182 Matching Annotations
  1. Last 7 days
  2. www.sciencedirect.com www.sciencedirect.com
    Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress
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    1. scibot 16 Nov 2024
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      DOI: 10.1016/j.cell.2024.10.012

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    sciencedirect.com/science/article/pii/S0092867424011887
  3. Oct 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Moesin contributes to heat shock gene response through direct binding to the Med15 subunit of the Mediator complex in the nucleus
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    1. scibot 04 Oct 2024
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      DOI: 10.1098/rsob.240110

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    ncbi.nlm.nih.gov/pmc/articles/PMC11444770/
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    Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation
    1
    1. scibot 02 Oct 2024
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      DOI: 10.1016/j.chembiol.2024.09.001

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    sciencedirect.com/science/article/pii/S2451945624003933
  6. Sep 2024
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RBN-2397, a PARP7 Inhibitor, Synergizes with Paclitaxel to Inhibit Proliferation and Migration of Ovarian Cancer Cells
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    1. scibot 18 Sep 2024
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      DOI: 10.1101/2024.08.20.608802

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    ncbi.nlm.nih.gov/pmc/articles/PMC11370341/
  8. Aug 2024
  9. www.cell.com www.cell.com
    Genome-scale exon perturbation screens uncover exons critical for cell fitness
    1
    1. scibot 13 Aug 2024
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      DOI: 10.1016/j.molcel.2024.05.024

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      RRID:AB_262051 DOI:10.1016/j.molcel.2024.05.024
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    cell.com/molecular-cell/abstract/S1097-2765(24)00447-7
  10. Jul 2024
  11. www.sciencedirect.com www.sciencedirect.com
    A hominoid-specific signaling axis regulating the tempo of synaptic maturation
    1
    1. scibot 25 Jul 2024
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    sciencedirect.com/science/article/pii/S2211124724008775
  12. www.cell.com www.cell.com
    DOT1L/H3K79me2 represses HIV-1 reactivation via recruiting DCAF1
    1
    1. scibot 18 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114368

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    cell.com/cell-reports/fulltext/S2211-1247(24)00696-X
  13. Jun 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning
    1
    1. scibot 27 Jun 2024
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      DOI: 10.7554/eLife.85560

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    ncbi.nlm.nih.gov/pmc/articles/PMC11189632/
  15. May 2024
  16. aacrjournals.org aacrjournals.org
    Germline mutations of Holliday junction resolvase genes in multiple primary malignancies involving lung cancer lead to PARP inhibitor sensitization
    2
    1. scibot 23 May 2024
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      DOI: 10.1158/1078-0432.CCR-22-3300

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      RRID:AB_262051 DOI:10.1158/1078-0432.CCR-22-3300
    2. scibot 23 May 2024
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      DOI: 10.1158/1078-0432.CCR-22-3300

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    aacrjournals.org/clincancerres/article/30/8/1607/742128/Germline-Mutations-of-Holliday-Junction-Resolvase
  17. www.sciencedirect.com www.sciencedirect.com
    Structural characterization of Thogoto Virus nucleoprotein provides insights into viral RNA encapsidation and RNP assembly
    1
    1. scibot 16 May 2024
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    sciencedirect.com/science/article/pii/S0969212624001424
  18. Apr 2024
  19. www.sciencedirect.com www.sciencedirect.com
    ISGylation by HERCs facilitates STING activation
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    1. scibot 23 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114135

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    sciencedirect.com/science/article/pii/S2211124724004637
  20. www.sciencedirect.com www.sciencedirect.com
    H2AK119ub1 differentially fine-tunes gene expression by modulating canonical PRC1- and H1-dependent chromatin compaction
    1
    1. scibot 11 Apr 2024
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      DOI: 10.1016/j.molcel.2024.02.017

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    sciencedirect.com/science/article/pii/S1097276524001369
  21. Mar 2024
  22. www.sciencedirect.com www.sciencedirect.com
    Inter-organ steroid hormone signaling promotes myoblast fusion via direct transcriptional regulation of a single key effector gene
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    1. scibot 21 Mar 2024
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      DOI: 10.1016/j.cub.2024.02.056

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    sciencedirect.com/science/article/pii/S0960982224002380
  23. www.sciencedirect.com www.sciencedirect.com
    Rim aperture of yeast autophagic membranes balances cargo inclusion with vesicle maturation
    2
    1. scibot 06 Mar 2024
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      DOI: 10.1016/j.devcel.2024.02.002

