26 Matching Annotations
  1. Sep 2024
  2. www.biorxiv.org www.biorxiv.org
    Type-II kinase inhibitors that target Parkinson’s Disease-associated LRRK2
    1
    1. scibot 28 Sep 2024
      RRID:AB_2713963

      DOI: 10.1101/2024.09.17.613365

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    biorxiv.org/content/10.1101/2024.09.17.613365v1
  3. Jun 2024
  4. www.sciencedirect.com www.sciencedirect.com
    A designed ankyrin-repeat protein that targets Parkinson’s disease-associated LRRK2
    1
    1. scibot 21 Jun 2024
      RRID:AB_2713963

      DOI: 10.1016/j.jbc.2024.107469

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    sciencedirect.com/science/article/pii/S0021925824019707
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell-autonomous role of leucine-rich repeat kinase in the protection of dopaminergic neuron survival
    1
    1. scibot 13 Jun 2024
      RRID:AB_2713963

      DOI: 10.7554/eLife.92673

      Resource: (Abcam Cat# ab133474, RRID:AB_2713963)

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    ncbi.nlm.nih.gov/pmc/articles/PMC11164531/
  6. May 2024
  7. elifesciences.org elifesciences.org
    Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survival
    1
    1. scibot 03 May 2024
      RRID:AB_2713963

      DOI: 10.7554/eLife.92673.3

      Resource: (Abcam Cat# ab133474, RRID:AB_2713963)

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    elifesciences.org/reviewed-preprints/92673
  8. Feb 2024
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lysosomal stress drives the release of pathogenic α-synuclein from macrophage lineage cells via the LRRK2-Rab10 pathway
    1
    1. scibot 06 Feb 2024
      RRID:AB_2713963

      DOI: 10.1016/j.isci.2024.108893

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    ncbi.nlm.nih.gov/pmc/articles/PMC10835446/
  10. Oct 2023
  11. www.biorxiv.org www.biorxiv.org
    Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survival
    1
    1. scibot 31 Oct 2023
      RRID:AB_2713963

      DOI: 10.1101/2023.10.06.561293

      Resource: (Abcam Cat# ab133474, RRID:AB_2713963)

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    biorxiv.org/content/10.1101/2023.10.06.561293v5
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LRRK2 G2019S promotes astrocytic inflammation induced by oligomeric α-synuclein through NF-κB pathway
    1
    1. scibot 27 Oct 2023
      AB_2713963

      DOI: 10.1016/j.isci.2023.108130

      Resource: (Abcam Cat# ab133474, RRID:AB_2713963)

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    ncbi.nlm.nih.gov/pmc/articles/PMC10590863/
  13. Mar 2023
  14. www.sciencedirect.com www.sciencedirect.com
    Secretion of VGF relies on the interplay between LRRK2 and post-Golgi v-SNAREs
    1
    1. scibot 11 Mar 2023
      RRID:AB_2713963

      DOI: 10.1016/j.celrep.2023.112221

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    sciencedirect.com/science/article/pii/S2211124723002322
  15. Feb 2023
  16. www.nature.com www.nature.com
    Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology
    1
    1. scibot 17 Feb 2023
      RRID:AB_2713963

      DOI: 10.1038/s41531-023-00465-5

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    nature.com/articles/s41531-023-00465-5
  17. Nov 2022
  18. www.nature.com www.nature.com
    R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations
    1
    1. scibot 15 Nov 2022
      RRID:AB_2713963

      DOI: 10.1038/s42003-022-04136-8

      Resource: (Abcam Cat# ab133474, RRID:AB_2713963)

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    nature.com/articles/s42003-022-04136-8
  19. Oct 2022
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    D2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia
    1
    1. scibot 26 Oct 2022
      RRID:AB_2713963

      DOI: 10.1016/j.isci.2022.105263

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    ncbi.nlm.nih.gov/pmc/articles/PMC9579025/
  21. Jul 2022
  22. www.nature.com www.nature.com
    LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease
    1
    1. scibot 27 Jul 2022
      RRID:AB_2713963

      DOI: 10.1038/s41531-022-00354-3

      Resource: (Abcam Cat# ab133474, RRID:AB_2713963)

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    nature.com/articles/s41531-022-00354-3
  23. www.sciencedirect.com www.sciencedirect.com
    Rapid macropinocytic transfer of α-synuclein to lysosomes
    1
    1. scibot 27 Jul 2022
      RRID:AB_2713963

      DOI: 10.1016/j.celrep.2022.111102

      Resource: (Abcam Cat# ab133474, RRID:AB_2713963)

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    sciencedirect.com/science/article/pii/S2211124722009044
  24. Dec 2021
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson’s disease
    1
    1. scibot 15 Dec 2021
      RRID:AB_2713963

      DOI: 10.7554/eLife.73753

      Resource: (Abcam Cat# ab133474, RRID:AB_2713963)

