Hypothesis

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54.241.53.176 54.241.53.176

1-s2.0-S2589004226010990-main-html.html

1
1. scibot 15 Apr 2026
  
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  AB_2687465
  
  DOI: 10.1016/j.isci.2026.115724
  
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54.241.53.176/3e4dd64cfd78cb2c721fb48c4f44096804ced4e8/1-s2.0-S2589004226010990-main-html.html
Apr 2026
www.sciencedirect.com www.sciencedirect.com

Gut-microbiota-derived 3-indoleacrylic acid alleviates neonatal necrotizing enterocolitis by inhibiting epithelial necroptosis

1
1. scibot 02 Apr 2026
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.xcrm.2026.102721
  
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sciencedirect.com/science/article/pii/S2666379126001382
Mar 2026
www.sciencedirect.com www.sciencedirect.com

Deubiquitinating enzyme MINDY2 regulates TNF-α-induced cell death by targeting RIPK1

1
1. scibot 24 Mar 2026
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.celrep.2026.117134
  
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sciencedirect.com/science/article/pii/S2211124726002123
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USP25 regulates atherosclerosis by restricting RIPK1-mediated inflammatory responses

1
1. scibot 20 Mar 2026
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.ebiom.2026.106213
  
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sciencedirect.com/science/article/pii/S2352396426000952
link.springer.com link.springer.com

Microglia Pyroptosis-Derived IL-18 Drives White Matter Injury in Developing Brain following Hypothermic Hypoxia-Ischemia

1
1. scibot 19 Mar 2026
  
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  RRID:AB_2687465
  
  DOI: 10.1007/s12264-026-01602-9
  
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link.springer.com/article/10.1007/s12264-026-01602-9
54.241.53.176 54.241.53.176

1-s2.0-S2589004226005791-main-html.html

1
1. scibot 05 Mar 2026
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.isci.2026.115204
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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54.241.53.176/d80caa1872fa30261141766ab05408cd109fb46c/1-s2.0-S2589004226005791-main-html.html
Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PHB2 mitigates intervertebral disc degeneration by modulating mitophagy to inhibit necroptosis in nucleus pulposus cells

1
1. scibot 28 Jan 2026
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.isci.2025.114365
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12824918/
Oct 2025
www.sciencedirect.com www.sciencedirect.com

Med20 regulates myelination in the peripheral nervous system by modulating ferroptosis of Schwann cells

1
1. scibot 18 Oct 2025
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.celrep.2025.116448
  
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sciencedirect.com/science/article/pii/S2211124725012197
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Spliceosome inhibition induces Z-RNA and ZBP1-driven cell death in small cell lung cancer

1
1. scibot 08 Oct 2025
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.celrep.2025.116384
  
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sciencedirect.com/science/article/pii/S2211124725011556
Aug 2025
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TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation

1
1. scibot 26 Aug 2025
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.celrep.2025.116186
  
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sciencedirect.com/science/article/pii/S221112472500957X
Jul 2025
www.sciencedirect.com www.sciencedirect.com

MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction

1
1. scibot 03 Jul 2025
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.molcel.2025.06.005
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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sciencedirect.com/science/article/pii/S1097276525005052
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection

1
1. scibot 19 May 2025
  
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  RRID:AB_2687465
  
  DOI: 10.1038/s44318-025-00412-5
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12048508/
Apr 2025
www.sciencedirect.com www.sciencedirect.com

ZBP1 senses splicing aberration through Z-RNA to promote cell death

1
1. scibot 24 Apr 2025
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.molcel.2025.03.023
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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sciencedirect.com/science/article/pii/S1097276525002990
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MLKL activity requires a splicing-regulated, druggable intramolecular interaction

1
1. scibot 10 Apr 2025
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.molcel.2025.03.015
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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sciencedirect.com/science/article/pii/S109727652500259X
Dec 2024
52.53.155.43 52.53.155.43

1-s2.0-S2589004224028086-main-html.html

1
1. scibot 19 Dec 2024
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.isci.2024.111581
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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52.53.155.43/9f2a0ef4271b61fdfbdda27575922c2ba8834710/1-s2.0-S2589004224028086-main-html.html
www.tandfonline.com www.tandfonline.com

Infant feces-derived Lactobacillus gasseri FWJL-4 mitigates experimental necrotizing enterocolitis via acetate production

