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Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changes

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  DOI: 10.1038/s41598-025-21716-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12572197/
Aug 2025
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Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer

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Jul 2025
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52.53.155.43/a363e4ae90be5a0c17cae72bbc9ca19379f34011/1-s2.0-S0016508525057324-main-html.html
May 2025
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Transcriptomic and epigenomic consequences of heterozygous loss-of-function mutations in AKAP11, a shared risk gene for bipolar disorder and schizophrenia

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Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory

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Mar 2025
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Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changes

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Feb 2025
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Leptin enhances the intracellular thyroid hormone activation in skeletal muscle to boost energy balance

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CRISPR screening identifies regulators of enhancer-mediated androgen receptor transcription in advanced prostate cancer

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cell.com/cell-reports/fulltext/S2211-1247(25)00083-X
Dec 2024
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Increased nuclear factor I-mediated chromatin access drives transition to androgen receptor splice variant dependence in prostate cancer

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Castrate-resistant prostate cancer response to taxane is determined by an HNF1-dependent apoptosis resistance circuit

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1-s2.0-S2589004224027627-main-html.html

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52.53.155.43/be73735e776800179984775526035e2a4ac8e07a/1-s2.0-S2589004224027627-main-html.html
Oct 2024
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H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone

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aacrjournals.org/cancerdiscovery/article/10/12/1968/2414/H3-3-G34W-Promotes-Growth-and-Impedes
Aug 2024
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TFE3 fusions direct an oncogenic transcriptional program that drives OXPHOS and unveils vulnerabilities in translocation renal cell carcinoma

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1. scibot 26 Aug 2024
  
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Trained immunity is regulated by T cell-induced CD40-TRAF6 signaling

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Jul 2024
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Innate immune training restores pro-reparative myeloid functions to promote remyelination in the aged central nervous system

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cell.com/immunity/fulltext/S1074-7613(24)00348-0
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Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent manner

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A transient transcriptional activation governs unpolarized-to-polarized morphogenesis during embryo implantation

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Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma

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cell.com/cell-reports/fulltext/S2211-1247(24)00678-8
Mar 2024
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Transcriptomic and epigenomic consequences of heterozygous loss of function mutations in AKAP11, the first large-effect shared risk gene for bipolar disorder and schizophrenia

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biorxiv.org/content/10.1101/2024.03.14.584883v1
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Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma

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ncbi.nlm.nih.gov/pmc/articles/PMC10542885/
Jan 2024
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Haplotype-specific assembly of shattered chromosomes in esophageal adenocarcinomas

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Dec 2023
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Heterogeneity and transcriptional drivers of triple-negative breast cancer

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Nov 2023
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Acid ceramidase regulates innate immune memory

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Transcription factor NFYa controls cardiomyocyte metabolism and proliferation during mouse fetal heart development

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Sep 2023
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Single-cell epigenome analysis identifies molecular events controlling direct conversion of human fibroblasts to pancreatic ductal-like cells

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Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma

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Aug 2023
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mcr-22-0916-html.html

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52.53.155.43/ee24162242ef05486fd8a6e1481e2011af4e24fe/mcr-22-0916-html.html
Jun 2023
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Survivin prevents the Polycomb Repressor Complex 2 from methylating Histone 3 lysine 27

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Apr 2023
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Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis

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Rewiring of master transcription factor cistromes during high-grade serous ovarian cancer development

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  DOI: 10.1101/2023.04.11.536378
  
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Genome graphs detect human polymorphisms in active epigenomic state during influenza infection

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Regulation of human trophoblast gene expression by endogenous retroviruses

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nature.com/articles/s41594-023-00960-6
Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 Stabilization and Chromatin Condensation

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  DOI: 10.1158/2767-9764.CRC-22-0255
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9949381/
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Epigenetic dosage identifies two major and functionally distinct β cell subtypes

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Chromatin profiling identifies transcriptional readthrough as a conserved mechanism for piRNA biogenesis in mosquitoes

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Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration

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Massively parallel characterization of CRISPR activator efficacy in human induced pluripotent stem cells and neurons

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Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia

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ONECUT2 regulates RANKL-dependent enterocyte and microfold cell differentiation in the small intestine; a multi-omics study

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FOXR2 is an epigenetically regulated pan-cancer oncogene that activates ETS transcriptional circuits

