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Aug 2025
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TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation

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  DOI: 10.1016/j.celrep.2025.116186
  
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sciencedirect.com/science/article/pii/S221112472500957X
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Ridaifen derivatives function as potent lysosomotropic agents, depending on their basic side chains.

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  DOI: 10.1016/j.ejphar.2025.178082
  
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sciencedirect.com/science/article/pii/S0014299925008362
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Mitochondrial damage triggers the concerted degradation of negative regulators of neuronal autophagy

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  DOI: 10.1038/s41467-025-62379-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12335601/
Jul 2025
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BPS Publications

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1. scibot 30 Jul 2025
  
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  DOI: 10.1111/bph.70122
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70122
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Lactoferrin attenuates renal fibrosis and uremic sarcopenia in a mouse model of adenine-induced chronic kidney disease

1
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  DOI: 10.1016/j.jnutbio.2025.110039
  
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sciencedirect.com/science/article/pii/S0955286325002025
Jun 2025
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DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation

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1. scibot 18 Jun 2025
  
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  DOI: 10.1038/s41594-025-01581-x
  
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nature.com/articles/s41594-025-01581-x
Feb 2025
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The Effects of Cathepsin B Inhibition in the Face of Diffuse Traumatic Brain Injury and Secondary Intracranial Pressure Elevation

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1. scibot 27 Feb 2025
  
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  DOI: 10.20944/preprints202405.1740.v1
  
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preprints.org/manuscript/202405.1740/v1
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Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST

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  DOI: 10.1016/j.cmet.2025.01.024
  
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sciencedirect.com/science/article/pii/S1550413125000245
Jan 2025
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Lysosomal activity in response to the incubation of pristine and functionalized carbon nanodots

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1. scibot 17 Jan 2025
  
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  DOI: 10.1016/j.isci.2024.111654
  
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sciencedirect.com/science/article/pii/S2589004224028815
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PDF-html.html

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  DOI: 10.1074/mcp.m113.031591
  
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52.53.155.43/3f93a1e6d9279abf85ecec7e26292c0f7687857c/1-s2.0-S2589004224028815-main-html.html
Dec 2024
52.53.155.43 52.53.155.43

PDF-html.html

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  DOI: 10.1074/mcp.m113.031591
  
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Nov 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Inhibition of cathepsin L ameliorates inflammation through the A20/NF-κB pathway in endotoxin-induced acute lung injury

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1. scibot 26 Nov 2024
  
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  DOI: 10.1016/j.isci.2024.111024
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11570319/
journals.lww.com journals.lww.com

Hub genes and key pathways of traumatic brain injury:... : Neural Regeneration Research

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1. scibot 07 Nov 2024
  
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  DOI: 10.4103/NRR.NRR-D-23-01633
  
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journals.lww.com/nrronline/fulltext/2026/04000/the_cullin3_ring_e3_ubiquitin_ligase_complex_and.44.aspx
52.53.155.43 52.53.155.43

enhanced_autophagic_clearance_of_amyloid___via.25-html.html

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1. scibot 07 Nov 2024
  
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  DOI: 10.4103/nrr.nrr-d-23-01633
  
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52.53.155.43/f837a450e4d673727102c6a319547882bc299234/enhanced_autophagic_clearance_of_amyloid___via.25-html.html
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread

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1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114484
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11316253/
Jul 2024
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The Effects of Cathepsin B Inhibition in the Face of Diffuse Traumatic Brain Injury and Secondary Intracranial Pressure Elevation

1
1. scibot 31 Jul 2024
  
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  DOI: 10.3390/biomedicines12071612
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11274534/
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Aging Differentially Affects Axonal Autophagosome Formation and Maturation

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1. scibot 20 Jul 2024
  
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  DOI: 10.1080/15548627.2023.2236485
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10621248/
May 2024
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scRank infers drug-responsive cell types from untreated scRNA-seq data using a target-perturbed gene regulatory network

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1. scibot 16 May 2024
  
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  DOI: 10.1016/j.xcrm.2024.101568
  
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sciencedirect.com/science/article/pii/S266637912400260X
Mar 2024
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P-tau217 correlates with neurodegeneration in Alzheimer’s disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy

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1. scibot 21 Mar 2024
  
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  DOI: 10.1016/j.neuron.2024.02.017
  
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  DOI: 10.1016/j.neuron.2024.02.017
  
