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A covalent inhibitor targeting Cys16 on RhoA in colorectal cancer

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1. scibot 06 Sep 2025
  
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  DOI: 10.1016/j.chembiol.2025.08.004
  
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sciencedirect.com/science/article/pii/S2451945625002557
Aug 2025
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Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver

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1. scibot 14 Aug 2025
  
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  DOI: 10.1126/sciadv.abf9141
  
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science.org/doi/10.1126/sciadv.abf9141
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Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression

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1. scibot 08 Aug 2025
  
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  DOI: 10.1016/j.ccell.2025.07.012
  
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sciencedirect.com/science/article/pii/S1535610825003186
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Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations

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1. scibot 06 Aug 2025
  
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  DOI: 10.1158/2159-8290.CD-24-1259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12319405/
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BPS Publications

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1. scibot 01 Aug 2025
  
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  DOI: 10.1111/bph.70137
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70137
Jul 2025
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ARID1A mutation drives gastric tumorigenesis via activating type 2 immune dominant microenvironment

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1. scibot 31 Jul 2025
  
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  DOI: 10.1016/j.isci.2025.113117
  
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sciencedirect.com/science/article/pii/S2589004225013781
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RUNX2 inhibition disrupts a PAX3::FOXO1-RUNX2 feed-forward loop and dismantles oncogenic gene programs in fusion-positive rhabdomyosarcoma

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1. scibot 30 Jul 2025
  
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  DOI: 10.1101/2025.07.21.665972
  
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biorxiv.org/content/10.1101/2025.07.21.665972v1
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The XPO1 inhibitor Eltanexor modulates the Wnt/β-catenin signaling pathway to reduce colorectal cancer tumorigenesis

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1. scibot 17 Jul 2025
  
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  DOI: 10.1158/2767-9764.CRC-25-0052
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12260813/
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Combined KRAS inhibition and immune therapy generates durable complete responses in an autochthonous PDAC model

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1. scibot 15 Jul 2025
  
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  DOI: 10.1158/2159-8290.CD-24-0489
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11858029/
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Unlocking the therapeutic potential of rigosertib as a selective therapy for ovarian cancer

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1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102218
  
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sciencedirect.com/science/article/pii/S2666379125002915
Jun 2025
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Trametinib potentiates anti-PD-1 efficacy in tumors established from chemotherapy-primed pancreatic cancer cells

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1. scibot 11 Jun 2025
  
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  DOI: 10.1158/1535-7163.MCT-23-0833
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11614707/
May 2025
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Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity

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1. scibot 31 May 2025
  
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  DOI: 10.1016/j.chom.2025.05.004
  
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sciencedirect.com/science/article/pii/S1931312825001830
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KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.ccell.2025.04.002
  
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sciencedirect.com/science/article/pii/S1535610825001394
Apr 2025
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Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation

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1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.ccell.2025.03.027
  
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sciencedirect.com/science/article/pii/S153561082500128X
Mar 2025
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Cross-kingdom-mediated detection of intestinal protozoa through NLRP6

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1. scibot 06 Mar 2025
  
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  DOI: 10.1016/j.chom.2025.02.008
  
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sciencedirect.com/science/article/pii/S1931312825000563
Feb 2025
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Protocol for 3D multiplexed fluorescent imaging of pulmonary TB lesions using Opal-TSA dyes for signal amplification

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1. scibot 25 Feb 2025
  
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  DOI: 10.1016/j.xpro.2025.103640
  
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sciencedirect.com/science/article/pii/S2666166725000462
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Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/0008-5472.CAN-23-3419
  
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aacrjournals.org/cancerres/article/84/18/2968/747793/Scribble-Deficiency-Promotes-Pancreatic-Ductal
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SMAD4 and KRAS Status Shape Cancer Cell-Stromal Crosstalk and Therapeutic Response in Pancreatic Cancer

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1. scibot 11 Feb 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-2330
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617379/
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Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases

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1. scibot 11 Feb 2025
  
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  DOI: 10.1016/j.xcrm.2025.101943
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11866499/
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Clioquinol inhibits angiogenesis by promoting VEGFR2 degradation and synergizes with AKT inhibition to suppress triple-negative breast cancer vascularization

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1. scibot 04 Feb 2025
  
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  DOI: 10.1007/s10456-024-09965-1
  
