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Targeting ADAR1 p150 triggers tumor inhibition and antitumor immunity to overcome immunotherapy resistance

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1. scibot 22 May 2026
  
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  DOI: 10.1016/j.isci.2026.115978
  
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sciencedirect.com/science/article/pii/S2589004226013532
May 2026
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5′-Triphosphate guanosine RNAs recruit GTP-binding proteins to suppress RIG-I/IFN type I signaling

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1. scibot 09 May 2026
  
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  DOI: 10.1016/j.molcel.2026.04.014
  
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sciencedirect.com/science/article/pii/S1097276526002686
Mar 2026
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ALG6 orchestrates coronavirus replication via the endoplasmic reticulum stress-autophagy axis

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1. scibot 20 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117108
  
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sciencedirect.com/science/article/pii/S2211124726001865
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ADAR1 regulates dsRNA formation in nuclear and mitochondrial transcripts through editing-dependent and -independent mechanisms

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1. scibot 10 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117026
  
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sciencedirect.com/science/article/pii/S221112472600104X
Feb 2026
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Broad-spectrum antiviral activity of antisense oligonucleotides targeting GBF1 against SARS-CoV-2 and influenza viruses

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1. scibot 26 Feb 2026
  
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  DOI: 10.1016/j.isci.2026.114851
  
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sciencedirect.com/science/article/pii/S2589004226002269
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Endogenous retrovirus-derived RNA-DNA hybrids induce microglial synaptic pruning in autism models

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1. scibot 26 Feb 2026
  
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  DOI: 10.1016/j.neuron.2026.01.011
  
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sciencedirect.com/science/article/pii/S0896627326000127
Jan 2026
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Pregnenolone promotes immune evasion through blocking endogenous retrovirus expression

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1. scibot 27 Jan 2026
  
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  DOI: 10.1016/j.cmet.2025.12.020
  
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sciencedirect.com/science/article/pii/S1550413125005844
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MAVS signaling exacerbates chondrocytes extracellular matrix degradation in osteoarthritis

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1. scibot 06 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116778
  
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sciencedirect.com/science/article/pii/S2211124725015505
Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Priming with DNMT Inhibitors Potentiates PD-1 Immunotherapy by Triggering Viral Mimicry in Relapsed/Refractory NK/T-cell Lymphoma

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1. scibot 06 Dec 2025
  
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  DOI: 10.1158/2159-8290.CD-25-0587
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12670078/
Sep 2025
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Repeats mimic pathogen-associated patterns across a vast evolutionary landscape

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1. scibot 25 Sep 2025
  
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  DOI: 10.1016/j.xgen.2025.101011
  
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sciencedirect.com/science/article/pii/S2666979X25002678
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ZBP1 pathway promotes tumor immunogenicity in the combination of anti-HER2 therapy and epigenetic therapy

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1. scibot 17 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116314
  
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sciencedirect.com/science/article/pii/S221112472501085X
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Pseudouridine synthase 1-targeted therapy activates antiviral immunity to boost cancer immunotherapy

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1. scibot 06 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116233
  
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sciencedirect.com/science/article/pii/S2211124725010046
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Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease

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1. scibot 03 Sep 2025
  
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  DOI: 10.1016/j.immuni.2025.07.024
  
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sciencedirect.com/science/article/pii/S1074761325003334
Jul 2025
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Multimodal CRISPR screens uncover DDX39B as a global repressor of A-to-I RNA editing

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116009
  
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sciencedirect.com/science/article/pii/S2211124725007806
May 2025
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Structural basis for OAS2 regulation and its antiviral function

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.molcel.2025.05.001
  
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sciencedirect.com/science/article/pii/S109727652500406X
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Prkra dimer senses double-stranded RNAs to dictate global translation efficiency

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.molcel.2025.04.005
  
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sciencedirect.com/science/article/pii/S1097276525003089
Apr 2025
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ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition

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1. scibot 24 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.04.004
  
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sciencedirect.com/science/article/pii/S1097276525003077
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ZBP1 senses splicing aberration through Z-RNA to promote cell death

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1. scibot 24 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.03.023
  
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sciencedirect.com/science/article/pii/S1097276525002990
Feb 2025
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Exposure of negative-sense viral RNA in the cytoplasm initiates innate immunity to West Nile virus

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1. scibot 07 Feb 2025
  
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  DOI: 10.1016/j.molcel.2025.01.015
  
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sciencedirect.com/science/article/pii/S1097276525000504
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Virus adaptation to heparan sulfate comes with capsid stability tradeoff

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1. scibot 18 Jan 2025
  
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  DOI: 10.7554/eLife.98441
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11717363/
Dec 2024
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RNA sensing induced by chromosome missegregation augments anti-tumor immunity

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.025
  
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sciencedirect.com/science/article/pii/S109727652400950X
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cGAS-like receptors drive a systemic STING-dependent host response in Drosophila

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1. scibot 17 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115081
  
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sciencedirect.com/science/article/pii/S2211124724014323
Nov 2024
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Zika virus remodels and hijacks IGF2BP2 ribonucleoprotein complex to promote viral replication organelle biogenesis

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1. scibot 26 Nov 2024
  
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  DOI: 10.7554/eLife.94347
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11578589/
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Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma

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1. scibot 08 Nov 2024
  
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  DOI: 10.1158/0008-5472.CAN-24-0134
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11532787/
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A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses

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1. scibot 08 Nov 2024
  
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  DOI: 10.1038/s44318-024-00238-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11535224/
Sep 2024
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Transcriptome-wide quantification of double-stranded RNAs in live mouse tissues by dsRIP-Seq

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1. scibot 24 Sep 2024
  
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  DOI: 10.1016/j.xpro.2021.100366
  
