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BLTP2 bridges the ER and MVB for exosome biogenesis at SCAMP3-dependent ER contacts

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1. scibot 27 Aug 2026
  
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  DOI: 10.1016/j.cub.2026.07.066
  
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sciencedirect.com/science/article/pii/S0960982226009978
Aug 2026
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BUB1 regulates cell proliferation and apoptosis in cervical cancer by AKT signaling and autophagosome-lysosome fusion via ACTN1

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  DOI: 10.1016/j.isci.2026.117040
  
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A stress-adaptive lipid kinase axis defines metabolic vulnerabilities in neuroendocrine prostate cancer

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  DOI: 10.1016/j.ccell.2026.07.003
  
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A Stress-Adaptive Lipid Kinase Axis Defines Metabolic Vulnerabilities in Neuroendocrine Prostate Cancer

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1. scibot 01 Aug 2026
  
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  DOI: 10.64898/2026.06.15.732391
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13411104/
Jul 2026
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A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions

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Trans-synaptic signaling through GRID1/glutamate receptor delta-1 and CBLN1/cerebellin-1 facilitates autophagic flux in central amygdala and prevents chronic pain

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1. scibot 03 Jul 2026
  
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  DOI: 10.1080/15548627.2025.2574968
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12758341/
Jun 2026
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Lipid transfer protein ORP3 mediates lysosomal repair via LC3B and ubiquitin-TAK1-p38 signaling

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1. scibot 18 Jun 2026
  
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  DOI: 10.64898/2026.06.09.731146
  
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Annexin A6 controls multi-organelle contact site formation and endolysosomal positioning, and remodels the STARD3 interactome

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1. scibot 16 Jun 2026
  
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A multi-subunit autophagic capture complex facilitates degradation of ER-stalled MHC class I in pancreatic cancer

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  DOI: 10.1016/j.molcel.2026.05.005
  
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May 2026
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FEBS Press

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1. scibot 30 May 2026
  
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Ferroptosis inhibition enhances liver and lung graft function

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1. scibot 09 May 2026
  
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  DOI: 10.1016/j.cell.2026.04.024
  
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Subcellular Redistribution of Endomembrane GPR15 Promotes NAD+-Mediated Metabolic Reprogramming and Boosts 5-FU Chemosensitivity in Colorectal Cancer

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1. scibot 06 May 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13136880/
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It’s Not Rewarding for Mitochondria: Dopamine-Induced Mitochondrial Dysfunction Activates cGAS-STING to Drive IL-6 Secretion in Macrophages

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1. scibot 01 May 2026
  
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  DOI: 10.64898/2026.04.23.719926
  
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biorxiv.org/content/10.64898/2026.04.23.719926v1
Apr 2026
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Phosphoproteomics identifies Rho-Kinase-associated phospho-signaling and autophagy-associated alterations in the medial prefrontal cortex of a schizophrenia-related mouse model

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1. scibot 29 Apr 2026
  
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Ubiquilin1 restricts influenza viral replication through trapping vRNP in the late endosomes

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  DOI: 10.1016/j.celrep.2026.117310
  
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FAM134B Controls Collagen I Dynamics in Hepatic Stellate Cell-Driven Fibrosis

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1. scibot 24 Apr 2026
  
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  DOI: 10.1152/ajpgi.00170.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12818557/
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Graded activation of the CLEAR network through mTORC1 suppression on cargo-harboring lysosomes

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1. scibot 11 Apr 2026
  
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  DOI: 10.1016/j.celrep.2026.117228
  
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Mar 2026
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Targeting the ferritinophagy-lysosome axis as a therapeutic vulnerability in gastroenteropancreatic neuroendocrine tumors

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1. scibot 26 Mar 2026
  
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  DOI: 10.1016/j.xcrm.2026.102695
  
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Control of lysosome function by the GTPase-activating protein TBC1D9B and its binding partner TMEM55B

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1. scibot 24 Mar 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12992710/
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Mouse germline cysts contain a fusome-like structure that mediates oocyte development

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  DOI: 10.7554/eLife.109358
  
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Feb 2026
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1-s2.0-S2589004226004311-main-html.html

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54.241.53.176/ec848ac32c78cddfb23f9dab7afd5557beac8c82/1-s2.0-S2589004226004311-main-html.html
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The lipid-metabolic enzyme HSD17B12 drives lysosomal degradation of PD-L1 potentiating anti-tumor immunity in a mouse model

