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Oct 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PARP inhibitor and PRMT5 inhibitor synergy is independent of BRCA1/2 and MTAP status in breast cancer cells

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1. scibot 25 Oct 2025
  
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  RRID:AB_2714013
  
  DOI: 10.1038/s41598-025-20696-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12540990/
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The catalytic efficiency of METTL16 affects cellular processes by governing the intracellular S-adenosylmethionine setpoint

1
1. scibot 10 Aug 2025
  
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  RRID:AB_2714013
  
  DOI: 10.1016/j.celrep.2025.115966
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12330366/
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The catalytic efficiency of METTL16 affects cellular processes by governing the intracellular S-adenosylmethionine setpoint

1
1. scibot 15 Jul 2025
  
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  RRID:AB_2714013
  
  DOI: 10.1016/j.celrep.2025.115966
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12330366/
Jun 2025
52.53.155.43 52.53.155.43

1-s2.0-S258900422501226X-main-html.html

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1. scibot 21 Jun 2025
  
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  RRID:AB_2714013
  
  DOI: 10.1016/j.isci.2025.112965
  
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52.53.155.43/d1f78810f1eafd7cac950f9c8a5713f79fe4d700/1-s2.0-S258900422501226X-main-html.html
Apr 2025
www.cell.com www.cell.com

PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms

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1. scibot 02 Apr 2025
  
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  RRID:AB_2714013
  
  DOI: 10.1016/j.celrep.2025.115484
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00255-4
Mar 2025
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Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma

1
1. scibot 29 Mar 2025
  
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  RRID:AB_2714013
  
  DOI: 10.1016/j.devcel.2025.02.016
  
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sciencedirect.com/science/article/pii/S1534580725001212
Jan 2025
www.sciencedirect.com www.sciencedirect.com

Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy

1
1. scibot 16 Jan 2025
  
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  RRID:AB_2714013
  
  DOI: 10.1016/j.celrep.2024.115205
  
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sciencedirect.com/science/article/pii/S2211124724015560
Sep 2024
www.sciencedirect.com www.sciencedirect.com

A chemical screen identifies PRMT5 as a therapeutic vulnerability for paclitaxel-resistant triple-negative breast cancer

1
1. scibot 04 Sep 2024
  
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  AB_2714013
  
  DOI: 10.1016/j.chembiol.2024.08.003
  
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sciencedirect.com/science/article/pii/S2451945624003234
May 2024
www.biorxiv.org www.biorxiv.org

Characterization of the skeletal muscle arginine methylome in health and disease reveals remodeling in Amyotrophic Lateral Sclerosis

1
1. scibot 03 May 2024
  
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  RRID:AB_2714013
  
  DOI: 10.1101/2024.01.08.574551
  
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biorxiv.org/content/10.1101/2024.01.08.574551v1
Dec 2023
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PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition

1
1. scibot 20 Dec 2023
  
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  RRID:AB_2714013
  
  DOI: 10.1016/j.xcrm.2023.101326
  
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sciencedirect.com/science/article/pii/S2666379123005438
Nov 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Antitumor effects of PRMT5 inhibition in sarcomas

1
1. scibot 09 Nov 2023
  
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  RRID:AB_2714013
  
  DOI: 10.1158/2767-9764.CRC-23-0239
  
  Resource: (Cell Signaling Technology Cat# 13222, RRID:AB_2714013)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10621483/
aacrjournals.org aacrjournals.org

MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer

1
1. scibot 03 Nov 2023
  
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  RRID:AB_2714013
  
  DOI: 10.1158/2159-8290.CD-23-0669
  
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aacrjournals.org/cancerdiscovery/article/13/11/2412/729848/MRTX1719-Is-an-MTA-Cooperative-PRMT5-Inhibitor
www.embopress.org www.embopress.org

MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression

1
1. scibot 03 Nov 2023
  
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  RRID:AB_2714013
  
  DOI: 10.15252/embj.2023114558
  
  Resource: (Cell Signaling Technology Cat# 13222, RRID:AB_2714013)
  
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embopress.org/doi/full/10.15252/embj.2023114558
Sep 2023
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Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistance

1
1. scibot 30 Sep 2023
  
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  RRID:AB_2714013
  
  DOI: 10.1016/j.ccell.2023.09.005
  
  Resource: (Cell Signaling Technology Cat# 13222, RRID:AB_2714013)
  
