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Jul 2026
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Proinflammatory signaling in Ewing sarcoma is driven by retroelement activity and counteracted by reverse transcriptase inhibitors

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1. scibot 23 Jul 2026
  
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  DOI: 10.1016/j.celrep.2026.117708
  
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sciencedirect.com/science/article/pii/S2211124726007862
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RNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunity

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1. scibot 21 Jul 2026
  
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  DOI: 10.1016/j.molcel.2026.06.036
  
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sciencedirect.com/science/article/pii/S1097276526004259
Jun 2026
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FANCA-dependent FEN1 recruitment suppresses transcription-replication conflicts and PARPi sensitivity

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1. scibot 17 Jun 2026
  
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sciencedirect.com/science/article/pii/S1097276526003515
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Ancestral DOF27 and GDH1 haplotypes drive rice adaptation to ammonium habitats

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1. scibot 16 Jun 2026
  
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  DOI: 10.1016/j.cub.2026.05.038
  
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sciencedirect.com/science/article/pii/S0960982226006433
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The modulation of AUF1 regulates the R-loop resolution activating the immune response in DDR

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1. scibot 06 Jun 2026
  
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  DOI: 10.1016/j.isci.2026.115900
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13196424/
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R-PLA enables enhanced detection of R-loops in mammalian cells using proximity ligation

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1. scibot 06 Jun 2026
  
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  DOI: 10.1016/j.crmeth.2026.101380
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13198002/
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NAT10-dependent N4-acetylcytidine reprograms R-loops and promotes cancer stem cell growth

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1. scibot 04 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117408
  
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sciencedirect.com/science/article/pii/S2211124726004869
Feb 2026
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Endogenous retrovirus-derived RNA-DNA hybrids induce microglial synaptic pruning in autism models

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1. scibot 26 Feb 2026
  
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  DOI: 10.1016/j.neuron.2026.01.011
  
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sciencedirect.com/science/article/pii/S0896627326000127
Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Nuclear exosome targeting complex safeguards hematopoietic stem cell self-renewal and genomic integrity through resolving R loops

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1. scibot 09 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116650
  
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sciencedirect.com:5037/science/article/pii/S2211124725014226
Nov 2025
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Rad53 regulates RNase H1, which promotes DNA replication through sites of transcription-replication conflict

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1. scibot 18 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116565
  
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sciencedirect.com/science/article/pii/S2211124725013373
Oct 2025
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Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma

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1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.drup.2025.101312
  
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sciencedirect.com/science/article/pii/S1368764625001153
Sep 2025
www.biorxiv.org www.biorxiv.org

Vitamin D3 ameliorates R-loop-induced replication stress and chromosomal instability in MED12-mutant uterine fibroids

1
1. scibot 23 Sep 2025
  
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  DOI: 10.1101/2025.09.17.676564
  
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biorxiv.org/content/10.1101/2025.09.17.676564v1
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DDX3X mutation and Epstein-Barr virus cooperate to induce R-loop-dependent oncogenesis

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1. scibot 06 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116237
  
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sciencedirect.com/science/article/pii/S2211124725010083
Aug 2025
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AND-1 is a critical regulator of R-loop dynamics and a target to overcome endocrine resistance

1
1. scibot 13 Aug 2025
  
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  DOI: 10.1126/sciadv.adv2453
  
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science.org/doi/10.1126/sciadv.adv2453
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AND-1 is a critical regulator of R-loop dynamics and a target to overcome endocrine resistance

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1. scibot 12 Aug 2025
  
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  DOI: 10.1126/sciadv.adv2453
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12327453/
May 2025
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MePCE promotes homologous recombination through coordinating R-loop resolution at DNA double-stranded breaks

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115740
  
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sciencedirect.com/science/article/pii/S221112472500511X
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PUS10-induced tRNA fragmentation impacts retrotransposon-driven inflammation

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115735
  
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sciencedirect.com/science/article/pii/S2211124725005066
Apr 2025
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ZBP1 senses splicing aberration through Z-RNA to promote cell death

1
1. scibot 24 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.03.023
  
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sciencedirect.com/science/article/pii/S1097276525002990
Feb 2025
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A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair

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1. scibot 19 Feb 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-0397
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11831107/
Dec 2024
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Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A

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1. scibot 21 Dec 2024
  
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sciencedirect.com/science/article/pii/S1097276524009894
Sep 2024
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Molecular basis of CX-5461-induced DNA damage response in primary vascular smooth muscle cells

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1. scibot 04 Sep 2024
  
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  DOI: 10.1016/j.heliyon.2024.e37227
  
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sciencedirect.com/science/article/pii/S2405844024132586
Aug 2024
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Deep learning-enhanced R-loop prediction provides mechanistic implications for repeat expansion diseases