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      DOI: 10.1016/j.devcel.2024.02.002

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    sciencedirect.com/science/article/pii/S153458072400073X
  24. www.sciencedirect.com www.sciencedirect.com
    Jasmonate signaling pathway confers salt tolerance through a NUCLEAR FACTOR-Y trimeric transcription factor complex in Arabidopsis
    1
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    sciencedirect.com/science/article/pii/S2211124724001530
  25. Feb 2024
  26. 52.53.155.43 52.53.155.43
    AURKA enhances the glycolysis and development of ovarian endometriosis through ERβ
    1
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      DOI: 10.1210/endocr/bqae018

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    52.53.155.43/763b9f4f88af8a11d49032bb21ea7f98fd438708/bqae018-html.html
  27. www.science.org www.science.org
    RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling
    1
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      DOI: 10.1126/scisignal.adg5289

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    science.org/doi/10.1126/scisignal.adg5289
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    Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion
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    1. scibot 13 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113760

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      DOI: 10.1016/j.celrep.2024.113760

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      DOI: 10.1016/j.celrep.2024.113760

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    sciencedirect.com/science/article/pii/S2211124724000883
  29. www.sciencedirect.com www.sciencedirect.com
    p53 promotes antiviral innate immunity by driving hexosamine metabolism
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    1. scibot 07 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113724

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    sciencedirect.com/science/article/pii/S2211124724000524
  30. Jan 2024
  31. www.science.org www.science.org
    RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling
    1
    1. scibot 20 Jan 2024
      RRID:AB_262051

      DOI: 10.1126/scisignal.adg5289

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    science.org/doi/10.1126/scisignal.adg5289
  32. Dec 2023
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ADAMTS-4 enhances oligodendrocyte differentiation and remyelination by cleaving NG2 proteoglycan and attenuating PDGFRα signaling
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    1. scibot 15 Dec 2023
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      DOI: 10.1523/JNEUROSCI.2146-22.2023

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    ncbi.nlm.nih.gov/pmc/articles/PMC10278682/
  34. Nov 2023
  35. www.sciencedirect.com www.sciencedirect.com
    Single-molecule quantitation of RNA-binding protein occupancy and stoichiometry defines a role for Yra1 (Aly/REF) in nuclear mRNP organization
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    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113415

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    sciencedirect.com/science/article/pii/S2211124723014274
  36. www.sciencedirect.com www.sciencedirect.com
    PTIR1 acts as an isoform of DDX58 and promotes tumor immune resistance through activation of UCHL5
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    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113388

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    sciencedirect.com/science/article/pii/S2211124723014006
  37. 52.53.155.43 52.53.155.43
    mvad090-html.html
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    1. scibot 10 Nov 2023
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      DOI: 10.1093/jb/mvad090

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      RRID:AB_262051

      DOI: 10.1093/jb/mvad090

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    52.53.155.43/c37b54a85bb2ab75b40e99c8cb130778e791e084/mvad090-html.html
  38. Sep 2023
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identifying G protein-coupled receptors involved in adipose tissue function using the innovative RNA-seq database FATTLAS
    2
    1. scibot 29 Sep 2023
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      DOI: 10.1016/j.isci.2023.107841

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      DOI: 10.1016/j.isci.2023.107841

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    ncbi.nlm.nih.gov/pmc/articles/PMC10520334/
  40. www.sciencedirect.com www.sciencedirect.com
    LAT1 (SLC7A5) catalyzes Copper(histidinate) transport switching from antiport to uniport mechanism.
    1
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      DOI: 10.1016/j.isci.2023.107738

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    sciencedirect.com/science/article/pii/S2589004223018151
  41. www.embopress.org www.embopress.org
    CCDC50 promotes tumor growth through regulation of lysosome homeostasis
    1
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      DOI: 10.15252/embr.202356948

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    embopress.org/doi/full/10.15252/embr.202356948
  42. Aug 2023
  43. 52.53.155.43 52.53.155.43
    PIIS2211124723009774-html.html
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      DOI: 10.1016/j.celrep.2023.112966

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    52.53.155.43/df40ddc1224afebdcd96952e1e9bc66ca1788f69/PIIS2211124723009774-html.html
  44. Jul 2023
  45. www.sciencedirect.com www.sciencedirect.com
    Phosphoribosyl-linked serine ubiquitination of USP14 by the SidE family effectors of Legionella excludes p62 from the bacterial phagosome
    1
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      DOI: 10.1016/j.celrep.2023.112817

