314 Matching Annotations
  1. Aug 2025
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    Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer
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    sciencedirect.com/science/article/pii/S153458072500499X
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    Transient gene melting governs the timing of oligodendrocyte maturation
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    sciencedirect.com/science/article/pii/S009286742500861X
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    Lysosomal TPC2 channel as a new target of chlorpromazine and Clomipramine to induce protective autophagy in L-BMAA-induced neurodegeneration
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    sciencedirect.com/science/article/pii/S0006295225004848
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    Subunit-specific roles of LRRC8 proteins in determining glutamate permeability of astrocytic volume-regulated anion channels
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    biorxiv.org/content/10.1101/2025.07.24.666608v1
  6. Jul 2025
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nanopore direct RNA sequencing of human transcriptomes reveals the complexity of mRNA modifications and crosstalk between regulatory features
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    pmc.ncbi.nlm.nih.gov/articles/PMC12230237/
  8. Jun 2025
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    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70084
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    Increased Activity‐Dependent Bulk Endocytosis in Huntington's Disease Results From Huntingtin Haploinsufficiency
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    pmc.ncbi.nlm.nih.gov/articles/PMC12181757/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechanistic Understanding of Dexamethasone-Mediated Protection against Remdesivir-Induced Hepatotoxicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12164689/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pathogenic MCT8V235L creates a steric clash that is alleviated by a compensating mutation of MCT8F285A
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    pmc.ncbi.nlm.nih.gov/articles/PMC12139598/
  13. May 2025
  14. dx.doi.org dx.doi.org
    Androgen Receptor PROTAC ARV-110 Ameliorates Metabolic Complications in a Mouse Model of Polycystic Ovary Syndrome
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    dx.doi.org/10.1210/endocr/bqaf091
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    De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses
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    sciencedirect.com/science/article/pii/S0092867425005148
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    Peroxisomes are critical for a unique metabolic demand and survival of alveolar macrophages
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    sciencedirect.com/science/article/pii/S2211124725003948
  17. Apr 2025
  18. 52.53.155.43 52.53.155.43
    Lysosome positioning affects NLRP3 inflammasome activation
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    52.53.155.43/5e725b42faf6f4894ebfb1897ac6165b04d7cac3/PDF-html.html
  19. Mar 2025
  20. www.biorxiv.org www.biorxiv.org
    The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis
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    biorxiv.org/content/10.1101/2025.03.18.644053v1
  21. Feb 2025
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils
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    pmc.ncbi.nlm.nih.gov/articles/PMC11846974/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-cell and spatial transcriptomics reveal a potential role of ATF3 in brain metastasis of lung adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11826269/
  24. aacrjournals.org aacrjournals.org
    Clonal Lineage Tracing with Somatic Delivery of Recordable Barcodes Reveals Migration Histories of Metastatic Prostate Cancer
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    aacrjournals.org/cancerdiscovery/article/14/10/1990/748601/Clonal-Lineage-Tracing-with-Somatic-Delivery-of
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    Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11811823/
  26. 52.53.155.43 52.53.155.43
    bph17305-sup-0001-sars cov 2 rucaparib supplementary 2-html.html
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    Dab1 expression level controls Reelin-induced PI3K-Akt activation in early GABAergic neurons
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  28. Jan 2025
  29. pubs.acs.org pubs.acs.org
    Tat-Beclin-1 Ameliorates Memory by Improving Neuronal Cytoarchitecture and Mitigating Mitochondrial Dysfunction in Scopolamine-Induced Amnesic Male Mice
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    pubs.acs.org/doi/10.1021/acsptsci.4c00283
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    Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase
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    The potential of lazertinib and amivantamab combination therapy as a treatment strategy for uncommon EGFR-mutated NSCLC
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    Traumatic brain injury causes early aggregation of beta-amyloid peptides and NOTCH3 reduction in vascular smooth muscle cells of leptomeningeal arteries
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    link.springer.com/article/10.1007/s00401-025-02848-9
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    Failure to repair damaged NAD(P)H blocks de novo serine synthesis in human cells
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    SLC7A5 is required for cancer cell growth under arginine-limited conditions
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  35. Dec 2024
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    Targeted macrophage mannose receptor (CD206)-specific protein delivery via engineered extracellular vesicles
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    Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease
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    DEP-1 is a brain insulin receptor phosphatase that prevents the simultaneous activation of counteracting metabolic pathways
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  40. Nov 2024
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    PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization
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    Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair
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  43. Oct 2024
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    Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model
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  45. Sep 2024
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Two-way Dispatched function in Sonic hedgehog shedding and transfer to high-density lipoproteins
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    ncbi.nlm.nih.gov/pmc/articles/PMC11412720/
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    Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium
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    sciencedirect.com/science/article/pii/S1931312824003202
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    Adipose ADM2 ameliorates NAFLD via promotion of ceramide catabolism
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  49. Aug 2024
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    TGM1/3-mediated transamidation of Exo70 promotes tumor metastasis upon LKB1 inactivation
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    Retinoic Acid Regulates Spermiogenesis Via Hoxb1 and Shh Signaling in Testicular Germ Cells
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    link.springer.com/article/10.1007/s43032-024-01648-y
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    Serum Amyloid A1/Toll-Like Receptor-4 Axis, an Important Link between Inflammation and Outcome of TBI Patients
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  53. www.embopress.org www.embopress.org
    EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics
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    embopress.org/doi/full/10.15252/embr.202050835
