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Jul 2026
www.science.org www.science.org

A targetable FTO/SLC7A11/CBS/CTH axis controls cysteine metabolism, growth and survival in NSCLC

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  DOI: 10.1126/sciadv.aed6463
  
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KRAS-mediated CCDC6 degradation drives xCT upregulation and ferroptosis evasion

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  DOI: 10.1007/s10495-026-02400-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13369686/
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A targetable FTO/SLC7A11/CBS/CTH axis controls cysteine metabolism, growth and survival in NSCLC

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pmc.ncbi.nlm.nih.gov/articles/PMC13330832/
Jun 2026
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LRP1 activated by AT2 cell-secreted MDK inhibits fibrotic ferroptosis in idiopathic pulmonary fibrosis

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  DOI: 10.1016/j.isci.2026.116212
  
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sciencedirect.com/science/article/pii/S2589004226015877
May 2026
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Hypoxia-driven lncRNA SHIELD promotes GPX4 translation and protects against ferroptosis in hepatocellular carcinoma

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  DOI: 10.1016/j.molcel.2026.04.026
  
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IL4i1 activity generates oncometabolites that rescue neuroblastoma cells from oxidative death

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  DOI: 10.1016/j.celrep.2026.117441
  
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DHODH-Mediated Suppression of Ferroptosis Supports Radioresistance and Represents a Therapeutic Vulnerability in Lung Cancer

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1. scibot 19 May 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-3728
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13179828/
Mar 2026
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Gcn2 deficiency triggers anemia and hypoxic intolerance in zebrafish

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1. scibot 27 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117192
  
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sciencedirect.com/science/article/pii/S2211124726002706
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1-s2.0-S2589004226008138-main-html.html

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  DOI: 10.1016/j.isci.2026.115438
  
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54.241.53.176/0fc3a104802ca36b8421ec45f4976d3f8ae7eba0/1-s2.0-S2589004226008138-main-html.html
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GPX4 Inhibitor Resistance and Metastatic Features in Triple-Negative Breast Cancer

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1. scibot 05 Mar 2026
  
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  DOI: 10.1002/advs.202523198
  
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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202523198
Feb 2026
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Functional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction

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1. scibot 26 Feb 2026
  
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  DOI: 10.1016/j.molcel.2026.02.002
  
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Jan 2026
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Metabolic reprogramming during human neuron differentiation indicates glutaminase as a key determinant in Fragile X syndrome

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  DOI: 10.1016/j.celrep.2025.116857
  
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Dec 2025
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TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence

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1. scibot 06 Dec 2025
  
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  DOI: 10.1038/s44318-025-00608-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12669767/
Oct 2025
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Vorapaxar enhanced mitochondria-associated ferroptosis primes cancer immunotherapy via targeting FOXO1/HMOX1 axis

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1. scibot 01 Oct 2025
  
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  DOI: 10.1016/j.xcrm.2025.102371
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12629800/
Aug 2025
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TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116186
  
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sciencedirect.com/science/article/pii/S221112472500957X
Jul 2025
www.cell.com www.cell.com

SLC7A11 protects amoeboid-disseminating cancer cells from oxidative stress

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1. scibot 19 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.115939
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00710-7
May 2025
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Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.immuni.2025.04.020
  
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sciencedirect.com/science/article/pii/S1074761325001839
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SLC7A11 is an unconventional H+ transporter in lysosomes

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.cell.2025.04.004
  
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sciencedirect.com/science/article/pii/S0092867425004064
Apr 2025
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Cytosolic cytochrome c represses ferroptosis

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1. scibot 15 Apr 2025
  
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  DOI: 10.1016/j.cmet.2025.03.014
  
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sciencedirect.com/science/article/pii/S1550413125001494
Feb 2025
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Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma

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1. scibot 11 Feb 2025
  
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  DOI: 10.1158/2159-8290.CD-24-0187
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11803400/
Jan 2025
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Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis

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1. scibot 30 Jan 2025
  
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  DOI: 10.1016/j.xcrm.2025.101928
  
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sciencedirect.com/science/article/pii/S2666379125000011
Dec 2024
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Proximity proteomic analysis of the NRF family reveals the Parkinson's disease protein ZNF746/PARIS as a co-complexed repressor of NRF2

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1. scibot 13 Dec 2024
  
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  DOI: 10.1126/scisignal.adi9018
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10760916/
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MYC Drives mRNA Pseudouridylation to Mitigate Proliferation-Induced Cellular Stress during Cancer Development

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1. scibot 12 Dec 2024
  
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  DOI: 10.1158/0008-5472.CAN-24-1102
  
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Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer

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  DOI: 10.1126/scisignal.adp1375
  
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science.org/doi/10.1126/scisignal.adp1375
Aug 2024
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CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism

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1. scibot 23 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114662
  
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Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.neuron.2024.07.020
  
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Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread

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  DOI: 10.1016/j.celrep.2024.114484
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11316253/
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In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma

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Herpotrichone A Exerts Neuroprotective Effects by Relieving Ferroptosis

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  DOI: 10.1021/acs.jafc.4c02418
  
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pubs.acs.org/doi/full/10.1021/acs.jafc.4c02418
May 2024
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Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers

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  DOI: 10.1016/j.molcel.2024.04.009
  
