189 Matching Annotations
  1. Oct 2026
  2. www.sciencedirect.com www.sciencedirect.com
    TM6SF2 acts at ER membrane contact sites to enable RAB7-dependent endolysosomal VLDL secretion and maintain Golgi structure
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    sciencedirect.com/science/article/pii/S2211124726011952
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    Dopamine-induced mitochondrial dysfunction activates cGAS-sTING to drive IL-6 secretion in macrophages
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    sciencedirect.com/science/article/pii/S2211124726011976
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    Targeting ZDHHC15-mediated S-acylation of CD155 reactivates anti-tumor immunity
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    sciencedirect.com/science/article/pii/S245194562600334X
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    Nitrate-responsive Sialin2 couples stress granule assembly and clearance to maintain neuronal homeostasis
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    sciencedirect.com/science/article/pii/S1534580726003497
  6. www.science.org www.science.org
    Cell-intrinsic functions of PD-L1 activate autophagy and prevent cytokine-induced apoptosis
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    science.org/doi/10.1126/sciadv.aec7037
  7. Sep 2026
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ATP13A4 gates extracellular polyamine levels to control excitatory synaptogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13534584/
  9. www.sciencedirect.com www.sciencedirect.com
    TBK1 phosphorylates HDAC3 to promote NDP52 deacetylation and accelerate intracellular bacterial clearance
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    sciencedirect.com/science/article/pii/S2211124726010053
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    Fast tumor accumulation and payload release of c-Met targeting aptamer-drug conjugate enables robust anti-tumor efficacy
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    sciencedirect.com/science/article/pii/S2666379126004222
  11. Aug 2026
  12. www.sciencedirect.com www.sciencedirect.com
    BLTP2 bridges the ER and MVB for exosome biogenesis at SCAMP3-dependent ER contacts
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    sciencedirect.com/science/article/pii/S0960982226009978
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    BUB1 regulates cell proliferation and apoptosis in cervical cancer by AKT signaling and autophagosome-lysosome fusion via ACTN1
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    sciencedirect.com/science/article/pii/S2589004226024181
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    A stress-adaptive lipid kinase axis defines metabolic vulnerabilities in neuroendocrine prostate cancer
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    sciencedirect.com/science/article/pii/S1535610826003120
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Stress-Adaptive Lipid Kinase Axis Defines Metabolic Vulnerabilities in Neuroendocrine Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13411104/
  16. Jul 2026
  17. www.sciencedirect.com www.sciencedirect.com
    A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions
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    sciencedirect.com/science/article/pii/S0092867426005830
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Trans-synaptic signaling through GRID1/glutamate receptor delta-1 and CBLN1/cerebellin-1 facilitates autophagic flux in central amygdala and prevents chronic pain
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    pmc.ncbi.nlm.nih.gov/articles/PMC12758341/
  19. Jun 2026
  20. www.biorxiv.org www.biorxiv.org
    Lipid transfer protein ORP3 mediates lysosomal repair via LC3B and ubiquitin-TAK1-p38 signaling
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    biorxiv.org/content/10.64898/2026.06.09.731146v1
  21. www.sciencedirect.com www.sciencedirect.com
    Annexin A6 controls multi-organelle contact site formation and endolysosomal positioning, and remodels the STARD3 interactome
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    sciencedirect.com/science/article/pii/S2589004226017621
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    A multi-subunit autophagic capture complex facilitates degradation of ER-stalled MHC class I in pancreatic cancer
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    sciencedirect.com/science/article/pii/S1097276526003114
  23. May 2026
  24. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.70596
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    Ferroptosis inhibition enhances liver and lung graft function
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    sciencedirect.com/science/article/pii/S0092867426004599
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Subcellular Redistribution of Endomembrane GPR15 Promotes NAD+-Mediated Metabolic Reprogramming and Boosts 5-FU Chemosensitivity in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13136880/
  27. www.biorxiv.org www.biorxiv.org
    It’s Not Rewarding for Mitochondria: Dopamine-Induced Mitochondrial Dysfunction Activates cGAS-STING to Drive IL-6 Secretion in Macrophages
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    biorxiv.org/content/10.64898/2026.04.23.719926v1
  28. Apr 2026
  29. www.sciencedirect.com www.sciencedirect.com
    Phosphoproteomics identifies Rho-Kinase-associated phospho-signaling and autophagy-associated alterations in the medial prefrontal cortex of a schizophrenia-related mouse model
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    sciencedirect.com/science/article/pii/S1043661826001167
  30. www.sciencedirect.com www.sciencedirect.com
