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Jul 2025
elifesciences.org elifesciences.org

Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation

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1. scibot 23 Jul 2025
  
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  DOI: 10.7554/eLife.106469
  
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elifesciences.org/articles/106469
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Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens

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1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116002
  
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sciencedirect.com/science/article/pii/S2211124725007739
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A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients

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1. scibot 15 Jul 2025
  
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  DOI: 10.1038/s41594-025-01610-9
  
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nature.com/articles/s41594-025-01610-9
Jun 2025
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Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.molcel.2025.05.030
  
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sciencedirect.com/science/article/pii/S1097276525004691
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Phosphatase activity is dispensable for PRL-3-mediated oncogenesis and tumor progression

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1. scibot 11 Jun 2025
  
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  DOI: 10.1101/2025.05.14.654016
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12132575/
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Phenotypic landscape of an invasive fungal pathogen reveals its unique biology

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.cell.2025.05.017
  
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sciencedirect.com/science/article/pii/S0092867425005677
May 2025
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A novel nonsense mutation of the glucocorticoid receptor gene causing glucocorticoid resistance with infertility

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1. scibot 28 May 2025
  
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  DOI: 10.1007/s12020-025-04280-1
  
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link.springer.com/article/10.1007/s12020-025-04280-1
Apr 2025
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PDZK1 inhibits MRP2-mediated oxaliplatin chemosensitivity in hepatocellular carcinoma

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1. scibot 24 Apr 2025
  
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  DOI: 10.1038/s41598-025-98085-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12008203/
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Synthetic deconvolution of an auxin-dependent transcriptional code

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1. scibot 17 Apr 2025
  
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  DOI: 10.1016/j.cell.2025.03.028
  
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sciencedirect.com/science/article/pii/S0092867425003460
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Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue

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1. scibot 08 Apr 2025
  
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  DOI: 10.1016/j.cmet.2025.03.009
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12137002/
Mar 2025
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The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity

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1. scibot 23 Mar 2025
  
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  DOI: 10.1101/2025.02.17.638704
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11870510/
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Binding domain mutations provide insight into CTCF’s relationship with chromatin and its contribution to gene regulation

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1. scibot 23 Mar 2025
  
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  DOI: 10.1016/j.xgen.2025.100813
  
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cell.com/cell-genomics/fulltext/S2666-979X(25)00069-2
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Macrophage-specific PHGDH protects against MAFLD by suppressing TAK1

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1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115426
  
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sciencedirect.com/science/article/pii/S2211124725001974
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

RNA binding protein ZCCHC24 promotes tumorigenicity in triple-negative breast cancer

1
1. scibot 11 Dec 2024
  
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  DOI: 10.1038/s44319-024-00282-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11624195/
Nov 2024
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Domestication-selected COG4-OsbZIP23 module regulates chilling tolerance in rice

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1. scibot 17 Nov 2024
  
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  DOI: 10.1016/j.celrep.2024.114965
  
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sciencedirect.com/science/article/pii/S2211124724013160
www.biorxiv.org www.biorxiv.org

Structure of the TXNL1-bound proteasome

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1. scibot 15 Nov 2024
  
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  DOI: 10.1101/2024.11.08.622741
  
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biorxiv.org/content/10.1101/2024.11.08.622741v1
Oct 2024
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Pervasive mislocalization of pathogenic coding variants underlying human disorders

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1. scibot 02 Oct 2024
  
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  DOI: 10.1016/j.cell.2024.09.003
  
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sciencedirect.com/science/article/pii/S0092867424010213
Aug 2024
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The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins

1
1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114627
  
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sciencedirect.com/science/article/pii/S221112472400977X
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The Chlamydia effector IncE employs two short linear motifs to reprogram host vesicle trafficking

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114624
  
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sciencedirect.com/science/article/pii/S2211124724009744
Jul 2024
www.cell.com www.cell.com

Characterization of a lipid-based jumbo phage compartment as a hub for early phage infection

