136 Matching Annotations
  1. Last 7 days
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular and pathological characterization of YAP1-expressing small cell lung cancer cell lines leads to reclassification as SMARCA4-deficient malignancies
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    1. scibot 03 May 2024
      RRID:AB_2650491

      DOI: 10.1158/1078-0432.CCR-23-2360

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    ncbi.nlm.nih.gov/pmc/articles/PMC11061608/
  3. www.sciencedirect.com www.sciencedirect.com
    Dietary intake and glutamine-serine metabolism control pathologic vascular stiffness
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    1. scibot 03 May 2024
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      DOI: 10.1016/j.cmet.2024.04.010

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    sciencedirect.com/science/article/pii/S155041312400130X
  4. Apr 2024
  5. www.sciencedirect.com www.sciencedirect.com
    Generation of human alveolar epithelial type I cells from pluripotent stem cells
    1
    1. scibot 23 Apr 2024
      Cell Signaling TechnologyCat#14074

      DOI: 10.1016/j.stem.2024.03.017

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    sciencedirect.com/science/article/pii/S1934590924000985
  6. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    α-Catenin promotes dermal fibroblasts proliferation and migration during wound healing via FAK/YAP activation
    1
    1. scibot 11 Apr 2024
      RRID:AB_2650491

      DOI: 10.1096/fj.202302251R

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202302251R
  7. www.sciencedirect.com www.sciencedirect.com
    NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo
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    1. scibot 05 Apr 2024
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      DOI: 10.1016/j.stem.2024.03.003

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    sciencedirect.com/science/article/pii/S1934590924000845
  8. Mar 2024
  9. www.sciencedirect.com www.sciencedirect.com
    Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
    1
    1. scibot 29 Mar 2024
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      DOI: 10.1016/j.chembiol.2024.02.013

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    sciencedirect.com/science/article/pii/S2451945624000874
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    Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity
    1
    1. scibot 27 Mar 2024
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      DOI: 10.1016/j.celrep.2024.114003

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    sciencedirect.com/science/article/pii/S2211124724003310
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TEAD1 is crucial for developmental myelination, Remak bundles, and functional regeneration of peripheral nerves
    1
    1. scibot 27 Mar 2024
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      DOI: 10.7554/eLife.87394

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    ncbi.nlm.nih.gov/pmc/articles/PMC10959528/
  12. Feb 2024
  13. 52.53.155.43 52.53.155.43
    d1-html.html
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    1. scibot 29 Feb 2024
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      DOI: 10.1158/1078-0432.ccr-23-2360

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    52.53.155.43/9d9c84a50a37d03d2f105a9516b773f31c793012/d1-html.html
  14. www.sciencedirect.com www.sciencedirect.com
    YAP mediates apoptosis through failed integrin adhesion reinforcement
    2
    1. scibot 23 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113811

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      DOI: 10.1016/j.celrep.2024.113811

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    sciencedirect.com/science/article/pii/S2211124724001396
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative modelling and analysis of signalling crosstalk reveal molecular switches coordinating YAP transcriptional activities
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    1. scibot 23 Feb 2024
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      DOI: 10.1016/j.isci.2024.109031

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    ncbi.nlm.nih.gov/pmc/articles/PMC10877689/
  16. 52.53.155.43 52.53.155.43
    YAP-mediated GPER signaling impedes proliferation and survival of prostate epithelium in benign prostatic hyperplasia
    1
    1. scibot 09 Feb 2024
      RRID:AB_2650491

      DOI: 10.1016/j.isci.2024.109125

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    52.53.155.43/3b983d9532a50e2ebeba730d1190ef88722ceb9a/PIIS2589004224003468-html.html
  17. www.sciencedirect.com www.sciencedirect.com
    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
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    1. scibot 09 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113714

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    sciencedirect.com/science/article/pii/S2211124724000421
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    YTHDF2-mediated circYAP1 drives immune escape and cancer progression through activating YAP1/TCF4-PD-L1 axis
    1
    1. scibot 01 Feb 2024
      RRID:AB_2650491

