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Co-targeting CDK4/6 enhances anti-cancer activity and alleviates immune-related adverse events of anti-PD-1 antibody for breast cancer

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  DOI: 10.1016/j.xcrm.2025.102429
  
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Oct 2025
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Intestinal Lachnospiraceae bacterium-derived propionate inhibits the progression of clear cell renal cell carcinoma

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  DOI: 10.1016/j.xcrm.2025.102410
  
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Sep 2025
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GATA2 decommissioning of enhancers: A mechanism to constrain inflammatory signaling

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  DOI: 10.1016/j.celrep.2025.116344
  
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TNFSF15 alleviates myeloid-derived suppressor cell-mediated cancer immunosuppression in mice

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1. scibot 23 Sep 2025
  
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  DOI: 10.1038/s41401-025-01663-y
  
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Aug 2025
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Hepatocyte metabolic adaptations during pregnancy and lactation

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1. scibot 29 Aug 2025
  
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  DOI: 10.1016/j.cell.2025.08.007
  
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1-s2.0-S2589004225016840-main-html.html

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52.53.155.43/23fa3039143e04e3669aa6d24e522324d4b71ce2/1-s2.0-S2589004225016840-main-html.html
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A long-lasting prolactin stimulates galactopoiesis in mice.

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Jul 2025
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1-s2.0-S2589004225013732-main-html.html

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1. scibot 16 Jul 2025
  
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52.53.155.43/73ec1f388f41da4ad69bbc809bebcfccf70e9065/1-s2.0-S2589004225013732-main-html.html
May 2025
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A novel synthesised STAT3 inhibitor exerts potent anti-tumour activity by inducing lysosome-dependent cell death

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1. scibot 20 May 2025
  
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  DOI: 10.1111/bph.70071
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70071
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A Novel Compound DBZ Alleviates Chronic Inflammatory Pain and Anxiety-Like Behaviors by Targeting the JAK2-STAT3 Signaling Pathway

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sciencedirect.com/science/article/pii/S0021925825020733
Apr 2025
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Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways

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1. scibot 04 Apr 2025
  
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  DOI: 10.1038/s41598-025-95766-5
  
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nature.com/articles/s41598-025-95766-5
Mar 2025
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IL-24 promotes atopic dermatitis-like inflammation through driving MRSA-induced allergic responses

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1. scibot 18 Mar 2025
  
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  DOI: 10.1093/procel/pwae030
  
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CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety

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1. scibot 11 Mar 2025
  
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  DOI: 10.1016/j.ccell.2025.02.006
  
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sciencedirect.com/science/article/pii/S1535610825000583
Feb 2025
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Engineered commensals for targeted nose-to-brain drug delivery

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  DOI: 10.1016/j.cell.2025.01.017
  
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Dec 2024
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Genetic and microenvironmental evolution of colorectal liver metastases under chemotherapy

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  DOI: 10.1016/j.xcrm.2024.101838
  
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Nov 2024
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Deciphering the composition and key driver genes of breast invasive micropapillary carcinoma by multi-omics analysis

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1. scibot 14 Nov 2024
  
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  DOI: 10.1016/j.isci.2024.111178
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11549989/
Sep 2024
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An ILK/STAT3 pathway controls glioblastoma stem cell plasticity

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1. scibot 27 Sep 2024
  
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  DOI: 10.1016/j.devcel.2024.09.003
  
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IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis

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1. scibot 26 Sep 2024
  
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Aug 2024
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β-adrenergic receptor inhibition enhances oncolytic herpes virus propagation through STAT3 activation in gastric cancer

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cellandbioscience.biomedcentral.com/articles/10.1186/s13578-021-00687-1
Jul 2024
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Intestinal epithelium dysfunctions cause IgA deposition in the kidney glomeruli of intestine-specific Ap1m2-deficient mice

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  DOI: 10.1016/j.ebiom.2024.105256
  
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TSPAN4 influences glioblastoma progression through regulating EGFR stability

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cell.com/iscience/fulltext/S2589-0042(24)01642-0
Jun 2024
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Anti-tumor effects of tirbanibulin in squamous cell carcinoma cells are mediated via disruption of tubulin-polymerization

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  DOI: 10.1007/s00403-024-03032-x
  
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May 2024
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Active substances and molecular mechanisms of Astragali Radix and Angelicae Sinensis Radix against idiopathic pulmonary fibrosis effects by network pharmacology and in vitro experiments

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1. scibot 14 May 2024
  
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Gingival-derived mesenchymal stem cells alleviate allergic asthma inflammation via HGF in animal models

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Mar 2024
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Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders

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  DOI: 10.1016/j.celrep.2024.113900
  
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Jan 2024
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MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning

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1. scibot 23 Jan 2024
  
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  DOI: 10.1186/s13578-023-01179-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10800076/
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miRNA-194-3p represses NF-κB in gliomas to attenuate iPSC genes and proneural to mesenchymal transition.

