72 Matching Annotations
  1. Mar 2024
  2. www.biorxiv.org www.biorxiv.org
    Transcriptomic and epigenomic consequences of heterozygous loss of function mutations in AKAP11, the first large-effect shared risk gene for bipolar disorder and schizophrenia
    1
    1. scibot 19 Mar 2024
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      DOI: 10.1101/2024.03.14.584883

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    biorxiv.org/content/10.1101/2024.03.14.584883v1
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma
    1
    1. scibot 03 Mar 2024
      RRID:AB_2637079

      DOI: 10.1158/1541-7786.MCR-22-0916

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    ncbi.nlm.nih.gov/pmc/articles/PMC10542885/
  4. Jan 2024
  5. www.sciencedirect.com www.sciencedirect.com
    Haplotype-specific assembly of shattered chromosomes in esophageal adenocarcinomas
    1
    1. scibot 19 Jan 2024
      RRID:AB_2637079

      DOI: 10.1016/j.xgen.2023.100484

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    sciencedirect.com/science/article/pii/S2666979X23003361
  6. Dec 2023
  7. www.sciencedirect.com www.sciencedirect.com
    Heterogeneity and transcriptional drivers of triple-negative breast cancer
    1
    1. scibot 16 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113564

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    sciencedirect.com/science/article/pii/S2211124723015760
  8. Nov 2023
  9. www.sciencedirect.com www.sciencedirect.com
    Acid ceramidase regulates innate immune memory
    1
    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113458

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    sciencedirect.com/science/article/pii/S2211124723014705
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    Transcription factor NFYa controls cardiomyocyte metabolism and proliferation during mouse fetal heart development
    1
    1. scibot 18 Nov 2023
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      DOI: 10.1016/j.devcel.2023.10.012

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    sciencedirect.com/science/article/pii/S1534580723005555
  11. Sep 2023
  12. www.sciencedirect.com www.sciencedirect.com
    Single-cell epigenome analysis identifies molecular events controlling direct conversion of human fibroblasts to pancreatic ductal-like cells
    1
    1. scibot 30 Sep 2023
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      DOI: 10.1016/j.devcel.2023.08.023

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    sciencedirect.com/science/article/pii/S1534580723004380
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    Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma
    1
    1. scibot 16 Sep 2023
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      DOI: 10.1016/j.celrep.2023.113132

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    sciencedirect.com/science/article/pii/S2211124723011440
  14. Aug 2023
  15. 52.53.155.43 52.53.155.43
    mcr-22-0916-html.html
    1
    1. scibot 09 Aug 2023
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      DOI: 10.1158/1541-7786.mcr-22-0916

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    52.53.155.43/ee24162242ef05486fd8a6e1481e2011af4e24fe/mcr-22-0916-html.html
  16. Jun 2023
  17. www.sciencedirect.com www.sciencedirect.com
    Survivin prevents the Polycomb Repressor Complex 2 from methylating Histone 3 lysine 27
    1
    1. scibot 16 Jun 2023
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      DOI: 10.1016/j.isci.2023.106976

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    sciencedirect.com/science/article/pii/S2589004223010532
  18. Apr 2023
  19. www.sciencedirect.com www.sciencedirect.com
    Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis
    1
    1. scibot 26 Apr 2023
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      DOI: 10.1016/j.xgen.2023.100306

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    sciencedirect.com/science/article/pii/S2666979X23000721
  20. www.biorxiv.org www.biorxiv.org
    Rewiring of master transcription factor cistromes during high-grade serous ovarian cancer development
    1
    1. scibot 20 Apr 2023
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      DOI: 10.1101/2023.04.11.536378

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    biorxiv.org/content/10.1101/2023.04.11.536378v1
  21. www.sciencedirect.com www.sciencedirect.com
    Genome graphs detect human polymorphisms in active epigenomic state during influenza infection
    1
    1. scibot 08 Apr 2023
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      DOI: 10.1016/j.xgen.2023.100294

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    sciencedirect.com/science/article/pii/S2666979X23000605
  22. www.nature.com www.nature.com
    Regulation of human trophoblast gene expression by endogenous retroviruses
    1
    1. scibot 05 Apr 2023
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      DOI: 10.1038/s41594-023-00960-6

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    nature.com/articles/s41594-023-00960-6
  23. Mar 2023
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 Stabilization and Chromatin Condensation
    1
    1. scibot 29 Mar 2023
      RRID:AB_2637079