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1. scibot 20 Jul 2024
  
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  DOI: 10.1016/j.chom.2024.05.016
  
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cell.com/cell-host-microbe/abstract/S1931-3128(24)00188-4
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Dimerization of hub protein DYNLL1 and bZIP transcription factor CREB3L1 enhances transcriptional activation of CREB3L1 target genes like arginine vasopressin

1
1. scibot 19 Jul 2024
  
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  DOI: 10.1016/j.peptides.2024.171269
  
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sciencedirect.com/science/article/pii/S0196978124001220
Apr 2024
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The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells

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1. scibot 04 Apr 2024
  
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  DOI: 10.1016/j.devcel.2024.03.018
  
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sciencedirect.com/science/article/pii/S1534580724001837
Mar 2024
rupress.org rupress.org

Rab32 family proteins regulate autophagosomal components recycling

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1. scibot 21 Mar 2024
  
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  DOI: 10.1083/jcb.202306040
  
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2. scibot 21 Mar 2024
  
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  DOI: 10.1083/jcb.202306040
  
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rupress.org/jcb/article/223/3/e202306040/276549/Rab32-family-proteins-regulate-autophagosomal
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Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells

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1. scibot 21 Mar 2024
  
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  DOI: 10.1016/j.cmet.2024.02.012
  
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sciencedirect.com/science/article/pii/S1550413124000597
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Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor

1
1. scibot 17 Mar 2024
  
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  DOI: 10.7554/eLife.90993
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10942784/
Feb 2024
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A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis

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1. scibot 29 Feb 2024
  
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  DOI: 10.1016/j.molcel.2024.02.002
  
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sciencedirect.com/science/article/pii/S1097276524000984
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The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins

1
1. scibot 17 Feb 2024
  
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  RRID:AB_2637089
  
  DOI: 10.1101/2024.01.30.577963
  
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biorxiv.org/content/10.1101/2024.01.30.577963v1
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Tissue‐specific expression differences in Ras‐related GTP‐binding proteins in male rats

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1. scibot 03 Feb 2024
  
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  DOI: 10.14814/phy2.15928
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10830385/
Jan 2024
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ULK phosphorylation of STX17 controls autophagosome maturation via FLNA

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1. scibot 05 Jan 2024
  
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  DOI: 10.1083/jcb.202211025
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10316704/
Dec 2023
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Exploiting the endogenous yeast nuclear proteome to identify short linear motifs in vivo

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1. scibot 02 Dec 2023
  
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  DOI: 10.1016/j.crmeth.2023.100637
  
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sciencedirect.com/science/article/pii/S2667237523003089
Nov 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

2
1. scibot 04 Nov 2023
  
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  DOI: 10.1126/science.adh5021
  
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  DOI: 10.1126/science.adh5021
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10617673/
Oct 2023
www.science.org www.science.org

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

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1. scibot 17 Oct 2023
  
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  DOI: 10.1126/science.adh5021
  
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science.org/doi/10.1126/science.adh5021
Aug 2023
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The C9ORF72 repeat expansion alters neurodevelopment

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1. scibot 17 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112983
  
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sciencedirect.com/science/article/pii/S2211124723009944
Jul 2023
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Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer

1
1. scibot 21 Jul 2023
  
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  DOI: 10.1016/j.ccell.2023.06.010
  
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sciencedirect.com/science/article/pii/S1535610823002350
Jun 2023
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Convergence of multiple RNA-silencing pathways on GW182/TNRC6

1
1. scibot 28 Jun 2023
  
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  DOI: 10.1016/j.molcel.2023.06.001
  
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Pathogen protein modularity enables elaborate mimicry of a host phosphatase

1
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Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis

1
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FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics

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A restrictor complex of ZC3H4, WDR82, and ARS2 integrates with PNUTS to control unproductive transcription

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May 2023
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s11684-022-0959-5-html.html

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Apr 2023
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A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer

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Systemwide disassembly and assembly of SCF ubiquitin ligase complexes