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sciencedirect.com/science/article/pii/S2666166721000733
Aug 2024
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Increased viral tolerance mediates by antiviral RNA interference in bat cells

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  DOI: 10.1016/j.celrep.2024.114581
  
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sciencedirect.com/science/article/pii/S2211124724009100
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Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8+ T cell responses

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1. scibot 02 Aug 2024
  
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  DOI: 10.1126/sciadv.adl1122
  
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science.org/doi/10.1126/sciadv.adl1122
Jul 2024
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RNA 5-methylcytosine marks mitochondrial double-stranded RNAs for degradation and cytosolic release

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1. scibot 17 Jul 2024
  
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  DOI: 10.1016/j.molcel.2024.06.023
  
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sciencedirect.com/science/article/pii/S1097276524005306
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8+ T cell responses

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1. scibot 09 Mar 2024
  
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  DOI: 10.1126/sciadv.adl1122
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10917340/
Feb 2024
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A SUMO E3 ligase promotes long non-coding RNA transcription to regulate small RNA-directed DNA elimination

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1. scibot 02 Feb 2024
  
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  DOI: 10.7554/eLife.95337
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10830130/
Jan 2024
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Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer

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1. scibot 23 Jan 2024
  
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  DOI: 10.1016/j.celrep.2024.113684
  
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sciencedirect.com/science/article/pii/S2211124724000123
Oct 2023
www.thelancet.com www.thelancet.com

Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death

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1. scibot 06 Oct 2023
  
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  DOI: 10.1016/j.ebiom.2023.104784
  
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thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00350-X/fulltext
Aug 2023
www.biorxiv.org www.biorxiv.org

Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses

1
1. scibot 28 Aug 2023
  
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  AB_2651015
  
  DOI: 10.1101/2023.08.19.553954
  
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biorxiv.org/content/10.1101/2023.08.19.553954v1
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Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response

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1. scibot 27 Aug 2023
  
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  DOI: 10.1016/j.isci.2023.107631
  
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sciencedirect.com/science/article/pii/S258900422301708X
Jul 2023
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TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry

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Jun 2023
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SINE RNA of the imprinted miRNA clusters mediates constitutive type III interferon expression and antiviral protection in hemochorial placentas

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Apr 2023
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Coronavirus Subverts ER-phagy by Hijacking FAM134B and ATL3 into p62 Condensates to Facilitate Viral Replication

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Mar 2023
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Mechanosensitive extrusion of Enterovirus A71-infected cells from colonic organoids

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Feb 2023
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Bat pluripotent stem cells reveal unusual entanglement between host and viruses

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Analysis of mitochondrial double-stranded RNAs in human cells

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Protocol for the analysis of double-stranded RNAs in virus-infected insect cells using anti-dsRNA antibodies

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SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy

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SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19

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Bortezomib inhibits ZIKV/DENV by interfering with viral polyprotein cleavage via the ERAD pathway

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P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

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Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas

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SARS-CoV-2 infection of human pluripotent stem cell-derived liver organoids reveals potential mechanisms of liver pathology

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SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA

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Jul 2022
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Potent Stimulation of the Androgen Receptor Instigates a Viral Mimicry Response in Prostate Cancer

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Resolution of R-loops by topoisomerase III-β (TOP3B) in coordination with the DEAD-box helicase DDX5

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Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells

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Jun 2022
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Invading viral DNA triggers dsRNA synthesis by RNA polymerase II to activate antiviral RNA interference in Drosophila

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Multi-color super-resolution imaging to study human coronavirus RNA during cellular infection

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Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences

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Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues

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Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome

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ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

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Jul 2021
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Sequential MAVS and MyD88/TRIF signaling triggers anti-viral responses of tick-borne encephalitis virus-infected murine astrocytes

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Jun 2021
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Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis

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TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity

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m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development

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Quantitative measurements of early alphaviral replication dynamics in single cells reveals the basis for superinfection exclusion

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Transcriptome-wide quantification of double-stranded RNAs in live mouse tissues by dsRIP-Seq

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Endogenous retrovirus expression activates type-I interferon signaling in an experimental mouse model of mesothelioma development

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Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer

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Feb 2021
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FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

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Jan 2021
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The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling

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Nov 2020
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Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies

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Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium

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ncbi.nlm.nih.gov/pmc/articles/PMC7505550/
Sep 2020
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Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication

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1. scibot 23 Sep 2020
  
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  DOI: 10.1016/j.molcel.2020.08.006
  
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ADAR1 Facilitates KSHV Lytic Reactivation by Modulating the RLR-Dependent Signaling Pathway

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1. scibot 07 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107564
  
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Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells

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1. scibot 05 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107863
  
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Jan 2020
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Non-coding RNA Transcription in Tetrahymena Meiotic Nuclei Requires Dedicated Mediator Complex-Associated Proteins

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  DOI: 10.1016/j.cub.2019.05.038
  
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The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers

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  DOI: 10.1016/j.chom.2019.08.010
  
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Viral Generated Inter-Organelle Contacts Redirect Lipid Flux for Genome Replication

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.cell.2019.05.030
  
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TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation

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  DOI: 10.1016/j.celrep.2019.05.040
  
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Untitled document

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  DOI: 10.1016/j.chom.2019.03.005
  
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Untitled document

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  DOI: 10.1016/j.celrep.2018.12.095
  
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Reciprocal Effects of Fibroblast Growth Factor Receptor Signaling on Dengue Virus Replication and Virion Production

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1. scibot 12 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.04.105
  
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Nov 2018
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PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs

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LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

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KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses

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Nov 2017
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Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine

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1. scibot 08 Nov 2017
  
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SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

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1. scibot 08 Nov 2017
  
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