177 Matching Annotations
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    A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions
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  3. Jul 2026
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    Trans-synaptic signaling through GRID1/glutamate receptor delta-1 and CBLN1/cerebellin-1 facilitates autophagic flux in central amygdala and prevents chronic pain
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    pmc.ncbi.nlm.nih.gov/articles/PMC12758341/
  5. Jun 2026
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    Lipid transfer protein ORP3 mediates lysosomal repair via LC3B and ubiquitin-TAK1-p38 signaling
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    biorxiv.org/content/10.64898/2026.06.09.731146v1
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    Annexin A6 controls multi-organelle contact site formation and endolysosomal positioning, and remodels the STARD3 interactome
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    A multi-subunit autophagic capture complex facilitates degradation of ER-stalled MHC class I in pancreatic cancer
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    Ferroptosis inhibition enhances liver and lung graft function
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    Subcellular Redistribution of Endomembrane GPR15 Promotes NAD+-Mediated Metabolic Reprogramming and Boosts 5-FU Chemosensitivity in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13136880/
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    It’s Not Rewarding for Mitochondria: Dopamine-Induced Mitochondrial Dysfunction Activates cGAS-STING to Drive IL-6 Secretion in Macrophages
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    biorxiv.org/content/10.64898/2026.04.23.719926v1
  14. Apr 2026
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    Phosphoproteomics identifies Rho-Kinase-associated phospho-signaling and autophagy-associated alterations in the medial prefrontal cortex of a schizophrenia-related mouse model
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    Ubiquilin1 restricts influenza viral replication through trapping vRNP in the late endosomes
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    FAM134B Controls Collagen I Dynamics in Hepatic Stellate Cell-Driven Fibrosis
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    Graded activation of the CLEAR network through mTORC1 suppression on cargo-harboring lysosomes
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  19. Mar 2026
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    Targeting the ferritinophagy-lysosome axis as a therapeutic vulnerability in gastroenteropancreatic neuroendocrine tumors
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    Control of lysosome function by the GTPase-activating protein TBC1D9B and its binding partner TMEM55B
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    Mouse germline cysts contain a fusome-like structure that mediates oocyte development
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    The lipid-metabolic enzyme HSD17B12 drives lysosomal degradation of PD-L1 potentiating anti-tumor immunity in a mouse model
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  26. Jan 2026
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    FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion
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    Lysosome-localized IRTKS condensates promote mTORC1 activity leading to MASLD and HCC
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    Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder
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    Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer
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  31. Dec 2025
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    TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence
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  37. Nov 2025
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  42. Sep 2025
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    Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    PKD3 localizes to late endosomes to maintain Rab7-dependent endolysosomal homeostasis
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    Impaired MAPT/tau-secretory lysosomes are linked to cognitive vulnerability in Alzheimer patients
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  48. Aug 2025
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    A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression
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    RNF13 Regulates the Endolysosomal Pathway Through Interaction with the Small GTPase Arl8B
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    Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling
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    Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens
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    RNF13 is a novel interactor of iduronate 2-sulfatase that modifies its glycosylation and maturation
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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  57. Jun 2025
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  65. May 2025
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  67. Apr 2025
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    The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage
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    LAMP2A-mediated neuronal hyperexcitability by enhancing NKAβ1 degradation underlies depression-induced allodynia
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  75. Mar 2025
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    Neuropilin 2 stabilises adherens junctions and protects against endothelial activation by promoting the interaction between VE cadherin and p120 catenin
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  78. Feb 2025
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    BACE1-dependent cleavage of GABAA receptor contributes to neural hyperexcitability and disease progression in Alzheimer’s disease
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  80. Jan 2025
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  82. Dec 2024
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    The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity
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  86. Nov 2024
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  88. Oct 2024
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    Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis
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  90. Sep 2024
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    A TBK1-independent primordial function of STING in lysosomal biogenesis
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  93. Aug 2024
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    Contactin -Associated protein1 Regulates Autophagy by Modulating the PI3K/AKT/mTOR Signaling Pathway and ATG4B Levels in Vitro and in Vivo
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  95. Jul 2024
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  98. Jun 2024
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    MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels
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  102. May 2024
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  104. Apr 2024
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    Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury
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  108. Mar 2024
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    Pooled CRISPR screening of high-content cellular phenotypes using ghost cytometry
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    Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin
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    Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells
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  232. Nov 2018
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    iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications
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    Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs
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    Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A
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  236. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II
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    Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
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  239. Nov 2017
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    Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma
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    Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17
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    Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
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