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Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting

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The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome

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A central chaperone-like role for 14-3-3 proteins in human cells

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CHD1 promotes sensitivity to Aurora kinase inhibitors by suppressing interaction of AURKA with its coactivator TPX2

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A posttranscriptional pathway regulates cell wall mRNA expression in budding yeast

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Nonstructural protein 1 widespread RNA decay phenotype varies among coronaviruses

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Executing cell-specific cross-linking immunoprecipitation and sequencing (seCLIP) in C. elegans

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The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER

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LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation

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Sep 2022
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Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair

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Aug 2022
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can-22-0631-html.html

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The evolution of a counter-defense mechanism in a virus constrains its host range

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trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans

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N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products

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BCL10 mutations define distinct dependencies guiding precision therapy for DLBCL

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Homozygous variant in KASH5 causes premature ovarian insufficiency by disordered meiotic homologous pairing

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Jun 2022
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A Phytophthora Effector Suppresses Trans-Kingdom RNAi to Promote Disease Susceptibility

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Tandem immuno-purification of affinity-tagged proteins from mouse testis extracts for MS analysis

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May 2022
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A somatic mutation in moesin drives progression into acute myeloid leukemia

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BAG6 prevents the aggregation of neurodegeneration-associated fragments of TDP43

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A somatic mutation in moesin drives progression into acute myeloid leukemia

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Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling

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Mar 2022
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FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis

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The XRN1-regulated RNA helicase activity of YTHDC2 ensures mouse fertility independently of m6A recognition

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The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth

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Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation

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An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function

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Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

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Identification and functional characterization of transcriptional activators in human cells

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Kel1 is a phosphorylation-regulated noise suppressor of the pheromone signaling pathway

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piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development

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GTP binding to translation factor eIF2B stimulates its guanine nucleotide exchange activity

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Variations of C14ORF39 and SYCE1 identified in idiopathic premature ovarian insufficiency and nonobstructive azoospermia

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1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development

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Gene bookmarking by the heat shock transcription factor programs the insulin-like signaling pathway

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The N-terminal domain of SARS-CoV-2 nsp1 plays key roles in suppression of cellular gene expression and preservation of viral gene expression

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Assembly principles of the human R2TP chaperone complex reveal the presence of R2T and R2P complexes

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HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis

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Mechanism of noncoding RNA-associated N6-methyladenosine recognition by an RNA processing complex during IgH DNA recombination

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Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity

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Protein inhibitor of activated STAT1 Ser503 phosphorylation‐mediated Elk‐1 SUMOylation promotes neuronal survival in APP/PS1 mice

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Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection

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Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs

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Intrinsically Disordered Protein TEX264 Mediates ER-phagy

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BMP signaling is enhanced intracellularly by FHL3 controlling WNT-dependent spatiotemporal emergence of the neural crest

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Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons

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Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling

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Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains

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NLR-1/CASPR Anchors F-Actin to Promote Gap Junction Formation

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Tyrosine Phosphorylation of the Myosin Regulatory Light Chain Controls Non-muscle Myosin II Assembly and Function in Migrating Cells

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TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation

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Plant roots employ cell-layer-specific programs to respond to pathogenic and beneficial microbes

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Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation

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Strand-specific ChIP-seq at DNA breaks distinguishes ssDNA versus dsDNA binding and refutes single-stranded nucleosomes

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GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer

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Basis of specificity for a conserved and promiscuous chromatin remodeling protein

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Functional proteomics protocol for the identification of interaction partners in Tetrahymena thermophila

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Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine

1
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  DOI: 10.1016/j.celrep.2021.108798
  
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Serotonin signaling by maternal neurons upon stress ensures progeny survival

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  DOI: 10.7554/eLife.55246
  
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Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication

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Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila

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ncbi.nlm.nih.gov/pmc/articles/PMC7861614/
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Ecd promotes U5 snRNP maturation and Prp8 stability

