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Inhibiting KRAS with CD47 and immune checkpoint overcomes intrinsic resistance to combined KRAS and immune checkpoint inhibitor therapy

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1. scibot 30 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102317
  
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sciencedirect.com/science/article/pii/S2666379125003908
Aug 2025
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AI-driven multimodal algorithm predicts immunotherapy and targeted therapy outcomes in clear cell renal cell carcinoma

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1. scibot 20 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102299
  
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A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression

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1. scibot 05 Aug 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-4774
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12317733/
Jul 2025
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The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer

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1. scibot 17 Jul 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-3844
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12260515/
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Protocol for studying the immune microenvironment of human hepatocellular carcinoma by Cell DIVE multiplex immunofluorescence imaging

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  DOI: 10.1016/j.xpro.2025.103946
  
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sciencedirect.com/science/article/pii/S2666166725003521
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RANKL/PD-1 dual blockade demonstrates survival benefit for patients with advanced lung adenocarcinoma harboring KRAS mutations

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1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102235
  
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Jun 2025
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Impact of the tumor immune contexture in microsatellite-stable metastatic colorectal cancer treated with avelumab, cetuximab, and irinotecan

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1. scibot 25 Jun 2025
  
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PD-L1 Expression is Mediated by microRNA Processing, Wnt/β-Catenin Signaling, and Chemotherapy in Wilms Tumor

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1. scibot 17 Jun 2025
  
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  DOI: 10.1002/pbc.31852
  
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onlinelibrary.wiley.com/doi/10.1002/pbc.31852
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BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAFV600E-mutant glioma

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1. scibot 13 Jun 2025
  
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  DOI: 10.1016/j.xcrm.2025.102183
  
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sciencedirect.com/science/article/pii/S2666379125002563
May 2025
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Phase II Trial of Atezolizumab and Bevacizumab for Treatment of HPV-Positive Unresectable or Metastatic Squamous Cell Carcinoma of the Anal Canal

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1. scibot 20 May 2025
  
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  DOI: 10.1158/1078-0432.CCR-24-1512
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12010964/
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1. scibot 20 May 2025
  
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  DOI: 10.1158/0008-5472.can-24-3844
  
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52.53.155.43/0976643c3f79ff08c8e38df9c7b0ed5aea42f921/PDF-html.html
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Spatial analysis identifies DC niches as predictors of pembrolizumab therapy in head and neck squamous cell cancer

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1. scibot 19 May 2025
  
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  DOI: 10.1016/j.xcrm.2025.102100
  
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sciencedirect.com/science/article/pii/S2666379125001739
Apr 2025
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Development of potent and selective tetrahydro-β-carboline-based HDAC6 inhibitors with promising activity against triple-negative breast cancer

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1. scibot 19 Apr 2025
  
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  RRID:AB_2687655
  
  DOI: 10.1039/d5md00086f
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12004265/
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Downregulation of PD-L1 expression by Wnt pathway inhibition to enhance PD-1 blockade efficacy in hepatocellular carcinoma

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1. scibot 11 Apr 2025
  
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  DOI: 10.1186/s13062-025-00645-8
  
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link.springer.com/article/10.1186/s13062-025-00645-8
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Unlocking the potential of novel Tetrahydro-β-Carboline-based HDAC6 inhibitors for colorectal Cancer therapy: Design, synthesis and biological evaluation

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1. scibot 10 Apr 2025
  
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  DOI: 10.1016/j.bioorg.2025.108454
  
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sciencedirect.com/science/article/pii/S0045206825003347
Mar 2025
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Genomic landscape and molecularly informed therapy in thymic carcinoma and other advanced thymic epithelial tumors

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1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.medj.2025.100612
  
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Distinct CD8+ T cell dynamics associate with response to neoadjuvant cancer immunotherapies

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1. scibot 14 Mar 2025
  
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  DOI: 10.1016/j.ccell.2025.02.026
  
