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Targeting the ferritinophagy-lysosome axis as a therapeutic vulnerability in gastroenteropancreatic neuroendocrine tumors

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1. scibot 26 Mar 2026
  
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  DOI: 10.1016/j.xcrm.2026.102695
  
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sciencedirect.com/science/article/pii/S2666379126001126
Mar 2026
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Mitochondrial control of glycerolipid synthesis by a PEP shuttle

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1. scibot 20 Mar 2026
  
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  DOI: 10.1016/j.cell.2026.02.017
  
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sciencedirect.com/science/article/pii/S0092867426002242
Jan 2026
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Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder

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1. scibot 23 Jan 2026
  
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  DOI: 10.1016/j.cell.2025.12.012
  
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sciencedirect.com/science/article/pii/S0092867425014254
Dec 2025
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Mitochondrial glutamine import sustains electron transport chain integrity independently of glutaminolysis in cancer

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1. scibot 23 Dec 2025
  
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  DOI: 10.1016/j.molcel.2025.12.001
  
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sciencedirect.com:5037/science/article/pii/S109727652500975X
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The TIM22 carrier translocase supports cell proliferation by facilitating mitochondrial iron uptake for Fe-S biogenesis

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1. scibot 20 Dec 2025
  
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  DOI: 10.1016/j.molcel.2025.11.022
  
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sciencedirect.com:5037/science/article/pii/S1097276525009396
Nov 2025
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Goblet cell-expressed microprotein FXYD3 determines gut homeostasis by maintaining mucus barrier integrity

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1. scibot 05 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116502
  
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sciencedirect.com/science/article/pii/S2211124725012732
Sep 2025
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α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation

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1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.molcel.2025.08.022
  
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sciencedirect.com/science/article/pii/S1097276525007075
Aug 2025
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A mechano-resistance mechanism in skin adapts to terrestrial locomotion

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1. scibot 08 Aug 2025
  
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  DOI: 10.1016/j.cell.2025.07.012
  
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cell.com/cell/abstract/S0092-8674(25)00801-3
Jul 2025
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Ce6 derivative photodynamic therapy triggers PANoptosis and enhances antitumor immunity with LAG3 blockade in cutaneous squamous cell carcinoma

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1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102239
  
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sciencedirect.com/science/article/pii/S266637912500312X
Jun 2025
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Preclinical studies of BB-1701, a HER2-targeting eribulin-containing ADC with potent bystander effect and ICD activity

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1. scibot 26 Jun 2025
  
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  DOI: 10.1093/abt/tbae019
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11259758/
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DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation

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1. scibot 18 Jun 2025
  
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  DOI: 10.1038/s41594-025-01581-x
  
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nature.com/articles/s41594-025-01581-x
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Pre-clinical characterization of novel multi-client inhibitors of Sec61 with broad anti-tumor activity

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.jpet.2025.103634
  
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sciencedirect.com/science/article/pii/S0022356525398472
May 2025
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Impact of ATF6 deletion on the embryonic brain development

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1. scibot 20 May 2025
  
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  DOI: 10.1016/j.isci.2025.112569
  
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sciencedirect.com/science/article/pii/S2589004225008302
Apr 2025
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Coronin1A regulates the trafficking of alpha synuclein in microglia

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1. scibot 17 Apr 2025
  
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  DOI: 10.1523/JNEUROSCI.1337-24.2025
  
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jneurosci.org/content/45/11/e1337242025
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Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue

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1. scibot 08 Apr 2025
  
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  DOI: 10.1016/j.cmet.2025.03.009
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12137002/
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RAF1 kinase contributes to autophagic lysosome reformation

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1. scibot 05 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115490
  
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sciencedirect.com/science/article/pii/S221112472500261X
Feb 2025
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BACE1-dependent cleavage of GABAA receptor contributes to neural hyperexcitability and disease progression in Alzheimer’s disease

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1. scibot 27 Feb 2025
  
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  DOI: 10.1016/j.neuron.2025.01.030
  
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sciencedirect.com/science/article/pii/S0896627325000789
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Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST

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1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.cmet.2025.01.024
  
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sciencedirect.com/science/article/pii/S1550413125000245
Dec 2024
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Lurbinectedin sensitizes PD-L1 blockade therapy by activating STING-IFN signaling in small-cell lung cancer

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1. scibot 10 Dec 2024
  
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  DOI: 10.1016/j.xcrm.2024.101852
  
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sciencedirect.com/science/article/pii/S2666379124006232
Oct 2024
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Type I IFN drives unconventional IL-1β secretion in lupus monocytes

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1. scibot 09 Oct 2024
  
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  DOI: 10.1016/j.immuni.2024.09.004
  