    Ubiquilin1 restricts influenza viral replication through trapping vRNP in the late endosomes
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    sciencedirect.com/science/article/pii/S2211124726003888
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FAM134B Controls Collagen I Dynamics in Hepatic Stellate Cell-Driven Fibrosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12818557/
  32. www.sciencedirect.com www.sciencedirect.com
    Graded activation of the CLEAR network through mTORC1 suppression on cargo-harboring lysosomes
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    sciencedirect.com/science/article/pii/S2211124726003062
  33. Mar 2026
  34. www.sciencedirect.com www.sciencedirect.com
    Targeting the ferritinophagy-lysosome axis as a therapeutic vulnerability in gastroenteropancreatic neuroendocrine tumors
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    sciencedirect.com/science/article/pii/S2666379126001126
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Control of lysosome function by the GTPase-activating protein TBC1D9B and its binding partner TMEM55B
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    pmc.ncbi.nlm.nih.gov/articles/PMC12992710/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mouse germline cysts contain a fusome-like structure that mediates oocyte development
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    pmc.ncbi.nlm.nih.gov/articles/PMC12978699/
  37. Feb 2026
  38. 54.241.53.176 54.241.53.176
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  39. journals.plos.org journals.plos.org
    The lipid-metabolic enzyme HSD17B12 drives lysosomal degradation of PD-L1 potentiating anti-tumor immunity in a mouse model
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    journals.plos.org/plosbiology/article
  40. Jan 2026
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion
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    pmc.ncbi.nlm.nih.gov/articles/PMC11770945/
  42. www.sciencedirect.com www.sciencedirect.com
    Lysosome-localized IRTKS condensates promote mTORC1 activity leading to MASLD and HCC
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    sciencedirect.com/science/article/pii/S2211124725016651
  43. www.sciencedirect.com www.sciencedirect.com
    Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder
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    sciencedirect.com/science/article/pii/S0092867425014254
  44. www.sciencedirect.com www.sciencedirect.com
    Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer
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    sciencedirect.com/science/article/pii/S266637912500607X
  45. Dec 2025
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12706091/
  47. 54.241.53.176 54.241.53.176
    misra-et-al-2025-fam134b-controls-collagen-i-dynamics-in-hepatic-stellate-cell-driven-fibrosis-html.html
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    54.241.53.176/7d61701eda67e5c30e5b80a91af04eaa9e6cd528/misra-et-al-2025-fam134b-controls-collagen-i-dynamics-in-hepatic-stellate-cell-driven-fibrosis-html.html
  48. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.70365
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment
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    pmc.ncbi.nlm.nih.gov/articles/PMC12685304/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence
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    pmc.ncbi.nlm.nih.gov/articles/PMC12669767/
  51. Nov 2025
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Claudin-4 as a dual regulator of genome stability and immune evasion in high grade serous ovarian cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12603150/
  53. 54.241.53.176 54.241.53.176
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  54. Oct 2025
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL
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    pmc.ncbi.nlm.nih.gov/articles/PMC12513720/
  56. Sep 2025
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12459955/
  58. www.sciencedirect.com www.sciencedirect.com
    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    sciencedirect.com/science/article/pii/S2666379125004367
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875910/
  60. www.sciencedirect.com www.sciencedirect.com
    PKD3 localizes to late endosomes to maintain Rab7-dependent endolysosomal homeostasis
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    sciencedirect.com/science/article/pii/S2589004225016694
  61. www.tandfonline.com www.tandfonline.com
    Impaired MAPT/tau-secretory lysosomes are linked to cognitive vulnerability in Alzheimer patients
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    tandfonline.com/doi/full/10.1080/15548627.2025.2552905
  62. Aug 2025
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12317733/
  64. www.biorxiv.org www.biorxiv.org
    RNF13 Regulates the Endolysosomal Pathway Through Interaction with the Small GTPase Arl8B
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    biorxiv.org/content/10.1101/2025.07.31.667977v1
  65. Jul 2025
  66. www.science.org www.science.org
    Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling
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    science.org/doi/10.1126/science.adm9805
  67. 52.53.155.43 52.53.155.43
    2025.07.14.664742v1.full-html.html
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    Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens
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    sciencedirect.com/science/article/pii/S2211124725007739
  69. www.biorxiv.org www.biorxiv.org
    RNF13 is a novel interactor of iduronate 2-sulfatase that modifies its glycosylation and maturation
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    biorxiv.org/content/10.1101/2025.06.20.660705v1