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link.springer.com/article/10.1007/s10456-024-09965-1
Jan 2025
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Endocrine-targeting therapies shift the breast microbiome to reduce estrogen receptor-α breast cancer risk

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1. scibot 03 Jan 2025
  
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  DOI: 10.1016/j.xcrm.2024.101880
  
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sciencedirect.com/science/article/pii/S2666379124006517
Dec 2024
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Mechanism of enhancing chemotherapy efficacy in pancreatic ductal adenocarcinoma with paricalcitol and hydroxychloroquine

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1. scibot 29 Dec 2024
  
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  DOI: 10.1016/j.xcrm.2024.101881
  
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cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00652-9
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Human iPSC-derived myelinating organoids and globoid cells to study Krabbe disease

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1. scibot 11 Dec 2024
  
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  DOI: 10.1371/journal.pone.0314858
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11620608/
Nov 2024
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Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer

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1. scibot 08 Nov 2024
  
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  DOI: 10.1158/0008-5472.CAN-23-3574
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11532783/
Sep 2024
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Dietary vitamin B3 supplementation induces the antitumor immunity against liver cancer via biased GPR109A signaling in myeloid cell

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.xcrm.2024.101718
  
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sciencedirect.com/science/article/pii/S2666379124004397
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Human iPSC-derived myelinating organoids and globoid cells to study Krabbe Disease

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1. scibot 05 Sep 2024
  
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  DOI: 10.1101/2024.07.19.604372
  
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52.53.155.43/094bf1894e7037610818c8319cb16bd0730a5b11/2024.07.19.604372v1.full-html.html
Aug 2024
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The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes

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1. scibot 19 Aug 2024
  
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  DOI: 10.1016/j.isci.2024.110499
  
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BCAA-producing Clostridium symbiosum promotes colorectal tumorigenesis through the modulation of host cholesterol metabolism

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1. scibot 19 Aug 2024
  
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  DOI: 10.1016/j.chom.2024.07.012
  
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Jul 2024
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Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK

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1. scibot 30 Jul 2024
  
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  DOI: 10.1016/j.chom.2024.07.001
  
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cell.com/cell-host-microbe/fulltext/S1931-3128(24)00254-3
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Monoacylglycerol acyltransferase-2 inhibits colorectal carcinogenesis in APCmin+/− mice

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1. scibot 27 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110205
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11269928/
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Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

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1. scibot 20 Jul 2024
  
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  DOI: 10.7554/eLife.91766
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11257678/
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Personalized drug screening using patient-derived organoid and its clinical relevance in gastric cancer

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1. scibot 19 Jul 2024
  
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  DOI: 10.1016/j.xcrm.2024.101627
  
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sciencedirect.com/science/article/pii/S2666379124003318
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Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease

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1. scibot 16 Jul 2024
  
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  DOI: 10.1016/j.chom.2024.06.013
  
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Deubiquitylase OTUD3 regulates integrated stress response to suppress progression and sorafenib resistance of liver cancer

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1. scibot 12 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114487
  
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sciencedirect.com/science/article/pii/S2211124724008167
Apr 2024
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Cancer immunotherapy via synergistic co-activation of myeloid receptors CD40 and Dectin-1

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1. scibot 24 Apr 2024
  
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  DOI: 10.1126/sciimmunol.adj5097
  
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Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged mice

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ΔNp63 regulates MDSC survival and metabolism in triple-negative breast cancer

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SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis

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ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis

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Roseburia intestinalis sensitizes colorectal cancer to radiotherapy through the butyrate/OR51E1/RALB axis

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Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice

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Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1

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ISX9 loaded thermoresponsive nanoparticles for hair follicle regrowth

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Influence of Vitamin D Deficiency on Cyclin D1-Induced Parathyroid Tumorigenesis

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Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation

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In vivo modeling of CLL transformation to Richter’s syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities

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Interactions between host and intestinal crypt-resided biofilms are controlled by epithelial fucosylation

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Oncogenic K-Ras suppresses global miRNA function

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Loss of Mettl3 enhances liver tumorigenesis by inducing hepatocyte dedifferentiation and hyperproliferation

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Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2

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Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer

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Altered gut microbiota of obesity subjects promotes colorectal carcinogenesis in mice

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Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression

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Integrative systems biology characterizes immune-mediated neurodevelopmental changes in murine Zika Virus microcephaly