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Jan 2026
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FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion

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1. scibot 28 Jan 2026
  
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Lysosome-localized IRTKS condensates promote mTORC1 activity leading to MASLD and HCC

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1. scibot 23 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116893
  
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Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder

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  DOI: 10.1016/j.cell.2025.12.012
  
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Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer

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  DOI: 10.1016/j.xcrm.2025.102534
  
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Dec 2025
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Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons

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  DOI: 10.1038/s44318-025-00609-8
  
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54.241.53.176 54.241.53.176

misra-et-al-2025-fam134b-controls-collagen-i-dynamics-in-hepatic-stellate-cell-driven-fibrosis-html.html

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  DOI: 10.6084/m9.figshare.30317422
  
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54.241.53.176/7d61701eda67e5c30e5b80a91af04eaa9e6cd528/misra-et-al-2025-fam134b-controls-collagen-i-dynamics-in-hepatic-stellate-cell-driven-fibrosis-html.html
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FEBS Press

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PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment

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  DOI: 10.7554/eLife.103817
  
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TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence

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  DOI: 10.1038/s44318-025-00608-9
  
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Nov 2025
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Claudin-4 as a dual regulator of genome stability and immune evasion in high grade serous ovarian cancer

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  DOI: 10.1038/s41598-025-23137-1
  
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54.241.53.176 54.241.53.176

1-s2.0-S2589004225023466-main-html.html

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.isci.2025.114085
  
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Oct 2025
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Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL

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1. scibot 14 Oct 2025
  
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  DOI: 10.7554/eLife.103996
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12513720/
Sep 2025
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Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response

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1. scibot 27 Sep 2025
  
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Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models

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Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer

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PKD3 localizes to late endosomes to maintain Rab7-dependent endolysosomal homeostasis

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Impaired MAPT/tau-secretory lysosomes are linked to cognitive vulnerability in Alzheimer patients

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A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression

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RNF13 Regulates the Endolysosomal Pathway Through Interaction with the Small GTPase Arl8B

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Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling

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Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens

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RNF13 is a novel interactor of iduronate 2-sulfatase that modifies its glycosylation and maturation

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Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models

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Cytokine-induced reprogramming of human macrophages toward Alzheimer’s disease-relevant molecular and cellular phenotypes in vitro

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DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation

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The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy

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ATG9A and ARFIP2 cooperate to control PI4P levels for lysosomal repair

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Microglia-drive IRF8 upregulates complement pathway in Parkinson's disease

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Large-scale manufacturing of human gallbladder epithelial cell products and derived hepatocytes via a chemically defined approach

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RabGAP1L modulates Rab7A and Rab10 to orchestrate cell-autonomous immunity

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The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage

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Astrocytic polyamine transport by ATP13A4 tunes excitatory synaptic transmission

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RAF1 kinase contributes to autophagic lysosome reformation

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Lysosome positioning affects NLRP3 inflammasome activation

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LAMP2A-mediated neuronal hyperexcitability by enhancing NKAβ1 degradation underlies depression-induced allodynia

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Neuropilin 2 stabilises adherens junctions and protects against endothelial activation by promoting the interaction between VE cadherin and p120 catenin

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PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD

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BACE1-dependent cleavage of GABAA receptor contributes to neural hyperexcitability and disease progression in Alzheimer’s disease

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Virus adaptation to heparan sulfate comes with capsid stability tradeoff

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Physiological shedding and C-terminal proteolytic processing of TMEM106B

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Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer

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The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity

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Everolimus alleviates CD4+ T cell inflammation by regulating autophagy and cellular redox homeostasis

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Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis

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A TBK1-independent primordial function of STING in lysosomal biogenesis

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TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival

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Contactin -Associated protein1 Regulates Autophagy by Modulating the PI3K/AKT/mTOR Signaling Pathway and ATG4B Levels in Vitro and in Vivo

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CircARAP2 controls sMICA-induced NK cell desensitization by erasing CTCF/PRC2-induced suppression in early endosome marker RAB5A

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The extracellular matrix integrates mitochondrial homeostasis

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MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels

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elife-92755-v2-html.html

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Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8

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Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists

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Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury

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elife-92755-v2-html.html

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Effectiveness of a novel gene nanotherapy based on putrescine for cancer treatment

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Pooled CRISPR screening of high-content cellular phenotypes using ghost cytometry

