Hypothesis

32 Matching Annotations

May 2026
www.pnas.org www.pnas.org

Metabolic stress conditions dictate MAPKAPK2-dependent efficiency of MEK1/2 inhibition in colorectal carcinoma

1
1. scibot 15 May 2026
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1073/pnas.2505331123
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

pnas.org/doi/10.1073/pnas.2505331123
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The SLC1A1/EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs

1
1. scibot 18 Nov 2025
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1038/s41467-025-64983-x
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12618888/
Jul 2025
www.sciencedirect.com www.sciencedirect.com

Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL

1
1. scibot 16 Jul 2025
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1016/j.cell.2025.06.027
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S0092867425007287
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Cold-inducible GOT1 activates the malate-aspartate shuttle in brown adipose tissue to support fuel preference for fatty acids

1
1. scibot 21 Jun 2025
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1016/j.celrep.2025.115888
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12294511/
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation

1
1. scibot 16 May 2025
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1016/j.celrep.2025.115625
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12184535/
Nov 2024
www.sciencedirect.com www.sciencedirect.com

ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion

1
1. scibot 24 Nov 2024
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1016/j.cmet.2024.10.015
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S155041312400411X
May 2024
www.sciencedirect.com www.sciencedirect.com

Targeted blocking of EGFR and GLUT1 by compound H reveals a new strategy for treatment of triple-negative breast cancer and nasopharyngeal carcinoma

1
1. scibot 07 May 2024
  
  in Public
  
  12939
  
  DOI: 10.1016/j.ejps.2024.106789
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @abever99
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S0928098724001003
Feb 2024
52.53.155.43 52.53.155.43

Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway

1
1. scibot 22 Feb 2024
  
  in Public
  
  RRID:AB_26 87899
  
  DOI: 10.1101/2023.10.02.560521
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @abever99
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

52.53.155.43/4a182fdd92d1ce35b13f136f7657c6c9ec6a6224/2023.10.02.560521v1.full-html.html
Jun 2023
52.53.155.43 52.53.155.43

Endothelial MRs mediate Western diet-induced lipid disorders and skeletal muscle insulin resistance in females

1
1. scibot 15 Jun 2023
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1210/endocr/bqad091
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

52.53.155.43/505020cd5ddad21196b5171a72c7e74f4f7d8201/bqad091-html.html
May 2023
www.degruyter.com www.degruyter.com

Inhibition of heterogeneous nuclear ribonucleoproteins A1 and oxidative stress reduces glycolysis pyruvate kinase M2 in chronic thromboembolic pulmonary hypertension

1
1. scibot 12 May 2023
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.2478/jtim-2022-0051
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

degruyter.com/document/doi/10.2478/jtim-2022-0051/html
Nov 2022
www.sciencedirect.com www.sciencedirect.com

Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease

1
1. scibot 01 Nov 2022
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1016/j.cmet.2022.10.002
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1550413122004533
Apr 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Ubiquitin-mediated receptor degradation contributes to development of tolerance to MrgC agonist-induced pain inhibition in neuropathic rats

1
1. scibot 02 Apr 2022
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1097/j.pain.0000000000002119
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7969388/
Dec 2021
www.frontiersin.org www.frontiersin.org

Extracellular Vesicles Induce an Aggressive Phenotype in Luminal Breast Cancer Cells Via PKM2 Phosphorylation

1
1. scibot 29 Dec 2021
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.3389/fonc.2021.785450
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

frontiersin.org/article/10.3389/fonc.2021.785450/full
Nov 2021
www.sciencedirect.com www.sciencedirect.com

TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment

1
1. scibot 17 Nov 2021
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1016/j.celrep.2021.110018
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S221112472101500X
www.sciencedirect.com www.sciencedirect.com

Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape

1
1. scibot 03 Nov 2021
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1016/j.cmet.2021.10.008
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1550413121004861
Sep 2021
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming

1
1. scibot 24 Sep 2021
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1016/j.cmet.2021.09.002
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

sciencedirect.com:5037/science/article/pii/S1550413121004216
Aug 2021
www.sciencedirect.com www.sciencedirect.com

ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma

1
1. scibot 01 Aug 2021
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1016/j.celrep.2021.109455
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S221112472100872X
Mar 2021
www.sciencedirect.com www.sciencedirect.com

SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells

1
1. scibot 17 Mar 2021
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1016/j.celrep.2021.108821
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124721001352
Feb 2021
www.nature.com www.nature.com

Metabolic conditioning of CD8 + effector T cells for adoptive cell therapy

1
1. scibot 26 Feb 2021
  
  in Public
  
  anti-Glut1
  
  DOI: 10.1038/s42255-020-0256-z
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899 RRIDCUR:Missing
Visit annotations in context