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    ncbi.nlm.nih.gov/pmc/articles/PMC8660019/
  26. Nov 2021
  27. link.springer.com link.springer.com
    Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein
    1
    1. scibot 09 Nov 2021
      RRID:AB_2713963

      DOI: 10.1186/s40478-021-01283-7

      Resource: (Abcam Cat# ab133474, RRID:AB_2713963)

      Curator: @scibot

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    link.springer.com/article/10.1186/s40478-021-01283-7
  28. Oct 2021
  29. link.springer.com link.springer.com
    NME1 Protects Against Neurotoxin-, α-Synuclein- and LRRK2-Induced Neurite Degeneration in Cell Models of Parkinson’s Disease
    2
    1. scibot 12 Oct 2021
      ab133474

      DOI: 10.1007/s12035-021-02569-6

      Resource: (Abcam Cat# ab133474, RRID:AB_2713963)

      Curator: @Naa003

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      RRIDCUR:Missing RRID:AB_2713963
    2. scibot 12 Oct 2021
      ab133474

      DOI: 10.1007/s12035-021-02569-6

      Resource: (Abcam Cat# ab133474, RRID:AB_2713963)

      Curator: @Naa003

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      RRIDCUR:Missing RRID:AB_2713963
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    link.springer.com/article/10.1007/s12035-021-02569-6
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LRRK2 Kinase Activity Does Not Alter Cell-Autonomous Tau Pathology Development in Primary Neurons
    1
    1. scibot 11 Oct 2021
      RRID:AB_2713963

      DOI: 10.3233/JPD-212562

      Resource: (Abcam Cat# ab133474, RRID:AB_2713963)

      Curator: @scibot

      SciCrunch record: RRID:AB_2713963

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    ncbi.nlm.nih.gov/pmc/articles/PMC8461695/
  31. Aug 2021
  32. link.springer.com link.springer.com
    Untitled document
    1
    1. scibot 12 Aug 2021
      RRID:AB_2713963

      DOI: 10.1186/s40478-019-0679-5

      Resource: (Abcam Cat# ab133474, RRID:AB_2713963)

      Curator: @scibot

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      RRID:AB_2713963
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    link.springer.com/article/10.1186/s40478-019-0679-5
  33. Jul 2021
  34. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
    Untitled document
    1
    1. scibot 29 Jul 2021
      RRID:AB_2713963

      DOI: 10.1186/s40478-019-0679-5

      Resource: (Abcam Cat# ab133474, RRID:AB_2713963)

      Curator: @scibot

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    actaneurocomms.biomedcentral.com/articles/10.1186/s40478-019-0679-5
  35. Mar 2021
  36. www.sciencedirect.com www.sciencedirect.com
    Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes
    1
    1. scibot 26 Mar 2021
      RRID:AB_2713963

      DOI: 10.1016/j.cub.2021.02.061

      Resource: (Abcam Cat# ab133474, RRID:AB_2713963)

      Curator: @Naa003

      SciCrunch record: RRID:AB_2713963

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      RRIDCUR:Validated RRID:AB_2713963
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    sciencedirect.com/science/article/pii/S0960982221003055
  37. Sep 2020
  38. www.sciencedirect.com www.sciencedirect.com
    The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network
    1
    1. scibot 14 Sep 2020
      RRID:AB_2713963

      DOI: 10.1016/j.celrep.2020.107614

      Resource: (Abcam Cat# ab133474, RRID:AB_2713963)

      Curator: @ethanbadger

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      RRID:AB_2713963 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124720305635
  39. Jan 2020
  40. onlinelibrary.wiley.com onlinelibrary.wiley.com
    LRRK2 phosphorylation on synapsin I regulates glutamate release at presynaptic sites
    1
    1. scibot 13 Jan 2020
      RRID:AB_2713963

      DOI: 10.1111/jnc.14778

      Resource: (Abcam Cat# ab133474, RRID:AB_2713963)

      Curator: @Naa003

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      RRID:AB_2713963 RRIDCUR:Validated
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14778
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
    1
    1. scibot 13 Jan 2020
      RRID:AB_2713963

      DOI: 10.1186/s40478-019-0679-5

      Resource: (Abcam Cat# ab133474, RRID:AB_2713963)

      Curator: @evieth

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      RRID:AB_2713963 RRIDCUR:Validated
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    ncbi.nlm.nih.gov/pmc/articles/PMC6391792/
  42. Nov 2018
  43. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
    LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons
    1
    1. scibot 05 Nov 2018
      AB_2713963

      Curator: @evieth

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      (Abcam Cat# ab133474, RRID:AB_2713963)

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      RRID:AB_2713963 RRIDCUR:Validated
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    actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0550-0
  44. Nov 2017
  45. www.sciencedirect.com www.sciencedirect.com
    Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways
    1
    1. scibot 08 Nov 2017
      Ab133474

      Curator: @Jmenke

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      (Abcam Cat# ab133474, RRID:AB_2713963)

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      RRID:AB_2713963 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S2405471216304458