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sciencedirect.com/science/article/pii/S1535610825000789
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PDF-html.html

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1. scibot 05 Mar 2025
  
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  DOI: 10.1158/1078-0432.ccr-24-1512
  
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52.53.155.43/bd54bfc20a8f6423db7f5fe71487b5cd257ee354/PDF-html.html
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The NF1 tumor suppressor regulates PD-L1 and immune evasion in melanoma

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1. scibot 04 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115365
  
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sciencedirect.com/science/article/pii/S2211124725001366
Feb 2025
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Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma

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1. scibot 21 Feb 2025
  
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  DOI: 10.1016/j.xcrm.2025.101977
  
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sciencedirect.com/science/article/pii/S2666379125000503
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Genomic mediators of acquired resistance to immunotherapy in metastatic melanoma

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1. scibot 14 Feb 2025
  
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  DOI: 10.1016/j.ccell.2025.01.009
  
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cell.com/cancer-cell/abstract/S1535-6108(25)00027-3
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TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma

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1. scibot 13 Feb 2025
  
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aacrjournals.org/cancerres/article/83/13/2262/727433/TGF-Antagonizes-IFN-Mediated-Adaptive-Immune
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USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation

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1. scibot 08 Feb 2025
  
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  DOI: 10.1038/s41467-025-56564-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11791202/
Jan 2025
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Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity

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1. scibot 15 Jan 2025
  
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  DOI: 10.1038/s41467-024-55667-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11711318/
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Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1

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1. scibot 14 Jan 2025
  
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  DOI: 10.1016/j.cmet.2024.11.012
  
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sciencedirect.com/science/article/pii/S1550413124004807
Dec 2024
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Atezolizumab, bevacizumab, pemetrexed and platinum for EGFR‐mutant NSCLC patients after EGFR TKI failure: A phase II study with immune cell profile analysis

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1. scibot 27 Dec 2024
  
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  DOI: 10.1002/ctm2.70149
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11666332/
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PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor

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1. scibot 21 Dec 2024
  
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  DOI: 10.1101/2024.11.29.626084
  
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ANLN promotes head and neck squamous cell carcinoma progression by upregulating PD-L1 via the ERK-MAPK pathway-html.html

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1. scibot 19 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111633
  
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52.53.155.43/7324a4302b92926502f88e0cd10bf0b0ca3de710/ANLN promotes head and neck squamous cell carcinoma progression by upregulating PD-L1 via the ERK-MAPK pathway-html.html
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Nucleo-cytosolic acetyl-CoA drives tumor immune evasion by regulating PD-L1 in melanoma

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  DOI: 10.1016/j.celrep.2024.115015
  
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sciencedirect.com/science/article/pii/S2211124724013664
Nov 2024
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ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion

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1. scibot 24 Nov 2024
  
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  DOI: 10.1016/j.cmet.2024.10.015
  
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Langerhans cells directly interact with resident T cells in the human epidermis

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1. scibot 17 Nov 2024
  
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  DOI: 10.1016/j.xjidi.2024.100324
  
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Multi-platform biomarkers of response to an immune checkpoint inhibitor in the neoadjuvant I-SPY 2 trial for early-stage breast cancer

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1. scibot 16 Nov 2024
  
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  DOI: 10.1016/j.xcrm.2024.101799
  
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Antagonistic roles of cGAS/STING signaling in colorectal cancer chemotherapy

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1. scibot 07 Nov 2024
  
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  DOI: 10.3389/fonc.2024.1441935
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11513249/
Oct 2024
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Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux

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1. scibot 05 Oct 2024
  
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  DOI: 10.1016/j.chembiol.2023.06.016
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11426993/
Aug 2024
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Role of Forkhead Box P3 in Interferon γ-mediated PD-L1 Expression and Bladder Cancer Epithelial-to-Mesenchymal Transition

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1. scibot 28 Aug 2024
  
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  DOI: 10.1158/2767-9764.CRC-23-0493
  
