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  1. Last 7 days
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    Astrocytes modulate brain phosphate homeostasis via polarized distribution of phosphate uptake transporter PiT2 and exporter XPR1
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      DOI: 10.1016/j.neuron.2024.06.020

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    sciencedirect.com/science/article/pii/S0896627324004550
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    Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular weight RNP complexes
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    ncbi.nlm.nih.gov/pmc/articles/PMC11233918/
  4. May 2024
  5. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia
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    Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors
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    mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
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    Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals
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    ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models
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    cell.com/iscience/abstract/S2589-0042(24)01022-8
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    An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins
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    sciencedirect.com/science/article/pii/S1097276524003253
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    Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer
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    sciencedirect.com/science/article/pii/S2211124724005023
  12. Mar 2024
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    A unique chaperoning mechanism in class A JDPs recognizes and stabilizes mutant p53
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    sciencedirect.com/science/article/pii/S1097276524001370
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    Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10527992/
  15. Jan 2024
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    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
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    1. scibot 26 Jan 2024
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      DOI: 10.1101/2023.05.04.539399

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    ncbi.nlm.nih.gov/pmc/articles/PMC10187264/
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    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
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    Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma
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    sciencedirect.com/science/article/pii/S1097276523010298
  19. Dec 2023
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    The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases
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    sciencedirect.com/science/article/pii/S2211124723015930
  21. Nov 2023
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    SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction
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    link.springer.com/article/10.1007/s00018-023-05011-3
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    Impact of Mutations Defining SARS-CoV-2 Omicron Subvariants BA.2.12.1 and BA.4/5 on Spike Function and Neutralization
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    sciencedirect.com/science/article/pii/S2589004223023763
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    HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
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    sciencedirect.com/science/article/pii/S2666379123004792
  25. Oct 2023
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    MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction
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      DOI: 10.1186/s13041-023-01064-4

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  27. Aug 2023
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    PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development
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    sciencedirect.com/science/article/abs/pii/S0092867423008620
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    USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase separation potential
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    sciencedirect.com/science/article/abs/pii/S2451945623002465
  30. 52.53.155.43 52.53.155.43
    NFYC-37 promotes tumor growth by activating the mevalonate pathway in bladder cancer
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    52.53.155.43/eb7aace05cf7a189f4453bfbeb3bcf344412f769/mmc4-html.html
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    mct-23-0025 (1)-html.html
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  32. Jul 2023
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    Loss of STING in parkin mutant flies suppresses muscle defects and mitochondria damage
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    ncbi.nlm.nih.gov/pmc/articles/PMC10368295/
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    Distinct layers of BRD4-PTEFb reveal bromodomain-independent function in transcriptional regulation
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    Alternative splicing and heparan sulfation converge on neurexin-1 to control glutamatergic transmission and autism-related behaviors
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    sciencedirect.com/science/article/pii/S2211124723007258
  36. Jun 2023
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    Acetate controls endothelial-to-mesenchymal transition
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    sciencedirect.com/science/article/pii/S1550413123002036
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    Restored autophagy is protective against PAK3-induced cardiac dysfunction
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  39. May 2023
  40. 52.53.155.43 52.53.155.43
    Extension of the DNAJB2a isoform in a dominant neuromyopathy family
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    A conditional strategy for cell-type-specific labeling of endogenous excitatory synapses in Drosophila
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    sciencedirect.com/science/article/pii/S2667237523001005
  42. Apr 2023
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    TERRA stability is regulated by RALY and polyadenylation in a telomere-specific manner
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    sciencedirect.com/science/article/pii/S2211124723004175
  44. Mar 2023
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    Redox proteomics combined with proximity labeling enables monitoring of localized cysteine oxidation in cells
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    sciencedirect.com/science/article/pii/S2451945623000557
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    COP I and II dependent trafficking controls ER-associated degradation in mammalian cells
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    sciencedirect.com/science/article/pii/S2589004223003097
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    BPS Publications
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      DOI: 10.1111/bph.16046

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16046
  48. Feb 2023
  49. www.sciencedirect.com www.sciencedirect.com
    Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames
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    sciencedirect.com/science/article/pii/S1097276523000758
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    RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex
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      DOI: 10.1016/j.celrep.2023.112097

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    sciencedirect.com/science/article/pii/S2211124723001080
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    Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules
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    sciencedirect.com/science/article/pii/S0092867422016294
  52. Jan 2023
  53. www.sciencedirect.com www.sciencedirect.com
    An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes
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      DOI: 10.1016/j.cell.2022.12.025

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  55. Dec 2022
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    The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation
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  57. Nov 2022
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    Genome-wide survey of D/E repeats in human proteins uncovers their instability and aids in identifying their role in the chromatin regulator ATAD2
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    B cell linker protein (BLNK) is a regulator of Met receptor signaling and trafficking in non-small cell lung cancer
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    OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis
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  63. Sep 2022
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    ISX9, a small molecule targeting Axin, activates Wnt/β-catenin signaling and promotes hair regrowth
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    In vivo characterization of Drosophila golgins reveals redundancy and plasticity of vesicle capture at the Golgi apparatus
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    BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer
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    Determinants of Spike Infectivity, Processing and Neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2
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    Direct Observation of Compartment-Specific Localization and Dynamics of Voltage-Gated Sodium Channels
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    An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma
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    The FUS::DDIT3 fusion oncoprotein inhibits BAF complex targeting and activity in myxoid liposarcoma
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    Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartments
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    Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation
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    Molecular basis for substrate recruitment to the PRMT5 methylosome
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    TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma
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    CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer
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    Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination
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    TNIK is a therapeutic target in Lung Squamous Cell Carcinoma and regulates FAK activation through Merlin.
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    The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
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    Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities
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    RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins
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  115. Apr 2021
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    FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer
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  119. Mar 2021
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  121. Feb 2021
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  124. Dec 2020
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    Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q
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    Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis
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    LRRTMs Organize Synapses through Differential Engagement of Neurexin and PTPσ
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  136. Jan 2020
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    Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers
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    The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma
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    p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas
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    Rinf Regulates Pluripotency Network Genes and Tet Enzymes in Embryonic Stem Cells
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    mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux
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    PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression
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    Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production
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  150. Nov 2018
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    Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes
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    Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis
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    The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma
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    Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens
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    Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer
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    Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling
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  158. Nov 2017
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    YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme
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    Coupled Caspase and N-End Rule Ligase Activities Allow Recognition and Degradation of Pluripotency Factor LIN-28 during Non-Apoptotic Development
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    Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms
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      Curator: @Jmenke

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      (Cell Signaling Technology Cat# 13202, RRID:AB_2687461)

      SciCrunch record: RRID:AB_2687461

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_2687461 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S0092867417306943