1
1. scibot 13 Dec 2024
  
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  RRID:AB_2687465
  
  DOI: 10.1080/19490976.2024.2430541
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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  SciCrunch record: RRID:AB_2687465
  
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tandfonline.com/doi/abs/10.1080/19490976.2024.2430541
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Infant feces-derived Lactobacillus gasseri FWJL-4 mitigates experimental necrotizing enterocolitis via acetate production

1
1. scibot 13 Dec 2024
  
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  RRID:AB_2687465
  
  DOI: 10.1080/19490976.2024.2430541
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11633162/
www.sciencedirect.com www.sciencedirect.com

Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity

1
1. scibot 02 Dec 2024
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.ccell.2024.10.014
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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sciencedirect.com/science/article/pii/S1535610824004021
Nov 2024
www.sciencedirect.com www.sciencedirect.com

Residue Y362 is crucial for FLIPL to impart catalytic activity to pro-caspase-8 to suppress necroptosis

1
1. scibot 11 Nov 2024
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.celrep.2024.114966
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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sciencedirect.com/science/article/pii/S2211124724013172
Sep 2024
www.sciencedirect.com www.sciencedirect.com

Cecal necroptosis triggers lethal cardiac dysfunction in TNF-induced severe SIRS

1
1. scibot 27 Sep 2024
  
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  AB_2687465
  
  DOI: 10.1016/j.celrep.2024.114778
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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sciencedirect.com/science/article/pii/S221112472401129X
www.sciencedirect.com www.sciencedirect.com

CD14 is a decision-maker between Fas-mediated death and inflammation

1
1. scibot 04 Sep 2024
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.celrep.2024.114685
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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sciencedirect.com/science/article/pii/S2211124724010362
Aug 2024
www.sciencedirect.com www.sciencedirect.com

Non-canonical autophosphorylation of RIPK1 drives timely pyroptosis to control Yersinia infection

1
1. scibot 22 Aug 2024
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.celrep.2024.114641
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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sciencedirect.com/science/article/pii/S2211124724009914
Jul 2024
www.cell.com www.cell.com

Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver

1
1. scibot 19 Jul 2024
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.celrep.2024.114400
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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cell.com/cell-reports/abstract/S2211-1247(24)00728-9
www.cell.com www.cell.com

Extracellular vesicles from alveolar macrophages harboring phagocytosed methicillin-resistant Staphylococcus aureus induce necroptosis

1
1. scibot 12 Jul 2024
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.celrep.2024.114453
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00782-4
May 2024
www.sciencedirect.com www.sciencedirect.com

A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death

1
1. scibot 24 May 2024
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.immuni.2024.04.025
  
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sciencedirect.com/science/article/pii/S1074761324002309
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Edaravone Dexborneol mitigates pathology in animal and cell culture models of Alzheimer’s disease by inhibiting neuroinflammation and neuronal necroptosis

1
1. scibot 30 Apr 2024
  
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  RRID:AB_2687465
  
  DOI: 10.1186/s13578-024-01230-8
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11056062/
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

1
1. scibot 11 Apr 2024
  
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  RRID:AB_2687465
  
  DOI: 10.1111/bph.16364
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16364
Mar 2024
52.53.155.43 52.53.155.43

NLRP6 induces RIP1 kinase-dependent necroptosis via TAK1-mediated p38MAPK/MK2 phosphorylation in S. Typhimurium infection

1
1. scibot 08 Mar 2024
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.isci.2024.109339
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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52.53.155.43/edc059b1f8d2daaa9b02a6bfc9253e0bab800af6/1-s2.0-S2589004224005601-main-html.html
Jan 2024
www.sciencedirect.com www.sciencedirect.com

Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells

1
1. scibot 19 Jan 2024
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.xcrm.2023.101377
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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sciencedirect.com/science/article/pii/S2666379123006067
Nov 2023
www.sciencedirect.com www.sciencedirect.com

Triggering endogenous Z-RNA sensing for anti-tumor therapy through ZBP1-dependent necroptosis

1
1. scibot 10 Nov 2023
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.celrep.2023.113377
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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sciencedirect.com/science/article/pii/S221112472301389X
Oct 2023
www.sciencedirect.com www.sciencedirect.com

Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases

1
1. scibot 27 Oct 2023
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.molcel.2023.09.025
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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sciencedirect.com/science/article/pii/S1097276523007529
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Chronic Carbon Disulfide Exposure Induces Parkinsonian Pathology via α-Synuclein Aggregation and Necrosome Complex Interaction

1
1. scibot 22 Sep 2023
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.isci.2023.107787
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10507234/
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Evidence for developmental vascular-associated necroptosis and its contribution to venous-lymphatic endothelial differentiation

1
1. scibot 16 Aug 2023
  
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  RRID:AB_2687465
  
  DOI: 10.3389/fcell.2023.1229788
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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  SciCrunch record: RRID:AB_2687465
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10416103/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Platelet ITGA2B inhibits caspase-8 and Rip3/Mlkl-dependent platelet death though PTPN6 during sepsis

1
1. scibot 10 Aug 2023
  
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  RRID:AB_2687465
  
  DOI: 10.1016/j.isci.2023.107414
  
  Resource: (Abcam Cat# ab196436, RRID:AB_2687465)
  
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  SciCrunch record: RRID:AB_2687465
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10404729/
Jul 2023
www.sciencedirect.com www.sciencedirect.com

Nucleoporin Seh1 maintains Schwann cell homeostasis by regulating genome stability and necroptosis

1
1. scibot 21 Jul 2023
  
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Sublethal necroptosis signaling promotes inflammation and liver cancer

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C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection

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Necrostatin-1 decreases necroptosis and inflammatory... : Neural Regeneration Research

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Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation

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Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis

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Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death

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Necrostatin-1 decreases necroptosis and inflammatory... : Neural Regeneration Research

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BPS Publications

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  DOI: 10.1111/bph.15702
  
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Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease

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Promyelocytic leukemia protein targets MK2 to promote cytotoxicity

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  DOI: 10.15252/embr.202052254
  
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Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins

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  DOI: 10.7554/eLife.44452
  
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Untitled document

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  DOI: 10.1016/j.ebiom.2018.10.017
  
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Jun 2021
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Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis

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  DOI: 10.1016/j.chom.2021.05.009
  
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Streptococcus pneumoniae binds to host GAPDH on dying lung epithelial cells worsening secondary infection following influenza

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  DOI: 10.1016/j.celrep.2021.109267
  
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May 2021
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RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis

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  DOI: 10.1016/j.celrep.2021.109112
  
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A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade

1
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  DOI: 10.1016/j.molcel.2020.09.004
  
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A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation

1
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Inhibition of MLKL-dependent necroptosis via downregulating interleukin-1R1 contributes to neuroprotection of hypoxic preconditioning in transient global cerebral ischemic rats

1
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  RRID:AB_2687465
  
  DOI: 10.1186/s12974-021-02141-y
  
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The multitargeted kinase inhibitor KW-2449 ameliorates cisplatin-induced nephrotoxicity by targeting RIPK1-mediated necroptosis

1
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  anti-mouse phospho-MLKL
  
  DOI: 10.1016/j.bcp.2021.114542
  
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Nov 2020
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Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3

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  DOI: 10.7554/eLife.61564
  
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G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program

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  DOI: 10.1016/j.celrep.2020.108341
  
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Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

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  DOI: 10.1016/j.cell.2020.02.050
  
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The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death

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  DOI: 10.1016/j.celrep.2020.107547
  
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Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis

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Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

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  DOI: 10.1016/j.immuni.2020.07.004
  
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Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation

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  RRID:AB_2687465
  
  DOI: 10.1016/j.celrep.2019.12.073
  
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RIPK3 Activation Leads to Cytokine Synthesis that Continues after Loss of Cell Membrane Integrity

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  RRID:AB_2687465
  
  DOI: 10.1016/j.celrep.2019.07.077
  
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O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3

1
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  RRID:AB_2687465
  
  DOI: 10.1016/j.immuni.2019.01.007
  
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Untitled document

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  DOI: 10.1111/bph.14653
  
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Axonal Degeneration Is Mediated by Necroptosis Activation

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  RRID:AB_2687465
  
  DOI: 10.1523/JNEUROSCI.0881-18.2019
  
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jneurosci.org/content/39/20/3832
Nov 2017
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MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

1
1. scibot 08 Nov 2017
  
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  Rabbit anti-mouse MLKL (phospho S345), Clone EPR9515(2)AbcamCat# ab196436
  
  Curator: @Jmenke
  
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