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Mar 2024
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ATF4-SLC7A11-GSH axis mediates the acquisition of immunosuppressive properties by activated CD4+ T cells in low arginine condition

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  DOI: 10.1016/j.celrep.2024.113995
  
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Jan 2024
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Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2

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1. scibot 12 Jan 2024
  
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  DOI: 10.1126/scisignal.adi9018
  
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science.org/doi/10.1126/scisignal.adi9018
Dec 2023
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TXNDC12 inhibits lipid peroxidation and ferroptosis

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1. scibot 06 Dec 2023
  
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  DOI: 10.1016/j.isci.2023.108393
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10690572/
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SMURF2 predisposes cancer cell toward ferroptosis in GPX4-independent manners by promoting GSTP1 degradation

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1. scibot 01 Dec 2023
  
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  DOI: 10.1016/j.molcel.2023.10.042
  
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sciencedirect.com/science/article/pii/S1097276523009139
Oct 2023
www.cell.com www.cell.com

AMER1 deficiency promotes the distant metastasis of colorectal cancer by inhibiting SLC7A11- and FTL-mediated ferroptosis

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1. scibot 06 Oct 2023
  
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  DOI: 10.1016/j.celrep.2023.113110
  
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cell.com/cell-reports/abstract/S2211-1247(23)01121-X
Aug 2023
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HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1

2
1. scibot 12 Aug 2023
  
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  RRID:AB_2687474
  
  DOI: 10.1016/j.celrep.2023.112945
  
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  DOI: 10.1016/j.celrep.2023.112945
  
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Jul 2023
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The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2

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  RRID:AB_2687474
  
  DOI: 10.1016/j.celrep.2023.112724
  
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Jun 2023
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Modulation of cellular metabolism by protein crotonylation regulates pancreatic cancer progression

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  RRID:AB_2687474
  
  DOI: 10.1016/j.celrep.2023.112666
  
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May 2023
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IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance

1
1. scibot 31 May 2023
  
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  RRID:AB_2687474
  
  DOI: 10.1016/j.molcel.2023.05.011
  
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Reprogramming of Iron Metabolism Confers Ferroptosis Resistance in ECM-Detached Cells

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1. scibot 27 May 2023
  
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  RRID:AB_2687474
  
  DOI: 10.1016/j.isci.2023.106827
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10209538/
Oct 2022
elifesciences.org elifesciences.org

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

1
1. scibot 19 Oct 2022
  
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  RRID:AB_2687474
  
  DOI: 10.7554/eLife.81083
  
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Apr 2022
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Stem cell factor SOX2 confers ferroptosis resistance in lung cancer via upregulation of SLC7A11

1
1. scibot 16 Apr 2022
  
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  AB_2687474
  
  DOI: 10.1158/0008-5472.CAN-21-0567
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8530936/
Mar 2022
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Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling

1
1. scibot 04 Mar 2022
  
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  RRID:AB_2687474
  
  DOI: 10.1016/j.molcel.2022.02.007
  
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Jan 2022
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Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness

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  RRID:AB_2687474
  
  DOI: 10.1016/j.cmet.2021.12.001
  
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Dec 2021
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Redox-sensitive cyclophilin A elicits chemoresistance through realigning cellular oxidative status in colorectal cancer

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  RRID:AB_2687474
  
  DOI: 10.1016/j.celrep.2021.110069
  
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Jun 2021
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KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition

1
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  RRID:AB_2687474
  
  DOI: 10.1016/j.isci.2021.102649
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8193145/
May 2021
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Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential

1
1. scibot 18 May 2021
  
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  RRID:AB_2687474
  
  DOI: 10.1016/j.immuni.2021.04.014
  
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sciencedirect.com/science/article/pii/S107476132100176X
Apr 2021
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Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation

1
1. scibot 29 Apr 2021
  
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  RRID:AB_2687474
  
  DOI: 10.1007/s00018-021-03818-6
  
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Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

1
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  RRID:AB_2687474
  
  DOI: 10.1016/j.ccell.2020.07.008
  
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Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS

1
1. scibot 14 Apr 2021
  
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  RRID:AB_2687474
  
  DOI: 10.1016/j.molcel.2021.02.033
  
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The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

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1. scibot 06 Apr 2021
  
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  RRID:AB_2687474
  
  DOI: 10.7554/eLife.63326
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7997658/
Dec 2020
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HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications

1
1. scibot 13 Dec 2020
  
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  RRID:AB_2687474
  
  DOI: 10.1016/j.celrep.2020.108487
  
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sciencedirect.com/science/article/pii/S2211124720314765
Jan 2020
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Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2687474
  
  DOI: 10.1016/j.cmet.2019.09.009
  
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Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2687474
  
  DOI: 10.1016/j.celrep.2019.08.076
  
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sciencedirect.com/science/article/pii/S2211124719311313
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Untitled document

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  RRID:AB_2687474
  
  DOI: 10.1016/j.ccell.2018.12.009
  
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Nov 2018
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AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

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Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase

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NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1097276517306573
Nov 2017
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mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT

1
1. scibot 08 Nov 2017
  
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  Rabbit Monoclonal anti-xCT/SLC7A11, Clone D2M7ACell SignalingCat#12691
  
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