33 Matching Annotations
  1. Last 7 days
  2. www.sciencedirect.com www.sciencedirect.com
    LKB1 inactivation elicits an NNMT-mediated methyl sink and confers dependence on PRMT5 in lung cancer
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    sciencedirect.com/science/article/pii/S2211124726005656
  3. Mar 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR-Drug Combinatorial Screening Identifies Effective Combination Treatments for MTAP-deleted cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13014710/
  5. www.biorxiv.org www.biorxiv.org
    PRMT5 is Frequently Upregulated and a Potential Therapeutic Target in MTAP-deficient Malignant Peripheral Nerve Sheath Tumors
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    biorxiv.org/content/10.64898/2026.03.09.710638v1
  6. Feb 2026
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Repression of PRMT activities sensitize human homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment
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    pmc.ncbi.nlm.nih.gov/articles/PMC12867483/
  8. Dec 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combination of the MTA-Cooperative PRMT5 Inhibitor BMS-986504 and KRAS Inhibitors is an Effective Treatment Strategy for MTAP-Deleted KRAS-Mutant Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12717533/
  10. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    COP9 signalosome and PRMT5 methylosome complexes are essential regulators of Lis1-dynein-based transport
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    sciencedirect.com:5037/science/article/pii/S2211124725015086
  11. Nov 2025
  12. www.sciencedirect.com www.sciencedirect.com
    ID1 boosts antiviral immunity by countering PRMT5-mediated STING methylation
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    sciencedirect.com/science/article/pii/S221112472501318X
  13. Oct 2025
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PARP inhibitor and PRMT5 inhibitor synergy is independent of BRCA1/2 and MTAP status in breast cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12540990/
  15. Aug 2025
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The catalytic efficiency of METTL16 affects cellular processes by governing the intracellular S-adenosylmethionine setpoint
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    pmc.ncbi.nlm.nih.gov/articles/PMC12330366/
  17. Jul 2025
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The catalytic efficiency of METTL16 affects cellular processes by governing the intracellular S-adenosylmethionine setpoint
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    pmc.ncbi.nlm.nih.gov/articles/PMC12330366/
  19. Jun 2025
  20. 52.53.155.43 52.53.155.43
    1-s2.0-S258900422501226X-main-html.html
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    52.53.155.43/d1f78810f1eafd7cac950f9c8a5713f79fe4d700/1-s2.0-S258900422501226X-main-html.html
  21. Apr 2025
  22. www.cell.com www.cell.com
    PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms
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    cell.com/cell-reports/fulltext/S2211-1247(25)00255-4
  23. Mar 2025
  24. www.sciencedirect.com www.sciencedirect.com
    Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma
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    sciencedirect.com/science/article/pii/S1534580725001212
  25. Jan 2025
  26. www.sciencedirect.com www.sciencedirect.com
    Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy
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    sciencedirect.com/science/article/pii/S2211124724015560
  27. Sep 2024
  28. www.sciencedirect.com www.sciencedirect.com
    A chemical screen identifies PRMT5 as a therapeutic vulnerability for paclitaxel-resistant triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S2451945624003234
  29. May 2024
  30. www.biorxiv.org www.biorxiv.org
    Characterization of the skeletal muscle arginine methylome in health and disease reveals remodeling in Amyotrophic Lateral Sclerosis
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    biorxiv.org/content/10.1101/2024.01.08.574551v1
  31. Dec 2023
  32. www.sciencedirect.com www.sciencedirect.com
    PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition
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    sciencedirect.com/science/article/pii/S2666379123005438
  33. Nov 2023
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antitumor effects of PRMT5 inhibition in sarcomas
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    ncbi.nlm.nih.gov/pmc/articles/PMC10621483/
  35. aacrjournals.org aacrjournals.org
    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
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    aacrjournals.org/cancerdiscovery/article/13/11/2412/729848/MRTX1719-Is-an-MTA-Cooperative-PRMT5-Inhibitor
  36. www.embopress.org www.embopress.org
    MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression
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    embopress.org/doi/full/10.15252/embj.2023114558
  37. Sep 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistance
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    sciencedirect.com/science/article/abs/pii/S1535610823003215
  39. Jun 2023
  40. 52.53.155.43 52.53.155.43
    Disease Tolerance Acquired Through Repeated Plasmodium Infection Involves Epigenetic Reprogramming of Innate Immune Cells
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    52.53.155.43/5bbec45c5ee0125efd6c9cfa2bbd025875f2b7a1/2023.04.19.537546v1.full-html.html
  41. Jan 2022
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation
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    ncbi.nlm.nih.gov/pmc/articles/PMC8765754/
  43. Sep 2021
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Independent transcriptomic and proteomic regulation by type I and II protein arginine methyltransferases
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    ncbi.nlm.nih.gov/pmc/articles/PMC8417332/
  45. Aug 2021
  46. www.sciencedirect.com www.sciencedirect.com
    Molecular basis for substrate recruitment to the PRMT5 methylosome
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    sciencedirect.com/science/article/pii/S1097276521005888
  47. www.physiology.org www.physiology.org
    Protein arginine methyltransferase biology in humans during acute and chronic skeletal muscle plasticity
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    physiology.org/doi/abs/10.1152/japplphysiol.00142.2019
  48. Jun 2021
  49. www.sciencedirect.com www.sciencedirect.com
    Pharmacologic modulation of RNA splicing enhances anti-tumor immunity
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    sciencedirect.com/science/article/pii/S0092867421006905
  50. Mar 2021
  51. www.sciencedirect.com www.sciencedirect.com
    MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage
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    sciencedirect.com/science/article/pii/S1535610820306589
  52. Sep 2020
  53. www.sciencedirect.com www.sciencedirect.com
    Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling
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    sciencedirect.com/science/article/pii/S2211124720300796
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protein arginine methyltransferase biology in humans during acute and chronic skeletal muscle plasticity
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    ncbi.nlm.nih.gov/pmc/articles/PMC6766709/
  55. Jan 2020
  56. www.sciencedirect.com www.sciencedirect.com
    Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation
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    sciencedirect.com/science/article/pii/S1535610819303307
  57. www.sciencedirect.com www.sciencedirect.com
    Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss
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    sciencedirect.com/science/article/pii/S1535610819302569
  58. Nov 2017
  59. www.sciencedirect.com www.sciencedirect.com
    Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma
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    sciencedirect.com/science/article/pii/S153561081730363X