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Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer

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Targeting PCSK9 reduces cancer cell stemness and enhances antitumor immunity in head and neck cancer

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A Wnt-induced lncRNA-DGCR5 splicing switch drives tumor-promoting inflammation in esophageal squamous cell carcinoma

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Immune mechanisms shape the clonal landscape during early progression of prostate cancer

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Early immune pressure initiated by tissue-resident memory T cells sculpts tumor evolution in non-small cell lung cancer

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A tissue injury sensing and repair pathway distinct from host pathogen defense

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Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression

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Tumor suppressive role of the musculoaponeurotic fibrosarcoma gene in colorectal cancer

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Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis

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Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development

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BPS Publications

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bcd-22-0082-html.html

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Elevated PAF1-RAD52 axis confers chemoresistance to human cancers

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Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma

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SETD2 haploinsufficiency enhances germinal center-associated AICDA somatic hypermutation to drive B cell lymphomagenesis

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Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer

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Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis

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Lipolysis-derived linoleic acid drives beige fat progenitor cell proliferation

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Obesity alters the mouse endometrial transcriptome in a cell context-dependent manner

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Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation

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A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation

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ISX9, a small molecule targeting Axin, activates Wnt/β-catenin signaling and promotes hair regrowth

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Aug 2022
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m6A regulation of cortical and retinal neurogenesis is mediated by the redundant m6A readers YTHDFs

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Single-cell and spatial mapping Identify cell types and signaling Networks in the human ureter

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cd-21-1514-html.html

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In vivo partial cellular reprogramming enhances liver plasticity and regeneration

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Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche

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Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer

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P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis

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Deficiency of Mesencephalic Astrocyte-derived Neurotrophic Factor Affects Neurogenesis in Mouse Brain

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Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin

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Epigenetic basis of oncogenic-Kras-mediated epithelial-cellular proliferation and plasticity

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Traf3 inactivation promotes the development of intrahepatic cholangiocarcinoma via NIK-mediated hepatocyte transdifferentiation

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Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions

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Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance

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Oral microbiota affects the efficacy and prognosis of radiotherapy for colorectal cancer in mouse models

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Glycogen accumulation and phase separation drives liver tumor initiation

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Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis

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Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and postabsorptive responses of mice in an age-dependent manner

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Exploring the longitudinal glioma microenvironment landscape uncovers reprogrammed pro-tumorigenic neutrophils in the bone marrow

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Untitled document

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Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

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Histone-deacetylase 8 drives the immune response and the growth of glioma

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DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity

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Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver

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RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness

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Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation

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TMPRSS11a is a novel age‐altered, tissue specific regulator of migration and wound healing

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The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation

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CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10

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Microbiota regulate innate immune signaling and protective immunity against cancer

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TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate

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Serial transplantation unmasks galectin-9 contribution to tumor immune escape in the MB49 murine model

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Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling

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Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway

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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

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ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation

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Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas

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Zinc-finger antiviral protein acts as a tumor suppressor in colorectal cancer

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OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis

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Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation

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BPS Publications

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FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth

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Stimulation of Hair Growth by Small Molecules that Activate Autophagy

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p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

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A mouse model of endometriosis mimicking the natural spread of invasive endometrium

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BPS Publications

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Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid

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Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis

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Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer

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Untitled document

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FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis

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Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

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SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis

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Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes

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TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer

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Environmental stimuli shape microglial plasticity in glioma

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Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells

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Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer

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Pioneer Factors FOXA1 and FOXA2 Assist Selective Glucocorticoid Receptor Signaling in Human Endometrial Cells

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academic.oup.com/endo/article/158/11/4076/4096797
Nov 2017
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academic.oup.com/jes/article/1/7/965/3861375
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academic.oup.com/jes/article/1/7/965/3861375/17-Estradiol-Promotes-Islet-Cell-Proliferation-in
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Androgen Stimulates Growth of Mouse Preantral Follicles In Vitro: Interaction With Follicle-Stimulating Hormone and With Growth Factors of the TGFβ Superfamily

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academic.oup.com/endo/article/158/4/920/2952607/Androgen-Stimulates-Growth-of-Mouse-Preantral
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CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development

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Macrophage PPARγ inhibits Gpr132 to mediate the anti-tumor effects of rosiglitazone

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ncbi.nlm.nih.gov/pmc/articles/PMC5047746/

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