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    The extracellular matrix integrates mitochondrial homeostasis
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  3. Jun 2024
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    MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels
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    elife-92755-v2-html.html
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    Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8
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  7. May 2024
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    Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists
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  9. Apr 2024
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    Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury
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    Effectiveness of a novel gene nanotherapy based on putrescine for cancer treatment
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      9091, Cell Signaling Technology

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  13. Mar 2024
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    Pooled CRISPR screening of high-content cellular phenotypes using ghost cytometry
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    Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin
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    Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells
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    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
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  18. Feb 2024
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    In vivo CRISPR knockout screen identifies p47 as a suppressor of HER2+ breast cancer metastasis by regulating NEMO trafficking and autophagy flux
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    Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis
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  21. Jan 2024
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    ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis
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  23. Dec 2023
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    Lysosomal dynamics regulate mammalian cortical neurogenesis
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    Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes
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    Nutrient-regulated control of lysosome function by signaling lipid conversion
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  27. Oct 2023
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
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    Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survival
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  32. Sep 2023
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    CCDC50 promotes tumor growth through regulation of lysosome homeostasis
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    Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection
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  35. Aug 2023
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    Two RNA-binding proteins mediate the sorting of miR223 from mitochondria into exosomes
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    Exosomal release of the virus-encoded chemokine receptor US28 contributes to chemokine scavenging
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  38. Jul 2023
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    A dual hit of α-synuclein internalization and immune challenge leads to formation and maintenance of Lewy body-like inclusions in human dopaminergic neurons
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  40. Jun 2023
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    Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
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    Annexin A6 mediates calcium-dependent exosome secretion during plasma membrane repair
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    Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer
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    aacrjournals.org/cancerres/article/83/8/1280/725099/Dysregulation-of-Mitochondrial-Translation-Caused
  44. May 2023
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    Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity
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  46. Apr 2023
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    Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals
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    Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation
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    ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion
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    The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein
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  51. Mar 2023
  52. www.ijbs.com www.ijbs.com
    IFNγ blockade in capillary leak site improves tumour chemotherapy by inhibiting lactate-induced endocytosis of vascular endothelial-cadherins
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    Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations
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    Celastrol directly binds with VAMP7 and RAB7 to inhibit autophagy and induce apoptosis in preadipocytes
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    A central chaperone-like role for 14-3-3 proteins in human cells
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    Two RNA-binding proteins mediate the sorting of miR223 from mitochondria into exosomes
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  58. Feb 2023
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    PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer
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    Membrane Targeting and GTPase Activity of Rab7 Are Required for Its Ubiquitination by RNF167
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  75. May 2022
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    Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer
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    An AMPKα2-specific phospho-switch controls lysosomal targeting for activation
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    Protein-lipid interaction at low pH induces oligomerization of the MakA cytotoxin from Vibrio cholerae
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  82. Jan 2022
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    <p>Dynamics of Endocytosis and Degradation of Antibody-Drug Conjugate T-DM1 in HER2 Positive Cancer Cells</p>
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  84. Nov 2021
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    RNF13 Dileucine Motif Variants L311S and L312P Interfere with Endosomal Localization and AP-3 Complex Association
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    Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug
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    Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy
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    Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy
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    Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy
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    A photo-cross-linking GlcNAc analog enables covalent capture of N-linked glycoprotein-binding partners on the cell surface
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    Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72
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    SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance
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    Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis
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    MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat
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    The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules
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  107. Jun 2021
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    Mammalian cells use the autophagy process to restrict avian influenza virus replication
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  109. May 2021
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    Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities
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    ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system
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    HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responses
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    sciencedirect.com/science/article/pii/S1931312821000366
  114. Feb 2021
  115. www.nature.com www.nature.com
    Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress
    1
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      anti-LAMP1

      DOI: 10.1038/s42255-020-00325-z

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  116. Jan 2021
  117. www.sciencedirect.com www.sciencedirect.com
    Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis
    1
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      RRID:AB_2687579

      DOI: 10.1016/j.celrep.2020.108683

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    sciencedirect.com/science/article/pii/S2211124720316727
  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
    1
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      RRID:AB_2687579

      DOI: 10.1016/j.cell.2020.12.024

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    ncbi.nlm.nih.gov/pmc/articles/PMC7868890/
  119. Dec 2020
  120. www.sciencedirect.com www.sciencedirect.com
    Spatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics
    1
    1. scibot 07 Dec 2020
      RRID:AB_2687579

      DOI: 10.1016/j.cell.2020.10.035

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    sciencedirect.com/science/article/pii/S0092867420313994
  121. Sep 2020
  122. www.sciencedirect.com www.sciencedirect.com
    Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors
    1
    1. scibot 26 Sep 2020
      RRID:AB_2687579

      DOI: 10.1016/j.chembiol.2020.02.003

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    sciencedirect.com/science/article/pii/S2451945620300672
  123. www.nature.com www.nature.com
    Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models
    1
    1. scibot 23 Sep 2020
      RRID:AB_2687579

      DOI: 10.1038/s41419-020-2322-6

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  124. www.sciencedirect.com www.sciencedirect.com
    Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation
    1
    1. scibot 23 Sep 2020
      RRID:AB_2687579