      DOI: 10.1016/j.isci.2023.108779

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    ncbi.nlm.nih.gov/pmc/articles/PMC10825049/
  19. Dec 2023
  20. www.sciencedirect.com www.sciencedirect.com
    YAP and TAZ couple osteoblast precursor mobilization to angiogenesis and mechanoregulation in murine bone development
    1
    1. scibot 23 Dec 2023
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      DOI: 10.1016/j.devcel.2023.11.029

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    sciencedirect.com/science/article/abs/pii/S1534580723006500
  21. www.sciencedirect.com www.sciencedirect.com
    Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses
    2
    1. scibot 17 Dec 2023
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      DOI: 10.1016/j.cell.2023.11.005

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    2. scibot 17 Dec 2023
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      DOI: 10.1016/j.cell.2023.11.005

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    sciencedirect.com/science/article/pii/S0092867423012205
  22. www.sciencedirect.com www.sciencedirect.com
    YAP targetome reveals activation of SPEM in gastric pre-neoplastic progression and regeneration
    1
    1. scibot 02 Dec 2023
      RRID:AB_2650491

      DOI: 10.1016/j.celrep.2023.113497

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    sciencedirect.com/science/article/pii/S2211124723015097
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway
    1
    1. scibot 01 Dec 2023
      AB_2650491

      DOI: 10.1038/s41419-023-06312-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10682431/
  24. Oct 2023
  25. www.sciencedirect.com www.sciencedirect.com
    High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma
    1
    1. scibot 28 Oct 2023
      RRID:AB_2650491

      DOI: 10.1016/j.xcrm.2023.101244

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    sciencedirect.com/science/article/pii/S2666379123004214
  26. link.springer.com link.springer.com
    Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity
    1
    1. scibot 17 Oct 2023
      RRID:AB_2650491

      DOI: 10.1186/s12967-023-04542-4

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    link.springer.com/article/10.1186/s12967-023-04542-4
  27. Sep 2023
  28. www.sciencedirect.com www.sciencedirect.com
    Discordant interactions between YAP1 and polycomb group protein SCML2 determine cell fate
    1
    1. scibot 30 Sep 2023
      RRID:AB_2650491

      DOI: 10.1016/j.isci.2023.107964

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    sciencedirect.com/science/article/pii/S2589004223020412
  29. www.sciencedirect.com www.sciencedirect.com
    LSR targets YAP to modulate intestinal Paneth cell differentiation
    1
    1. scibot 14 Sep 2023
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      DOI: 10.1016/j.celrep.2023.113118

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    sciencedirect.com/science/article/pii/S2211124723011300
  30. www.sciencedirect.com www.sciencedirect.com
    3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages
    1
    1. scibot 08 Sep 2023
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      DOI: 10.1016/j.stem.2023.08.005

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    sciencedirect.com/science/article/pii/S1934590923002886
  31. Aug 2023
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reduced smooth muscle-fibroblasts transformation potentially decreases intestinal wound healing and colitis-associated cancer in ageing mice
    1
    1. scibot 12 Aug 2023
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      DOI: 10.1038/s41392-023-01554-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC10409725/
  33. Jul 2023
  34. www.nature.com www.nature.com
    MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice
    1
    1. scibot 14 Jul 2023
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      DOI: 10.1038/s41536-023-00310-6

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    nature.com/articles/s41536-023-00310-6
  35. www.sciencedirect.com www.sciencedirect.com
    Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes and contributes to contractile dysfunction induced by pressure overload
    1
    1. scibot 01 Jul 2023
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      DOI: 10.1016/j.isci.2023.107146

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    sciencedirect.com/science/article/pii/S2589004223012233
  36. Jun 2023
  37. www.sciencedirect.com www.sciencedirect.com
    TRIM21 is a druggable target for the treatment of metastatic colorectal cancer through ubiquitination and activation of MST2
    1
    1. scibot 24 Jun 2023
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      DOI: 10.1016/j.chembiol.2023.05.009

