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Nociceptive innervation limits tertiary lymphoid structures to promote lung cancer

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1. scibot 20 May 2026
  
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  DOI: 10.1016/j.cell.2026.04.038
  
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sciencedirect.com/science/article/pii/S0092867426005052
May 2026
dx.doi.org dx.doi.org

VEGF-C-mediated cardiac lymphangiogenesis promotes inflammation resolution in autoimmune acute myocarditis in mice

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1. scibot 15 May 2026
  
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  DOI: 10.1093/cvr/cvag057
  
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dx.doi.org/10.1093/cvr/cvag057
www-cell-com.eproxy.lib.hku.hk www-cell-com.eproxy.lib.hku.hk

Whole-genome doubling drives immune evasion by silencing antigen presentation

1
1. scibot 08 May 2026
  
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  DOI: 10.1016/j.ccell.2026.04.007
  
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www-cell-com.eproxy.lib.hku.hk/cancer-cell/fulltext/S1535-6108(26)00218-7
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The circadian gene Dec2 promotes pancreatic cancer progression and dormancy through immune evasion

1
1. scibot 01 May 2026
  
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  DOI: 10.1016/j.devcel.2026.04.001
  
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sciencedirect.com/science/article/pii/S1534580726001243
Apr 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Nerves Stimulate Cross-talk Between Gastric Cancer and Group 3 Innate Lymphoid Cells to Enhance Immunosuppression

1
1. scibot 17 Apr 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-3092
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13080324/
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Pan-cancer macrophage atlas uncovers that MHC-IIhigh TAMs induce Treg activation through physical interactions

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1. scibot 15 Apr 2026
  
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  DOI: 10.1016/j.celrep.2026.117230
  
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sciencedirect.com/science/article/pii/S2211124726003086
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Histone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinoma

1
1. scibot 02 Apr 2026
  
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  DOI: 10.1016/j.xcrm.2026.102717
  
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sciencedirect.com/science/article/pii/S2666379126001345
Mar 2026
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Reconstruction of T cell infiltration in an osteosarcoma PDX-organoid interactive biobank for personalized immunotherapy

1
1. scibot 03 Mar 2026
  
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  DOI: 10.1016/j.xcrm.2026.102644
  
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sciencedirect.com/science/article/pii/S2666379126000613
Feb 2026
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Therapeutic Effect of Gemcitabine Combined With Angelica Polysaccharide on Triple Negative Breast Cancer in Mice

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1. scibot 19 Feb 2026
  
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  DOI: 10.1177/15347354251414897
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12909758/
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Chemotherapy triggers immune evasion by fostering LEPR+ Kupffer cell differentiation in liver metastases

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1. scibot 13 Feb 2026
  
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  DOI: 10.1016/j.ccell.2026.01.010
  
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sciencedirect.com/science/article/pii/S1535610826000498
54.241.53.176 54.241.53.176

1-s2.0-S2589004226002336-main-html.html

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1. scibot 10 Feb 2026
  
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  DOI: 10.1016/j.isci.2026.114858
  
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54.241.53.176/e86b13a815c53c6ac4146180b2283f50e62e856a/1-s2.0-S2589004226002336-main-html.html
advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD-L1 and T Cell Senescence

1
1. scibot 06 Feb 2026
  
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  DOI: 10.1002/advs.202506239
  
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advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202506239
Jan 2026
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Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in pancreatic cancer cells

1
1. scibot 30 Jan 2026
  
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  AB_2686917
  
  DOI: 10.1038/s41419-025-08362-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12847887/
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Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth

1
1. scibot 23 Jan 2026
  
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  DOI: 10.1016/j.ccell.2025.12.021
  
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sciencedirect.com/science/article/pii/S1535610825005550
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Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis

1
1. scibot 15 Jan 2026
  
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  DOI: 10.1016/j.cell.2025.12.032
  
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sciencedirect.com/science/article/pii/S0092867425014813
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CCL5 deficiency aggravates acute DSS-induced colitis by restricting IL-33-induced formation of Tregs in intestinal tract

