo/article/158/8/2503/3861370/Protective-Role-of-Complement-C3-Against-Cytokine
  65. academic.oup.com academic.oup.com
    The Inhibitory G Protein α-Subunit, Gαz, Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice
    1
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    academic.oup.com/endo/article/158/6/1645/3611548/The-Inhibitory-G-Protein-Subunit-G-z-Promotes-Type
  66. www.sciencedirect.com www.sciencedirect.com
    Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors
    1
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    sciencedirect.com/science/article/pii/S1534580717300758
  67. www.sciencedirect.com www.sciencedirect.com
    Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes
    1
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    sciencedirect.com/science/article/pii/S1550413117301705
  68. www.sciencedirect.com www.sciencedirect.com
    Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity
    1
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    sciencedirect.com/science/article/pii/S0092867416315318