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Jan 2026
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BRD2 bridges TFIID and MOF-H4K16ac-containing nucleosomes to promote transcriptional initiation

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  DOI: 10.1016/j.molcel.2025.12.010
  
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Nov 2025
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A triple-action PROTAC for wild-type p53 cancer therapy

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Oct 2025
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arroyo-gomez-et-al-2025-functional-landscape-of-ubiquitin-linkages-couples-k29-linked-ubiquitylation-to-epigenome-html.html

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Jul 2025
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Chromosomal tethering and mitotic transcription promote ecDNA nuclear inheritance

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Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma Cells

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Jun 2025
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Bromodomain and Extra-Terminal Family Proteins BRD2, BRD3, and BRD4 Contribute to H19-Dependent Transcriptional Regulation of Cell Adhesion Molecules, Modulating Metastatic Dissemination Program in Prostate Cancer

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PDF-html.html

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Mar 2025
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BET inhibitor in combination with BCG vaccine enhances antitumor efficacy and orchestrates T cell reprogramming for melanoma

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Dec 2024
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TurboCas: A method for locus-specific labeling of genomic regions and isolating their associated protein interactome

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Aug 2024
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Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies

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The BET PROTAC inhibitor GNE-987 displays anti-tumor effects by targeting super-enhancers regulated gene in osteosarcoma

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Jul 2024
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Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance

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Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis

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cell.com/cell-reports/fulltext/S2211-1247(24)00760-5
Jun 2024
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Protocol for the comprehensive biochemical and cellular profiling of small-molecule degraders using CoraFluor TR-FRET technology

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May 2024
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Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma

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Apr 2024
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HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression

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STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma

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Feb 2024
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A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis

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Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting

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HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance

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  DOI: 10.1101/2023.12.05.570182
  
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The cyclimids: Degron-inspired cereblon binders for targeted protein degradation

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Nov 2023
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Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells

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Oct 2023
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PIIS0092867423009650-html.html

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Jul 2023
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Distinct layers of BRD4-PTEFb reveal bromodomain-independent function in transcriptional regulation

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Apr 2023
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Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis

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Feb 2023
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Loss of VOPP1 Contributes to BET Inhibitor Acquired Resistance in Non–Small Cell Lung Cancer Cells

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Nov 2022
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Cloning BRD4 long isoform into overexpression vectors for stable overexpression of BRD4-L in mammalian cells

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Sep 2022
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BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer

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Jun 2022
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A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader

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Mar 2022
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Profiling of diverse tumor types establishes the broad utility of VHL-based ProTaCs and triages candidate ubiquitin ligases

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Feb 2022
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The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation

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Sep 2021
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A strategy to assess the cellular activity of E3 ligase components against neo-substrates using electrophilic probes

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SPT5 stabilization of promoter-proximal RNA polymerase II

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sciencedirect.com/science/article/pii/S1097276521006468
Aug 2021
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1. scibot 09 Aug 2021
  
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  RRID:AB_2687578
  
  DOI: 10.7554/eLife.39023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6279352/
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Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer

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1. scibot 05 Aug 2021
  
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  RRID:AB_2687578
  
  DOI: 10.1038/s41467-021-24687-4
  
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nature.com/articles/s41467-021-24687-4
Mar 2021
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TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains

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1. scibot 29 Mar 2021
  
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  RRID:AB_2687578
  
  DOI: 10.1016/j.molcel.2021.01.023
  
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Jan 2020
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Expression and clinical value of PD‐L1 which is regulated by BRD4 in tongue squamous cell carcinoma

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1. scibot 13 Jan 2020
  
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  RRID:AB_2687578
  
  DOI: 10.1002/jcb.29420
  
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1. scibot 13 Jan 2020
  
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  RRID:AB_2687578
  
  DOI: 10.7554/eLife.41913
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6336405/
Nov 2018
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Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy

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1. scibot 05 Nov 2018
  
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  RRID:AB_2687578
  
  Curator: @Jmenke
  
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Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2687578
  
  Curator: @Jmenke
  
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BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency

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  RRID:AB_2687578
  
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Systematic Functional Annotation of Somatic Mutations in Cancer

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Nov 2017
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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

1
1. scibot 08 Nov 2017
  
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  Rabbit monoclonal anti-BRD4 (clone E2A7X) (human specific) (long isoform)Cell Signaling TechnologyCat#: 13440S
  
  Curator: @Jmenke
  
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