116 Matching Annotations
  1. Dec 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Physiological shedding and C-terminal proteolytic processing of TMEM106B
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    sciencedirect.com/science/article/pii/S221112472401458X
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11601497/
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    The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity
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  5. Nov 2024
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Everolimus alleviates CD4+ T cell inflammation by regulating autophagy and cellular redox homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11493941/
  7. Oct 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis
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  9. Sep 2024
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    A TBK1-independent primordial function of STING in lysosomal biogenesis
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    sciencedirect.com/science/article/pii/S1097276524007032
  11. www.cell.com www.cell.com
    TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival
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    1. scibot 12 Sep 2024
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    cell.com/cell/fulltext/S0092-8674(24)00911-5
  12. Aug 2024
  13. link.springer.com link.springer.com
    Contactin -Associated protein1 Regulates Autophagy by Modulating the PI3K/AKT/mTOR Signaling Pathway and ATG4B Levels in Vitro and in Vivo
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  14. Jul 2024
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    CircARAP2 controls sMICA-induced NK cell desensitization by erasing CTCF/PRC2-induced suppression in early endosome marker RAB5A
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    The extracellular matrix integrates mitochondrial homeostasis
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  17. Jun 2024
  18. www.sciencedirect.com www.sciencedirect.com
    MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels
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  19. 52.53.155.43 52.53.155.43
    elife-92755-v2-html.html
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  20. www.sciencedirect.com www.sciencedirect.com
    Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8
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  21. May 2024
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists
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  23. Apr 2024
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury
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  25. 52.53.155.43 52.53.155.43
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  26. pubs.rsc.org pubs.rsc.org
    Effectiveness of a novel gene nanotherapy based on putrescine for cancer treatment
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      9091, Cell Signaling Technology

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  27. Mar 2024
  28. www.sciencedirect.com www.sciencedirect.com
    Pooled CRISPR screening of high-content cellular phenotypes using ghost cytometry
    1
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  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin
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    Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells
    1
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  31. www.sciencedirect.com www.sciencedirect.com
    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
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  32. Feb 2024
  33. www.sciencedirect.com www.sciencedirect.com
    In vivo CRISPR knockout screen identifies p47 as a suppressor of HER2+ breast cancer metastasis by regulating NEMO trafficking and autophagy flux
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    Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis
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  35. Jan 2024
  36. www.sciencedirect.com www.sciencedirect.com
    ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis
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    sciencedirect.com/science/article/pii/S1550413123004655
  37. Dec 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Lysosomal dynamics regulate mammalian cortical neurogenesis
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  39. elifesciences.org elifesciences.org
    Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes
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    1. scibot 15 Dec 2023
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  40. www.sciencedirect.com www.sciencedirect.com
    Nutrient-regulated control of lysosome function by signaling lipid conversion
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  41. Oct 2023
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
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      DOI: 10.3390/cancers15205082

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  43. 52.53.155.43 52.53.155.43
    mvad079-html.html
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  44. www.biorxiv.org www.biorxiv.org
    Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survival
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      DOI: 10.1101/2023.10.06.560832

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  45. 52.53.155.43 52.53.155.43
    s41586-023-06657-6_reference-html.html
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  46. Sep 2023
  47. www.embopress.org www.embopress.org
    CCDC50 promotes tumor growth through regulation of lysosome homeostasis
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      DOI: 10.15252/embr.202356948

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  48. www.sciencedirect.com www.sciencedirect.com
    Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection
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  49. Aug 2023
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Two RNA-binding proteins mediate the sorting of miR223 from mitochondria into exosomes
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    Exosomal release of the virus-encoded chemokine receptor US28 contributes to chemokine scavenging
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  52. Jul 2023
  53. 52.53.155.43 52.53.155.43
    A dual hit of α-synuclein internalization and immune challenge leads to formation and maintenance of Lewy body-like inclusions in human dopaminergic neurons
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  54. Jun 2023
  55. www.sciencedirect.com www.sciencedirect.com
    Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
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  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Annexin A6 mediates calcium-dependent exosome secretion during plasma membrane repair
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      DOI: 10.7554/eLife.86556

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  57. aacrjournals.org aacrjournals.org
    Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer
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      DOI: 10.1158/0008-5472.CAN-22-2525

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    aacrjournals.org/cancerres/article/83/8/1280/725099/Dysregulation-of-Mitochondrial-Translation-Caused
  58. May 2023
  59. www.sciencedirect.com www.sciencedirect.com
    Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity
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    Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72
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  117. pubs.acs.org pubs.acs.org
    Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis
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      DOI: 10.1021/acsnano.9b04397

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  118. www.nature.com www.nature.com
    MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat
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  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  120. pubs.acs.org pubs.acs.org
    The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules
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      DOI: 10.1021/acsinfecdis.0c00349

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  121. Jun 2021
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    Mammalian cells use the autophagy process to restrict avian influenza virus replication
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  123. May 2021
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    Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities
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    ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system
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  126. Apr 2021
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    HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responses
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  128. Feb 2021
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    Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress
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  130. Jan 2021
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    Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis
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  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
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  133. Dec 2020
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  135. Sep 2020
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    Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors
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      DOI: 10.1016/j.chembiol.2020.02.003

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  137. www.nature.com www.nature.com
    Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models
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      DOI: 10.1038/s41419-020-2322-6

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    Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation
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    Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis
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      DOI: 10.1016/j.chembiol.2020.04.003

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    Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2
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      RRID:AB_2687579

      DOI: 10.1016/j.immuni.2020.03.009

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    Shared PPARα/γ Target Genes Regulate Brown Adipocyte Thermogenic Function
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      LAMP1

      DOI: 10.1016/j.celrep.2020.02.032

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    sciencedirect.com/science/article/pii/S2211124720301935
  142. Jan 2020
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    Regulation of Autophagic Flux by the 20S Proteasome
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      RRID:AB_2687579

      DOI: 10.1016/j.chembiol.2019.07.002

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    RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres
    1
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      RRID:AB_2687579

      DOI: 10.1016/j.molcel.2019.06.043

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  145. www.jneurosci.org www.jneurosci.org
    Sensory Axon Growth Requires Spatiotemporal Integration of CaSR and TrkB Signaling
    1
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      RRID:AB_2687579

      DOI: 10.1523/JNEUROSCI.0027-19.2019

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    Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons
    1
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      RRID:AB_2687579

      DOI: 10.1016/j.stem.2019.08.013

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    LC3C-Mediated Autophagy Selectively Regulates the Met RTK and HGF-Stimulated Migration and Invasion
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      RRID:AB_2687579

      DOI: 10.1016/j.celrep.2019.11.063

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      DOI: 10.1016/j.molcel.2018.12.017

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      DOI: 10.1016/j.devcel.2019.03.011

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  151. Nov 2018
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    iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications
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      9091

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    Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs
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    Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A
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  155. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II
    1
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  156. www.nature.com www.nature.com
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    Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
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  158. Nov 2017
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    Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma
    1
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      9091S

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    Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17
    1
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      Rabbit polyclonal anti-Lamp1Cell Signaling TechnologyCat#:D2D11

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    Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
    1
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      Rabbit monoclonal anti-LAMP1 (clone D2D11)Cell Signaling TechnologyCat#: 9091P

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