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    sciencedirect.com/science/article/pii/S2451945623001526
  38. May 2023
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FAP promotes metastasis and chemoresistance via regulating YAP1 and macrophages in mucinous colorectal adenocarcinoma
    1
    1. scibot 23 May 2023
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      DOI: 10.1016/j.isci.2023.106600

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    ncbi.nlm.nih.gov/pmc/articles/PMC10196996/
  40. www.sciencedirect.com www.sciencedirect.com
    KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells
    1
    1. scibot 05 May 2023
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      DOI: 10.1016/j.celrep.2022.111077

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    sciencedirect.com/science/article/pii/S2211124722008750
  41. Apr 2023
  42. www.sciencedirect.com www.sciencedirect.com
    Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers
    1
    1. scibot 27 Apr 2023
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      DOI: 10.1016/j.stem.2023.01.009

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    sciencedirect.com/science/article/pii/S1934590923000097
  43. www.sciencedirect.com www.sciencedirect.com
    Lysine long-chain fatty acylation regulates the TEAD transcription factor
    1
    1. scibot 15 Apr 2023
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      DOI: 10.1016/j.celrep.2023.112388

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    sciencedirect.com/science/article/pii/S2211124723003996
  44. www.sciencedirect.com www.sciencedirect.com
    Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation
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    1. scibot 07 Apr 2023
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      DOI: 10.1016/j.stem.2023.03.005

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    sciencedirect.com/science/article/pii/S1934590923000760
  45. Mar 2023
  46. www.embopress.org www.embopress.org
    Two Hippo signaling modules orchestrate liver size and tumorigenesis
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    1. scibot 16 Mar 2023
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      DOI: 10.15252/embj.2022112126

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      DOI: 10.15252/embj.2022112126

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    embopress.org/doi/10.15252/embj.2022112126
  47. Jan 2023
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
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    1. scibot 15 Jan 2023
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      DOI: 10.1158/2159-8290.CD-22-0489

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    ncbi.nlm.nih.gov/pmc/articles/PMC9827110/
  49. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 14 Jan 2023
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      DOI: 10.1111/bph.16007

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16007
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy
    1
    1. scibot 12 Jan 2023
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      DOI: 10.1158/1535-7163.MCT-21-0964

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    ncbi.nlm.nih.gov/pmc/articles/PMC9630827/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combined control of the fibroblast contractile program by YAP and TAZ
    1
    1. scibot 06 Jan 2023
      RRID:AB_2650491

      DOI: 10.1152/ajplung.00210.2021

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    ncbi.nlm.nih.gov/pmc/articles/PMC8721907/
  52. Dec 2022
  53. www.sciencedirect.com www.sciencedirect.com
    The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model
    1
    1. scibot 24 Dec 2022
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      DOI: 10.1016/j.celrep.2022.111837

