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Nov 2026
www.sciencedirect.com www.sciencedirect.com

RAStoERK: A reference interaction atlas for insights into signaling and disease

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  DOI: 10.1016/j.celrep.2026.118201
  
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sciencedirect.com/science/article/pii/S2211124726012805
Jul 2026
academic.oup.com academic.oup.com

Thyroid Hormone Receptor Beta Suppresses Cancer Cell Activity by Differential Regulation of Glycogen Metabolism

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1. scibot 01 Jul 2026
  
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  DOI: 10.1210/endocr/bqaf156
  
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academic.oup.com/endo/article-abstract/166/12/bqaf156/8300492
Jun 2026
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Suppression of ATM kinase signaling accelerates cellular senescence

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1. scibot 13 Jun 2026
  
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  DOI: 10.1016/j.stemcr.2026.102956
  
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sciencedirect.com/science/article/pii/S2213671126001670
Mar 2026
54.241.53.176 54.241.53.176

1-s2.0-S0014488626001093-main-html.html

1
1. scibot 27 Mar 2026
  
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  AB_2636978
  
  DOI: 10.1016/j.expneurol.2026.115746
  
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54.241.53.176/814560218394612df452f7eba6e42f0b6b87b6c6/1-s2.0-S0014488626001093-main-html.html
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Panx1 deficiency exacerbates GAN diet-induced obesity by destabilizing β-catenin via GSK3β

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1. scibot 21 Mar 2026
  
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  DOI: 10.1016/j.isci.2026.115098
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12999355/
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Discovery of MARK2 as a physiological kinase for PER2 in the mammalian clock

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1. scibot 17 Mar 2026
  
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  DOI: 10.1016/j.chembiol.2026.02.007
  
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Feb 2026
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Transglutaminase 2 exacerbates ovarian cancer survival by directly inactivating GSK3β

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1. scibot 10 Feb 2026
  
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  DOI: 10.1038/s41419-026-08447-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12876850/
54.241.53.176 54.241.53.176

1-s2.0-S2589004226002452-main-html.html

1
1. scibot 03 Feb 2026
  
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  AB_2636978
  
  DOI: 10.1016/j.isci.2026.114870
  
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54.241.53.176/ffc49d45fee722a021ca51a97f54a62bab4b127a/1-s2.0-S2589004226002452-main-html.html
Dec 2025
54.241.53.176 54.241.53.176

1-s2.0-S2589004225025404-main-html.html

1
1. scibot 09 Dec 2025
  
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  RRID:AB_2636978
  
  DOI: 10.1016/j.isci.2025.114279
  
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54.241.53.176/91848baea2783d76c3a2268cf866a68ea99b11d4/1-s2.0-S2589004225025404-main-html.html
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SM08502-Mediated β-Catenin Repression Synergizes with Olaparib to Inhibit Tumor Progression

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1. scibot 06 Dec 2025
  
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  DOI: 10.1158/2767-9764.CRC-25-0267
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12676110/
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Inhibition of glycolysis and stimulation of mitochondrial biogenesis lead to increased ROS levels and cell death in HNF-1ß positive clear cell carcinoma

1
1. scibot 05 Dec 2025
  
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  DOI: 10.1038/s41419-025-08243-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12669797/
Oct 2025
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Neuroprotection against beta-amyloid toxicity by the novel estrogen receptor modulator STX requires convergent signaling pathways

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1. scibot 02 Oct 2025
  
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  DOI: 10.3389/fnmol.2025.1670646
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12464056/
Aug 2025
www.degruyterbrill.com www.degruyterbrill.com

KRAS-driven pancreatic ductal adenocarcinoma cell lines harbour putative cancer stem cells

1
1. scibot 05 Aug 2025
  
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  RRID:AB_2636978
  
  DOI: 10.1515/oncologie-2025-0171
  
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degruyterbrill.com/document/doi/10.1515/oncologie-2025-0171/html
Jul 2025
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Ceftriaxone ameliorates tau phosphorylation and mislocalization in APP/PS1 AD mice by inhibiting endoplasmic reticulum stress

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.neuropharm.2025.110600
  
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sciencedirect.com/science/article/pii/S0028390825003089
Jun 2025
www.cell.com www.cell.com

BAG2 releases SAMD4B upon sensing of arginine deficiency to promote tumor cell survival

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1. scibot 28 Jun 2025
  
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  AB_2636978
  
  DOI: 10.1016/j.molcel.2025.05.035
  
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cell.com/molecular-cell/fulltext/S1097-2765(25)00499-X
May 2025
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TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells

1
1. scibot 16 May 2025
  
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  AB_2636978
  
  DOI: 10.1111/tra.70005
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12052438/
Apr 2025
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PI3K/AKT signaling mediates stress-inducible amyloid formation through c-Myc

1
1. scibot 24 Apr 2025
  
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  RRID:AB_2636978
  
  DOI: 10.1016/j.celrep.2025.115617
  
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sciencedirect.com/science/article/pii/S2211124725003882
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A single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory gene expression