  54. onlinelibrary.wiley.com onlinelibrary.wiley.com
    HOXA5 localization in postnatal and adult mouse brain is suggestive of regulatory roles in postmitotic neurons
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    onlinelibrary.wiley.com/doi/10.1002/cne.24123/full
  55. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Neuroactive molecules and growth factors modulate cytoskeletal protein expression during astroglial cell proliferation and differentiation in culture
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    onlinelibrary.wiley.com/doi/10.1002/jnr.23678/full
  56. Jul 2024
  57. www.biorxiv.org www.biorxiv.org
    The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization
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    biorxiv.org/content/10.1101/2024.07.22.604482v1
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    Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
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    In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss
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    science.org/doi/10.1126/sciadv.adk2299
  60. Jun 2024
  61. www.science.org www.science.org
    In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss
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    Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function
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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective regulation of chemosensitivity in glioblastoma by phosphatidylinositol 3-kinase beta
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    ncbi.nlm.nih.gov/pmc/articles/PMC11133927/
  64. May 2024
  65. www.biorxiv.org www.biorxiv.org
    Sex-focused analyses of M83 A53T hemizygous mouse model with recombinant human alpha-synuclein preformed fibril injection identifies female resilience to disease progression: A combined magnetic resonance imaging and behavioural study
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    Discovery of a novel potent EGFR inhibitor against EGFR activating mutations and on-target resistance in NSCLC
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    aacrjournals.org/clincancerres/article/30/8/1582/742134/Discovery-of-a-Novel-Potent-EGFR-Inhibitor-Against
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    Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals
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    Glycerol Phenylbutyrate treatment of two patients with Monocarboxylate Transporter 8 deficiency
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    SARS-CoV-2 infection exacerbates the cellular pathology of Parkinson’s disease in human dopaminergic neurons and a mouse model
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    Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model
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    biorxiv.org/content/10.1101/2024.01.24.577107v1
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ER-stress in mouse serotonin neurons triggers a depressive phenotype alleviated by ketamine targeting eIF2α signaling
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  72. Apr 2024
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    HSV-1 employs UL56 to antagonize expression and function of cGAMP channels
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    HIF1α-dependent uncoupling of glycolysis suppresses tumor cell proliferation
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    Human iPSC 4R tauopathy model uncovers modifiers of tau propagation
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  76. Mar 2024
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MicroRNA-148b secreted by bovine oviductal extracellular vesicles enhance embryo quality through BPM/TGF-beta pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10960404/
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    Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity
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    Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor
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  80. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The Hydrophilic Metabolite UMP Alleviates Obesity Traits through a HIF2α-ACER2-Ceramide Signaling Axis
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    IκBζ is a dual-use coactivator of NF-κB and POU transcription factors
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    IGF1R deficiency in vascular smooth muscle cells impairs myogenic autoregulation and cognition in mice
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  83. Feb 2024
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A tangible method to assess native ferroptosis suppressor activity
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    Ultrafine particulate matter pollution and dysfunction of endoplasmic reticulum Ca2+ store: A pathomechanism shared with amyotrophic lateral sclerosis motor neurons?
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    Brazilin is a natural product inhibitor of the NLRP3 inflammasome
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    Subsets of interferon signaling predict response to immune checkpoint blockade in melanoma patients
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    H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in pediatric high-grade glioma cells
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  89. Dec 2023
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    Prothymosin α accelerates dengue virus-induced thrombocytopenia
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    SON is an essential m6A target for hematopoietic stem cell fate
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    Microcircuit failure in STXBP1 encephalopathy leads to hyperexcitability
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    Leakage beyond the primary lesion: A temporal analysis of cerebrovascular dysregulation at sites of hippocampal secondary neurodegeneration following cortical photothrombotic stroke
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    onlinelibrary.wiley.com/doi/10.1111/jnc.16008
  94. Nov 2023
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    PAK1-dependent mechanotransduction enables myofibroblast nuclear adaptation and chromatin organization during fibrosis
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  96. www.embopress.org www.embopress.org
    Breast adipose tissue-derived extracellular vesicles from obese women alter tumor cell metabolism
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    V-ATPase recruitment to ER exit sites switches COPII-mediated transport to lysosomal degradation
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    CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline
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  99. Oct 2023
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LRRK2 G2019S promotes astrocytic inflammation induced by oligomeric α-synuclein through NF-κB pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10590863/
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    Endothelial barrier dysfunction in systemic inflammation is mediated by soluble VE-cadherin interfering VE-PTP signaling
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    Tonic activin signaling shapes cellular and synaptic properties of CA1 neurons mainly in dorsal hippocampus
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    cell.com/iscience/abstract/S2589-0042(23)02078-3
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    Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
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  104. Sep 2023
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    PARP1 inhibition protects mice against Japanese encephalitis virus infection
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    A co-opted endogenous retroviral envelope promotes cell survival by controlling CTR1-mediated copper transport and homeostasis
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    Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice
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