      DOI: 10.1158/2767-9764.CRC-22-0255

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    ncbi.nlm.nih.gov/pmc/articles/PMC9949381/
  25. europepmc.org europepmc.org
    Epigenetic dosage identifies two major and functionally distinct β cell subtypes
    1
    1. scibot 28 Mar 2023
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      DOI: 10.1016/j.cmet.2023.03.008

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    europepmc.org/article/med/36948185
  26. europepmc.org europepmc.org
    Chromatin profiling identifies transcriptional readthrough as a conserved mechanism for piRNA biogenesis in mosquitoes
    1
    1. scibot 18 Mar 2023
      RRID:AB_2637079

      DOI: 10.1016/j.celrep.2023.112257

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    europepmc.org/article/med/36930642
  27. www.sciencedirect.com www.sciencedirect.com
    Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration
    1
    1. scibot 17 Mar 2023
      RRID:AB_2637079

      DOI: 10.1016/j.cell.2023.02.023

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    sciencedirect.com/science/article/pii/S0092867423001666
  28. www.sciencedirect.com www.sciencedirect.com
    Massively parallel characterization of CRISPR activator efficacy in human induced pluripotent stem cells and neurons
    1
    1. scibot 16 Mar 2023
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      DOI: 10.1016/j.molcel.2023.02.011

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    sciencedirect.com/science/article/pii/S1097276523001144
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia
    1
    1. scibot 05 Mar 2023
      RRID:AB_2637079

      DOI: 10.1158/2159-8290.CD-22-0424

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    ncbi.nlm.nih.gov/pmc/articles/PMC9975662/
  30. Jan 2023
  31. academic.oup.com academic.oup.com
    ONECUT2 regulates RANKL-dependent enterocyte and microfold cell differentiation in the small intestine; a multi-omics study
    1
    1. scibot 25 Jan 2023
      RRID:AB_2637079

      DOI: 10.1093/nar/gkac1236

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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac1236/6981654
  32. Nov 2022
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FOXR2 is an epigenetically regulated pan-cancer oncogene that activates ETS transcriptional circuits
    1
    1. scibot 02 Nov 2022
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      DOI: 10.1158/0008-5472.CAN-22-0671

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    ncbi.nlm.nih.gov/pmc/articles/PMC9437574/
  34. Oct 2022
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BCOR and BCORL1 Mutations Drive Epigenetic Reprogramming and Oncogenic Signaling by Unlinking PRC1.1 from Target Genes
    1
    1. scibot 12 Oct 2022
      RRID:AB_2637079

      DOI: 10.1158/2643-3230.BCD-21-0115

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    ncbi.nlm.nih.gov/pmc/articles/PMC9414116/
  36. Jul 2022
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptional and Epigenetic Consequences of DMSO Treatment on HepaRG Cells
    1
    1. scibot 30 Jul 2022
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      DOI: 10.3390/cells11152298

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    ncbi.nlm.nih.gov/pmc/articles/PMC9331440/
  38. Jun 2022
  39. link.springer.com link.springer.com
    Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance
    1
    1. scibot 25 Jun 2022
      RRID:AB_2637079

      DOI: 10.1186/s13059-022-02702-1

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    link.springer.com/article/10.1186/s13059-022-02702-1
  40. May 2022
  41. www.sciencedirect.com www.sciencedirect.com
    Twist2-driven chromatin remodeling governs the postnatal maturation of dermal fibroblasts
    1
    1. scibot 19 May 2022
      RRID:AB_2637079

      DOI: 10.1016/j.celrep.2022.110821

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    sciencedirect.com/science/article/pii/S2211124722005927
  42. Apr 2022
  43. www.sciencedirect.com www.sciencedirect.com
    The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes
    1
    1. scibot 22 Apr 2022
      RRID:AB_2637079

      DOI: 10.1016/j.stem.2022.03.015

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    sciencedirect.com/science/article/pii/S1934590922001503
  44. www.sciencedirect.com www.sciencedirect.com
    Immune disease variants modulate gene expression in regulatory CD4+ T cells
    1
    1. scibot 07 Apr 2022
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      DOI: 10.1016/j.xgen.2022.100117

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    sciencedirect.com/science/article/pii/S2666979X22000416
  45. Mar 2022
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit
    1
    1. scibot 11 Mar 2022
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      DOI: 10.7554/eLife.71094

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    ncbi.nlm.nih.gov/pmc/articles/PMC8903835/
  47. www.sciencedirect.com www.sciencedirect.com
    MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape
    1
    1. scibot 04 Mar 2022
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      DOI: 10.1016/j.molcel.2022.02.013