1
1. scibot 08 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115530
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12014907/
Mar 2025
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Induction of Triple-Negative Breast Cancer Cell Death and Chemosensitivity Using mTORC2-Directed RNAi Nanomedicine

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1. scibot 21 Mar 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0261
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11921867/
Feb 2025
52.53.155.43 52.53.155.43

PI3K/AKT Signaling Mediates Stress-Inducible Amyloid Aggregation Through c-myc

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1. scibot 06 Feb 2025
  
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  AB_2636978
  
  DOI: 10.1101/2024.09.05.611538
  
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52.53.155.43/15e44188d52367f113b80590d3658c7c4b4df9b2/2024.09.05.611538v1.full-html.html
Jan 2025
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CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions

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1. scibot 16 Jan 2025
  
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  DOI: 10.1016/j.neuron.2024.12.016
  
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sciencedirect.com/science/article/pii/S0896627324009152
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Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation

1
1. scibot 16 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115204
  
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sciencedirect.com/science/article/pii/S2211124724015559
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Mitochondrial uncouplers inhibit oncogenic E2F1 activity and prostate cancer growth

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1. scibot 14 Jan 2025
  
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  DOI: 10.1016/j.xcrm.2024.101890
  
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sciencedirect.com/science/article/pii/S266637912400661X
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Calcineurin: An essential regulator of sleep revealed by biochemical, chemical biological, and genetic approaches

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  DOI: 10.1016/j.chembiol.2024.12.003
  
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sciencedirect.com/science/article/pii/S2451945624005130
Dec 2024
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MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115104
  
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sciencedirect.com/science/article/pii/S2211124724014554
Nov 2024
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Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981

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1. scibot 15 Nov 2024
  
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  DOI: 10.1016/j.isci.2024.111133
  
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sciencedirect.com/science/article/pii/S2589004224023587
Sep 2024
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IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis

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1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.cmet.2024.08.012
  
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sciencedirect.com/science/article/pii/S1550413124003644
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“β-Hydroxybutyrate Recapitulates the Beneficial Effects of Ketogenic Metabolic Therapy in Polycystic Kidney Disease”

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110773
  
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Glycogen synthase kinase‐3ß supports serotonin transporter function and trafficking in a phosphorylation‐dependent manner

1
1. scibot 25 Sep 2024
  
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  DOI: 10.1111/jnc.15152
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15152
Aug 2024
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MiR-137-3p mechanisms of action and blood-brain barrier penetrating and neuron-targeting lipid nanoparticles deliver miR-137-3p for the treatment of Alzheimer's disease

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1. scibot 23 Aug 2024
  
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  DOI: 10.1016/j.jddst.2024.106100
  
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sciencedirect.com/science/article/pii/S177322472400769X
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer

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1. scibot 22 Aug 2024
  
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  DOI: 10.1158/2767-9764.CRC-24-0111
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11320024/
www.cell.com www.cell.com

Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11

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1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.cmet.2024.07.014
  
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cell.com/cell-metabolism/fulltext/S1550-4131(24)00285-7
Jun 2024
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Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.isci.2024.110199
  
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sciencedirect.com/science/article/pii/S258900422401424X
May 2024
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Differential regulation of G protein-coupled receptor-associated proteins in the caudate and the putamen of cynomolgus macaques following chronic ethanol drinking

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1. scibot 30 May 2024
  
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  RRID:AB_2636978
  
  DOI: 10.1111/jnc.16134
  
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Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus

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Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling

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Islet resident macrophage-derived miR-155 promotes β-cell decompensation via targeting PDX1

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Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats

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ALK upregulates POSTN and WNT signaling to drive neuroblastoma

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Concurrent targeting of GSK3 and MEK as a therapeutic strategy to treat pancreatic ductal adenocarcinoma

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The relevance between abnormally elevated serum ceramide and cognitive impairment in Alzheimer’s disease model mice and its mechanism

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miRNA-194-3p represses NF-κB in gliomas to attenuate iPSC genes and proneural to mesenchymal transition.

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Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease

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Kinin B1 receptor controls maternal adiponectin levels and influences offspring weight gain

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Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma

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Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling

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CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling

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Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling

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Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration

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Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis

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AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells

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16p11.2 haploinsufficiency reduces mitochondrial biogenesis in brain endothelial cells and alters brain metabolism in adult mice

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Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease

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Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness

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Metformin Prevents Endothelial Oxidative Stress and Microvascular Insulin Resistance during Obesity Development in Male Rats

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PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6

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TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways

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Supramolecular assembly of GSK3α as a cellular response to amino acid starvation

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Active APPL1 sequestration by Plasmodium favors liver-stage development

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Tumor Microenvironment Acidity Triggers Lipid Accumulation in Liver Cancer via SCD1 Activation

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Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy

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Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney

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Neddylation is essential for β-catenin degradation in Wnt signaling pathway

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Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake

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Crry silencing alleviates Alzheimer’s disease injury by regulating neuroinflammatory cytokines and the complement system

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Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells

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SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes

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Oct 2021
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Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2

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miR-103-3p targets Ndel1 to regulate neural stem cell proliferation and differentiation