1
1. scibot 09 Jan 2026
  
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  RRID:AB_2686917
  
  DOI: 10.1042/CS20256734
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12862953/
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Uridine depletion impairs CD8⁺ T cell antitumor activity through N-glycosylation

1
1. scibot 06 Jan 2026
  
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  DOI: 10.1016/j.cmet.2025.11.016
  
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sciencedirect.com/science/article/pii/S1550413125005303
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Inhibition of PAK2 in endothelial cells suppresses tumor angiogenesis and promotes immune sensitization through CXCL10

1
1. scibot 06 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116840
  
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sciencedirect.com/science/article/pii/S2211124725016122
Dec 2025
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Hepatic adaptation to chronic metabolic stress primes tumorigenesis

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1. scibot 23 Dec 2025
  
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  DOI: 10.1016/j.cell.2025.11.031
  
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RAS(ON) multi-selective inhibition drives antitumor immunity in preclinical models of NRAS-mutant melanoma

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1. scibot 03 Dec 2025
  
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  DOI: 10.1158/2326-6066.CIR-25-0744
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12666865/
Nov 2025
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MHC-II-restricted neoantigen vaccine reverses immune microenvironment and overcomes resistance to immune-checkpoint inhibitors in cold tumors

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1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.medj.2025.100936
  
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sciencedirect.com:5037/science/article/pii/S2666634025003630
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Hybrid apoptotic body decorated supramolecular hydrogel system for melanoma cancer immunoediting

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.cej.2025.171086
  
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sciencedirect.com/science/article/pii/S1385894725119323
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Regulatory T cell stability determines the efficiency of bile duct regeneration during cholangitis

1
1. scibot 18 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116557
  
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sciencedirect.com/science/article/pii/S2211124725013282
Oct 2025
54.241.53.176 54.241.53.176

2025.10.24.684274v1.full-html.html

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1. scibot 30 Oct 2025
  
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  DOI: 10.1101/2025.10.24.684274
  
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54.241.53.176/560b23241d86210770f41b5bc2071167c8b2fca6/2025.10.24.684274v1.full-html.html
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Inter- and intra-tumoral ALDH1 heterogeneity in breast cancer identifies therapeutic opportunities for ALDH1A-specific inhibitors

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1. scibot 01 Oct 2025
  
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  DOI: 10.1016/j.chembiol.2025.09.003
  
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sciencedirect.com/science/article/pii/S2451945625002685
Sep 2025
www.biorxiv.org www.biorxiv.org

Lactate Blocks Tertiary Lymphoid Structure Formation by Inhibiting B Cell Chemotaxis

1
1. scibot 10 Sep 2025
  
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  DOI: 10.1101/2025.08.30.673054
  
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biorxiv.org/content/10.1101/2025.08.30.673054v1
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Pseudouridine synthase 1-targeted therapy activates antiviral immunity to boost cancer immunotherapy

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1. scibot 06 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116233
  
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sciencedirect.com/science/article/pii/S2211124725010046
Aug 2025
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Biomimetic nanoimmunotherapy boosts spatiotemporal PANoptosis and reshapes desmoplastic tumor microenvironment

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102312
  
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The absence of IL17A favours cytotoxic cell function and improves antigen-specific immunotherapies in pancreatic adenocarcinoma

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1. scibot 21 Aug 2025
  
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  DOI: 10.1002/ctm2.70442
  
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onlinelibrary.wiley.com/doi/10.1002/ctm2.70442
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Targeting the MYC oncogene with a selective bi-steric mTORC1 inhibitor elicits tumor regression in MYC-driven cancers

1
1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.chembiol.2025.07.004
  
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sciencedirect.com/science/article/pii/S2451945625002272
Jul 2025
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Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

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1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.ccell.2025.06.021
  
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sciencedirect.com/science/article/pii/S1535610825002715
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Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL

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1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.cell.2025.06.027
  
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Combined KRAS inhibition and immune therapy generates durable complete responses in an autochthonous PDAC model

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1. scibot 15 Jul 2025
  
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  DOI: 10.1158/2159-8290.CD-24-0489
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11858029/
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AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis