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  DOI: 10.1093/nar/gkaa1274
  
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Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development

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  DOI: 10.1016/j.cell.2020.10.038
  
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Formation of the CenH3-Deficient Holocentromere in Lepidoptera Avoids Active Chromatin

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Atg43 tethers isolation membranes to mitochondria to promote starvation-induced mitophagy in fission yeast

1
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Activation of CpG-Rich Promoters Mediated by MLL Drives MOZ-Rearranged Leukemia

1
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Morphine and Naloxone Facilitate Neural Stem Cells Proliferation via a TET1-Dependent and Receptor-Independent Pathway

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A Non-structural 1 Protein G53D Substitution Attenuates a Clinically Tested Live Dengue Vaccine

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Cep97 Is Required for Centriole Structural Integrity and Cilia Formation in Drosophila

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CenH3-Independent Kinetochore Assembly in Lepidoptera Requires CCAN, Including CENP-T

2
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Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex

1
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A terminal selector prevents a Hox transcriptional switch to safeguard motor neuron identity throughout life

1
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METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation

1
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Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

1
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  DOI: 10.1016/j.molcel.2018.11.006
  
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cell.com/molecular-cell/abstract/S1097-2765(18)30948-1
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Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma

1
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  DOI: 10.1016/j.celrep.2020.107522
  
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A Kinesin adapter directly mediates dendritic mRNA localization during neural development in mice

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  DOI: 10.1074/jbc.RA118.005616
  
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Senataxin Ortholog Sen1 Limits DNA:RNA Hybrid Accumulation at DNA Double-Strand Breaks to Control End Resection and Repair Fidelity

1
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Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity

1
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  DOI: 10.1016/j.chom.2019.09.012
  
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Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection

2
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  DOI: 10.1016/j.molcel.2019.11.007
  
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An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma

1
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PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development

1
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Naa10p Inhibits Beige Adipocyte-Mediated Thermogenesis through N-α-acetylation of Pgc1α

1
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3′ Uridylation Confers miRNAs with Non-canonical Target Repertoires

1
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53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

1
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Endosome and Golgi‐associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism

1
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  DOI: 10.15252/embj.2018101433
  
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embopress.org/lookup/doi/10.15252/embj.2018101433
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N6-Methyladenosine Modification Controls Circular RNA Immunity

1
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  DOI: 10.1016/j.molcel.2019.07.016
  
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Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation

1
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Untitled document

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  DOI: 10.1016/j.ebiom.2019.03.075
  
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Untitled document

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  DOI: 10.1016/j.molcel.2018.11.033
  
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Rapid Depletion of DIS3, EXOSC10, or XRN2 Reveals the Immediate Impact of Exoribonucleolysis on Nuclear RNA Metabolism and Transcriptional Control

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Characterization of MCU-Binding Proteins MCUR1 and CCDC90B — Representatives of a Protein Family Conserved in Prokaryotes and Eukaryotic Organelles

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Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease

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Argonaute-miRNA Complexes Silence Target mRNAs in the Nucleus of Mammalian Stem Cells

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Active N6-Methyladenine Demethylation by DMAD Regulates Gene Expression by Coordinating with Polycomb Protein in Neurons

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Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment

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Arabidopsis Serrate Coordinates Histone Methyltransferases ATXR5/6 and RNA Processing Factor RDR6 to Regulate Transposon Expression

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Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau

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5-HT 2A receptor-dependent phosphorylation of mGlu 2 receptor at Serine 843 promotes mGlu 2 receptor-operated G i/o signaling

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Chromatin Accessibility Dynamics during iPSC Reprogramming

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Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells

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MPK3- and MPK6-Mediated ICE1 Phosphorylation Negatively Regulates ICE1 Stability and Freezing Tolerance in Arabidopsis

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A Bacterial Type III Effector Targets the Master Regulator of Salicylic Acid Signaling, NPR1, to Subvert Plant Immunity

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USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin

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Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide

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RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis

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The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity

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