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  1. Last 7 days
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    Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
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    sciencedirect.com/science/article/pii/S221112472400439X
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    The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia
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    sciencedirect.com/science/article/pii/S1535610824000941
  4. Apr 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The deubiquitinase cofactor UAF1 interacts with USP1 and plays an essential role in spermiogenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10999478/
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    Dimethyl fumarate covalently modifies Cys673 of NLRP3 to exert anti-inflammatory effects
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    ncbi.nlm.nih.gov/pmc/articles/PMC10995871/
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    Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10998861/
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    Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling
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    sciencedirect.com/science/article/pii/S2211124724004030
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    SRRM2 phase separation drives assembly of nuclear speckle subcompartments
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    sciencedirect.com/science/article/pii/S2211124724001554
  10. Mar 2024
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    Metaplastic regeneration in the mouse stomach requires a reactive oxygen species pathway
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    sciencedirect.com/science/article/pii/S1534580724001424
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    Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity
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    sciencedirect.com/science/article/pii/S2211124724003310
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    Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis
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    nature.com/articles/s41388-024-03008-1
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    Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions
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    sciencedirect.com/science/article/pii/S1074761324000906
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    Dietary protein restriction regulates skeletal muscle fiber metabolic characteristics associated with the FGF21-ERK1/2 pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10915561/
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    Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization
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    sciencedirect.com/science/article/pii/S1550413124000573
  17. Feb 2024
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    Helicobacter pylori CagA-mediated ether lipid biosynthesis promotes ferroptosis susceptibility in gastric cancer
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    BPS Publications
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      DOI: 10.1111/bph.16282

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16282
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    Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion
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    sciencedirect.com/science/article/pii/S2211124724000883
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    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
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      DOI: 10.1101/2023.12.05.570182

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      DOI: 10.1101/2023.12.05.570182

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      DOI: 10.1101/2023.12.05.570182

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    biorxiv.org/content/10.1101/2023.12.05.570182v1
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Investigating HMGB1 as a Potential Serum Biomarker for Early Diabetic Nephropathy Monitoring by Quantitative Proteomics
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    ncbi.nlm.nih.gov/pmc/articles/PMC10830865/
  23. Jan 2024
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    Serine synthesis sustains macrophage IL-1β production via NAD+-dependent protein acetylation
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    sciencedirect.com/science/article/pii/S1097276524000030
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    Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells
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    sciencedirect.com/science/article/pii/S1534580724000029
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    Exercise enhances placental labyrinth trophoblast development by activation of PGC-1α and FNDC5/irisin
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      DOI: 10.1093/biolre/ioad151

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    dx.doi.org/10.1093/biolre/ioad151
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    OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB
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    sciencedirect.com/science/article/pii/S1097276523010195
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    CHTOP Alleviates Cerebral Ischemia/Reperfusion-Induced Injury by Regulating RNA Alternative Splicing
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    ncbi.nlm.nih.gov/pmc/articles/PMC10770728/
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    Down-regulating nuclear factor of activated T cells 1 alleviates cognitive deficits in a mouse model of sepsis-associated encephalopathy, possibly by stimulating hippocampal neurogenesis
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      DOI: 10.1016/j.brainres.2023.148731

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    sciencedirect.com/science/article/pii/S0006899323005024
  30. Dec 2023
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    Hexamethylene amiloride synergizes with venetoclax to induce lysosome-dependent cell death in acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2589004223027682
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    YTHDF3 modulates the Cbln1 level by recruiting BTG2 and is implicated in the impaired cognition of prenatal hypoxia offspring
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      DOI: 10.1016/j.isci.2023.108703

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    sciencedirect.com/science/article/pii/S2589004223027803
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    Metabolic regulation of homologous recombination repair by MRE11 lactylation
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      DOI: 10.1016/j.cell.2023.11.022

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    sciencedirect.com/science/article/pii/S009286742301276X
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    Choroid plexus mast cells drive tumor-associated hydrocephalus
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      DOI: 10.1016/j.cell.2023.11.001

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    sciencedirect.com/science/article/pii/S0092867423011820
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    Upregulation of UHRF1 Promotes PINK1-mediated Mitophagy to Alleviates Ferroptosis in Diabetic Nephropathy
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      DOI: 10.1007/s10753-023-01940-0