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1. scibot 02 Jul 2025
  
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  DOI: 10.1016/j.jid.2023.12.017
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11193656/
Jun 2025
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BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAFV600E-mutant glioma

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1. scibot 13 Jun 2025
  
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  DOI: 10.1016/j.xcrm.2025.102183
  
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Cisplatin and temozolomide combinatorial treatment triggers hypermutability and immune surveillance in experimental cancer models

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Induction of a mismatch repair deficient genotype by tailored chemical mutagenesis in experimental models of cancer

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The low-dose CHK1 inhibitor prexasertib triggers VDAC1 dephosphorylation to activate mtDNA-STING signaling and synergize immunotherapy

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Carvedilol sensitizes chemotherapy by targeting STING to boost anti-tumor immunity

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Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer

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Lung CD4+ resident memory T cells use airway secretory cells to stimulate and regulate onset of allergic airway neutrophilic disease

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The balance between IFN-γ and ERK/MAPK signaling activities ensures lifelong maintenance of intestinal stem cells

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Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy

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Negative regulation of lymphangiogenesis by Tenascin-C delays the resolution of inflammation

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Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment

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Three-dimensional characteristics of T cells and vasculature in the development of mouse esophageal cancer

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EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function

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strobl-et-al-2024-jak-stat1-as-therapeutic-target-for-egfr-deficiency-associated-inflammation-and-scarring-alopecia-html.html

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JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia

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Microarray analysis of signalling interactions between inflammation and angiogenesis in subchondral bone in temporomandibular joint osteoarthritis

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SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8+ T cell activation

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Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation

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Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer

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Engineering an energy-dissipating hybrid tissue in vivo for obesity treatment

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Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity

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Ablation of Atp5if1 impairs metabolic reprogramming and proliferation of T lymphocytes and compromises mouse survival

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Apr 2024
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ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion

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Phototruncation cell tracking with near-infrared photoimmunotherapy using heptamethine cyanine dye to visualise migratory dynamics of immune cells

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A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer

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Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege

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Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis

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Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity

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AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis

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Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells

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Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer

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Sep 2023
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Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity

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Select symbionts drive high IgA levels in the mouse intestine

1
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  DOI: 10.1016/j.chom.2023.09.001
  
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Lymphatic endothelial transcription factor Tbx1 promotes an immunosuppressive microenvironment to facilitate post-myocardial infarction repair

1
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  DOI: 10.1016/j.immuni.2023.07.019
  
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Jul 2023
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Interventional hydrogel microsphere vaccine as an immune amplifier for activated antitumour immunity after ablation therapy

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  DOI: 10.1038/s41467-023-39759-w
  
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May 2023
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ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy

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  DOI: 10.1038/s41467-023-38605-3
  
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Immune landscape of a genetically engineered murine model of glioma compared to human glioma by single-cell sequencing

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  DOI: 10.1172/jci.insight.148990
  
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Apr 2023
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Semi-Supervised Analysis of myeloid and T cell behaviour in ex vivo ovarian tumour slices reveals changes in cell motility after treatments

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Steroid Receptor Coactivator-3 is a Key Modulator of Regulatory T Cell-Mediated Tumor Evasion

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  DOI: 10.1101/2023.03.28.534575
  
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52.53.155.43 52.53.155.43

Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B cell fate decisions and yields T cell-depleted lymphomas

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  DOI: 10.1101/2023.02.13.528351
  
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T cell immune deficiency rather than chromosome instability predisposes patients with short telomere syndromes to squamous cancers

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  DOI: 10.1016/j.ccell.2023.03.005
  
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Feb 2023
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IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment

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Opioid-induced fragile-like regulatory T cells contribute to withdrawal

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  DOI: 10.1016/j.cell.2022.12.030
  
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SSRN-id4272137-html.html

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  DOI: 10.1016/j.ygyno.2006.12.033
  
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Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy

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  DOI: 10.1158/2159-8290.CD-21-0003
  
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Dec 2022
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Across-cancer immune responses induced by nanovaccines or microvaccines to prevent different cancers and cancer metastasis

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Nov 2022
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An immunocompetent rectal cancer model to study radiation therapy

