67 Matching Annotations
  1. Last 7 days
  2. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70201
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    O304 is a mitochondrial uncoupler which extends C. elegans lifespan and induces vasorelaxation of rat mesenteric arteries
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    sciencedirect.com/science/article/pii/S0009279725004181
  4. Sep 2025
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    Pathogenic phosphorylation of linear ubiquitin machinery causes inflammasome sensor degradation
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    sciencedirect.com/science/article/pii/S2211124725010575
  6. Jul 2025
  7. behavioralandbrainfunctions.biomedcentral.com behavioralandbrainfunctions.biomedcentral.com
    C18:0 GM3 ganglioside’s efficacy in LPS-induced parkinsonism: neuroprotection, inflammatory inhibition and gliosis mitigation
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    behavioralandbrainfunctions.biomedcentral.com/articles/10.1186/s12993-025-00289-8
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    Alistipes finegoldii augments the efficacy of immunotherapy against solid tumors
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    sciencedirect.com/science/article/pii/S1535610825002739
  9. www.cell.com www.cell.com
    A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner
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    cell.com/cell-chemical-biology/fulltext/S2451-9456(25)00200-4
  10. May 2025
  11. elifesciences.org elifesciences.org
    ATP-release pannexin channels are gated by lysophospholipids
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    elifesciences.org/articles/107067
  12. Apr 2025
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Constructed transferrin receptor-targeted liposome for the delivery of fluvoxamine to improve prognosis in a traumatic brain injury mouse model
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    pmc.ncbi.nlm.nih.gov/articles/PMC12001850/
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    Constructed transferrin receptor-targeted liposome for the delivery of fluvoxamine to improve prognosis in a traumatic brain injury mouse model
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    tandfonline.com/doi/abs/10.1080/10717544.2025.2486840
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    Cannabinoid CB2 receptor controls chronic itch by regulating spinal microglial activation and synaptic transmission
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    sciencedirect.com/science/article/pii/S2211124725003304
  16. Feb 2025
  17. aacrjournals.org aacrjournals.org
    LRRC75A-AS1 drives the epithelial-mesenchymal transition in cervical cancer by binding IGF2BP1 and inhibiting SYVN1-mediated NLRP3 ubiquitination
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    aacrjournals.org/mcr/article/22/12/1075/750095/LRRC75A-AS1-Drives-the-Epithelial-Mesenchymal
  18. Dec 2024
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11624267/
  20. Nov 2024
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    Vitamin D alleviates HFD-induced hepatic fibrosis by inhibiting DNMT1 to affect the TGFβ1/Smad3 pathway
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    sciencedirect.com/science/article/pii/S2589004224024878
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Arctiin Alleviates Atopic Dermatitis Against Inflammation and Pyroptosis Through Suppressing TLR4/MyD88/NF-κB and NLRP3/Caspase-1/GSDMD Signaling Pathways
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    pmc.ncbi.nlm.nih.gov/articles/PMC11539860/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial transplantation confers protection against the effects of ischemic stroke by repressing microglial pyroptosis and promoting neurogenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11467935/
  24. Oct 2024
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming
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    ncbi.nlm.nih.gov/pmc/articles/PMC11438333/
  26. Jul 2024
  27. www.sciencedirect.com www.sciencedirect.com
    TERT activation targets DNA methylation and multiple aging hallmarks
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    sciencedirect.com/science/article/pii/S0092867424005920
  28. www.nature.com www.nature.com
    Table 1 Antibody table.