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Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

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Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells

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Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH

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In vivo CRISPR knockout screen identifies p47 as a suppressor of HER2+ breast cancer metastasis by regulating NEMO trafficking and autophagy flux

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Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis

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ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis

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Lysosomal dynamics regulate mammalian cortical neurogenesis

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Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes

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Nutrient-regulated control of lysosome function by signaling lipid conversion

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A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer

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mvad079-html.html

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Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survival

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s41586-023-06657-6_reference-html.html

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CCDC50 promotes tumor growth through regulation of lysosome homeostasis

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Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection

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Two RNA-binding proteins mediate the sorting of miR223 from mitochondria into exosomes

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Exosomal release of the virus-encoded chemokine receptor US28 contributes to chemokine scavenging

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A dual hit of α-synuclein internalization and immune challenge leads to formation and maintenance of Lewy body-like inclusions in human dopaminergic neurons

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Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation

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Annexin A6 mediates calcium-dependent exosome secretion during plasma membrane repair

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Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer

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Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity

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Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals

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Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation

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ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion

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The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein

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IFNγ blockade in capillary leak site improves tumour chemotherapy by inhibiting lactate-induced endocytosis of vascular endothelial-cadherins

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Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations

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Celastrol directly binds with VAMP7 and RAB7 to inhibit autophagy and induce apoptosis in preadipocytes

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A central chaperone-like role for 14-3-3 proteins in human cells

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Two RNA-binding proteins mediate the sorting of miR223 from mitochondria into exosomes

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A glycine-serine-alanine-rich peptide ameliorates Alzheimer-type neurodegeneration

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GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis

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The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins

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Protocol to purify and detect ubiquitinated phospholipids in budding yeast and human cell lines

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PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer

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Ubiquitination of phosphatidylethanolamine in organellar membranes

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Increasing cell size remodels the proteome and promotes senescence

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Membrane Targeting and GTPase Activity of Rab7 Are Required for Its Ubiquitination by RNF167

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Rapid macropinocytic transfer of α-synuclein to lysosomes

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Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1

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Itaconate is a lysosomal inducer that promotes antibacterial innate immunity

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Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis

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Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer

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Amniogenesis occurs in two independent waves in primates

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An AMPKα2-specific phospho-switch controls lysosomal targeting for activation

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Protein-lipid interaction at low pH induces oligomerization of the MakA cytotoxin from Vibrio cholerae

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<p>Dynamics of Endocytosis and Degradation of Antibody-Drug Conjugate T-DM1 in HER2 Positive Cancer Cells</p>

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RNF13 Dileucine Motif Variants L311S and L312P Interfere with Endosomal Localization and AP-3 Complex Association

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De novo peptide grafting to a self-assembling nanocapsule yields a hepatocyte growth factor receptor agonist

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Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug

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Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy

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Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy

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NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression

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Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic

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Compromised mitochondrial quality control triggers lipin1-related rhabdomyolysis

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Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy

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A photo-cross-linking GlcNAc analog enables covalent capture of N-linked glycoprotein-binding partners on the cell surface

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Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C

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Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72

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SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance

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Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

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MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat

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The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules

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Mammalian cells use the autophagy process to restrict avian influenza virus replication

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Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities

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ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system

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HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responses

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Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress

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Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis

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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

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Spatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics

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Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors

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Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models

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Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation

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Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis

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Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2

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Shared PPARα/γ Target Genes Regulate Brown Adipocyte Thermogenic Function

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Regulation of Autophagic Flux by the 20S Proteasome

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RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres

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Sensory Axon Growth Requires Spatiotemporal Integration of CaSR and TrkB Signaling

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Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons

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LC3C-Mediated Autophagy Selectively Regulates the Met RTK and HGF-Stimulated Migration and Invasion

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iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications

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Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs

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Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

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Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II

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Untitled document

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nature.com/articles/s41419-018-0871-8
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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

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sciencedirect.com/science/article/pii/S0092867418305865
Nov 2017
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Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma

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1. scibot 09 Nov 2017
  
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Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17

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1. scibot 08 Nov 2017
  
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  Rabbit polyclonal anti-Lamp1Cell Signaling TechnologyCat#:D2D11
  
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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

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1. scibot 08 Nov 2017
  
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  Rabbit monoclonal anti-LAMP1 (clone D2D11)Cell Signaling TechnologyCat#: 9091P
  
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