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Patient-derived tumor organoids mimic treatment-induced DNA damage response in glioblastoma

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Statins inhibit paclitaxel-induced PD-L1 expression and increase CD8+ T cytotoxicity for better prognosis in breast cancer

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"Expression and prognostic relevance of PD-1, PD-L1 and CTLA-4 immune checkpoints in adrenocortical carcinoma"

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Proteasome inhibitors restore the STAT1 pathway and enhance the expression of MHC class I on human colon cancer cells

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Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis

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Cyclin dependent kinase 9 inhibition reduced programmed death-ligand 1 expression and improved treatment efficacy in hepatocellular carcinoma

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Distinctive multicellular immunosuppressive hubs confer different intervention strategies for left- and right-sided colon cancers

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Decision model for durable clinical benefit from front- or late-line immunotherapy alone or with chemotherapy in non-small cell lung cancer

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SETD2 loss and ATR inhibition synergize to promote cGAS signaling and immunotherapy response in renal cell carcinoma

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Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon

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Biomarkers of Pathological Complete Response to Neoadjuvant Immunotherapy in Mismatch Repair Deficiency Colorectal Cancer

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Genomic characteristics and immune landscape of super multiple primary lung cancer

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Circulating cancer-specific CD8 T cell frequency is associated with response to PD-1 blockade in Merkel cell carcinoma

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Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor

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Subsets of interferon signaling predict response to immune checkpoint blockade in melanoma patients

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Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors

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Benzosceptrin C induces lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting DHHC3

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A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma

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Tumor-immune microenvironment and NRF2 associate with clinical efficacy of PD-1 blockade combined with chemotherapy in lung squamous cell carcinoma

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E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC

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Efficacy of sequential chemoradiotherapy combined with toripalimab in de novo metastatic nasopharyngeal carcinoma: A phase II trial

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Multi-kingdom gut microbiota analyses define bacterial-fungal interplay and microbial markers of pan-cancer immunotherapy across cohorts

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Anti-PD-1 immunotherapy with androgen deprivation therapy induces robust immune infiltration in metastatic castration-sensitive prostate cancer

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PD-L1 and HIF-2α Upregulation in Head and Neck Paragangliomas after Embolization

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Spatial metabolomics identifies distinct tumor-specific and stroma-specific subtypes in patients with lung squamous cell carcinoma

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Targeting VCP potentiates immune checkpoint therapy for colorectal cancer

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Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy

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Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity

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Engineering of dendritic cell bispecific extracellular vesicles for tumor-targeting immunotherapy

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Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin

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Clinical features associated with outcomes and biomarker analysis of dabrafenib plus trametinib treatment in patients with BRAF-mutant melanoma brain metastases

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Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors

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TOPK mediates immune evasion of Renal Cell Carcinoma via upregulating the expression of PD-L1

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Glycolytic enzyme HK2 promotes PD-L1 expression and breast cancer cell immune evasion

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ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation

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Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer

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Association of PD-1/PD-L1 Co-location with Immunotherapy Outcomes in Non-Small Cell Lung Cancer

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Premorbid use of selective beta-blockers improves sepsis incidence and course: Human cohort and animal model studies

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Apatinib remodels the immunosuppressive tumor ecosystem of gastric cancer enhancing anti-PD-1 immunotherapy

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Phenotypic plasticity and reduced tissue retention of exhausted tumor-infiltrating T cells following neoadjuvant immunotherapy in head and neck cancer

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MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer

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Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy

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Characterization of glycometabolism and tumor immune microenvironment for predicting clinical outcomes in gastric cancer

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Genomic and immune landscape Of metastatic pheochromocytoma and paraganglioma

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HRS regulates small extracellular vesicle PD-L1 secretion and is associated with anti-PD-1 treatment efficacy

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Cabozantinib plus durvalumab in advanced gastroesophageal cancer and other gastrointestinal malignancies: Phase Ib CAMILLA trial results

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Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance

