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CDK4/6 Inhibition Reverses MEIS2 Suppression of CRL4CRBN to Enhance Immunomodulatory Drug Therapy in Multiple Myeloma

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1. scibot 21 Oct 2025
  
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  DOI: 10.1101/2025.10.14.681840
  
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biorxiv.org/content/10.1101/2025.10.14.681840v1
Aug 2025
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Design of multi-target peptide modulators for protein chaperone networks

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.str.2025.07.021
  
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sciencedirect.com/science/article/pii/S0969212625002692
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A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.molcel.2025.07.023
  
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sciencedirect.com/science/article/pii/S109727652500646X
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1-s2.0-S2589004225015652-main-html.html

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1. scibot 07 Aug 2025
  
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  AB_2631166
  
  DOI: 10.1016/j.isci.2025.113304
  
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52.53.155.43/85cee3d161a0de2e88ed1ed9d4903a9813261aae/1-s2.0-S2589004225015652-main-html.html
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CDK4 loss-of-function mutations cause microcephaly and short stature

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1. scibot 20 May 2025
  
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  DOI: 10.1101/gad.352311.124
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617628/
Apr 2025
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Profiling the Activity of the Potent and Highly Selective CDK2 Inhibitor BLU-222 Reveals Determinants of Response in CCNE1-Aberrant Ovarian and Endometrial Tumors

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1. scibot 05 Apr 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-2360
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11967718/
Mar 2025
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CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety

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1. scibot 11 Mar 2025
  
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  DOI: 10.1016/j.ccell.2025.02.006
  
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sciencedirect.com/science/article/pii/S1535610825000583
Feb 2025
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Biguanides antithetically regulate tumor properties by the dose-dependent mitochondrial reprogramming-driven c-Src pathway

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1. scibot 11 Feb 2025
  
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  DOI: 10.1016/j.xcrm.2025.101941
  
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sciencedirect.com/science/article/pii/S266637912500014X
Jan 2025
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CDKN2A/B homozygous deletion sensitizes IDH-mutant glioma to CDK4/6 inhibition

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1. scibot 25 Jan 2025
  
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  DOI: 10.1158/1078-0432.CCR-24-0562
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11250907/
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ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs

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1. scibot 25 Jan 2025
  
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  DOI: 10.1158/0008-5472.CAN-23-2115
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11250573/
Dec 2024
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1-s2.0-S2589004224027329-main-html.html

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1. scibot 06 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111505
  
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52.53.155.43/3c53ef10f625befcd704a131cd24200ff9587189/1-s2.0-S2589004224027329-main-html.html
Nov 2024
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p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb

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1. scibot 21 Nov 2024
  
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  DOI: 10.1038/s44318-024-00246-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11574164/
Sep 2024
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Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy

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1. scibot 10 Sep 2024
  
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  DOI: 10.1016/j.cell.2024.08.013
  
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sciencedirect.com/science/article/pii/S0092867424009048
Jul 2024
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A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC

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1. scibot 31 Jul 2024
  
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  DOI: 10.1158/2767-9764.CRC-24-0247
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11284272/
Jun 2024
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Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer

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1. scibot 28 Jun 2024
  
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  DOI: 10.1038/s41388-024-03081-6
  
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link.springer.com/article/10.1038/s41388-024-03081-6
Apr 2024
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The MYCN 5′ UTR as a therapeutic target in neuroblastoma

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1. scibot 25 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114134
  
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sciencedirect.com/science/article/pii/S2211124724004625
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Bisbiguanide analogs induce mitochondrial stress to inhibit lung cancer cell invasion

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1. scibot 20 Apr 2024
  
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  DOI: 10.1016/j.isci.2024.109591
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11022046/
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Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer

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1. scibot 18 Apr 2024
  
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  RRID:AB_2631166
  
  DOI: 10.21203/rs.3.rs-4095949/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10996809/
Feb 2024
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YAP-mediated GPER signaling impedes proliferation and survival of prostate epithelium in benign prostatic hyperplasia

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1. scibot 09 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.109125
  
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52.53.155.43/3b983d9532a50e2ebeba730d1190ef88722ceb9a/PIIS2589004224003468-html.html
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Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer

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1. scibot 01 Feb 2024
  
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  DOI: 10.1038/s41698-024-00496-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
Dec 2023
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Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation

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1. scibot 29 Dec 2023
  
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  DOI: 10.1002/advs.202305620
  
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onlinelibrary.wiley.com/doi/10.1002/advs.202305620
Nov 2023
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Pan-cancer tRNA-derived fragment CAT1 coordinates RBPMS to stabilize NOTCH2 mRNA to promote tumorigenesis

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1. scibot 17 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113408
  
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sciencedirect.com/science/article/pii/S2211124723014201
Jul 2023
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Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer

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1. scibot 14 Jul 2023
  
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  DOI: 10.1016/j.xcrm.2023.101120
  
