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Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response

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SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer

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Aug 2025
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Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance

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Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells

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Jul 2025
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Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer

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Jun 2025
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A CXCR4 partial agonist improves immunotherapy by targeting immunosuppressive neutrophils and cancer-driven granulopoiesis

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Apr 2025
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52.53.155.43/bea453311b69bdd211b414284d8c5a68ab7fa2b9/PDF-html.html
Mar 2025
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Immune Checkpoint Blockade Delays Cancer Development and Extends Survival in DNA Polymerase Mutator Syndromes

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pmc.ncbi.nlm.nih.gov/articles/PMC11907192/
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Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells

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Feb 2025
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Bacteria-derived 3-hydroxydodecanoic acid induces a potent anti-tumor immune response via the GPR84 receptor

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Potentiating anti-tumor immunity by re-engaging immune synapse molecules

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Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma

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  DOI: 10.1016/j.xcrm.2025.101977
  
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cir-24-0484-html.html

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  DOI: 10.1158/2326-6066.CIR-24-0484
  
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52.53.155.43/907147dca7b0350ae4d97a7f04ddc5ad1538a91e/cir-24-0484-html.html
Jan 2025
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PDF-html.html

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52.53.155.43/5dbe0329a290152b5bf622779f0aec9126a25d19/PDF-html.html
Dec 2024
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Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1

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Enhancing Immune Response and Survival in Hepatocellular Carcinoma with Novel Oncolytic Jurona Virus and Immune Checkpoint Blockade

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1. scibot 06 Dec 2024
  
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  DOI: 10.1016/j.omton.2024.200913
  
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52.53.155.43/b17d322494c44a28e0d2e52b4d7ea9e056092d31/Enhancing Immune Response and Survival in Hepatocellular Carcinoma with Novel Oncolytic Jurona Virus and Immune Checkpoint Blockade-html.html
Nov 2024
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Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint

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1. scibot 24 Nov 2024
  
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Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

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1. scibot 08 Nov 2024
  
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  DOI: 10.1158/2326-6066.CIR-24-0463
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11532741/
Oct 2024
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Trem2 deficiency attenuates breast cancer tumor growth in lean, but not obese or weight loss, mice and is associated with alterations of clonal T cell populations

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  DOI: 10.1101/2024.09.25.614811
  
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biorxiv.org/content/10.1101/2024.09.25.614811v1
Sep 2024
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Protocol to quantify the activation dynamics of tumor-associated T cells in mice by functional intravital microscopy

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Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation

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Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity

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Voluntary exercise sensitizes cancer immunotherapy via the collagen inhibition-orchestrated inflammatory tumor immune microenvironment

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Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation

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Aug 2024
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Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8+ T cell exhaustion and anti-PD-1 resistance

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  DOI: 10.1016/j.xcrm.2024.101686
  
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TNFR1 signaling promotes pancreatic tumor growth by limiting dendritic cell number and function

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Jul 2024
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Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer

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  DOI: 10.1126/science.adh4567
  
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science.org/doi/10.1126/science.adh4567
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Immune Checkpoint Inhibition-related Neuroinflammation Disrupts Cognitive Function

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  DOI: 10.1101/2024.07.01.601087
  
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biorxiv.org/content/10.1101/2024.07.01.601087v1
May 2024
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A computational pipeline for identifying gene targets and signalling pathways in cancer cells to improve lymphocyte infiltration and immune checkpoint therapy efficacy

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  DOI: 10.1016/j.ebiom.2024.105167
  
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sciencedirect.com/science/article/pii/S2352396424002020
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Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance

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  DOI: 10.1016/j.immuni.2024.04.024
  
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Circadian tumor infiltration and function of CD8+ T cells dictate immunotherapy efficacy

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  DOI: 10.1016/j.cell.2024.04.015
  
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sciencedirect.com/science/article/pii/S0092867424004100
Apr 2024
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Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity

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The diversity of inhibitory receptor co-expression patterns of exhausted CD8+ T cells in oropharyngeal carcinoma

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  DOI: 10.1016/j.isci.2024.109668
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11035373/
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IGSF8 is an innate immune checkpoint and cancer immunotherapy target