      DOI: 10.1016/j.molcel.2020.01.003

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    sciencedirect.com/science/article/pii/S1097276520300034
  125. www.sciencedirect.com www.sciencedirect.com
    Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis
    1
    1. scibot 17 Sep 2020
      RRID:AB_2687579

      DOI: 10.1016/j.chembiol.2020.04.003

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    sciencedirect.com/science/article/pii/S2451945620301173
  126. www.sciencedirect.com www.sciencedirect.com
    Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2
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    1. scibot 05 Sep 2020
      RRID:AB_2687579

      DOI: 10.1016/j.immuni.2020.03.009

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    sciencedirect.com/science/article/pii/S1074761320301229
  127. www.sciencedirect.com www.sciencedirect.com
    Shared PPARα/γ Target Genes Regulate Brown Adipocyte Thermogenic Function
    1
    1. scibot 04 Sep 2020
      LAMP1

      DOI: 10.1016/j.celrep.2020.02.032

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    sciencedirect.com/science/article/pii/S2211124720301935
  128. Jan 2020
  129. www.sciencedirect.com www.sciencedirect.com
    Regulation of Autophagic Flux by the 20S Proteasome
    1
    1. scibot 13 Jan 2020
      RRID:AB_2687579

      DOI: 10.1016/j.chembiol.2019.07.002

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    sciencedirect.com/science/article/pii/S2451945619302107
  130. www.sciencedirect.com www.sciencedirect.com
    RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres
    1
    1. scibot 13 Jan 2020
      RRID:AB_2687579

      DOI: 10.1016/j.molcel.2019.06.043

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    sciencedirect.com/science/article/pii/S1097276519305003
  131. www.jneurosci.org www.jneurosci.org
    Sensory Axon Growth Requires Spatiotemporal Integration of CaSR and TrkB Signaling
    1
    1. scibot 13 Jan 2020
      RRID:AB_2687579

      DOI: 10.1523/JNEUROSCI.0027-19.2019

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    jneurosci.org/content/39/30/5842
  132. www.sciencedirect.com www.sciencedirect.com
    Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons
    1
    1. scibot 13 Jan 2020
      RRID:AB_2687579

      DOI: 10.1016/j.stem.2019.08.013

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    sciencedirect.com/science/article/pii/S1934590919303480
  133. www.sciencedirect.com www.sciencedirect.com
    LC3C-Mediated Autophagy Selectively Regulates the Met RTK and HGF-Stimulated Migration and Invasion
    1
    1. scibot 13 Jan 2020
      RRID:AB_2687579

      DOI: 10.1016/j.celrep.2019.11.063

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    sciencedirect.com/science/article/pii/S2211124719315542
  134. www.sciencedirect.com www.sciencedirect.com
    Untitled document
    1
    1. scibot 13 Jan 2020
      RRID:AB_2687579

      DOI: 10.1016/j.molcel.2018.12.017

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    sciencedirect.com/science/article/pii/S1097276518310712
  135. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:AB_2687579

      DOI: 10.1016/j.devcel.2019.04.014

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    sciencedirect.com/science/article/pii/S1534580719302849
  136. www.sciencedirect.com www.sciencedirect.com
    Untitled document
    1
    1. scibot 12 Jan 2020
      RRID:AB_2687579

      DOI: 10.1016/j.devcel.2019.03.011

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    sciencedirect.com/science/article/pii/S1534580719301881
  137. Nov 2018
  138. www.sciencedirect.com www.sciencedirect.com
    iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications
    1
    1. scibot 05 Nov 2018
      9091

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S0092867418302903
  139. www.sciencedirect.com www.sciencedirect.com
    Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs
    1
    1. scibot 05 Nov 2018
      RRID:AB_2687579

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S0092867418310353
  140. www.sciencedirect.com www.sciencedirect.com
    Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A
    1
    1. scibot 05 Nov 2018
      RRID:AB_2687579

      Curator: @evieth

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    sciencedirect.com/science/article/pii/S155041311830514X
  141. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II
    1
    1. scibot 05 Nov 2018
      RRID:AB_2687579

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    ncbi.nlm.nih.gov/pmc/articles/PMC6057917/
  142. www.nature.com www.nature.com
    Untitled document
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    1. scibot 05 Nov 2018
      RRID:AB_2687579

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    nature.com/articles/s41419-018-0871-8
  143. www.sciencedirect.com www.sciencedirect.com
    Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
    1
    1. scibot 05 Nov 2018
      RRID:AB_2687579

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    sciencedirect.com/science/article/pii/S0092867418305865
  144. Nov 2017
  145. www.sciencedirect.com www.sciencedirect.com
    Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma
    1
    1. scibot 09 Nov 2017
      9091S

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S153561081730346X
  146. www.sciencedirect.com www.sciencedirect.com
    Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17
    1
    1. scibot 08 Nov 2017
      Rabbit polyclonal anti-Lamp1Cell Signaling TechnologyCat#:D2D11

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1097276517301247
  147. www.sciencedirect.com www.sciencedirect.com
    Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
    1
    1. scibot 08 Nov 2017
      Rabbit monoclonal anti-LAMP1 (clone D2D11)Cell Signaling TechnologyCat#: 9091P

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S109727651730312X