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    nature.com/articles/s41420-024-02048-6/tables/1
  29. May 2024
  30. 52.53.155.43 52.53.155.43
    mcr-23-0478-html.html
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  31. Apr 2024
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Association of DNA methylation/demethylation with the functional outcome of stroke in a hyperinflammatory state
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    ncbi.nlm.nih.gov/pmc/articles/PMC11034580/
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  34. Mar 2024
  35. www.sciencedirect.com www.sciencedirect.com
    Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L
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    sciencedirect.com/science/article/pii/S2211124724003267
  36. Jan 2024
  37. dx.doi.org dx.doi.org
    cwad087-html.html
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    dx.doi.org/10.1093/glycob/cwad087
  38. Dec 2023
  39. www.sciencedirect.com www.sciencedirect.com
    ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation
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    sciencedirect.com/science/article/pii/S1097276523009607
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Macrophage IL-1β-positive microvesicles exhibit thrombo-inflammatory properties and are detectable in patients with active juvenile idiopathic arthritis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10703381/
  41. Nov 2023
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC10675918/
  43. dx.doi.org dx.doi.org
    cwad087-html.html
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    dx.doi.org/10.1093/glycob/cwad087
  44. Oct 2023
  45. www.sciencedirect.com www.sciencedirect.com
    HDL inhibits pancreatic acinar cell NLRP3 inflammasome activation and protect against acinar cell pyroptosis in acute pancreatitis
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    sciencedirect.com/science/article/pii/S1567576923012754
  46. Sep 2023
  47. 52.53.155.43 52.53.155.43
    Molecular Oncology - 2023 - Horie-html.html
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    52.53.155.43/b5e8e877c627d157950951119edc64db79086ad6/Molecular Oncology - 2023 - Horie-html.html
  48. Aug 2023
  49. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    HIF-1α inhibition in macrophages preserves acute liver failure by reducing IL-1β production
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202300428RR
  50. May 2023
  51. www.sciencedirect.com www.sciencedirect.com
    IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance
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    sciencedirect.com/science/article/pii/S1097276523003350
  52. Mar 2023
  53. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    CARD-only proteins regulate in vivo inflammasome responses and ameliorate gout
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    pubmed.ncbi.nlm.nih.gov/36930645/
  54. Jan 2023
  55. www.sciencedirect.com www.sciencedirect.com
    Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy
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    sciencedirect.com/science/article/pii/S1097276522011376
  56. Dec 2022
  57. www.sciencedirect.com www.sciencedirect.com
    Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis
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    sciencedirect.com/science/article/pii/S2211124722016205
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Low-dose ganciclovir ameliorates dextran sulfate sodium-induced ulcerative colitis through inhibiting macrophage STING activation in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC9714675/
  59. Nov 2022
  60. www.sciencedirect.com www.sciencedirect.com
    Commensal cow Roseburia reduces gut-dysbiosis-induced mastitis through inhibiting bacterial translocation by producing butyrate in mice
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    sciencedirect.com/science/article/pii/S2211124722015558
  61. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15949
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection
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    ncbi.nlm.nih.gov/pmc/articles/PMC9623368/
  63. Jun 2022
  64. www.sciencedirect.com www.sciencedirect.com
    Targeting EP2 receptor with multifaceted mechanisms for high-risk neuroblastoma
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    sciencedirect.com/science/article/pii/S2211124722007896
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    Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease
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    sciencedirect.com/science/article/pii/S0896627322004500
  66. Apr 2022
  67. www.sciencedirect.com www.sciencedirect.com
    Hexokinase 1 cellular localization regulates the metabolic fate of glucose
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    sciencedirect.com/science/article/pii/S1097276522001666
  68. Mar 2022
  69. www.sciencedirect.com www.sciencedirect.com
    Delicate regulation of IL-1β-mediated inflammation by cyclophilin A
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    sciencedirect.com/science/article/pii/S2211124722002492
  70. Feb 2022
  71. www.sciencedirect.com www.sciencedirect.com
    Macrophage IL-1β promotes arteriogenesis by autocrine STAT3- and NF-κB-mediated transcription of pro-angiogenic VEGF-A
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    sciencedirect.com/science/article/pii/S2211124722000213