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  DOI: 10.1016/j.cell.2024.03.039
  
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Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade

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  DOI: 10.1038/s41467-024-47069-y
  
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nature.com/articles/s41467-024-47069-y
Mar 2024
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Vitamin D binding protein (VDBP) hijacks twist1 to inhibit vasculogenic mimicry in hepatocellular carcinoma

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Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer

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S100A9+CD14+ monocytes contribute to anti-PD-1 immunotherapy resistance in advanced hepatocellular carcinoma by attenuating T cell-mediated antitumor function

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Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth

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Feb 2024
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UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity

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RNA methyltransferase FTSJ3 regulates the type I interferon pathway to promote hepatocellular carcinoma immune evasion

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Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade

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Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors

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Dec 2023
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Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth

1
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cd-22-1301-html.html

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Oct 2023
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The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody enhances response to anti-PD-1 immunotherapy

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Sep 2023
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Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity

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Sex-Biased T-cell Exhaustion Drives Differential Immune Responses in Glioblastoma

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KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells

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CD39 inhibition and VISTA blockade may overcome radiotherapy resistance by targeting exhausted CD8+ T cells and immunosuppressive myeloid cells

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Selective targeting of IL2Rβγ combined with radiotherapy triggers CD8- and NK-mediated immunity, abrogating metastasis in HNSCC

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Membrane-localized neoantigens predict the efficacy of cancer immunotherapy

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Jul 2023
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Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNF-α

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Cancer-associated mesothelial cells are regulated by the anti-Müllerian hormone axis

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Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma

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Synergistic effects of combined immunotherapy strategies in a model of multifocal hepatocellular carcinoma

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Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy

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Feb 2023
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IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment

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Jul 2022
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Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

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Jun 2022
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Poroptosis: a form of cell death depending on plasma membrane nanopores formation

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Apr 2022
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mDKN-01, a Novel Anti-DKK1 mAb, Enhances Innate Immune Responses in the Tumor Microenvironment

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Feb 2022
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Flow cytometric analysis of CD4+ T cell reactivation following anti-PD1 immunotherapy in a transgenic mouse model

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Nov 2021
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Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

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Glut1 expression in tumor-associated neutrophils promotes lung cancer growth and resistance to radiotherapy

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Oct 2021
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Rapid Serial Immunoprofiling of the Tumor Immune Microenvironment by Fine Needle Sampling

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Sep 2021
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Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors

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Antigen and checkpoint receptor engagement recalibrates T cell receptor signal strength

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Activating a collaborative innate-adaptive immune response to control metastasis

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1. scibot 03 Sep 2021
  
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  DOI: 10.1016/j.ccell.2021.08.005
  
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sciencedirect.com/science/article/pii/S1535610821004451
Aug 2021
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Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors

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1. scibot 28 Aug 2021
  
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  DOI: 10.1016/j.chom.2021.08.001
  
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Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts

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1. scibot 17 Aug 2021
  
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  DOI: 10.1016/j.celrep.2021.109422
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8362934/
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The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer

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1. scibot 15 Aug 2021
  
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  DOI: 10.1016/j.ccell.2021.07.007
  
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Jul 2021
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Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

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1. scibot 30 Jul 2021
  
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  DOI: 10.1016/j.cell.2018.10.038
  
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Jun 2021
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Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop

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1. scibot 22 Jun 2021
  
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  DOI: 10.1016/j.cell.2021.05.027
  
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May 2021
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Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress

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1. scibot 08 May 2021
  
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  DOI: 10.1016/j.molcel.2021.02.038
  
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sciencedirect.com/science/article/pii/S1097276521001684
Dec 2020
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FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

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1. scibot 31 Dec 2020
  
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  DOI: 10.1016/j.cell.2020.11.042
  
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Sep 2020
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The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

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1. scibot 26 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107827
  
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sciencedirect.com/science/article/pii/S2211124720308081
Jan 2020
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UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.cell.2019.08.032
  
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Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.08.068
  
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Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.immuni.2019.06.017
  
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PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.immuni.2019.11.003
  
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RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.ccell.2018.10.006
  
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Nov 2018
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Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures

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1. scibot 05 Nov 2018
  
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