  70. www.biorxiv.org www.biorxiv.org
    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    biorxiv.org/content/10.1101/2025.06.18.660406v1
  71. Jun 2025
  72. www.sciencedirect.com www.sciencedirect.com
    Cytokine-induced reprogramming of human macrophages toward Alzheimer’s disease-relevant molecular and cellular phenotypes in vitro
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  73. 52.53.155.43 52.53.155.43
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  74. www.nature.com www.nature.com
    DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation
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    nature.com/articles/s41594-025-01581-x
  75. 52.53.155.43 52.53.155.43
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    The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy
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    sciencedirect.com/science/article/pii/S2211124725006412
  77. www.sciencedirect.com www.sciencedirect.com
    ATG9A and ARFIP2 cooperate to control PI4P levels for lysosomal repair
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    sciencedirect.com/science/article/pii/S1534580725003181
  78. www.sciencedirect.com www.sciencedirect.com
    Microglia-drive IRF8 upregulates complement pathway in Parkinson's disease
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    sciencedirect.com/science/article/pii/S0925443925002765
  79. May 2025
  80. www.cell.com www.cell.com
    Large-scale manufacturing of human gallbladder epithelial cell products and derived hepatocytes via a chemically defined approach
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    cell.com/trends/biotechnology/abstract/S0167-7799(25)00136-2
  81. Apr 2025
  82. www.sciencedirect.com www.sciencedirect.com
    RabGAP1L modulates Rab7A and Rab10 to orchestrate cell-autonomous immunity
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    sciencedirect.com/science/article/pii/S2211124725003705
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage
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    pmc.ncbi.nlm.nih.gov/articles/PMC12081312/
  84. www.medrxiv.org www.medrxiv.org
    Astrocytic polyamine transport by ATP13A4 tunes excitatory synaptic transmission
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    medrxiv.org/content/10.1101/2025.04.04.25325117v1
  85. 52.53.155.43 52.53.155.43
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  86. www.sciencedirect.com www.sciencedirect.com
    RAF1 kinase contributes to autophagic lysosome reformation
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    sciencedirect.com/science/article/pii/S221112472500261X
  87. 52.53.155.43 52.53.155.43
    Lysosome positioning affects NLRP3 inflammasome activation
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    LAMP2A-mediated neuronal hyperexcitability by enhancing NKAβ1 degradation underlies depression-induced allodynia
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    sciencedirect.com/science/article/pii/S2211124725002608
  89. Mar 2025
  90. www.biorxiv.org www.biorxiv.org
    Neuropilin 2 stabilises adherens junctions and protects against endothelial activation by promoting the interaction between VE cadherin and p120 catenin
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    biorxiv.org/content/10.1101/2025.03.09.642194v1
  91. www.sciencedirect.com www.sciencedirect.com
    PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD
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    sciencedirect.com/science/article/pii/S0896627325001187
  92. Feb 2025
  93. www.sciencedirect.com www.sciencedirect.com
    BACE1-dependent cleavage of GABAA receptor contributes to neural hyperexcitability and disease progression in Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S0896627325000789
  94. Jan 2025
  95. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Virus adaptation to heparan sulfate comes with capsid stability tradeoff
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    pmc.ncbi.nlm.nih.gov/articles/PMC11717363/
  96. Dec 2024
  97. www.sciencedirect.com www.sciencedirect.com
    Physiological shedding and C-terminal proteolytic processing of TMEM106B
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    sciencedirect.com/science/article/pii/S221112472401458X
  98. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11601497/
  99. www.sciencedirect.com www.sciencedirect.com
    The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity
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    sciencedirect.com/science/article/pii/S2211124724013846
  100. Nov 2024
  101. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Everolimus alleviates CD4+ T cell inflammation by regulating autophagy and cellular redox homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11493941/
  102. Oct 2024
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11449124/
  104. Sep 2024
  105. www.sciencedirect.com www.sciencedirect.com
    A TBK1-independent primordial function of STING in lysosomal biogenesis
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    sciencedirect.com/science/article/pii/S1097276524007032
  106. www.sciencedirect.com www.sciencedirect.com
    TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival
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    sciencedirect.com/science/article/pii/S0092867424009115
  107. Aug 2024
  108. link.springer.com link.springer.com
    Contactin -Associated protein1 Regulates Autophagy by Modulating the PI3K/AKT/mTOR Signaling Pathway and ATG4B Levels in Vitro and in Vivo
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    link.springer.com/article/10.1007/s12035-024-04425-9
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