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chemogenetic manipulation of microglia inhibits neuroinflammation and neuropathic pain in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC7897256/
  73. Dec 2021
  74. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15720
  75. Sep 2021
  76. www.nature.com www.nature.com
    Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation
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    nature.com/articles/s41401-021-00754-w
  77. Aug 2021
  78. www.sciencedirect.com www.sciencedirect.com
    Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death
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    sciencedirect.com/science/article/pii/S0092867421008850
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    sciencedirect.com/science/article/pii/S2211124718315316
  80. Jul 2021
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6372082/
  82. www.sciencedirect.com www.sciencedirect.com
    β2-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression
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    sciencedirect.com/science/article/pii/S1074761321002648
  83. Jun 2021
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC8188380/
  85. Apr 2021
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optogenetic activation of spinal microglia triggers chronic pain in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC8011727/
  87. Feb 2021
  88. www.cell.com www.cell.com
    Legionella-Infected Macrophages Engage the Alveolar Epithelium to Metabolically Reprogram Myeloid Cells and Promote Antibacterial Inflammation
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    cell.com/cell-host-microbe/fulltext/S1931-3128(20)30422-4
  89. Jan 2021
  90. www.sciencedirect.com www.sciencedirect.com
    Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation
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    sciencedirect.com/science/article/pii/S1535610820306607
  91. Sep 2020
  92. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15182
  93. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15026
  94. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Astaxanthin attenuates hepatic damages and mitochondrial dysfunction in nonalcoholic fatty liver disease by up‐regulating the FGF21/PGC‐1α pathway
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15099
  95. May 2020
  96. link.springer.com link.springer.com
    Distribution of IL-1β immunoreactive cells in pancreatic biopsies from living volunteers with new-onset type 1 diabetes: comparison with donors without diabetes and with longer duration of disease
    1
    1. nPOD_Curator 15 May 2020
      The immunohistochemical specificity of anti-IL-1β (catalogue no. 12242; Cell Signaling Technology) has been validated by the manufacturer. Thus, by immunohistochemistry, it successfully detects IL-1β immunoreactive cells in human colonic sections from individuals with chronic colitis. Further, by western blotting, the same antibody detects mature recombinant human and mouse IL-1β and the human precursor (molecular mass of 34 kDa) in extracts of Raw 264.7 and human monocyte-derived THP-1 cells, following exposure to Brefeldin and lipopolysaccharide (LPS), respectively. Anti-IL-1β was replaced with diluent to act as negative controls. As further controls, paraffin sections of THP-1 cells, harvested after incubation with LPS (100 ng/ml for 3 h) and without (from Cell Signaling Technology), were evaluated in this laboratory for IL-1β immunohistochemical specificity. The immunostaining protocol for IL-1β was tested with formalin-fixed tonsil sections, supplied by Department of Surgery, University of Auckland. Sections from selected pancreas and tonsil were immunostained for IL-1β in two separate sections. They were then exposed to rabbit anti-CD68 or rabbit anti-CD3, followed by donkey anti-rabbit IgG-biotin and then streptavidin–Alexa 568. Pancreatic sections were immunostained subsequently for insulin as above, followed by donkey anti-guinea pig IgG–Alexa 488.

      IHC for IL-1b

      obiwan:Method PMID:29589071 RRID:AB_2715503
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    link.springer.com/article/10.1007/s00125-018-4600-8
  97. Jan 2020
  98. iovs.arvojournals.org iovs.arvojournals.org
    Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All-trans Retinal
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    iovs.arvojournals.org/article.aspx
  99. www.sciencedirect.com www.sciencedirect.com
    Exercise Reverses Behavioral and Synaptic Abnormalities after Maternal Inflammation
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    sciencedirect.com/science/article/pii/S2211124719306266
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    sciencedirect.com/science/article/pii/S1097276518309882
  101. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Inactivation of endothelial adenosine A2A receptors protects mice from cerebral ischaemia‐induced brain injury
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14673
  102. Nov 2018
  103. www.sciencedirect.com www.sciencedirect.com
    Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages
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    sciencedirect.com/science/article/pii/S1074761318303844
  104. Nov 2017
  105. www.sciencedirect.com www.sciencedirect.com
    NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation
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    sciencedirect.com/science/article/pii/S1097276517306147