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sciencedirect.com/science/article/pii/S2666379123002483
Jun 2023
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Mechanism underlying follicular hyperproliferation and oncogenesis in hidradenitis suppurativa

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1. scibot 24 Jun 2023
  
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  DOI: 10.1016/j.isci.2023.106896
  
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sciencedirect.com/science/article/pii/S2589004223009732
May 2023
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Modeling breast cancer proliferation, drug synergies, and alternating therapies

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1. scibot 19 May 2023
  
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  DOI: 10.1016/j.isci.2023.106714
  
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sciencedirect.com/science/article/pii/S2589004223007915
Feb 2023
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Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

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1. scibot 03 Feb 2023
  
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  DOI: 10.1016/j.molcel.2023.01.015
  
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sciencedirect.com/science/article/pii/S1097276523000382
Aug 2022
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Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach

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1. scibot 23 Aug 2022
  
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  DOI: 10.1016/j.crmeth.2022.100271
  
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sciencedirect.com/science/article/pii/S2667237522001485
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Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE

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1. scibot 16 Aug 2022
  
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  DOI: 10.1016/j.isci.2022.104872
  
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Jul 2022
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A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase

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  DOI: 10.1016/j.devcel.2022.06.008
  
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sciencedirect.com/science/article/pii/S1534580722004488
Mar 2022
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Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma

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1. scibot 05 Mar 2022
  
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  DOI: 10.1038/s41467-022-28515-1
  
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nature.com/articles/s41467-022-28515-1
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CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities

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  DOI: 10.1016/j.celrep.2022.110448
  
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sciencedirect.com/science/article/pii/S2211124722001759
Dec 2021
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KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma

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1. scibot 18 Dec 2021
  
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  DOI: 10.1038/s41467-021-27502-2
  
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nature.com/articles/s41467-021-27502-2
Nov 2021
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RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site

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1. scibot 03 Nov 2021
  
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  DOI: 10.1016/j.celrep.2021.109934
  
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sciencedirect.com/science/article/pii/S2211124721014078
Sep 2021
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Rack1 is essential for corticogenesis by preventing p21-dependent senescence in neural stem cells

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1. scibot 01 Sep 2021
  
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  DOI: 10.1016/j.celrep.2021.109639
  
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sciencedirect.com/science/article/pii/S2211124721010822
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Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome

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1. scibot 01 Sep 2021
  
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  DOI: 10.1016/j.celrep.2021.109597
  
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sciencedirect.com/science/article/pii/S2211124721010354
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  RRID:AB_2631166
  
  DOI: 10.7554/eLife.40856
  
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  RRID:AB_2631166
  
  DOI: 10.1016/j.ccell.2018.11.006
  
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Jul 2021
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RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway

1
1. scibot 31 Jul 2021
  
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  CDK4
  
  DOI: 10.1186/s40659-019-0268-x
  
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  RRID:AB_2631166
  
  DOI: 10.1016/j.chembiol.2018.11.006
  
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Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK

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1. scibot 22 May 2021
  
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  RRID:AB_2631166
  
  DOI: 10.1016/j.devcel.2021.04.030
  
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Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer

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1. scibot 07 May 2021
  
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  RRID:AB_2631166
  
  DOI: 10.1016/j.molcel.2020.04.027
  
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Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG

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1. scibot 14 Apr 2021
  
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  RRID:AB_2631166
  
  DOI: 10.1016/j.celrep.2021.108994
  
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Jan 2021
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A novel ligand of the translationally controlled tumor protein (TCTP) identified by virtual drug screening for cancer differentiation therapy

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1. scibot 28 Jan 2021
  
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  RRID:AB_2631166
  
  DOI: 10.1007/s10637-020-01042-w
  
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Nov 2020
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p75NTR Promotes Astrocyte Proliferation in Response to Cortical Stab Wound

1
1. scibot 25 Nov 2020
  
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  anti-CDK4
  
  DOI: 10.1007/s10571-020-01006-x
  
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Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531

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  RRID:AB_2631166
  
  DOI: 10.7554/eLife.56913
  
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KIF15 promotes the evolution of gastric cancer cells through inhibition of reactive oxygen species‐mediated apoptosis

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1. scibot 06 Sep 2020
  
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  RRID:AB_2631166
  
  DOI: 10.1002/jcp.29743
  
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Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner

1
1. scibot 04 Sep 2020
  
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  RRID:AB_2631166
  
  DOI: 10.1016/j.celrep.2020.107858
  
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Jan 2020
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MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2631166
  
  DOI: 10.1016/j.celrep.2019.02.023
  
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1. scibot 13 Jan 2020
  
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  DOI: 10.7554/eLife.40856
  
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  RRID:AB_2631166
  
  DOI: 10.1016/j.chembiol.2019.03.012
  
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Nov 2018
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Testosterone regulates myosin II isoforms expression and functional activity in the rat prostate

1
1. scibot 05 Nov 2018
  
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  AB_2631166
  
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Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding

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Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2631166
  
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A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader

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