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May 2026
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A blood-brain barrier-like vascular gate limits immunotherapy efficacy in neuroendocrine cancers

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1. scibot 08 May 2026
  
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  DOI: 10.1016/j.cell.2026.04.017
  
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pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Preclinical Characterization and Clinical Activity of RNK08954, a Highly Selective and Orally Bioavailable KRAS G12D Inhibitor

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  DOI: 10.1158/2159-8290.CD-25-1346
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13133609/
Apr 2026
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Functional genetic screens reveal key pathways instructing the molecular phenotypes of tumor-associated macrophages

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  DOI: 10.1158/2326-6066.CIR-25-0488
  
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aacrjournals.org/cancerimmunolres/article/13/12/2054/768330/Functional-Genetic-Screens-Reveal-Key-Pathways
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cd-25-1346-html.html

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54.241.53.176/86f1cde136cae9cb2b05401d7da6d7a0a1acbc52/cd-25-1346-html.html
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Activation of T cell-intrinsic p53 by acetylation elicits antitumor immunity to boost cancer immunotherapy

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1. scibot 23 Apr 2026
  
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aacrjournals.org/cancerdiscovery/article/16/1/155/771238/Activation-of-T-Cell-Intrinsic-p53-by-Acetylation
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Organ injury in systemic autoimmunity is mediated by stem-like CD8+ T cells arising from tissue-draining lymph nodes

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1. scibot 23 Apr 2026
  
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Mar 2026
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Radiotherapy synergizes with an inducible AAV-based immunotherapy platform to program local and systemic antitumor immunity

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1-s2.0-S2589004226007479-main-html.html

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54.241.53.176/e72524355eb321529f4dd9a65278a0820d03292a/1-s2.0-S2589004226007479-main-html.html
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Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer

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Feb 2026
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A Folate Receptor β-Targeted TLR7 Agonist Significantly Augments Checkpoint Inhibitor Potencies by Reprogramming Tumor-Associated Macrophages and Myeloid-Derived Suppressor Cells

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1. scibot 24 Feb 2026
  
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  DOI: 10.1021/acs.jmedchem.5c03277
  
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pubs.acs.org/doi/full/10.1021/acs.jmedchem.5c03277
Jan 2026
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PD-L1 is an intrinsic switch for natural killer cell-mediated, TRAIL-dependent antiviral function

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  DOI: 10.1016/j.celrep.2026.116939
  
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sciencedirect.com/science/article/pii/S2211124726000173
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METTL3/CD98-mediated glutamate efflux in CAFs drives CD8+ T cell exhaustion and impedes neoadjuvant immunochemotherapy

1
1. scibot 29 Jan 2026
  
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  DOI: 10.1016/j.celrep.2026.116933
  
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Microbiota utilization of intestinal amino acids modulates cancer progression and anticancer immunity

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1. scibot 06 Jan 2026
  
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  DOI: 10.1016/j.chom.2025.12.003
  
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sciencedirect.com/science/article/pii/S1931312825005220
Nov 2025
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Vitamin B6 preserves the stemness-like phenotypes and antitumor ability of CD8+ T cells

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1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.devcel.2025.10.017
  
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sciencedirect.com:5037/science/article/pii/S1534580725006914
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An immunometabolic prodrug strategy overcomes DHODH inhibitor resistance in refractory melanoma

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1. scibot 18 Nov 2025
  
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  DOI: 10.1186/s13046-025-03566-6
  
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link.springer.com/article/10.1186/s13046-025-03566-6
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Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions

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1. scibot 18 Nov 2025
  
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Sep 2025
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Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4

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1. scibot 27 Sep 2025
  
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  DOI: 10.1016/j.immuni.2025.09.003
  
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Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

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1. scibot 07 Sep 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-4378
  
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Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response

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  DOI: 10.1016/j.celrep.2025.115698
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12404271/
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SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer

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Aug 2025
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Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance

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Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells

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Jul 2025
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Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer

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1. scibot 02 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102211
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12281435/
Jun 2025
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A CXCR4 partial agonist improves immunotherapy by targeting immunosuppressive neutrophils and cancer-driven granulopoiesis

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Apr 2025
52.53.155.43 52.53.155.43

PDF-html.html

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  DOI: 10.1158/1078-0432.ccr-24-4024
  
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52.53.155.43/bea453311b69bdd211b414284d8c5a68ab7fa2b9/PDF-html.html
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Immune Checkpoint Blockade Delays Cancer Development and Extends Survival in DNA Polymerase Mutator Syndromes

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  DOI: 10.1158/0008-5472.CAN-24-2589
  
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Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells

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Feb 2025
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Bacteria-derived 3-hydroxydodecanoic acid induces a potent anti-tumor immune response via the GPR84 receptor

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Potentiating anti-tumor immunity by re-engaging immune synapse molecules

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  DOI: 10.1016/j.xcrm.2025.101975
  
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Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma

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  DOI: 10.1016/j.xcrm.2025.101977
  
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cir-24-0484-html.html

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  DOI: 10.1158/2326-6066.CIR-24-0484
  