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  DOI: 10.1016/j.isci.2023.108650
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10788216/
Dec 2023
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A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling

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  DOI: 10.1016/j.isci.2023.108568
  
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Apoptosis releases hydrogen sulfide to inhibit Th17 cell differentiation

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  DOI: 10.1016/j.cmet.2023.11.012
  
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Nov 2023
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AGC kinase inhibitors regulate STING signaling through SGK-dependent and SGK-independent mechanisms

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  DOI: 10.1016/j.chembiol.2023.10.008
  
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Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration

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  DOI: 10.1016/j.cmet.2023.10.017
  
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  DOI: 10.1016/j.cmet.2023.10.017
  
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Detection of early prognostic biomarkers for metastasis of Ewing's sarcoma in pediatric patients

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  DOI: 10.1016/j.lfs.2023.122237
  
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Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk

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  DOI: 10.1016/j.stem.2023.08.002
  
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sciencedirect.com/science/article/pii/S1934590923002850
Sep 2023
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Crizotinib has Preclinical Efficacy in Philadelphia-negative Myeloproliferative Neoplasms

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  DOI: 10.1158/1078-0432.CCR-22-1763
  
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In vivo modeling of CLL transformation to Richter’s syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities

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Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma

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New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation

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FEBS Press

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Potential targets and mechanisms of photobiomodulation for... : Neural Regeneration Research

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DUSP4 promotes esophageal squamous cell carcinoma progression by dephosphorylating HSP90β

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Cross-activation of FGF, NODAL, and WNT pathways constrains BMP-signaling-mediated induction of the totipotent state in mouse embryonic stem cells

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The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation

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Restricting genomic actions of innate immune mediators on fetal hematopoietic progenitor cells

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943-html.html

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Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1

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Genetic Val66Met BDNF Variant Increases Hyperphagia on Fat-rich Diets in Mice

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Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity

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Prdm14 promotes mouse ESC self-renewal and PGCLC specification through enhancement of Stat3 activity

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STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization

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Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer

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Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation

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Identifying a confused cell identity for esophageal squamous cell carcinoma

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Identification of serum and glucocorticoid-regulated kinase 1 as a regulator of signal transducer and activator of transcription 3 signaling

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PDIA3 inhibits mitochondrial respiratory function in brain endothelial cells and C. elegans through STAT3 signaling and decreases survival after OGD

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BPS Publications

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Nitric Oxide Induces a Janus Kinase-1-Dependent Inflammatory Response in Primary Murine Astrocytes - John D. Nowery, Rylee N. Cisney, Jacob W. Feldmann, Gordon P. Meares, 2021

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Sugar causes obesity and metabolic syndrome in mice independently of sweet taste

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Establishment, maintenance, and recall of inflammatory memory

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A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer

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Lower androgen levels promote abnormal cartilage development in female patients with adolescent idiopathic scoliosis

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Coupling of GPR30 mediated neurogenesis and protection with astroglial Aromatase-STAT3 signaling in rat hippocampus after global cerebral ischemia

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Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition

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Uncovering the RNA-binding protein landscape in the pluripotency network of human embryonic stem cells

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May 2021
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Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation

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Nanog is a promising chemo‐resistant stemness marker and therapeutic target by iron chelators for esophageal cancer

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PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells

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Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice

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Def6 regulates endogenous type-I interferon responses in osteoblasts and suppresses osteogenesis

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Natural Product Trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer

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STAT3‐dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer

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MyD88 in myofibroblasts enhances colitis-associated tumorigenesis via promoting macrophage M2 polarization

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Sphingosylphosphorylcholine alleviates hypoxia-caused apoptosis in cardiac myofibroblasts via CaM/p38/STAT3 pathway

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Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity

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Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone

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A Bartonella Effector Acts as Signaling Hub for Intrinsic STAT3 Activation to Trigger Anti-inflammatory Responses

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Sugar causes obesity and metabolic syndrome in mice independently of sweet taste | American Journal of Physiology-Endocrinology and Metabolism

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Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring

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The Oncogenic Kaposi’s Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family

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Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin–FAK and uPAR signaling

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Nociceptor deletion of Tsc2 enhances axon regeneration by inducing a conditioning injury response in dorsal root ganglia

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Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA

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Salmonella Effector SteE Converts the Mammalian Serine/Threonine Kinase GSK3 into a Tyrosine Kinase to Direct Macrophage Polarization

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A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

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MAPK Erk5 in leptin receptor-expressing neurons controls body weight and systemic energy homeostasis in female mice

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A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism

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Untitled document

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Untitled document

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Untitled document

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Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice

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Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling

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Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1

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The control of oligodendrocyte bioenergetics by interferon-gamma (IFN-γ) and Src homology region 2 domain-containing phosphatase-1 (SHP-1)

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