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    sciencedirect.com/science/article/pii/S2211124723008288
  46. Jun 2023
  47. 52.53.155.43 52.53.155.43
    4405.full-html.html
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      DOI: 10.1523/jneurosci.2146-22.2023

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    52.53.155.43/29ab334110de858c7a6937a4817b3955d437811a/4405.full-html.html
  48. May 2023
  49. www.mdpi.com www.mdpi.com
    Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral Responses
    1
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      DOI: 10.3390/cells10102600

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    mdpi.com/2073-4409/10/10/2600/htm
  50. Apr 2023
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS
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      DOI: 10.7554/eLife.79452

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    ncbi.nlm.nih.gov/pmc/articles/PMC10076021/
  52. www.sciencedirect.com www.sciencedirect.com
    γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons
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      DOI: 10.1016/j.neuron.2023.03.012

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    sciencedirect.com/science/article/pii/S0896627323002088
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Z-REX: shepherding reactive electrophiles to specific proteins expressed tissue specifically or ubiquitously, and recording the resultant functional electrophile-induced redox responses in larval fish
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      DOI: 10.1038/s41596-023-00809-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC11150335/
  54. www.sciencedirect.com www.sciencedirect.com
    Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis
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      DOI: 10.1016/j.celrep.2023.112327

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    sciencedirect.com/science/article/pii/S2211124723003388
  55. Mar 2023
  56. www.sciencedirect.com www.sciencedirect.com
    A central chaperone-like role for 14-3-3 proteins in human cells
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    Targeting androgen receptor and the variants by an orally bioavailable Proteolysis Targeting Chimeras compound in castration resistant prostate cancer
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  59. Feb 2023
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    ARMS-NF-κB signaling regulates intracellular ROS to induce autophagy-associated cell death upon oxidative stress
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  61. Jan 2023
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    Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning
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    GSNOR deficiency promotes tumor growth via FAK1 S-nitrosylation
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    CYLD deubiquitinates plakoglobin to promote Cx43 membrane targeting and gap junction assembly in the heart
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    Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression
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    MsrB1-regulated GAPDH oxidation plays programmatic roles in shaping metabolic and inflammatory signatures during macrophage activation
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    CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors
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    Krüppel-like factor 5 rewires NANOG regulatory network to activate human naive pluripotency specific LTR7Ys and promote naive pluripotency
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    UBP12 and UBP13 deubiquitinases destabilize the CRY2 blue light receptor to regulate Arabidopsis growth
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    Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct Smad pathways
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    ROPGAP-dependent interaction between brassinosteroid and ROP2-GTPase signaling controls pavement cell shape in Arabidopsis
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    Androgen signaling connects short isoform production to breakpoint formation at Ewing sarcoma breakpoint region 1
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    Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism
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    Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria
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  118. Jul 2021
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    Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment
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      mouse monoclonal anti-HA

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  120. onlinelibrary.wiley.com onlinelibrary.wiley.com
    FipoQ/FBXO33, a Cullin‐1‐based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein
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    Dual function of VGLL4 in muscle regeneration
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    Secretion of Tau via an Unconventional Non-vesicular Mechanism
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    Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers
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    The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance
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  128. May 2021
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    VEGF counteracts amyloid-β-induced synaptic dysfunction
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    Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling
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    Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains
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    The GSK3-like Kinase BIN2 Is a Molecular Switch between the Salt Stress Response and Growth Recovery in Arabidopsis thaliana
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    PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis
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  134. Apr 2021
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    SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization
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  139. Mar 2021
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    Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy
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  141. Feb 2021
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    The Ligand of Ate1 is intrinsically disordered and participates in nucleolar phase separation regulated by Jumonji Domain Containing 6
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    A positive feedback loop between Flower and PI(4,5)P2 at periactive zones controls bulk endocytosis in Drosophila
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    Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells
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  145. Jan 2021
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    The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling
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  147. Nov 2020
  148. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Poly(A)-Binding Protein Regulates the Efficiency of Translation Termination
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    Type-IInterferon-Inducible SERTAD3 Inhibits Influenza A Virus Replication by Blocking the Assembly of Viral RNA Polymerase Complex
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  150. Oct 2020
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    CRISPR-Csy4-Mediated Editing of Rotavirus Double-Stranded RNA Genome
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    PKCε SUMOylation Is Required for Mediating the Nociceptive Signaling of Inflammatory Pain
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  153. Sep 2020
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    Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating
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    Structural modeling, mutation analysis, and in vitro expression of usherin, a major protein in inherited retinal degeneration and hearing loss
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    A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells
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    ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair
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    FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function
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    Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution
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    The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation
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    A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites
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    Hsp90 Co-chaperones Form Plastic Genetic Networks Adapted to Client Maturation
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  164. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice
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    TGF-β-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Development and Maintenance
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    Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity
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    Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core
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    ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia
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    The Human Cytomegalovirus pUL145 Isoforms Act as Viral DDB1-Cullin-Associated Factors to Instruct Host Protein Degradation to Impede Innate Immunity
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    The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function
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    The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers
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    Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury
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    Non-coding RNA Transcription in Tetrahymena Meiotic Nuclei Requires Dedicated Mediator Complex-Associated Proteins
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    Usp9X Controls Ankyrin-Repeat Domain Protein Homeostasis during Dendritic Spine Development
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    Rad52 Restrains Resection at DNA Double-Strand Break Ends in Yeast
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    Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons
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    Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate
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    Transcriptional profiling aligned with in situ expression image analysis reveals mosaically‐expressed molecular markers for GABA neuron sub‐groups in the ventral tegmental area
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    Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation
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    Reciprocal Effects of Fibroblast Growth Factor Receptor Signaling on Dengue Virus Replication and Virion Production
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    Plk4 Regulates Centriole Asymmetry and Spindle Orientation in Neural Stem Cells
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    FipoQ/FBXO33, a Cullin‐1‐based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein
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    The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival
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      RRID:AB_262051