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sciencedirect.com/science/article/pii/S0896627324001272
Feb 2024
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Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion

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1. scibot 13 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113760
  
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  DOI: 10.1016/j.celrep.2024.113760
  
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sciencedirect.com/science/article/pii/S2211124724000883
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Lysosomal stress drives the release of pathogenic α-synuclein from macrophage lineage cells via the LRRK2-Rab10 pathway

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1. scibot 06 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.108893
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10835446/
Jan 2024
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ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis

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1. scibot 11 Jan 2024
  
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  DOI: 10.1016/j.cmet.2023.12.015
  
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sciencedirect.com/science/article/pii/S1550413123004655
Oct 2023
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Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance

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1. scibot 17 Oct 2023
  
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  DOI: 10.1126/sciadv.abo3610
  
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science.org/doi/10.1126/sciadv.abo3610
Sep 2023
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Effects of HMGB1/RAGE/cathespin B inhibitors on alleviating hippocampal injury by regulating microglial pyroptosis and caspase activation in neonatal hypoxic–ischemic brain damage

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1. scibot 29 Sep 2023
  
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  DOI: 10.1111/jnc.15965
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15965
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CCDC50 promotes tumor growth through regulation of lysosome homeostasis

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1. scibot 12 Sep 2023
  
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  DOI: 10.15252/embr.202356948
  
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embopress.org/doi/full/10.15252/embr.202356948
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Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection

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  DOI: 10.1016/j.devcel.2023.08.013
  
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Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion

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  DOI: 10.1016/j.celrep.2023.113042
  
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sciencedirect.com/science/article/pii/S2211124723010537
Apr 2023
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An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation

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1. scibot 27 Apr 2023
  
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  DOI: 10.1126/sciadv.adf8966
  
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  DOI: 10.1126/sciadv.adf8966
  
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science.org/doi/10.1126/sciadv.adf8966
Jan 2023
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ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal pH homeostasis

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1. scibot 02 Jan 2023
  
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  DOI: 10.1016/j.celrep.2022.111911
  
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sciencedirect.com/science/article/pii/S2211124722018101
Dec 2022
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Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis

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  DOI: 10.1016/j.celrep.2022.111742
  
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sciencedirect.com/science/article/pii/S2211124722016205
Oct 2022
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Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein

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1. scibot 28 Oct 2022
  
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  DOI: 10.1016/j.chembiol.2022.10.006
  
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sciencedirect.com/science/article/pii/S2451945622003609
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Enhanced delivery of antibodies across the blood-brain barrier via TEMs with inherent receptor-mediated phagocytosis

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1. scibot 20 Oct 2022
  
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  DOI: 10.1016/j.medj.2022.09.007
  
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sciencedirect.com/science/article/pii/S2666634022004081
Sep 2022
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Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance

1
1. scibot 11 Sep 2022
  
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  DOI: 10.1016/j.ccell.2022.08.012
  
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Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance

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  AB_2687580
  
  DOI: 10.1126/sciadv.abo3610
  
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Itaconate is a lysosomal inducer that promotes antibacterial innate immunity

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  DOI: 10.1016/j.molcel.2022.05.009
  
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May 2022
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Cathepsin B Relocalization in Late Membrane Disrupted Neurons Following Diffuse Brain Injury in Rats - Martina L. Hernandez, Michael Marone, Karen M. Gorse, Audrey D. Lafrenaye, 2022

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  DOI: 10.1177/17590914221099112
  
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Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells

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  DOI: 10.1158/0008-5472.CAN-20-3371
  
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The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules

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  DOI: 10.1021/acsinfecdis.0c00349
  
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Oncogene-regulated release of extracellular vesicles

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  DOI: 10.1016/j.devcel.2021.05.014
  
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Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis

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  DOI: 10.1016/j.celrep.2021.108826
  
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Sep 2020
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Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma

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  DOI: 10.1016/j.ccell.2020.03.016
  
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Jan 2020
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Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All-trans Retinal

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  DOI: 10.1167/iovs.18-26360
  
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Untitled document

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  DOI: 10.1016/j.devcel.2019.03.011
  
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Nov 2017
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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

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1. scibot 08 Nov 2017
  
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  Rabbit monoclonal anti-Cathepsin B (clone D1C7Y)Cell Signaling TechnologyCat#: 31718S
  
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