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    sciencedirect.com/science/article/pii/S1097276522001186
  48. Feb 2022
  49. www.sciencedirect.com www.sciencedirect.com
    A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer
    1
    1. scibot 23 Feb 2022
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      DOI: 10.1016/j.celrep.2022.110417

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    sciencedirect.com/science/article/pii/S2211124722001413
  50. Oct 2021
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenomic and Transcriptomic Dynamics During Human Heart Organogenesis
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    1. scibot 13 Oct 2021
      RRID:AB_2637079

      DOI: 10.1161/CIRCRESAHA.120.316704

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    ncbi.nlm.nih.gov/pmc/articles/PMC7554226/
  52. Aug 2021
  53. www.sciencedirect.com www.sciencedirect.com
    NPAS4 regulates the transcriptional response of the suprachiasmatic nucleus to light and circadian behavior
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      DOI: 10.1016/j.neuron.2021.07.026

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    sciencedirect.com/science/article/pii/S0896627321005705
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    ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer
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      DOI: 10.1016/j.ccell.2019.01.008

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    sciencedirect.com/science/article/pii/S153561081930042X
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes
    1
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      DOI: 10.1016/j.cmet.2018.04.013

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    ncbi.nlm.nih.gov/pmc/articles/PMC5989056/
  56. www.sciencedirect.com www.sciencedirect.com
    The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer
    1
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      RRID:AB_2637079

      DOI: 10.1016/j.celrep.2019.09.032

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    sciencedirect.com/science/article/pii/S2211124719312203
  57. Jul 2021
  58. www.sciencedirect.com www.sciencedirect.com
    Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes
    1
    1. scibot 31 Jul 2021
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      DOI: 10.1016/j.celrep.2018.12.098

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    sciencedirect.com/science/article/pii/S2211124718320588
  59. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 28 Jul 2021
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      DOI: 10.1016/j.celrep.2019.03.076

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    sciencedirect.com/science/article/pii/S2211124719304061
  60. www.sciencedirect.com www.sciencedirect.com
    Comparative Analysis of Immune Cells Reveals a Conserved Regulatory Lexicon
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    1. scibot 27 Jul 2021
      RRID:AB_267079

      DOI: 10.1016/j.cels.2018.01.002

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  61. Jun 2021
  62. cancerres.aacrjournals.org cancerres.aacrjournals.org
    STIM1 Mediates Calcium-dependent Epigenetic Reprogramming in Pancreatic Cancer
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  63. May 2021
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    Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation
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    Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth
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  66. www.cell.com www.cell.com
    The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia
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    Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment
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  68. Apr 2021
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    Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma
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    A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation
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  71. Mar 2021
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria
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  73. Feb 2021
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    Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis
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    Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma
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    Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy
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  77. Jan 2021
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    Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination
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  79. Sep 2020
  80. www.cell.com www.cell.com
    Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development
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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ACTIVATE: RANDOMIZED CLINICAL TRIAL OF BCG VACCINATION AGAINST INFECTION IN THE ELDERLY
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  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling
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  83. www.nature.com www.nature.com
    FiTAc-seq: fixed-tissue ChIP-seq for H3K27ac profiling and super-enhancer analysis of FFPE tissues
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      DOI: 10.1038/s41596-020-0340-6

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  84. www.sciencedirect.com www.sciencedirect.com
    The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts
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  85. www.sciencedirect.com www.sciencedirect.com
    Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
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      DOI: 10.1016/j.ccell.2019.12.006

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  86. Jan 2020
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock
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      DOI: 10.7554/eLife.45205

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  88. www.sciencedirect.com www.sciencedirect.com
    The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer
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      DOI: 10.1016/j.celrep.2019.09.032

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    sciencedirect.com/science/article/pii/S2211124719312203
  89. www.sciencedirect.com www.sciencedirect.com
    TET2 Regulates the Neuroinflammatory Response in Microglia
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    sciencedirect.com/science/article/pii/S2211124719311908
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    Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma
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      RRID:AB_2637079

      DOI: 10.1016/j.immuni.2019.08.006

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    sciencedirect.com/science/article/pii/S1074761319303322
  91. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.stem.2019.03.022

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    sciencedirect.com/science/article/pii/S1934590919301213
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    Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes
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      DOI: 10.1016/j.celrep.2018.12.098

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  94. Nov 2018
  95. www.sciencedirect.com www.sciencedirect.com
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    The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity
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    A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding Driver in Advanced Prostate Cancer
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    Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations
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    Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors
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  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes
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    ncbi.nlm.nih.gov/pmc/articles/PMC5989056/
  101. Nov 2017
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth
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