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Aug 2025
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Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size

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  DOI: 10.1101/2025.07.23.666188
  
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biorxiv.org/content/10.1101/2025.07.23.666188v1
Jul 2025
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ARID1A mutation drives gastric tumorigenesis via activating type 2 immune dominant microenvironment

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Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling

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  DOI: 10.1126/science.adm9805
  
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science.org/doi/10.1126/science.adm9805
Jun 2025
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PTEN neddylation aggravates CDK4/6 inhibitor resistance in breast cancer

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  DOI: 10.1038/s41388-025-03468-z
  
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52.53.155.43/de242f5c9d14208174da1148bf800061ebe1b9cf/1-s2.0-S2666247725000648-main-html.html
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PTEN protein phosphatase activity regulates metastasis by targeting PKCδ

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sciencedirect.com/science/article/pii/S2589004225010028
May 2025
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YTHDF1 differentiates the contributing roles of mTORC1 in aging

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sciencedirect.com/science/article/pii/S1097276525004083
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KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation

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pmc.ncbi.nlm.nih.gov/articles/PMC12091147/
Apr 2025
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1-s2.0-S2212877825000584-main-html.html

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52.53.155.43/284b8517565b9764dbe5c0470f72829f488a110b/1-s2.0-S2212877825000584-main-html.html
Mar 2025
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Treadmill exercise in combination with acousto-optic and... : Neural Regeneration Research

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  DOI: 10.4103/NRR.NRR-D-23-01681
  
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journals.lww.com/nrronline/fulltext/2025/09000/treadmill_exercise_in_combination_with.31.aspx
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KCTD20 suppression mitigates excitotoxicity in tauopathy patient organoids

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  DOI: 10.1016/j.neuron.2025.02.001
  
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sciencedirect.com/science/article/pii/S089662732500114X
Feb 2025
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Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer

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  DOI: 10.1158/0008-5472.CAN-23-3987
  
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aacrjournals.org/cancerres/article/84/20/3371/749080/Cancer-Associated-Fibroblasts-Expressing-Sulfatase
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Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases

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  DOI: 10.1016/j.xcrm.2025.101943
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11866499/
Jan 2025
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Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment

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  DOI: 10.1158/2326-6066.CIR-23-1092
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11712038/
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Non-cell-autonomous regulation of mTORC2 by Hedgehog signaling maintains lipid homeostasis

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  DOI: 10.1016/j.celrep.2024.115191
  
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sciencedirect.com/science/article/pii/S2211124724015420
Dec 2024
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FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology

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  DOI: 10.1016/j.cmet.2024.11.001
  
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sciencedirect.com/science/article/pii/S1550413124004479
Sep 2024
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Endothelial metabolic control of insulin sensitivity through resident macrophages

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  DOI: 10.1016/j.cmet.2024.08.008
  
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sciencedirect.com/science/article/pii/S1550413124003358
Aug 2024
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Sex-Dimorphic Effects of Glucose Transporter-2 Gene Knockdown on Hypothalamic Primary Astrocyte Phosphoinositide-3-kinase (PI3K)/Protein Kinase B (PKB/Akt)/Mammalian Target of Rapamycin (mTOR) Cascade Protein Expression and Phosphorylation

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  DOI: 10.1016/j.mce.2024.112341
  
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sciencedirect.com/science/article/pii/S0303720724001977
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Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

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  DOI: 10.1126/science.adk0775
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11301402/
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In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma

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Jul 2024
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Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

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science.org/doi/10.1126/science.adk0775
May 2024
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eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer

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  DOI: 10.1126/scisignal.adh4475
  
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BPS Publications

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  DOI: 10.1111/bph.16356
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16356
Mar 2024
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Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats

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ncbi.nlm.nih.gov/pmc/articles/PMC10920058/
Feb 2024
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An integrative proteomics approach identifies tyrosine kinase KIT as a therapeutic target for SPINK1-positive prostate cancer

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TMED2 promotes glioma tumorigenesis by being involved in EGFR recycling transport

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  DOI: 10.1016/j.ijbiomac.2024.130055
  
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Cell-intrinsic PD-L1 ablation sustains effector CD8+ T cell responses and promotes antitumor T cell therapy

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Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer

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  DOI: 10.1038/s41698-024-00496-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
Jan 2024
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Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints

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  DOI: 10.1038/s41388-024-02947-z
  
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nature.com/articles/s41388-024-02947-z
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Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease

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  DOI: 10.1016/j.jbc.2024.105641
  
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Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development

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  DOI: 10.1016/j.ebiom.2021.103287
  
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Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model

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  DOI: 10.1016/j.jbc.2023.105619
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10839450/
Nov 2023
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Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation

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FUS-dependent microRNA deregulations identify TRIB2 as a druggable target for ALS motor neurons

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  DOI: 10.1016/j.isci.2023.108152
  
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  DOI: 10.1016/j.isci.2023.108152
  
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Oct 2023
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N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes

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High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma

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Aug 2023
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PIIS2589004223016838-html.html

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Jul 2023
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mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching

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Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints