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52.53.155.43/907147dca7b0350ae4d97a7f04ddc5ad1538a91e/cir-24-0484-html.html
Jan 2025
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PDF-html.html

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52.53.155.43/5dbe0329a290152b5bf622779f0aec9126a25d19/PDF-html.html
Dec 2024
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Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1

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1. scibot 14 Dec 2024
  
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Enhancing Immune Response and Survival in Hepatocellular Carcinoma with Novel Oncolytic Jurona Virus and Immune Checkpoint Blockade

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1. scibot 06 Dec 2024
  
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  DOI: 10.1016/j.omton.2024.200913
  
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52.53.155.43/b17d322494c44a28e0d2e52b4d7ea9e056092d31/Enhancing Immune Response and Survival in Hepatocellular Carcinoma with Novel Oncolytic Jurona Virus and Immune Checkpoint Blockade-html.html
Nov 2024
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Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint

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Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

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Oct 2024
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Trem2 deficiency attenuates breast cancer tumor growth in lean, but not obese or weight loss, mice and is associated with alterations of clonal T cell populations

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Protocol to quantify the activation dynamics of tumor-associated T cells in mice by functional intravital microscopy

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Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation

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Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity

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Voluntary exercise sensitizes cancer immunotherapy via the collagen inhibition-orchestrated inflammatory tumor immune microenvironment

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Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation

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Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8+ T cell exhaustion and anti-PD-1 resistance

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TNFR1 signaling promotes pancreatic tumor growth by limiting dendritic cell number and function

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Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer

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Immune Checkpoint Inhibition-related Neuroinflammation Disrupts Cognitive Function

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May 2024
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A computational pipeline for identifying gene targets and signalling pathways in cancer cells to improve lymphocyte infiltration and immune checkpoint therapy efficacy

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Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance

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Circadian tumor infiltration and function of CD8+ T cells dictate immunotherapy efficacy

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Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity

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The diversity of inhibitory receptor co-expression patterns of exhausted CD8+ T cells in oropharyngeal carcinoma

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IGSF8 is an innate immune checkpoint and cancer immunotherapy target

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Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade

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Mar 2024
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Vitamin D binding protein (VDBP) hijacks twist1 to inhibit vasculogenic mimicry in hepatocellular carcinoma

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Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer

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S100A9+CD14+ monocytes contribute to anti-PD-1 immunotherapy resistance in advanced hepatocellular carcinoma by attenuating T cell-mediated antitumor function

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Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth

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Feb 2024
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UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity

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RNA methyltransferase FTSJ3 regulates the type I interferon pathway to promote hepatocellular carcinoma immune evasion

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Jan 2024
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Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade

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Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors

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Dec 2023
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Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth

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cd-22-1301-html.html

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Oct 2023
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The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody enhances response to anti-PD-1 immunotherapy

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Sep 2023
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Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity

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Sex-Biased T-cell Exhaustion Drives Differential Immune Responses in Glioblastoma

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Aug 2023
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KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells

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CD39 inhibition and VISTA blockade may overcome radiotherapy resistance by targeting exhausted CD8+ T cells and immunosuppressive myeloid cells

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Selective targeting of IL2Rβγ combined with radiotherapy triggers CD8- and NK-mediated immunity, abrogating metastasis in HNSCC

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Membrane-localized neoantigens predict the efficacy of cancer immunotherapy

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Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNF-α

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Cancer-associated mesothelial cells are regulated by the anti-Müllerian hormone axis

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Apr 2023
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Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma

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Synergistic effects of combined immunotherapy strategies in a model of multifocal hepatocellular carcinoma

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Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy

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Feb 2023
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IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment

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Jul 2022
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Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

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Jun 2022
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Poroptosis: a form of cell death depending on plasma membrane nanopores formation

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Apr 2022
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mDKN-01, a Novel Anti-DKK1 mAb, Enhances Innate Immune Responses in the Tumor Microenvironment

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Feb 2022
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Flow cytometric analysis of CD4+ T cell reactivation following anti-PD1 immunotherapy in a transgenic mouse model

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Nov 2021
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Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

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Glut1 expression in tumor-associated neutrophils promotes lung cancer growth and resistance to radiotherapy

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Oct 2021
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Rapid Serial Immunoprofiling of the Tumor Immune Microenvironment by Fine Needle Sampling

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Sep 2021
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Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors

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  DOI: 10.1016/j.cell.2021.08.020
  
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Antigen and checkpoint receptor engagement recalibrates T cell receptor signal strength

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Activating a collaborative innate-adaptive immune response to control metastasis

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Aug 2021
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Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors

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  DOI: 10.1016/j.chom.2021.08.001
  
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Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts

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The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer

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Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

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  DOI: 10.1016/j.cell.2018.10.038
  
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Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop

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  DOI: 10.1016/j.cell.2021.05.027
  
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Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress

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  DOI: 10.1016/j.molcel.2021.02.038
  
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Dec 2020
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FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

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Sep 2020
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The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

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UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

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Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy

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Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ

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PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways

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RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer

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  DOI: 10.1016/j.ccell.2018.10.006
  
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Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures

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