Hypothesis

150 Matching Annotations

Aug 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225016529-main-html.html

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1. scibot 20 Aug 2025
  
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  DOI: 10.1016
  
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52.53.155.43/4f4fe074a3a34390503819ded993b7919366019b/1-s2.0-S2589004225016529-main-html.html
www.science.org www.science.org

AND-1 is a critical regulator of R-loop dynamics and a target to overcome endocrine resistance

1
1. scibot 13 Aug 2025
  
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  RRID: AB_2687461
  
  DOI: 10.1126/sciadv.adv2453
  
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science.org/doi/10.1126/sciadv.adv2453
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

AND-1 is a critical regulator of R-loop dynamics and a target to overcome endocrine resistance

1
1. scibot 12 Aug 2025
  
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  AB_2687461
  
  DOI: 10.1126/sciadv.adv2453
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12327453/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance

1
1. scibot 11 Aug 2025
  
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  RRID:AB_2687461
  
  DOI: 10.1101/2025.06.11.659120
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12262427/
52.53.155.43 52.53.155.43

2025.07.28.667286v1.full-html.html

1
1. scibot 05 Aug 2025
  
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  AB_2687461
  
  DOI: 10.1101/2025.07.28.667286
  
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52.53.155.43/165413b63039cde87b71311a2546711f9824fa49/2025.07.28.667286v1.full-html.html
Jul 2025
www.science.org www.science.org

Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology

1
1. scibot 22 Jul 2025
  
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  DOI: 10.1126/sciadv.adu6354
  
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science.org/doi/10.1126/sciadv.adu6354
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology

1
1. scibot 20 Jul 2025
  
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  DOI: 10.1126/sciadv.adu6354
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12273755/
www.biorxiv.org www.biorxiv.org

RNF13 is a novel interactor of iduronate 2-sulfatase that modifies its glycosylation and maturation

1
1. scibot 12 Jul 2025
  
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  RRID:AB_2687461
  
  DOI: 10.1101/2025.06.20.660705
  
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biorxiv.org/content/10.1101/2025.06.20.660705v1
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation

1
1. scibot 11 Jun 2025
  
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  RRID:AB_2687461
  
  DOI: 10.1038/s44319-025-00444-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12116916/
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Genetic Screen in a Pre-Clinical Model of Sarcoma Development Defines Drivers and Therapeutic Vulnerabilities

1
1. scibot 20 May 2025
  
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  DOI: 10.1158/1078-0432.CCR-24-1238
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11530313/
www.sciencedirect.com www.sciencedirect.com

Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo

1
1. scibot 18 May 2025
  
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  DOI: 10.1016/j.neuron.2025.04.010
  
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sciencedirect.com/science/article/pii/S0896627325002934
Apr 2025
www.embopress.org www.embopress.org

TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation

1
1. scibot 13 Apr 2025
  
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  RRID:AB_2687461
  
  DOI: 10.1038/s44319-025-00444-2
  
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embopress.org/doi/10.1038/s44319-025-00444-2
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STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders

1
1. scibot 05 Apr 2025
  
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  RRID:AB_2687461
  
  DOI: 10.1016/j.molcel.2025.03.008
  
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sciencedirect.com/science/article/pii/S1097276525002011
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A CRISPR mis-insertion in the Zic3 5′UTR inhibits in vivo translation and is predicted to result in formation of an mRNA stem-loop hairpin

1
1. scibot 02 Apr 2025
  
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  RRID:AB_2687461
  
  DOI: 10.1242/bio.061677
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11957448/
Mar 2025
www.sciencedirect.com www.sciencedirect.com

SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response

1
1. scibot 29 Mar 2025
  
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  RRID:AB_2687461
  
  DOI: 10.1016/j.celrep.2025.115434
  
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sciencedirect.com/science/article/pii/S2211124725002050
www.cell.com www.cell.com

Glucose modulates IRF6 transcription factor dimerization to enable epidermal differentiation

1
1. scibot 24 Mar 2025
  
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  RRID:AB_2687461
  
  DOI: 10.1016/j.stem.2025.02.017
  
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cell.com/cell-stem-cell/fulltext/S1934-5909(25)00088-8
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Tenascin-C Potentiates Wnt Signaling in Thyroid Cancer