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Multiplex chromogenic immunohistochemistry to stain and analyze paraffin tissue sections from the mouse or human

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Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts

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NF-κB-regulated VentX expression mediates tumoricidal effects of chemotherapeutics at noncytotoxic concentrations

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Defining the origin, evolution, and immune composition of SDH-deficient renal cell carcinoma

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Cancer cell intrinsic TIM-3 induces glioblastoma progression

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Integrated proteogenomic characterization across major histological types of pituitary neuroendocrine tumors

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Defining the Immune Checkpoint Landscape in Human Colorectal Cancer Highlights the Relevance of the TIGIT/CD155 Axis for Optimizing Immunotherapy

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PSEN1 is associated with colon cancer development via potential influences on PD-L1 nuclear translocation and tumor-immune interactions

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Gemcitabine combined with apatinib and toripalimab in recurrent or metastatic nasopharyngeal carcinoma

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Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα

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Multiregional single-cell proteogenomic analysis of ccRCC reveals cytokine drivers of intratumor spatial heterogeneity

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NRF2 Serves A Critical Role In Regulation Of Immune Checkpoint Proteins (ICPs) During Trophoblast Differentiation

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Delamination of trophoblast-like syncytia from the amniotic ectodermal analogue in human primed embryonic stem cell-based differentiation model

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The SETDB1–TRIM28 complex suppresses antitumor immunity

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WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC

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Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

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Intra-Tumoral CD8+ T-Cell Infiltration and PD-L1 Positivity in Homologous Recombination Deficient Pancreatic Ductal Adenocarcinoma

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Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-dependent Manner

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An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer

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PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II

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PD-L1 expression and patient outcomes in gastrointestinal neuroendocrine neoplasm: a meta-analysis

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Radiation induces epithelial to mesenchymal transition via upregulation of PD-L1 in nasopharyngeal carcinoma cell

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ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression

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Multiomic profiling of checkpoint inhibitor-treated melanoma: Identifying predictors of response and resistance, and markers of biological discordance

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Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance

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PD-L1 expression on circulating tumor cells and platelets in patients with metastatic breast cancer

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Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification

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Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation

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Neoadjuvant presurgical PD-1 inhibition in oral cavity squamous cell carcinoma

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Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy

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Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

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Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy

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Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions

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Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment.

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PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR

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Kynurenine/Tryptophan Ratio as a Potential Blood-Based Biomarker in Non-Small Cell Lung Cancer

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Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity

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Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus

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HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins

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Comprehensive molecular analysis of genomic profiles and PD-L1 expression in lung adenocarcinoma with a high-grade fetal adenocarcinoma component

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An optimized protocol for patient-derived xenograft in humanized mice to evaluate the role of IL-34 in immunotherapeutic resistance

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The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation

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Blocking Fra-1 sensitizes triple-negative breast cancer to PARP inhibitor

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Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma

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Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing

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A distinct innate immune signature marks progression from mild to severe COVID-19

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Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells

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Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma

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Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance

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Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras

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FOXD3 Regulates VISTA Expression in Melanoma

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Indoleamine 2,3-Dioxygenase 2 Immunohistochemical Expression in Resected Human Non-small Cell Lung Cancer: A Potential New Prognostic Tool

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  DOI: 10.3389/fimmu.2020.00839
  
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Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity

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  DOI: 10.1016/j.celrep.2020.01.076
  
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Tracing Oncogene Rearrangements in the Mutational History of Lung Adenocarcinoma

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  DOI: 10.1016/j.cell.2019.05.013
  
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Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy

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  DOI: 10.1016/j.ccell.2019.06.008
  
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Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy

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The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer

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  DOI: 10.1016/j.celrep.2019.04.098
  
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Untitled document

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Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy

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Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

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  DOI: 10.1016/j.cell.2019.02.016
  
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Integrated Multi-omic Analysis of Esthesioneuroblastomas Identifies Two Subgroups Linked to Cell Ontogeny

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Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient

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