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    sciencedirect.com/science/article/pii/S2211124718309550
  204. www.sciencedirect.com www.sciencedirect.com
    Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function
    1
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      RRID:AB_262051

      Curator: @evieth

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    sciencedirect.com/science/article/pii/S2211124718307757
  205. europepmc.org europepmc.org
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    europepmc.org/articles/PMC5957528/
  206. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  207. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S1931312818301987
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    A Dendritic Guidance Receptor Complex Brings Together Distinct Actin Regulators to Drive Efficient F-Actin Assembly and Branching
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    sciencedirect.com/science/article/pii/S1534580718302831
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    cell.com/cell-host-microbe/abstract/S1931-3128(18)30198-7
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    A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline
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    Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors
    1
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      Curator: @Jmenke

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    Injury Activates Ca2+/Calmodulin-Dependent Phosphorylation of JAV1-JAZ8-WRKY51 Complex for Jasmonate Biosynthesis
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    sciencedirect.com/science/article/pii/S1097276518302168
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    MPK3- and MPK6-Mediated ICE1 Phosphorylation Negatively Regulates ICE1 Stability and Freezing Tolerance in Arabidopsis
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    Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly
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    sciencedirect.com/science/article/pii/S0092867418301533
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    OsMAPK3 Phosphorylates OsbHLH002/OsICE1 and Inhibits Its Ubiquitination to Activate OsTPP1 and Enhances Rice Chilling Tolerance
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  216. europepmc.org europepmc.org
    Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex.
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  217. Nov 2017
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    The Plasticity of the Hsp90 Co-chaperone System
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    Retrograde Synaptic Inhibition Is Mediated by α-Neurexin Binding to the α2δ Subunits of N-Type Calcium Channels
    1
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      AB_262051

      Curator: @chewbeccax

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    Plasma Membrane CRPK1-Mediated Phosphorylation of 14-3-3 Proteins Induces Their Nuclear Import to Fine-Tune CBF Signaling during Cold Response
    1
    1. scibot 08 Nov 2017
      Cat#H3663

      Curator: @Zeljana_Babic

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    sciencedirect.com/science/article/pii/S1097276517301314
  221. www.sciencedirect.com www.sciencedirect.com
    Gene Resistance to Transcriptional Reprogramming following Nuclear Transfer Is Directly Mediated by Multiple Chromatin-Repressive Pathways
    1
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      Curator: @Zeljana_Babic

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    sciencedirect.com/science/article/pii/S1097276517300564
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    NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres
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      AB_262051

      Curator: @Zeljana_Babic

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    sciencedirect.com/science/article/pii/S1097276517300424
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    Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening
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    1. scibot 08 Nov 2017
      AB_262051

      Curator: @Zeljana_Babic

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    sciencedirect.com/science/article/pii/S1097276516308644
  224. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drosophila neprilysins control insulin signaling and food intake via cleavage of regulatory peptides
    1
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      AB_262051

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    ncbi.nlm.nih.gov/pmc/articles/PMC5140268/