1
1. scibot 23 Feb 2025
  
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  RRID:AB_2687461
  
  DOI: 10.1210/endocr/bqaf030
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11843548/
Jan 2025
www.sciencedirect.com www.sciencedirect.com

A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis

1
1. scibot 30 Jan 2025
  
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  RRID:AB_2687461
  
  DOI: 10.1016/j.immuni.2025.01.003
  
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sciencedirect.com/science/article/pii/S1074761325000263
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

FOXR2 Targets LHX6+/DLX+ Neural Lineages to Drive Central Nervous System Neuroblastoma

1
1. scibot 25 Jan 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-2248
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11733536/
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mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase

1
1. scibot 14 Jan 2025
  
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  RRID:AB_2687461
  
  DOI: 10.1016/j.celrep.2024.115179
  
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sciencedirect.com/science/article/pii/S2211124724015304
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Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control

1
1. scibot 07 Jan 2025
  
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  RRID:AB_2687461
  
  DOI: 10.1016/j.devcel.2024.12.024
  
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sciencedirect.com/science/article/pii/S1534580724007639
www.cell.com www.cell.com

The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A

1
1. scibot 05 Jan 2025
  
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  RRID:AB_2687461
  
  DOI: 10.1016/j.celrep.2024.115087
  
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cell.com/cell-reports/fulltext/S2211-1247(24)01438-4
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CCDC134 controls TLR biogenesis through the ER chaperone Gp96

1
1. scibot 13 Dec 2024
  
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  RRID:AB_2687461
  
  DOI: 10.1084/jem.20240825
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11629888/
Nov 2024
52.53.155.43 52.53.155.43

can-24-2248-html.html

1
1. scibot 08 Nov 2024
  
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  RRID:AB_2687461
  
  DOI: 10.1158/0008-5472.can-24-2248
  
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52.53.155.43/cb43348561561308018a10a52d14c612773d9356/can-24-2248-html.html
Sep 2024
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

1
1. scibot 27 Sep 2024
  
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  RRID:AB_2687461
  
  DOI: 10.1111/bph.17320
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17320
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A TBK1-independent primordial function of STING in lysosomal biogenesis

1
1. scibot 25 Sep 2024
  
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  AB_2687461
  
  DOI: 10.1016/j.molcel.2024.08.026
  
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sciencedirect.com/science/article/pii/S1097276524007032
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Protein UFMylation regulates early events during ribosomal DNA-damage response

1
1. scibot 17 Sep 2024
  
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  DOI: 10.1016/j.celrep.2024.114738
  
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sciencedirect.com/science/article/pii/S2211124724010891
Aug 2024
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The RNA-binding protein EIF4A3 promotes axon development by direct control of the cytoskeleton

1
1. scibot 27 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114666
  
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sciencedirect.com/science/article/pii/S2211124724010179
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CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism

1
1. scibot 23 Aug 2024
  
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  AB_2687461
  
  DOI: 10.1016/j.celrep.2024.114662
  
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sciencedirect.com/science/article/pii/S2211124724010131
www.cell.com www.cell.com

SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation

1
1. scibot 18 Aug 2024
  
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  RRID:AB_2687461
  
  DOI: 10.1016/j.celrep.2024.114536
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00865-9
Jul 2024
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Astrocytes modulate brain phosphate homeostasis via polarized distribution of phosphate uptake transporter PiT2 and exporter XPR1

1
1. scibot 17 Jul 2024
  
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  DOI: 10.1016/j.neuron.2024.06.020
  
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sciencedirect.com/science/article/pii/S0896627324004550
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular weight RNP complexes

1
1. scibot 14 Jul 2024
  
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  RRID:AB_2687461
  
  DOI: 10.1016/j.isci.2024.110109
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11233918/
May 2024
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia

1
1. scibot 25 May 2024
  
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  AB_2687461
  
  DOI: 10.1113/JP285339
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/JP285339
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors

1
1. scibot 24 May 2024
  
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  RRID:AB_2687461
  
  DOI: 10.1016/j.isci.2024.109860
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11108982/
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mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway

1
1. scibot 24 May 2024
  
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  RRID:AB_2687461
  
  DOI: 10.1016/j.molcel.2024.04.026
  
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Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals

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ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models

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An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins

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Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer

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A unique chaperoning mechanism in class A JDPs recognizes and stabilizes mutant p53

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Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma

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Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma

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Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma

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Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma

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The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases

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SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction