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BCOR and BCORL1 Mutations Drive Epigenetic Reprogramming and Oncogenic Signaling by Unlinking PRC1.1 from Target Genes

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Transcriptional and Epigenetic Consequences of DMSO Treatment on HepaRG Cells

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Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance

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Twist2-driven chromatin remodeling governs the postnatal maturation of dermal fibroblasts

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The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes

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Immune disease variants modulate gene expression in regulatory CD4+ T cells

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Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit

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MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape

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A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer

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Epigenomic and Transcriptomic Dynamics During Human Heart Organogenesis

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NPAS4 regulates the transcriptional response of the suprachiasmatic nucleus to light and circadian behavior

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ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer

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The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes

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The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer

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Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes

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Untitled document

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Comparative Analysis of Immune Cells Reveals a Conserved Regulatory Lexicon

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STIM1 Mediates Calcium-dependent Epigenetic Reprogramming in Pancreatic Cancer

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Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation

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Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth

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The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia

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Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment

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Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma

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A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation

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Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria

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Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

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Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma

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Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy

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Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination

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sciencedirect.com/science/article/pii/S2666379120302408
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Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development

1
1. scibot 25 Sep 2020
  
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  DOI: 10.1016/j.celrep.2019.03.076
  
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cell.com/cell-reports/abstract/S2211-1247(19)30406-1
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ACTIVATE: RANDOMIZED CLINICAL TRIAL OF BCG VACCINATION AGAINST INFECTION IN THE ELDERLY

1
1. scibot 23 Sep 2020
  
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  RRID:AB_8580
  
  DOI: 10.1016/j.cell.2020.08.051
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7462457/
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GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling

1
1. scibot 17 Sep 2020
  
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  RRID:AB_2637079
  
  DOI: 10.7554/eLife.50670
  
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FiTAc-seq: fixed-tissue ChIP-seq for H3K27ac profiling and super-enhancer analysis of FFPE tissues

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1. scibot 17 Sep 2020
  
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  RRID:AB_2637079
  
  DOI: 10.1038/s41596-020-0340-6
  
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nature.com/articles/s41596-020-0340-6
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The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts

1
1. scibot 07 Sep 2020
  
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  RRID:AB_2637079
  
  DOI: 10.1016/j.celrep.2020.107917
  
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Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

1
1. scibot 07 Sep 2020
  
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  RRID:AB_2637079
  
  DOI: 10.1016/j.ccell.2019.12.006
  
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sciencedirect.com/science/article/pii/S1535610819305768
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Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock

1
1. scibot 13 Jan 2020
  
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  DOI: 10.7554/eLife.45205
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6570483/
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The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer

2
1. scibot 13 Jan 2020
  
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  RRID:AB_2637079
  
  DOI: 10.1016/j.celrep.2019.09.032
  
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2. scibot 13 Jan 2020
  
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  RRID:AB_2637079
  
  DOI: 10.1016/j.celrep.2019.09.032
  
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TET2 Regulates the Neuroinflammatory Response in Microglia

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2637079
  
  DOI: 10.1016/j.celrep.2019.09.013
  
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sciencedirect.com/science/article/pii/S2211124719311908
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Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2637079
  
  DOI: 10.1016/j.immuni.2019.08.006
  
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sciencedirect.com/science/article/pii/S1074761319303322
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Untitled document

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2637079
  
  DOI: 10.1016/j.stem.2019.03.022
  
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Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2637079
  
  DOI: 10.1016/j.celrep.2018.12.098
  
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sciencedirect.com/science/article/pii/S2211124718320588
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Untitled document

1
1. scibot 12 Jan 2020
  
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  RRID:AB_2637079
  
  DOI: 10.1016/j.ccell.2019.04.004
  
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sciencedirect.com/science/article/pii/S1535610819301990
Nov 2018
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Untitled document

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2637079
  
  Curator: @evieth
  
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The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2637079
  
  Curator: @Jmenke
  
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A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding Driver in Advanced Prostate Cancer

1
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Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2637079
  
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Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors

1
1. scibot 05 Nov 2018
  
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The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2637079
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5989056/
Nov 2017
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Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth

1
1. scibot 08 Nov 2017
  
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  AB_2637079
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5461110/

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