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    link.springer.com/article/10.1007/s10753-023-01940-0
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    Autophagy is involved in degradation of AQP1 in response to an acute decrement in tonicity
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    sciencedirect.com/science/article/pii/S2589004223025622
  37. Nov 2023
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    A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis in mice via binding and relocating acetyl-coA carboxylase
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    sciencedirect.com/science/article/pii/S2211124723014651
  39. www.nature.com www.nature.com
    ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury
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      DOI: 10.1038/s41467-023-43439-0

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    nature.com/articles/s41467-023-43439-0
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    Targeting PRMT1-mediated SRSF1 methylation to suppress oncogenic exon inclusion events and breast tumorigenesis
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      DOI: 10.1016/j.celrep.2023.113385

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    sciencedirect.com/science/article/pii/S2211124723013979
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    AKAP150 from Nucleus Accumbens Dopamine D1 and D2 Receptor-Expressing Medium Spiny Neurons Regulates Morphine Withdrawal
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      DOI: 10.1016/j.isci.2023.108227

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    sciencedirect.com/science/article/pii/S2589004223023040
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    Culin5 aggravates hypoxic pulmonary hypertension by activating TRAF6/NF-κB/HIF-1α/VEGF
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      DOI: 10.1016/j.isci.2023.108199

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    sciencedirect.com/science/article/pii/S2589004223022769
  43. Oct 2023
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    K+/Cl− cotransporter 2 (KCC2) and Na+/[... formula ...] cotransporter 1 (NBCe1) interaction modulates profile of KCC2 phosphorylation
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    Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3
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    The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB
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    MRPL12-ANT3 interaction involves in acute kidney injury via regulating MPTP of tubular epithelial cells
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    Potential targets and mechanisms of photobiomodulation for... : Neural Regeneration Research
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    Characterisation of dominant-negative GH receptor variants reveals a potential therapeutic target for short stature
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    Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
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    PPT1 Regulation Of HSP90α Depalmitoylation Participates In The Pathogenesis Of Hyperandrogenism
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  103. academic.oup.com academic.oup.com
    iTRAQ-based proteomic analysis unveils ACSL4 as a novel potential regulator of human endometrial receptivity
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    SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2
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    Targeting BCAT1 combined with α-ketoglutarate triggers metabolic synthetic lethality in glioblastoma
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    The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region
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  114. Dec 2022
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    Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages
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  119. Nov 2022
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    NVP-BHG712 against postmenopausal osteoporosis in mice by targeting Cathepsin K
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  129. Oct 2022
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    Cortisol stimulates local progesterone withdrawal through induction of AKR1C1 in human amnion fibroblasts at parturition
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    Argininosuccinate lyase drives activation of mutant TERT promoter in glioblastomas
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    Androgen receptor suppresses β-adrenoceptor-mediated CREB activation and thermogenesis in brown adipose tissue of male mice
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    Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation
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    Necroptosis plays a crucial role in the exacerbation of... : Neural Regeneration Research
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    FBXL6 depletion restrains clear cell renal cell carcinoma progression
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  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration
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  138. Sep 2022
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    CTCF DNA-binding domain undergoes dynamic and selective protein–protein interactions
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    Alpha-Momorcharin Inhibits Proinflammatory Cytokine Expression by M1 Macrophages but Not Anti-Inflammatory Cytokine Expression by M2 Macrophages
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  141. Aug 2022
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    Chronic spinal cord compression associated with... : Neural Regeneration Research
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    A Novel ER Stress Mediator TMTC3 Promotes Squamous Cell Carcinoma Progression by Activating GRP78/PERK Signaling Pathway
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    NF-κB and AP-1 are required for the lipopolysaccharide-induced expression of MCP-1, CXCL1, and Cx43 in cultured rat dorsal spinal cord astrocytes
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  145. Jul 2022
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    Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma
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  147. nyaspubs.onlinelibrary.wiley.com nyaspubs.onlinelibrary.wiley.com
    Identification by RNA-Seq of let-7 clusters as prenatal biomarkers for nonsyndromic cleft lip with palate
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  148. Jun 2022
  149. 52.53.155.43 52.53.155.43
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    The Role of Ciliopathy-Associated Type 3 Adenylyl Cyclase in Infanticidal Behavior in Virgin Adult Male Mice
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    BMP4 Exerts Anti-Neurogenic Effect via Inducing Id3 during Aging
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  152. May 2022
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    SM22α-lineage niche cells regulate intramembranous bone regeneration via PDGFRβ-triggered hydrogen sulfide production
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  154. Apr 2022
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    GM1 ganglioside modifies microglial and neuroinflammatory responses to α-synuclein in the rat AAV-A53T α-synuclein model of Parkinson's disease
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    An oxygen-adaptive interaction between SNHG12 and occludin maintains blood-brain barrier integrity
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  157. Mar 2022
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    Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine
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  159. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    TIMP2 mediates endoplasmic reticulum stress contributing to sepsis-induced acute kidney injury
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  160. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VPS28 regulates brain vasculature by controlling neuronal VEGF trafficking through extracellular vesicle secretion
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    Single-cell sequencing reveals the new existence form of dermal papilla cells in the hair follicle regeneration of cashmere goats
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  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYCT1 alters the glycogen shunt by regulating selective translation of RACK1-mediated enzymes
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  163. journals.lww.com journals.lww.com
    Urolithin A alleviates blood-brain barrier disruption and... : Neural Regeneration Research
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  164. Feb 2022
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    Dysregulated lipid metabolism blunts the sensitivity of cancer cells to EZH2 inhibitor
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    Suppression of premature transcription termination leads to reduced mRNA isoform diversity and neurodegeneration
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    The spliceosome component Usp39 controls B cell development by regulating immunoglobulin gene rearrangement
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    Nicotinamide N-methyltransferase ameliorates renal fibrosis by its metabolite 1-methylnicotinamide inhibiting the TGF-β1/Smad3 pathway
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  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The ALDH Family Contributes to Immunocyte Infiltration, Proliferation and Epithelial-Mesenchymal Transformation in Glioma
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    Proteomics Study Reveals the Anti-Depressive Mechanisms and the Compatibility Advantage of Chaihu-Shugan-San in a Rat Model of Chronic Unpredictable Mild Stress
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  171. Jan 2022
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    Structure and transport mechanism of the human cholesterol transporter ABCG1
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    Identification of G protein-coupled receptor 55 (GPR55) as a target of curcumin
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    4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone provokes progression from chronic pancreatitis to pancreatic intraepithelial neoplasia
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  175. Dec 2021
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    MIR337-3p Enhances Mycobacterial Pathogenicity Involving TLR4/MYD88 and STAT3 Signals, Impairing VDR Antimicrobial Response and Fast-Acting Immunity
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  177. Nov 2021
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    Cadherin-12 Regulates Neurite Outgrowth Through the PKA/Rac1/Cdc42 Pathway in Cortical Neurons
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  179. Oct 2021
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    Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation
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    Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome
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    ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis
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    Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosis
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  184. Sep 2021
  185. www.sciencedirect.com www.sciencedirect.com
    Revisiting astrocyte to neuron conversion with lineage tracing in vivo
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  186. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation
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      DOI: 10.7554/eLife.62394

