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A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

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1. scibot 24 Apr 2026
  
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  DOI: 10.1111/acel.70352
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12816977/
Feb 2025
dx.doi.org dx.doi.org

The roles of Growth Hormone dependent JAK-STAT5 and Lyn kinase signalling in determining lifespan and cancer incidence

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1. scibot 20 Feb 2025
  
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  DOI: 10.1210/endocr/bqae136
  
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dx.doi.org/10.1210/endocr/bqae136
Dec 2024
www.nature.com www.nature.com

Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

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1. scibot 21 Dec 2024
  
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  DOI: 10.1038/s41586-024-08348-2
  
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nature.com/articles/s41586-024-08348-2
Oct 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

NAPRT silencing in FH-deficient renal cell carcinoma confers therapeutic vulnerabilities via NAD+ depletion

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1. scibot 04 Oct 2024
  
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  DOI: 10.1158/1541-7786.MCR-23-1003
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11445649/
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

YZL-51N functions as a selective inhibitor of SIRT7 by NAD+ competition to impede DNA damage repair

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1. scibot 01 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110014
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11214487/
Jun 2024
www.sciencedirect.com www.sciencedirect.com

Cardioprotective effect of Cinnamamide derivative compound 10 against myocardial ischemia-reperfusion through regulating cardiac autophagy via Sirt1

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1. scibot 06 Jun 2024
  
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  DOI: 10.1016/j.biopha.2024.116819
  
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sciencedirect.com/science/article/pii/S0753332224007030
May 2024
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia

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1. scibot 25 May 2024
  
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  DOI: 10.1113/JP285339
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/JP285339
Mar 2024
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The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA

2
1. scibot 14 Mar 2024
  
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  DOI: 10.1016/j.devcel.2024.02.008
  
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2. scibot 14 Mar 2024
  
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  RRID:AB_2636969
  
  DOI: 10.1016/j.devcel.2024.02.008
  
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sciencedirect.com/science/article/pii/S1534580724001072
Feb 2024
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Cardiac injury activates STING signaling via upregulating SIRT6 in macrophages after myocardial infarction

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1. scibot 02 Feb 2024
  
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  DOI: 10.1016/j.lfs.2024.122474
  
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sciencedirect.com/science/article/pii/S0024320524000638
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Sirt6 regulates proliferation of neural precursor cells and cortical neurogenesis in mice

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1. scibot 02 Feb 2024
  
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  DOI: 10.1016/j.isci.2023.108706
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10823065/
Nov 2023
www.embopress.org www.embopress.org

SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1

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1. scibot 03 Nov 2023
  
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  RRID:AB_2636969
  
  DOI: 10.15252/embr.202357500
  
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embopress.org/doi/10.15252/embr.202357500
Oct 2023
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Glutathione dynamics is a potential predictive and therapeutic trait for neoadjuvant chemotherapy response in bladder cancer

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1. scibot 14 Oct 2023
  
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  RRID:AB_2636969
  
  DOI: 10.1016/j.xcrm.2023.101224
  
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sciencedirect.com/science/article/pii/S2666379123003981
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine

1
1. scibot 10 Aug 2023
  
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  RRID:AB_2636969
  
  DOI: 10.1038/s41419-023-06018-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10403574/
Jul 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Overexpression of Sirt6 ameliorates sleep deprivation induced-cognitive impairment by modulating glutamatergic neuron function

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1. scibot 25 Jul 2023
  
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  RRID:AB_2636969
  
  DOI: 10.4103/1673-5374.371370
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10360083/
Jun 2023
portlandpress.com portlandpress.com

Akt2 deficiency alleviates oxidative stress in the heart and liver via upregulating SIRT6 during high-fat diet-induced obesity

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1. scibot 30 Jun 2023
  
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  RRID:AB_2636969
  
  DOI: 10.1042/CS20230433
  
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portlandpress.com/clinsci/article/137/10/823/233046/Akt2-deficiency-alleviates-oxidative-stress-in-the
Apr 2023
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Protocol to purify the histone deacetylase SIRT6 and assess its activity in vitro

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1. scibot 06 Apr 2023
  
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  RRID:AB_2636969
  
  DOI: 10.1016/j.xpro.2023.102206
  
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sciencedirect.com/science/article/pii/S2666166723001648
Nov 2022
www.researchsquare.com www.researchsquare.com

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1. scibot 11 Nov 2022
  
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  RRID:AB_2636969
  
  DOI: 10.21203/rs.3.rs-658360/v1
  
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researchsquare.com/article/rs-7216019/'https://www.researchsquare.com/article/rs-7216019/v1
Oct 2022
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Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation

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1. scibot 09 Oct 2022
  
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  DOI: 10.1016/j.molcel.2022.09.018
  
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sciencedirect.com/science/article/pii/S1097276522009078
Jul 2022
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 27 Jul 2022
  
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  RRID:AB_2636969
  
  DOI: 10.1111/bph.15899
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15899
Jun 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

High-intensity interval training remodels the proteome and acetylome of human skeletal muscle

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1. scibot 04 Jun 2022
  
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  RRID:AB_2636969
  
  DOI: 10.7554/eLife.69802
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9154743/
Nov 2021
www.nature.com www.nature.com

Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with krüppel-like factor 10 deficiency

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1. scibot 06 Nov 2021
  
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  RRID:AB_2636969
  
  DOI: 10.1038/s12276-021-00687-8
  
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nature.com/articles/s12276-021-00687-8
Jun 2021
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ

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1. scibot 02 Jun 2021
  
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  RRID:AB_2636969
  
  DOI: 10.1016/j.celrep.2021.109190
  
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pubmed.ncbi.nlm.nih.gov/34077730/
Apr 2021
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Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in Mice

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1. scibot 29 Apr 2021
  
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  RRID:AB_2636969
  
  DOI: 10.1016/j.cmet.2020.04.018
  
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sciencedirect.com/science/article/pii/S1550413120302357
Jan 2020
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Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

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1. scibot 13 Jan 2020
  
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  RRID:AB_2636969
  
  DOI: 10.1016/j.molcel.2019.07.023
  
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sciencedirect.com/science/article/pii/S1097276519305532
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SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

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1. scibot 13 Jan 2020
  
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  RRID:AB_2636969
  
  DOI: 10.1016/j.celrep.2019.11.067
  
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sciencedirect.com/science/article/pii/S221112471931558X
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing

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1. scibot 13 Jan 2020
  
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  RRID:AB_2636969
  
  DOI: 10.1016/j.molcel.2019.06.034
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6907403/
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Untitled document

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1. scibot 12 Jan 2020
  
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  RRID:AB_2636969
  
  DOI: 10.1016/j.cmet.2019.03.001
  
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sciencedirect.com/science/article/pii/S1550413119301299
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Untitled document

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1. scibot 12 Jan 2020
  
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  RRID:AB_2636969
  
  DOI: 10.1016/j.devcel.2019.03.011
  
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sciencedirect.com/science/article/pii/S1534580719301881