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sciencedirect.com/science/article/pii/S1074761324004485
Sep 2024
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Cytoplasmic polyadenylation by TENT5A is required for proper bone formation

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1. scibot 25 Sep 2024
  
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  RRID:AB_2275208
  
  DOI: 10.1016/j.celrep.2021.109015
  
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sciencedirect.com/science/article/pii/S2211124721003296
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TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival

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1. scibot 12 Sep 2024
  
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  DOI: 10.1016/j.cell.2024.08.020
  
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sciencedirect.com/science/article/pii/S0092867424009115
Aug 2024
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Hyperglycemia induced cathepsin L maturation linked to diabetic comorbidities and COVID-19 mortality

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1. scibot 22 Aug 2024
  
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  DOI: 10.7554/eLife.92826
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11329274/
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Rapid phagosome isolation enables unbiased multiomic analysis of human microglial phagosomes

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.immuni.2024.07.019
  
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sciencedirect.com/science/article/pii/S1074761324003686
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SOX10 loss sensitizes melanoma cells to cytokine-mediated inflammatory cell death

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1. scibot 18 Aug 2024
  
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  DOI: 10.1158/1541-7786.MCR-23-0290
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10842433/
Jul 2024
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AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

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1. scibot 18 Jul 2024
  
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  DOI: 10.1038/s41422-024-00985-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11442470/
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Protocol for qualitative analysis of lysosome immunoprecipitation from patient-derived glioblastoma stem-like cells

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1. scibot 07 Jul 2024
  
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  DOI: 10.1016/j.xpro.2024.103121
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11215108/
Jun 2024
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Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8

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1. scibot 04 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114316
  
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sciencedirect.com/science/article/pii/S2211124724006442
Apr 2024
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

Calcineurin regulates synaptic Ca2+-permeable AMPA receptors in hypothalamic presympathetic neurons via α2δ-1-mediated GluA1/GluA2 assembly

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1. scibot 25 Apr 2024
  
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  DOI: 10.1113/JP286081
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/JP286081
Mar 2024
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Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease

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1. scibot 06 Mar 2024
  
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  DOI: 10.1016/j.molcel.2024.02.006
  
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sciencedirect.com/science/article/pii/S1097276524001254
Feb 2024
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NEMF-mediated Listerin-independent mitochondrial translational surveillance by E3 ligase Pirh2 and mitochondrial protease ClpXP

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1. scibot 29 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113860
  
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sciencedirect.com/science/article/pii/S2211124724001888
Jan 2024
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TALK-1-mediated alterations of β-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet

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1. scibot 18 Jan 2024
  
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  DOI: 10.1016/j.celrep.2024.113673
  
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sciencedirect.com/science/article/pii/S2211124724000019
Dec 2023
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Profiling nuclear cysteine ligandability and effects on nuclear localization using proximity labeling-coupled chemoproteomics

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1. scibot 17 Dec 2023
  
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  DOI: 10.1016/j.chembiol.2023.11.010
  
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sciencedirect.com/science/article/pii/S2451945623004257
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Isolating plasma extracellular vesicles from mouse blood using size-exclusion chromatography, density gradient, and ultracentrifugation

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1. scibot 15 Dec 2023
  
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  DOI: 10.1016/j.xpro.2023.102740
  
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sciencedirect.com/science/article/pii/S2666166723007074
Oct 2023
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Targeting VCP potentiates immune checkpoint therapy for colorectal cancer

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1. scibot 27 Oct 2023
  
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  RRID:AB_2688013
  
  DOI: 10.1016/j.celrep.2023.113318
  
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sciencedirect.com/science/article/pii/S221112472301330X
Aug 2023
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Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting

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  DOI: 10.1016/j.cmet.2023.07.002
  
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Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals

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Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles

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  DOI: 10.1038/s41598-023-30728-3
  
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Bile acids target mitofusin 2 to differentially regulate innate immunity in physiological versus cholestatic conditions

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Role for N-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 Spike maturation and viral infectivity

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Role for <i>N</i>-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 Spike maturation and viral infectivity.

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Jul 2022
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Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death

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α2δ-1 Protein Promotes Synaptic Expression of Ca2+ Permeable–AMPA Receptors by Inhibiting GluA1/GluA2 Heteromeric Assembly in the Hypothalamus in Hypertension

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Aug 2021
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Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose

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Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes

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Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study

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Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study

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Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance

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  DOI: 10.1016/j.ccell.2020.12.023
  
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Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis

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Jan 2021
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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

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Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain

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Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses

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  DOI: 10.1016/j.exer.2018.06.015
  
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Abnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B−/− Mice

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TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress

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An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State

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Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses

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Untitled document

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The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling

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