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    YAP regulates the liver size during the fasting-refeeding transition in mice
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  55. Nov 2022
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    Multiphase coalescence mediates Hippo pathway activation
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  57. Oct 2022
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel NF2 Splicing Mutant Causes Neurofibromatosis Type 2 via Liquid-liquid Phase Separation with LATS and Hippo Pathway.
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  59. elifesciences.org elifesciences.org
    Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury
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    Spatial epitope barcoding reveals clonal tumor patch behaviors
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    Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer
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  62. Sep 2022
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    A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation
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  64. Aug 2022
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    Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers
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    Pressure and curvature control of the cell cycle in epithelia growing under spherical confinement
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    Whole-mount immunofluorescence staining of mesenchymal progenitors in murine plantaris muscle
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  68. Jul 2022
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrin β3 Promotes Resistance to EGFR-TKI in Non-Small-Cell Lung Cancer by Upregulating AXL through the YAP Pathway
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  70. May 2022
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    JAM-A Signals Through the Hippo Pathway to Regulate Intestinal Epithelial Proliferation
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  72. Apr 2022
  73. www.sciencedirect.com www.sciencedirect.com
    WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy
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  74. aacrjournals.org aacrjournals.org
    FREQUENCY AND GENOMIC ASPECTS OF INTRINSIC RESISTANCE TO VISMODEGIB IN LOCALLY ADVANCED BASAL CELL CARCINOMA
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epithelia
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  76. Mar 2022
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair
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  78. www.embopress.org www.embopress.org
    Human cerebral organoids reveal progenitor pathology in EML1-linked cortical malformation
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  79. Feb 2022
  80. www.sciencedirect.com www.sciencedirect.com
    Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction
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    RNA localization in confined cells depends on cellular mechanical activity and contributes to confined migration
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  82. Jan 2022
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    Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion
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    Adaptive differentiation promotes intestinal villus recovery
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  85. Dec 2021
  86. www.nature.com www.nature.com
    A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis
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    Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps
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    Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load
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  89. Oct 2021
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    Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma
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    Lentiviral-mediated ectopic expression of YAP and TAZ in YAPoff cancer cell lines
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  92. Sep 2021
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    Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation
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      DOI: 10.1038/s41401-021-00754-w

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    Senescent immune cells release grancalcin to promote skeletal aging
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  95. Aug 2021
  96. www.sciencedirect.com www.sciencedirect.com
    Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis
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  101. Jul 2021
  102. www.nature.com www.nature.com
    Treatment of type 2 diabetes with the designer cytokine IC7Fc
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      YAP1

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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  104. onlinelibrary.wiley.com onlinelibrary.wiley.com
    EphA2‐to‐YAP Pathway Drives Gastric Cancer Growth and Therapy Resistance
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      anti‐YAP antibody

      DOI: 10.1002/ijc.32609

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  105. dev.biologists.org dev.biologists.org
    Yap and its subcellular localization have distinct compartment-specific roles in the developing lung
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      rabbit anti-Yap

      DOI: 10.1242/dev.175810

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    dev.biologists.org/content/146/9/dev175810
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6231326/
  107. www.sciencedirect.com www.sciencedirect.com
    Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity
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  108. www.sciencedirect.com www.sciencedirect.com
    Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis
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      DOI: 10.1016/j.celrep.2021.109347

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    Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer
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  127. Oct 2020
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  129. Sep 2020
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    Axon-dependent expression of YAP/TAZ mediates Schwann cell remyelination but not proliferation after nerve injury
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    Macrophage K63-Linked Ubiquitination of YAP Promotes Its Nuclear Localization and Exacerbates Atherosclerosis
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    Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
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    MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation
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    YAP1 regulates chondrogenic differentiation of ATDC5 promoted by temporary TNF-α stimulation through AMPK signaling pathway
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    Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development
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    Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation
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    A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling
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    A Non-canonical Role of YAP/TEAD Is Required for Activation of Estrogen-Regulated Enhancers in Breast Cancer
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    Sphingosine 1‐phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes
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    The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes
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    Epiblast Formation by TEAD-YAP-Dependent Expression of Pluripotency Factors and Competitive Elimination of Unspecified Cells
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    YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression
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      RRID:AB_2650491

      DOI: 10.1016/j.ccell.2019.01.009

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      DOI: 10.1016/j.stem.2019.04.004

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  158. Nov 2018
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    Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy
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    Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction
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    Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs
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    Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS
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    SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis
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    Paneth Cell Multipotency Induced by Notch Activation following Injury
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    Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization
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      Curator: @evieth

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  168. Nov 2017
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    A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer
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    YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme
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    The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity
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      14074

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    RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma
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      Anti-Rabbit YAP1Cell Signaling TechnologyCat# 14074

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    Dissection of the interaction between the intrinsically disordered YAP protein and the transcription factor TEAD
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      14074

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