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1. scibot 19 Aug 2024
  
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  DOI: 10.1016/j.isci.2024.110584
  
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sciencedirect.com/science/article/pii/S2589004224018091
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TOP1 and R-loops facilitate transcriptional DSBs at hypertranscribed cancer driver genes

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1. scibot 23 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.109082
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10875566/
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Protocol for detection of in vitro R-loop formation using dot blots

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1. scibot 02 Feb 2024
  
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  DOI: 10.1016/j.xpro.2024.102857
  
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sciencedirect.com/science/article/pii/S2666166724000224
Dec 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality

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1. scibot 20 Dec 2023
  
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  DOI: 10.1158/0008-5472.CAN-22-2948
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10722143/
Jul 2023
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MEF2A suppresses stress responses that trigger DDX41-dependent IFN production

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1. scibot 21 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112805
  
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sciencedirect.com/science/article/pii/S2211124723008161
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Mechanisms of insertions at a DNA double-strand break

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1. scibot 06 Jul 2023
  
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  DOI: 10.1016/j.molcel.2023.06.016
  
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sciencedirect.com/science/article/abs/pii/S1097276523004616
May 2023
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EWSR1 maintains centromere identity

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1. scibot 27 May 2023
  
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  DOI: 10.1016/j.celrep.2023.112568
  
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sciencedirect.com/science/article/pii/S221112472300579X
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Phase separation of HRLP regulates flowering time in Arabidopsis

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1. scibot 05 May 2023
  
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  DOI: 10.1126/sciadv.abn5488
  
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science.org/doi/10.1126/sciadv.abn5488
Feb 2023
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RNA-DNA hybrids prevent resection at dysfunctional telomeres

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  DOI: 10.1016/j.celrep.2023.112077
  
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sciencedirect.com/science/article/pii/S2211124723000888
Jan 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

THOC5 complexes with DDX5, DDX17, and CDK12 to regulate R loop structures and transcription elongation rate

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1. scibot 06 Jan 2023
  
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  DOI: 10.1016/j.isci.2022.105784
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9800341/
Oct 2022
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RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA

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1. scibot 20 Oct 2022
  
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  DOI: 10.1016/j.molcel.2022.09.025
  
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sciencedirect.com/science/article/pii/S1097276522009352
Sep 2022
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Regulation of Claspin by the p38 stress-activated protein kinase protects cells from DNA damage

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1. scibot 21 Sep 2022
  
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  DOI: 10.1016/j.celrep.2022.111375
  
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sciencedirect.com/science/article/pii/S2211124722012074
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

CANCER-ASSOCIATED SF3B1 MUTATIONS CONFER A BRCA-LIKE CELLULAR PHENOTYPE AND SYNTHETIC LETHALITY TO PARP INHIBITORS

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1. scibot 02 Sep 2022
  
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  DOI: 10.1158/0008-5472.CAN-21-1843
  
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pubmed.ncbi.nlm.nih.gov/35027467/
Jul 2022
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Sen1 is a key regulator of transcription-driven conflicts

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1. scibot 15 Jul 2022
  
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  DOI: 10.1016/j.molcel.2022.06.021
  
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sciencedirect.com/science/article/pii/S1097276522006049
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Phase separation of HRLP regulates flowering time in Arabidopsis

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DDX41 is required for cGAS-STING activation against DNA virus infection

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Detection of RNA-DNA hybrids by immunostaining in meiotic nuclei of Saccharomyces cerevisiae

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MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells

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HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia

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RNA-DNA hybrids regulate meiotic recombination

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SLFN11 is Widely Expressed in Pediatric Sarcoma and Induces Variable Sensitization to Replicative Stress Caused By DNA-Damaging Agents

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CX-5461 Treatment Leads to Cytosolic DNA-Mediated STING Activation in Ovarian Cancer

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Aberrant RNA methylation triggers recruitment of an alkylation repair complex

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Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair

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NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer

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Mechanism of noncoding RNA-associated N6-methyladenosine recognition by an RNA processing complex during IgH DNA recombination

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Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer

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Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination

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The integrated stress response induces R-loops and hinders replication fork progression

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A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability

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Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome

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Transposase-assisted tagmentation of RNA/DNA hybrid duplexes

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Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription

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Sen1 Is Recruited to Replication Forks via Ctf4 and Mrc1 and Promotes Genome Stability

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A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability

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RNase H1 and H2 Are Differentially Regulated to Process RNA-DNA Hybrids

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Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops

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Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming

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Untitled document

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Untitled document

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Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer

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The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations

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Nov 2017
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Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair

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Telomere Length Determines TERRA and R-Loop Regulation through the Cell Cycle

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