Tags

RRID:AB_2687899

RRIDCUR:Missing

Annotators

scibot

URL

nature.com/articles/s42255-020-0256-z
www.sciencedirect.com www.sciencedirect.com

PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis

1
1. scibot 25 Feb 2021
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1016/j.celrep.2021.108767
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRIDCUR:Validated RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

RRIDCUR:Validated

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124721000802
www.cell.com www.cell.com

Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab

1
1. scibot 24 Feb 2021
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1016/j.celrep.2020.01.012
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

cell.com/cell-reports/abstract/S2211-1247(20)30021-8
www.sciencedirect.com www.sciencedirect.com

The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma

1
1. scibot 20 Feb 2021
  
  in Public
  
  Rabbit monoclonal anti-GLUT1
  
  DOI: 10.1016/j.molcel.2020.12.046
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRIDCUR:Missing RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

RRIDCUR:Missing

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1097276520309886
Sep 2020
www.cell.com www.cell.com

Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab

1
1. scibot 26 Sep 2020
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1016/j.celrep.2020.01.012
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899 RRIDCUR:Validated
Visit annotations in context

Tags

RRID:AB_2687899

RRIDCUR:Validated

Annotators

scibot

URL

cell.com/cell-reports/abstract/S2211-1247(20)30021-8
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes

1
1. scibot 15 Sep 2020
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1038/s41598-020-69913-z
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899 RRIDCUR:Validated
Visit annotations in context

Tags

RRID:AB_2687899

RRIDCUR:Validated

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7400764/
www.sciencedirect.com www.sciencedirect.com

Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis

1
1. scibot 06 Sep 2020
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1016/j.chembiol.2020.04.003
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899 RRIDCUR:Validated
Visit annotations in context

Tags

RRID:AB_2687899

RRIDCUR:Validated

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2451945620301173
www.mdpi.com www.mdpi.com

Myoferlin Is a Yet Unknown Interactor of the Mitochondrial Dynamics’ Machinery in Pancreas Cancer Cells

1
1. scibot 03 Sep 2020
  
  in Public
  
  GLUT1
  
  DOI: 10.3390/cancers12061643
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2687899
  
  Curator comments: Glut1 (D3J3A) Rabbit Antibody Cell Signaling Technology Cat# 12939
  
  What is this?
  
  RRID:AB_2687899 RRIDCUR:Missing
Visit annotations in context

Tags

RRID:AB_2687899

RRIDCUR:Missing

Annotators

scibot

URL

mdpi.com/2072-6694/12/6/1643
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters

1
1. scibot 13 Jan 2020
  
  in Public
  
  AB_2687899
  
  DOI: 10.1016/j.chembiol.2019.05.009
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @Naa003
  
  SciCrunch record: AB_2687899
  
  What is this?
  
  RRID:AB_2687899 RRIDCUR:Validated
Visit annotations in context

Tags

RRID:AB_2687899

RRIDCUR:Validated

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2451945619301783
www.nature.com www.nature.com

eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1038/s41467-019-13086-5
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899 RRIDCUR:Validated
Visit annotations in context

Tags

RRID:AB_2687899

RRIDCUR:Validated

Annotators

scibot

URL

nature.com/articles/s41467-019-13086-5
www.sciencedirect.com www.sciencedirect.com

UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1016/j.celrep.2019.07.097
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899 RRIDCUR:Validated
Visit annotations in context

Tags

RRID:AB_2687899

RRIDCUR:Validated

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124719310137
www.sciencedirect.com www.sciencedirect.com

Protective role of GPR120 in the maintenance of pregnancy by promoting decidualization via regulation of glucose metabolism

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2687899
  
  DOI: 10.1016/j.ebiom.2018.12.019
  
  Resource: (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2687899
  
  What is this?
  
  RRID:AB_2687899 RRIDCUR:Validated
Visit annotations in context

Tags

RRID:AB_2687899

RRIDCUR:Validated

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2352396418305966
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_2687899
  
  Resource used:
  
  (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  SciCrunch record: RRID:AB_2687899
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_2687899
Visit annotations in context

Tags

RRID:AB_2687899

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1550413118305072
Nov 2017
www.sciencedirect.com www.sciencedirect.com

Paraoxonase 2 Facilitates Pancreatic Cancer Growth and Metastasis by Stimulating GLUT1-Mediated Glucose Transport

1
1. scibot 08 Nov 2017
  
  in Public
  
  GLUT1Cell Signaling TechnologyCat#12939
  
  Curator: @Jmenke
  
  Resource used:
  
  (Cell Signaling Technology Cat# 12939, RRID:AB_2687899)
  
  SciCrunch record: RRID:AB_2687899
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_2687899 RRIDCUR:Missing
Visit annotations in context

Tags

RRID:AB_2687899

RRIDCUR:Missing

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1097276517305087