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  DOI: 10.1016/j.crmeth.2022.100353
  
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Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer

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  DOI: 10.1016/j.celrep.2022.111596
  
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Oct 2022
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Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy

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  DOI: 10.1016/j.cmet.2022.09.021
  
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PARP-inhibition reprograms macrophages toward an anti-tumor phenotype

1
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Inflammatory Monocytes Promote Granuloma-Mediated Control of Persistent Salmonella Infection

1
1. scibot 22 Sep 2022
  
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  DOI: 10.1128/iai.00070-22
  
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Aug 2022
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Butyrate-producing Eubacterium rectale suppresses lymphomagenesis by alleviating the TNF-induced TLR4/MyD88/NF-κB axis

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Low ferroptosis score predicts chemotherapy responsiveness and immune-activation in colorectal cancer

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  DOI: 10.1002/cam4.4956
  
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Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells

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  DOI: 10.1016/j.devcel.2022.06.006
  
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The immunometabolite S-2-hydroxyglutarate exacerbates perioperative ischemic brain injury and cognitive dysfunction by enhancing CD8+ T lymphocyte-mediated neurotoxicity

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  DOI: 10.1186/s12974-022-02537-4
  
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May 2022
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Topical therapy for regression and melanoma prevention of congenital giant nevi

1
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Apr 2022
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Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T cell lymphoma

1
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  DOI: 10.1016/j.celrep.2022.110695
  
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Mar 2022
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Spatial CRISPR genomics identifies regulators of the tumor microenvironment

1
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  DOI: 10.1016/j.cell.2022.02.015
  
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Inflammatory Monocytes Promote Granuloma-Mediated Control of Persistent Salmonella Infection

1
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  DOI: 10.1128/iai.00070-22
  
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journals.asm.org/doi/full/10.1128/iai.00070-22
Dec 2021
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AMP-activated protein kinase alpha1 promotes tumor development via FOXP3 elevation in tumor-infiltrating Treg cells

1
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  DOI: 10.1016/j.isci.2021.103570
  
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Nov 2021
mct.aacrjournals.org mct.aacrjournals.org

Simultaneously Combined Cancer Cell- and CTLA4-Targeted NIR-PIT Causes a Synergistic Treatment Effect in Syngeneic Mouse Models

1
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  DOI: 10.1158/1535-7163.MCT-21-0470
  
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Sep 2021
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Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion

1
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  DOI: 10.1016/j.ccell.2021.08.008
  
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Aug 2021
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CXCL10/CXCR3 signaling contributes to an inflammatory microenvironment and its blockade enhances progression of murine pancreatic precancerous lesions

1
1. scibot 19 Aug 2021
  
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  DOI: 10.7554/eLife.60646
  
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Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts

1
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  DOI: 10.1016/j.celrep.2021.109422
  
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The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer

1
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  DOI: 10.1016/j.ccell.2021.07.007
  
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Trichinella spiralis Paramyosin Induces Colonic Regulatory T Cells to Mitigate Inflammatory Bowel Disease

1
1. scibot 05 Aug 2021
  
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  DOI: 10.3389/fcell.2021.695015
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8320175/
Jul 2021
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T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

1
1. scibot 30 Jul 2021
  
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  RRID:AB_2686917
  
  DOI: 10.1016/j.cell.2018.10.008
  
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Jun 2021
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Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection

1
1. scibot 18 Jun 2021
  
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Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome

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Characterizing the tumor microenvironment of metastatic ovarian cancer by single-cell transcriptomics

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FEBS Press

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MYC ASO Impedes Tumorigenesis and Elicits Oncogene Addiction in Autochthonous Transgenic Mouse Models of HCC and RCC

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Vezatin is required for the maturation of the neuromuscular synapse

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Cuprizone‐induced demyelination triggers a CD8‐pronounced T cell recruitment

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Table 1 Antibodies.

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Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance

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Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s

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An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses

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Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis

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Vezatin is required for the maturation of the neuromuscular synapse

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Laquinimod ameliorates secondary brain inflammation

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Untitled document

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Untitled document

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