164 Matching Annotations
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    Targeting the ferritinophagy-lysosome axis as a therapeutic vulnerability in gastroenteropancreatic neuroendocrine tumors
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    Control of lysosome function by the GTPase-activating protein TBC1D9B and its binding partner TMEM55B
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  4. Mar 2026
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    Mouse germline cysts contain a fusome-like structure that mediates oocyte development
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    The lipid-metabolic enzyme HSD17B12 drives lysosomal degradation of PD-L1 potentiating anti-tumor immunity in a mouse model
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  9. Jan 2026
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    FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion
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    Lysosome-localized IRTKS condensates promote mTORC1 activity leading to MASLD and HCC
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    Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder
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    Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer
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  14. Dec 2025
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    Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons
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    PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment
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    TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence
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  20. Nov 2025
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    Claudin-4 as a dual regulator of genome stability and immune evasion in high grade serous ovarian cancer
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    Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL
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  25. Sep 2025
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    Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    PKD3 localizes to late endosomes to maintain Rab7-dependent endolysosomal homeostasis
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  31. Aug 2025
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    RNF13 Regulates the Endolysosomal Pathway Through Interaction with the Small GTPase Arl8B
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    RNF13 is a novel interactor of iduronate 2-sulfatase that modifies its glycosylation and maturation
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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  40. Jun 2025
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    The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage
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  58. Mar 2025
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  61. Feb 2025
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  65. Dec 2024
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  69. Nov 2024
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  71. Oct 2024
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  73. Sep 2024
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  76. Aug 2024
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  78. Jul 2024
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  81. Jun 2024
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  85. May 2024
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  87. Apr 2024
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  91. Mar 2024
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  96. Feb 2024
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    In vivo CRISPR knockout screen identifies p47 as a suppressor of HER2+ breast cancer metastasis by regulating NEMO trafficking and autophagy flux
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  99. Jan 2024
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    ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis
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  101. Dec 2023
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    Lysosomal dynamics regulate mammalian cortical neurogenesis
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    Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes
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    Nutrient-regulated control of lysosome function by signaling lipid conversion
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  105. Oct 2023
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
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    Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survival
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  110. Sep 2023
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    CCDC50 promotes tumor growth through regulation of lysosome homeostasis
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  113. Aug 2023
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    Two RNA-binding proteins mediate the sorting of miR223 from mitochondria into exosomes
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