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Inhibition of AXL receptor tyrosine kinase enhances brown adipose tissue functionality in mice

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  DOI: 10.1038/s41467-023-39715-8
  
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Cell Competition Shapes Metastatic Latency and Relapse

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  DOI: 10.1158/2159-8290.CD-22-0236
  
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Jun 2023
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Identification of XAF1 as an endogenous AKT inhibitor

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HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis

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  DOI: 10.1126/sciadv.ade1155
  
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Macrophage-derived cathepsin S remodels the extracellular matrix to promote liver fibrogenesis

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May 2023
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Actuation of single downstream nodes in growth factor network steers immune cell migration

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Venlafaxine antagonizes the noradrenaline-promoted colon cancer progression by inhibiting the norepinephrine transporter

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Apr 2023
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Optimal HSF1 activation in response to acute cold stress in BAT requires nuclear TXNIP

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Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

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Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort

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  DOI: 10.1038/s41398-023-02411-8
  
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Feb 2023
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IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells

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PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6

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Jan 2023
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mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system

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  DOI: 10.1523/JNEUROSCI.0010-22.2022
  
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The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region

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The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation

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  DOI: 10.1158/0008-5472.CAN-22-0446
  
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Nov 2022
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Neuronal-epithelial cross-talk drives acinar specification via NRG1-ERBB3-mTORC2 signaling

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Disruption of mTORC1 rescues neuronal overgrowth and synapse function dysregulated by Pten loss

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KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice

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Hepatic ER stress suppresses adipose browning through ATF4-CIRP-ANGPTL3 cascade

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  Rabbit polyclonal anti-pAKT (Thr308)
  
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The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling

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Aug 2022
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Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

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Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging

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May 2022
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Stromal AR inhibits prostate tumor progression by restraining secretory luminal epithelial cells

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Triple targeting of HER receptors overcomes heregulin-mediated resistance to EGFR blockade in colorectal cancer

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Mar 2022
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Coordinated changes in glycosylation regulate the germinal center through CD22

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Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake

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Feb 2022
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Supplementing Soy-Based Diet with Creatine in Rats: Implications for Cardiac Cell Signaling and Response to Doxorubicin

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  DOI: 10.3390/nu14030583
  
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Renal Klotho and inorganic phosphate are extrinsic factors that antagonistically regulate hematopoietic stem cell maintenance

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  DOI: 10.1016/j.celrep.2022.110392
  
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Autophagic and apoptotic cell death induced by the quinoline derivative 2-(6-methoxynaphthalen-2-yl)quinolin-4-amine in pancreatic cancer cells is via ER stress and inhibition of Akt/mTOR signaling pathway

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Jan 2022
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ACE2 pathway regulates thermogenesis and energy metabolism

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SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes

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GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure

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Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation

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GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway

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RNF8-mediated regulation of Akt promotes lung cancer cell survival and resistance to DNA damage

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Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation

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Delivery of membrane impermeable molecules to primary mouse T lymphocytes

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NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms

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Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system

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Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis

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GSK3-CRMP2 signaling mediates axonal regeneration induced by Pten knockout

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12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat

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Akt3-mTOR regulates hippocampal neurogenesis in adult mouse

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Thyroid hormone receptor beta inhibits the PI3K-Akt-mTOR signaling axis in anaplastic thyroid cancer cell lines via genomic mechanisms

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Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target

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Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity

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OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin

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NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma

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Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses

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Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression

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The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction

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Deciphering the signaling network of breast cancer improves drug sensitivity prediction

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Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum

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Cell Lineage-Based Stratification for Glioblastoma

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Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer

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Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development

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PKN1 Is a Novel Regulator of Hippocampal GluA1 Levels

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Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice

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Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies

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A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve

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The kinase PDK1 is critical for promoting T follicular helper cell differentiation

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Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice

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Impact of WIN site inhibitor on the WDR5 interactome

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ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence

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Deletion of PDK1 in oligodendrocyte lineage cells causes white matter abnormality and myelination defect in the central nervous system

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miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling

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The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling

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Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR

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Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer

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Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers

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Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells

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Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers

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Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1

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Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis

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Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1

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Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

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miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer

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Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease

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OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin

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α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development

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Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes

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CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways

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The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling

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Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells

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Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss

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LncRNA MEG3 contributes to adenosine‐induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K‐AKT‐mTOR and beclin‐1 signaling pathway

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GSK3-CRMP2 signaling mediates axonal regeneration induced by Pten knockout

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Untitled document

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Pink1 regulates FKBP5 interaction with AKT/PHLPP and protects neurons from neurotoxin stress induced by MPP+

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Untitled document

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TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency

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Lysosome Positioning Influences mTORC2 and AKT Signaling

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Fatty acid receptor GPR120 promotes breast cancer chemoresistance by upregulating ABC transporters expression and fatty acid synthesis

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Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors

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Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection

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Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis

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Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis

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Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells

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A Split-Abl Kinase for Direct Activation in Cells

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Boosting CNS axon regeneration by harnessing antagonistic effects of GSK3 activity

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Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

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SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation

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Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS

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