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Impact of Mutations Defining SARS-CoV-2 Omicron Subvariants BA.2.12.1 and BA.4/5 on Spike Function and Neutralization

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HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B

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MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction

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PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development

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USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase separation potential

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NFYC-37 promotes tumor growth by activating the mevalonate pathway in bladder cancer

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mct-23-0025 (1)-html.html

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Loss of STING in parkin mutant flies suppresses muscle defects and mitochondria damage

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Distinct layers of BRD4-PTEFb reveal bromodomain-independent function in transcriptional regulation

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Alternative splicing and heparan sulfation converge on neurexin-1 to control glutamatergic transmission and autism-related behaviors

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Acetate controls endothelial-to-mesenchymal transition

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Restored autophagy is protective against PAK3-induced cardiac dysfunction

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Extension of the DNAJB2a isoform in a dominant neuromyopathy family

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A conditional strategy for cell-type-specific labeling of endogenous excitatory synapses in Drosophila

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TERRA stability is regulated by RALY and polyadenylation in a telomere-specific manner

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Redox proteomics combined with proximity labeling enables monitoring of localized cysteine oxidation in cells

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COP I and II dependent trafficking controls ER-associated degradation in mammalian cells

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BPS Publications

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Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames

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RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex

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Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules

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An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes

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Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation

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The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation

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Genome-wide survey of D/E repeats in human proteins uncovers their instability and aids in identifying their role in the chromatin regulator ATAD2

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B cell linker protein (BLNK) is a regulator of Met receptor signaling and trafficking in non-small cell lung cancer

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A multienzyme S-nitrosylation cascade regulates cholesterol homeostasis

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OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis

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ISX9, a small molecule targeting Axin, activates Wnt/β-catenin signaling and promotes hair regrowth

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In vivo characterization of Drosophila golgins reveals redundancy and plasticity of vesicle capture at the Golgi apparatus

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BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer

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PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis

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Determinants of Spike Infectivity, Processing and Neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2

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Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID

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Direct Observation of Compartment-Specific Localization and Dynamics of Voltage-Gated Sodium Channels

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An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma

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Supramolecular assembly of GSK3α as a cellular response to amino acid starvation

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Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy

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Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis

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CCT2 is an aggrephagy receptor for clearance of solid protein aggregates

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The FUS::DDIT3 fusion oncoprotein inhibits BAF complex targeting and activity in myxoid liposarcoma

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FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer

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Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartments

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Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling

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YAP1 and PRDM14 converge to promote cell survival and tumorigenesis

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Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation

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Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation

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AKIRIN2 controls the nuclear import of proteasomes in vertebrates

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Characterization of the subunit composition and structure of adult human glycine receptors

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USP8 deubiquitinates the leptin receptor and is necessary for leptin-mediated synapse formation

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GIPC proteins negatively modulate Plexind1 signaling during vascular development

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Untitled document

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Molecular basis for substrate recruitment to the PRMT5 methylosome

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TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma

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TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma

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CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer

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Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination

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TNIK is a therapeutic target in Lung Squamous Cell Carcinoma and regulates FAK activation through Merlin.

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The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

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Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities

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RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins

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A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms

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FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer

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Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia

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Autophagy blockade limits HER2+ breast cancer tumorigenesis by perturbing HER2 trafficking and promoting release via small extracellular vesicles

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Leptin controls glutamatergic synaptogenesis and NMDA-receptor trafficking via Fyn kinase regulation of NR2B

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Diverse viral proteases activate the NLRP1 inflammasome

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Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

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Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis

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Glycometabolic Regulation of the Biogenesis of Small Extracellular Vesicles

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LRRTMs Organize Synapses through Differential Engagement of Neurexin and PTPσ

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FOXD3 Regulates VISTA Expression in Melanoma

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Selective PP2A Enhancement through Biased Heterotrimer Stabilization

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The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer

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A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion

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A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay

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Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

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Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers

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The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma

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p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

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Rinf Regulates Pluripotency Network Genes and Tet Enzymes in Embryonic Stem Cells

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BPS Publications

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mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux

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PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression

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Untitled document

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Untitled document

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Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production

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Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes

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Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis

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The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma

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Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

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Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer

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Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling

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YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme

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Coupled Caspase and N-End Rule Ligase Activities Allow Recognition and Degradation of Pluripotency Factor LIN-28 during Non-Apoptotic Development

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Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms

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