1
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  DOI: 10.4103/1673-5374.317987
  
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An extensive and dynamic trans-omic network illustrating prominent regulatory mechanisms in response to insulin in the liver

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Nonenzymatic function of DPP4 in diabetes-associated mitochondrial dysfunction and cognitive impairment

1
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  DOI: 10.1002/alz.12437
  
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Untitled document

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Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines

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Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation

1
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  DOI: 10.1016/j.molcel.2021.07.013
  
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Untitled document

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Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway

1
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  DOI: 10.1210/en.2017-00287
  
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The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3

1
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Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

1
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  GSK3β (D5C5Z) XP® Rabbit mAb
  
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Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway

2
1. scibot 28 Jul 2021
  
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  AB_2636978
  
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  RRID:AB_2636978
  
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Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target

1
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A kinome screen reveals that Nemo-like kinase is a key suppressor of hepatic gluconeogenesis

1
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  DOI: 10.1016/j.cmet.2021.04.006
  
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An isocaloric moderately high-fat diet extends lifespan in male rats and Drosophila

1
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  RRID:AB_26369787
  
  DOI: 10.1016/j.cmet.2020.12.017
  
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A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance

1
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  RRID:AB_2636978
  
  DOI: 10.1016/j.cmet.2020.08.001
  
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Mar 2021
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DHCR24 Knockdown Lead to Hyperphosphorylation of Tau at Thr181, Thr231, Ser262, Ser396, and Ser422 Sites by Membrane Lipid-Raft Dependent PP2A Signaling in SH-SY5Y Cells

1
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  RRID:AB_2636978
  
  DOI: 10.1007/s11064-021-03273-6
  
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Feb 2021
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Long-term kappa-carrageenan consumption leads to moderate metabolic disorder by blocking insulin binding

1
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  RRID:AB_2636978
  
  DOI: 10.1016/j.phrs.2020.105417
  
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Maternal high fat diet multigenerationally impairs hippocampal synaptic plasticity and memory in male rat offspring

2
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  RRID:AB_2636978
  
  DOI: 10.1210/endocr/bqaa214
  
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  DOI: 10.1210/endocr/bqaa214
  
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Myeloid-derived Growth Factor Promotes Intestinal Glucagon-like Peptide-1 Production in Male Mice with Type 2 Diabetes

1
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  RRID:AB_2636978
  
  DOI: 10.1210/endocr/bqaa003
  
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Jan 2021
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The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity

1
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  DOI: 10.1186/s12943-021-01308-8
  
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GSK-3β Disrupts Neuronal Oscillatory Function to Inhibit Learning and Memory in Male Rats

1
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  rabbit anti-GSK3β
  
  DOI: 10.1007/s10571-020-01020-z
  
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Oct 2020
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Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation

1
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The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development

1
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Sep 2020
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microRNA‐9‐5p alleviates blood‐brain barrier damage and neuroinflammation after traumatic brain injury

1
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  DOI: 10.1111/jnc.14963
  
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The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function

1
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  DOI: 10.1016/j.celrep.2020.108140
  
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BPS Publications

1
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  RRID:AB_2636978
  
  DOI: 10.1111/bph.14980
  
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HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

1
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  RRID:AB_2636978
  
  DOI: 10.1016/j.celrep.2020.107625
  
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BPS Publications

1
1. scibot 09 Sep 2020
  
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  RRID:AB_2636978
  
  DOI: 10.1111/bph.14912
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14912
onlinelibrary.wiley.com onlinelibrary.wiley.com

Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice

1
1. scibot 04 Sep 2020
  
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  RRID:AB_2636978
  
  DOI: 10.1111/jnc.14954
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.14954
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Disc1 Carrier Mice Exhibit Alterations in Neural pIGF-1Rβ and Related Kinase Expression

1
1. scibot 04 Sep 2020
  
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  Rabbit anti-GSK-3β
  
  DOI: 10.3389/fncel.2020.00094
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7214624/
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Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis

1
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  GSK3β
  
  DOI: 10.1126/scisignal.aax2364
  
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stke.sciencemag.org/content/13/621/eaax2364
Jan 2020
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Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination

1
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  RRID:AB_2636978
  
  DOI: 10.1016/j.celrep.2019.09.020
  
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Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain

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Targeting Degradation of the Transcription Factor C/EBPβ Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages

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  DOI: 10.1016/j.immuni.2019.06.014
  
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BPS Publications

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  DOI: 10.1111/bph.14802
  
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The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling

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  DOI: 10.1016/j.celrep.2019.08.091
  
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The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3

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  DOI: 10.1016/j.chom.2019.11.012
  
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KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

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  DOI: 10.1016/j.ccell.2018.10.001
  
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Lysosome Positioning Influences mTORC2 and AKT Signaling

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Untitled document

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Untitled document

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Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling

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Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles

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In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver

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AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells

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TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

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Boosting CNS axon regeneration by harnessing antagonistic effects of GSK3 activity

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β-TrCP1 Is a Vacillatory Regulator of Wnt Signaling

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