71 Matching Annotations
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    Overcoming ADC resistance in advanced colorectal cancer by dual targeting of TROP2 and PERK to suppress Wnt/β-catenin signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC13198297/
  3. Jun 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FET Fusion Oncoproteins Disrupt Physiologic DNA Repair and Create a Targetable Opportunity for ATR Inhibitor Therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13223543/
  5. May 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DHODH-Mediated Suppression of Ferroptosis Supports Radioresistance and Represents a Therapeutic Vulnerability in Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13179828/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    JIN-A02, a Mutant-Selective Fourth-Generation EGFR inhibitor, Overcomes C797S-Mediated Resistance and Demonstrates Intracranial Activity in NSCLC
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    pmc.ncbi.nlm.nih.gov/articles/PMC13133602/
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    Cross-tissue atlas of mucosa-associated lymphoid tissue lymphomas reveals intratumoral heterogeneity and microenvironmental subtypes
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    sciencedirect.com/science/article/pii/S2666379126002028
  9. Jan 2026
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    microRNA 146a suppresses tumor progression and enhances therapeutic sensitivity by targeting the EGFR pathway in BRCA1-associated basal-like breast cancers
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    sciencedirect.com/science/article/pii/S2667394025000383
  11. Dec 2025
  12. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Anti-mitotic agent SB-216 overcomes taxane resistance in castration-resistant prostate cancer and exhibits anti-tumour efficacy in pancreatic cancer
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70294
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    Deprivation of EGFR signal causes senolysis in PDAC with CDK4/6 inhibition
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    nature.com/articles/s41418-025-01634-0
  14. Nov 2025
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    Patient-derived organoids to study glycosylation dynamics during gastric disease
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    sciencedirect.com/science/article/pii/S221112472501321X
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    WDFY2 promotes MRN complex formation required for homologous recombination-mediated DNA repair
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    sciencedirect.com/science/article/pii/S2211124725012914
  17. Jul 2025
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    HIF-independent oxygen sensing via KDM6A regulates ferroptosis
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    sciencedirect.com/science/article/pii/S1097276525005805
  19. May 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming
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    pmc.ncbi.nlm.nih.gov/articles/PMC12118437/
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    Spatial and multiomics analysis of human and mouse lung adenocarcinoma precursors reveals TIM-3 as a putative target for precancer interception
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    sciencedirect.com/science/article/pii/S153561082500162X
  22. Apr 2025
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pan-KRAS Inhibitors BI-2493 and BI-2865 Display Potent Antitumor Activity in Tumors with KRAS Wild-type Allele Amplification
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962398/
  24. Jan 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs
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    pmc.ncbi.nlm.nih.gov/articles/PMC11250573/
  26. Jul 2024
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    CircEZH2 Promotes Gallbladder Cancer Progression and Lipid Metabolism Reprogramming through the miR-556-5p/SCD1 Axis
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    sciencedirect.com/science/article/pii/S2589004224016535
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    Tongue orthotopic xenografts to study fusion-negative rhabdomyosarcoma invasion and metastasis in live animals
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    cell.com/cell-reports-methods/abstract/S2667-2375(24)00158-9
  29. Jun 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The bidirectional role of GABAA and GABAB receptors during the differentiation process of neural precursor cells of the subventricular zone
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    ncbi.nlm.nih.gov/pmc/articles/PMC11195948/
  31. May 2024
  32. www.biorxiv.org www.biorxiv.org
    The bidirectional role of GABAA and GABAB receptors during the differentiation process of neural precursor cells of the subventricular zone
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    biorxiv.org/content/10.1101/2024.03.19.585835v1
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    Discovery of a novel potent EGFR inhibitor against EGFR activating mutations and on-target resistance in NSCLC
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    Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers
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    sciencedirect.com/science/article/pii/S1097276524003241
  35. Apr 2024
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    IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling
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    sciencedirect.com/science/article/pii/S2211124724004169
  37. Mar 2024
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    The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
  39. Feb 2024
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stromal-derived MAOB promotes prostate cancer growth and progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10857382/
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    Mitochondrial-encoded complex I impairment induces a targetable dependency on aerobic fermentation in Hürthle cell carcinoma of the thyroid
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    ncbi.nlm.nih.gov/pmc/articles/PMC10524862/
  42. Jan 2024
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    Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer
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    Antitumor efficacy of a sequence-specific DNA-targeted γPNA-based c-Myc inhibitor
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    Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer
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  46. Nov 2023
  47. link.springer.com link.springer.com
    Aloperine targets lysosomes to inhibit late autophagy and induces cell death through apoptosis and paraptosis in glioblastoma
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    link.springer.com/article/10.1186/s43556-023-00155-x
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    Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids
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    sciencedirect.com/science/article/pii/S2211124723013669
  49. Aug 2023
  50. aacrjournals.org aacrjournals.org
    Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer
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  51. Jun 2023
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    Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones
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  53. May 2023
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    A Wnt-induced lncRNA-DGCR5 splicing switch drives tumor-promoting inflammation in esophageal squamous cell carcinoma
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  55. Apr 2023
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    CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth
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  57. Jan 2023
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MOZ and Menin-MLL Complexes are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor
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    ncbi.nlm.nih.gov/pmc/articles/PMC9453853/
  59. Dec 2022
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    PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing
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    sciencedirect.com/science/article/pii/S1097276522010991
  61. Oct 2022
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel NF2 Splicing Mutant Causes Neurofibromatosis Type 2 via Liquid-liquid Phase Separation with LATS and Hippo Pathway.