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    HOXA5 Is Recognized as a Prognostic-Related Biomarker and Promotes Glioma Progression Through Affecting Cell Cycle
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      DOI: 10.3389/fonc.2021.633430

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    Viral targeting of glioblastoma stem cells with patient-specific genetic and post-translational p53 deregulations
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    Growth Hormone Receptor (GHR) 6Ω Pseudoexon Activation: a Novel Cause of Severe Growth Hormone Insensitivity
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      DOI: 10.1210/clinem/dgab550

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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgab550/6329461
  190. Aug 2021
  191. www.sciencedirect.com www.sciencedirect.com
    Genetically variant human pluripotent stem cells selectively eliminate wild-type counterparts through YAP-mediated cell competition
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  192. www.sciencedirect.com www.sciencedirect.com
    Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis
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  193. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.scr.2018.101360

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  194. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      DOI: 10.1111/bph.14822

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  195. Jul 2021
  196. link.springer.com link.springer.com
    RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway
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      β-actin

      DOI: 10.1186/s40659-019-0268-x

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  197. www.sciencedirect.com www.sciencedirect.com
    Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense
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      Anti-β-Actin

      DOI: 10.1016/j.molcel.2019.11.003

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  198. elifesciences.org elifesciences.org
    USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication
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      beta Actin Mouse McAb

