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pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Wnt10b signaling regulates replication stress–induced chromosomal instability in human cancer

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1. scibot 07 Sep 2025
  
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  DOI: 10.26508/lsa.202503295
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12373720/
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss

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1. scibot 23 Jun 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0506
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12179588/
52.53.155.43 52.53.155.43

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1. scibot 12 Jun 2025
  
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  DOI: 10.1158/2767-9764.crc-24-0506
  
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52.53.155.43/57fca004bcca4ef73bc4f20824e92935b6a3b58f/PDF-html.html
Dec 2024
www.cell.com www.cell.com

The histone H3.3 K27M mutation suppresses Ser31phosphorylation and mitotic fidelity, which can directly drive gliomagenesis

1
1. scibot 29 Dec 2024
  
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  DOI: 10.1016/j.cub.2024.11.035
  
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cell.com/current-biology/abstract/S0960-9822(24)01575-6
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks

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1. scibot 22 Jun 2024
  
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  RRID:AB_2687562
  
  DOI: 10.1083/jcb.202402144
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11169917/
Apr 2024
rupress.org rupress.org

DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response

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1. scibot 25 Apr 2024
  
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  DOI: 10.1083/jcb.202303141
  
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2. scibot 25 Apr 2024
  
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  RRID:AB_2687562
  
  DOI: 10.1083/jcb.202303141
  
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rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
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Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates

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1. scibot 09 Apr 2024
  
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  RRID:AB_2687562
  
  DOI: 10.1016/j.celrep.2024.114064
  
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2. scibot 09 Apr 2024
  
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  RRID:AB_2687562
  
  DOI: 10.1016/j.celrep.2024.114064
  
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sciencedirect.com/science/article/pii/S2211124724003929
Jun 2023
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PTBP1 enforces ATR-CHK1 signalling determining the potency of CDC7 inhibitors

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1. scibot 09 Jun 2023
  
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  DOI: 10.1016/j.isci.2023.106951
  
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sciencedirect.com/science/article/pii/S2589004223010283
Jun 2022
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A function for Ataxia telangiectasia and Rad3-related (ATR) kinase in cytokinetic abscission

1
1. scibot 17 Jun 2022
  
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  DOI: 10.1016/j.isci.2022.104536
  
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sciencedirect.com/science/article/pii/S2589004222008070
Apr 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress

1
1. scibot 05 Apr 2022
  
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  DOI: 10.1038/s41598-022-09308-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8971416/
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53

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1. scibot 05 Aug 2021
  
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  DOI: 10.7554/eLife.70429
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8321552/
Jul 2021
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An optogenetic proximity labeling approach to probe the composition of inducible biomolecular condensates in cultured cells

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1. scibot 23 Jul 2021
  
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  DOI: 10.1016/j.xpro.2021.100677
  
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sciencedirect.com/science/article/pii/S2666166721003841
May 2021
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TopBP1 assembles nuclear condensates to switch on ATR signaling

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1. scibot 08 May 2021
  
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  DOI: 10.1016/j.molcel.2020.12.049
  
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sciencedirect.com/science/article/pii/S1097276520309916
Apr 2021
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Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity

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1. scibot 29 Apr 2021
  
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  DOI: 10.1016/j.cmet.2020.07.001
  
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sciencedirect.com/science/article/pii/S1550413120303594
Sep 2020
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ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition

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1. scibot 17 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.108096
  
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  RRIDCUR:Validated RRID:AB_2687562
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sciencedirect.com/science/article/pii/S2211124720310858
Jan 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

1
1. scibot 13 Jan 2020
  
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  DOI: 10.7554/eLife.44353
  
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  Curator: @evieth
  
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  RRID:AB_2687562 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC6561707/
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Preclinical study using androgen receptor (AR) degradation enhancer to increase radiotherapy efficacy via targeting radiation-increased AR to better suppress prostate cancer progression

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2687562
  
  DOI: 10.1016/j.ebiom.2018.12.050
  
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sciencedirect.com/science/article/pii/S2352396418306273
Nov 2018
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MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1535610818302691
Nov 2017
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A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability

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1. scibot 08 Nov 2017
  
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  Rabbit polyclonal anti-phospho-ATR (T1989)GeneTexCat#GTX128145
  
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sciencedirect.com/science/article/pii/S0092867417305378