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    ncbi.nlm.nih.gov/pmc/articles/PMC9589172/
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    Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival
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  64. Jun 2022
  65. 52.53.155.43 52.53.155.43
    cd-21-0646-html.html
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    Preclinical modeling of leiomyosarcoma identifies susceptibility to transcriptional CDK inhibitors through antagonism of E2F-driven oncogenic gene expression.
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    aacrjournals.org/clincancerres/article/28/11/2397/698931/Preclinical-Modeling-of-Leiomyosarcoma-Identifies
  67. Feb 2022
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bidirectional Crosstalk between MAOA and AR Promotes Hormone-Dependent and Castration-Resistant Prostate Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC8373824/
  69. Jan 2022
  70. journals.sagepub.com journals.sagepub.com
    Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021
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    journals.sagepub.com/doi/full/10.1177/24725552211038362
  71. Dec 2021
  72. journals.sagepub.com journals.sagepub.com
    Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021
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    A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis
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    nature.com/articles/s41467-021-27452-9
  74. Nov 2021
  75. journals.sagepub.com journals.sagepub.com
    Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021
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    RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site
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    sciencedirect.com/science/article/pii/S2211124721014078
  77. Oct 2021
  78. academic.oup.com academic.oup.com
    Hsa_circ_0023990 promotes tumor growth and glycolysis in dedifferentiated TC via targeting miR-485-5p/FOXM1 axis
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    academic.oup.com/endo/article/162/12/bqab172/6355332
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    Charting oncogenicity of genes and variants across lineages via multiplexed screens in teratomas
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  80. Aug 2021
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  83. Jul 2021
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    Inhibition of LTA4H by bestatin in human and mouse colorectal cancer
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  87. Jun 2021
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition
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    ncbi.nlm.nih.gov/pmc/articles/PMC8193145/
  89. Apr 2021
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    Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids
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    sciencedirect.com/science/article/pii/S1934590921001557
  91. Feb 2021
  92. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo
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    onlinelibrary.wiley.com/doi/full/10.1002/mc.23284
  93. Oct 2020
  94. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma
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    pubmed.ncbi.nlm.nih.gov/33086062/
  95. Sep 2020
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    KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer
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  97. cancerres.aacrjournals.org cancerres.aacrjournals.org
    A Novel Bioengineered MicroRNA-127 Prodrug Suppresses The Growth And Metastatic Potential Of Triple Negative Breast Cancer Cells
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    cancerres.aacrjournals.org/content/80/3/418
  98. Jan 2020
  99. www.cell.com www.cell.com
    miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer
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    cell.com/cell-reports/fulltext/S2211-1247(19)31576-1
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    A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer
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    sciencedirect.com/science/article/pii/S1550413119305170
  101. Nov 2018
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    CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness
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  103. Nov 2017
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    In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming
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    Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma
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    IGF1R Expression in Ovarian Granulosa Cells is Essential for Steroidogenesis, Follicle Survival, and Fertility in Female Mice
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    academic.oup.com/endo/article/158/7/2309/3605334/IGF1R-Expression-in-Ovarian-Granulosa-Cells-Is