      DOI: 10.7554/eLife.48318

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  199. www.sciencedirect.com www.sciencedirect.com
    The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation
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  200. Jun 2021
  201. elifesciences.org elifesciences.org
    Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells
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  202. May 2021
  203. journals.physiology.org journals.physiology.org
    A novel tonicity-responsive microRNA miR-23a-5p modulates renal cell survival under osmotic stress through targeting heat shock protein 70 HSPA1B
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      DOI: 10.1152/ajpcell.00441.2020

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    Selective Translation of Cell Fate Regulators Mediates Tolerance to Broad Oncogenic Stress
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      DOI: 10.1016/j.stem.2020.05.007

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    Vertebrate cells differentially interpret ciliary and extraciliary cAMP
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      DOI: 10.1016/j.cell.2021.04.002

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    The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability
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  207. Apr 2021
  208. www.sciencedirect.com www.sciencedirect.com
    Acetylation of Cytidine Residues Boosts HIV-1 Gene Expression by Increasing Viral RNA Stability
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      DOI: 10.1016/j.chom.2020.05.011

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  209. www.cell.com www.cell.com
    Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance
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    Integrative Proteomic Characterization of Human Lung Adenocarcinoma
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      DOI: 10.1016/j.cell.2020.05.043

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    sciencedirect.com/science/article/pii/S0092867420306760
  211. Mar 2021
  212. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Asparagine Synthetase-Mediated l-Asparagine Metabolism Disorder Promotes the Perineural Invasion of Oral Squamous Cell Carcinoma
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      DOI: 10.3389/fonc.2021.637226

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  213. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Circadian clock genes promote glioma progression by affecting tumour immune infiltration and tumour cell proliferation
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  214. link.springer.com link.springer.com
    DHCR24 Knockdown Lead to Hyperphosphorylation of Tau at Thr181, Thr231, Ser262, Ser396, and Ser422 Sites by Membrane Lipid-Raft Dependent PP2A Signaling in SH-SY5Y Cells
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      DOI: 10.1007/s11064-021-03273-6

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    Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function
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  216. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence
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      DOI: 10.1096/fj.202001855RR

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  217. Feb 2021
  218. journals.plos.org journals.plos.org
    Harmine inhibits breast cancer cell migration and invasion by inducing the degradation of Twist1
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      anti-beta actin

      DOI: 10.1371/journal.pone.0247652

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  219. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Regulation of the firing activity by PKA‐PKC‐Src family kinases in cultured neurons of hypothalamic arcuate nucleus
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      DOI: 10.1002/jnr.24516

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  220. Dec 2020
  221. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes
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  222. Oct 2020
  223. onlinelibrary.wiley.com onlinelibrary.wiley.com
    IL‐1/IL‐1R signaling induced by all‐trans‐retinal contributes to complement alternative pathway activation in retinal pigment epithelium
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      DOI: 10.1002/jcp.30103

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  224. Sep 2020
  225. www.sciencedirect.com www.sciencedirect.com
    Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation
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    Pathogenic Variants in CEP85L Cause Sporadic and Familial Posterior Predominant Lissencephaly
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      DOI: 10.1016/j.neuron.2020.01.027

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  227. www.jbc.org www.jbc.org
    The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of alpha-synuclein
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    Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense
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  229. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  230. onlinelibrary.wiley.com onlinelibrary.wiley.com
    MicroRNA‐127‐5p impairs function of granulosa cells via HMGB2 gene in premature ovarian insufficiency
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      DOI: 10.1002/jcp.29725

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    1. scibot 03 Sep 2020
      RRID:AB_2687938

      DOI: 10.1111/bph.15159

      Resource: (Proteintech Cat# 66009-1-Ig, RRID:AB_2687938)

      Curator: @Naa003

      SciCrunch record: RRID:AB_2687938

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      RRID:AB_2687938 RRIDCUR:Validated
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15159
  232. Jan 2020
  233. www.jbc.org www.jbc.org
    Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia
    1
    1. scibot 13 Jan 2020
      RRID:AB_2687938

      DOI: 10.1074/jbc.RA118.006425

      Resource: (Proteintech Cat# 66009-1-Ig, RRID:AB_2687938)

      Curator: @Naa003

      SciCrunch record: RRID:AB_2687938

      What is this?

      RRID:AB_2687938 RRIDCUR:Validated
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    jbc.org/content/294/35/12921.full