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sciencedirect.com/science/article/abs/pii/S1535610823003215
Jun 2023
52.53.155.43 52.53.155.43

Disease Tolerance Acquired Through Repeated Plasmodium Infection Involves Epigenetic Reprogramming of Innate Immune Cells

1
1. scibot 01 Jun 2023
  
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  RRID:AB_2714013
  
  DOI: 10.1101/2023.04.19.537546
  
  Resource: (Cell Signaling Technology Cat# 13222, RRID:AB_2714013)
  
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52.53.155.43/5bbec45c5ee0125efd6c9cfa2bbd025875f2b7a1/2023.04.19.537546v1.full-html.html
Jan 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation

1
1. scibot 22 Jan 2022
  
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  RRID:AB_2714013
  
  DOI: 10.7554/eLife.72867
  
  Resource: (Cell Signaling Technology Cat# 13222, RRID:AB_2714013)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8765754/
Sep 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Independent transcriptomic and proteomic regulation by type I and II protein arginine methyltransferases

1
1. scibot 14 Sep 2021
  
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  RRID:AB_2714013
  
  DOI: 10.1016/j.isci.2021.102971
  
  Resource: (Cell Signaling Technology Cat# 13222, RRID:AB_2714013)
  
  Curator: @evieth
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8417332/
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Molecular basis for substrate recruitment to the PRMT5 methylosome

1
1. scibot 06 Aug 2021
  
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  AB_2714013
  
  DOI: 10.1016/j.molcel.2021.07.019
  
  Resource: (Cell Signaling Technology Cat# 13222, RRID:AB_2714013)
  
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sciencedirect.com/science/article/pii/S1097276521005888
www.physiology.org www.physiology.org

Protein arginine methyltransferase biology in humans during acute and chronic skeletal muscle plasticity

1
1. scibot 02 Aug 2021
  
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  RRID:AB_2714013
  
  DOI: 10.1152/japplphysiol.00142.2019
  
  Resource: (Cell Signaling Technology Cat# 13222, RRID:AB_2714013)
  
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physiology.org/doi/abs/10.1152/japplphysiol.00142.2019
Jun 2021
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Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

1
1. scibot 25 Jun 2021
  
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  RRID:AB_2714013
  
  DOI: 10.1016/j.cell.2021.05.038
  
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sciencedirect.com/science/article/pii/S0092867421006905
Mar 2021
www.sciencedirect.com www.sciencedirect.com

MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage

1
1. scibot 01 Mar 2021
  
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  RRID:AB_2714013
  
  DOI: 10.1016/j.ccell.2020.12.010
  
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sciencedirect.com/science/article/pii/S1535610820306589
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling

1
1. scibot 23 Sep 2020
  
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  RRID:AB_2714013
  
  DOI: 10.1016/j.celrep.2020.01.054
  
  Resource: (Cell Signaling Technology Cat# 13222, RRID:AB_2714013)
  
  Curator: @ethanbadger
  
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  RRID:AB_2714013 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720300796
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Protein arginine methyltransferase biology in humans during acute and chronic skeletal muscle plasticity

1
1. scibot 16 Sep 2020
  
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  RRID:AB_2714013
  
  DOI: 10.1152/japplphysiol.00142.2019
  
  Resource: (Cell Signaling Technology Cat# 13222, RRID:AB_2714013)
  
  Curator: @evieth
  
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  RRIDCUR:Validated RRID:AB_2714013
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ncbi.nlm.nih.gov/pmc/articles/PMC6766709/
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2714013
  
  DOI: 10.1016/j.ccell.2019.07.003
  
  Resource: (Cell Signaling Technology Cat# 13222, RRID:AB_2714013)
  
  Curator: @ethanbadger
  
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  RRID:AB_2714013 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610819303307
www.sciencedirect.com www.sciencedirect.com

Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2714013
  
  DOI: 10.1016/j.ccell.2019.05.014
  
  Resource: (Cell Signaling Technology Cat# 13222, RRID:AB_2714013)
  
  Curator: @ethanbadger
  
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  RRID:AB_2714013 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610819302569
Nov 2017
www.sciencedirect.com www.sciencedirect.com

Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma

1
1. scibot 08 Nov 2017
  
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  13222
  
  Curator: @Jmenke
  
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  (Cell Signaling Technology Cat# 13222, RRID:AB_2714013)
  
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  RRID:AB_2714013 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S153561081730363X