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NAT-A exhibits anti-tumor activity against acquired epidermal growth factor receptor- tyrosine kinase inhibitor-resistant non-small cell lung cancer via inhibiting the β-catenin/PKM2 axis

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1. scibot 01 Oct 2026
  
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  DOI: 10.1016/j.tranon.2026.103042
  
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sciencedirect.com/science/article/pii/S1936523326003785
Mar 2026
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Pyruvate is a natural suppressor of interferon signaling by inducing STAT1 protein pyruvylation

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1. scibot 03 Mar 2026
  
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  DOI: 10.1016/j.cell.2026.01.023
  
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sciencedirect.com/science/article/pii/S0092867426001108
Nov 2025
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Menin-MLL1 complex cooperates with NF-Y to promote hepatocellular carcinoma survival

1
1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116619
  
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sciencedirect.com:5037/science/article/pii/S2211124725013919
Sep 2025
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Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity

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1. scibot 12 Sep 2025
  
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  DOI: 10.1016/j.neuron.2025.08.016
  
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sciencedirect.com/science/article/pii/S0896627325006221
Jun 2025
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Pyruvate kinase M2 (PKM2) tetramerization protects against hepatic stellate cell activation and liver fibrosis

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1. scibot 13 Jun 2025
  
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  DOI: 10.1016/j.ajpath.2020.08.002
  
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sciencedirect.com/science/article/pii/S0002944020303722
Jan 2025
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Metabolic reprogramming of macrophages by PKM2 promotes IL-10 production via adenosine

1
1. scibot 14 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115172
  
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sciencedirect.com/science/article/pii/S2211124724015237
Nov 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Imbalance in glucose metabolism regulates the transition of microglia from homeostasis to Disease Associated Microglia stage 1

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1. scibot 23 Nov 2024
  
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  DOI: 10.1523/JNEUROSCI.1563-23.2024
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11097271/
Sep 2024
onlinelibrary.wiley.com onlinelibrary.wiley.com

Function of a complex of p-Y42 RhoA GTPase and pyruvate kinase M2 in EGF signaling pathway in glioma cells

1
1. scibot 27 Sep 2024
  
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  DOI: 10.1111/jnc.16210
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.16210
Aug 2024
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SIRT1 improves lactate homeostasis in the brain to alleviate parkinsonism via deacetylation and inhibition of PKM2

1
1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.xcrm.2024.101684
  
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sciencedirect.com/science/article/pii/S2666379124004051
Jul 2024
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Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells

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1. scibot 31 Jul 2024
  
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  DOI: 10.1016/j.stem.2024.07.003
  
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sciencedirect.com/science/article/pii/S1934590924002534
May 2024
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An evolutionarily conserved mechanism controls reversible amyloids of pyruvate kinase via pH-sensing regions

1
1. scibot 24 May 2024
  
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  DOI: 10.1016/j.devcel.2024.04.018
  
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sciencedirect.com/science/article/pii/S1534580724002715
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Retinal metabolism displays evidence for uncoupling of glycolysis and oxidative phosphorylation via Cori-, Cahill-, and mini-Krebs-cycle

1
1. scibot 15 May 2024
  
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  DOI: 10.7554/eLife.91141
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11090511/
Apr 2024
52.53.155.43 52.53.155.43

JNEUROSCI.1563-23.2024.full (1)-html.html

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1. scibot 26 Apr 2024
  
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  DOI: 10.1523/jneurosci.1563-23.2024
  
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52.53.155.43/3d13c66ed91f2e0714f85e7c6a7de97c0df74a89/JNEUROSCI.1563-23.2024.full (1)-html.html
Jan 2024
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Augmentation of scleral glycolysis promotes myopia through histone lactylation

1
1. scibot 19 Jan 2024
  
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  RRID:AB_2715534
  
  DOI: 10.1016/j.cmet.2023.12.023
  
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sciencedirect.com/science/article/pii/S1550413123004746
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Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer

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1. scibot 06 Jan 2024
  
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  DOI: 10.1016/j.cmet.2023.12.003
  
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sciencedirect.com/science/article/pii/S1550413123004552
May 2023
www.degruyter.com www.degruyter.com

Inhibition of heterogeneous nuclear ribonucleoproteins A1 and oxidative stress reduces glycolysis pyruvate kinase M2 in chronic thromboembolic pulmonary hypertension

1
1. scibot 12 May 2023
  
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  RRID:AB_2715534
  
  DOI: 10.2478/jtim-2022-0051
  
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degruyter.com/document/doi/10.2478/jtim-2022-0051/html
Apr 2023
www.nature.com www.nature.com

The RNA-binding protein landscapes differ between mammalian organs and cultured cells

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1. scibot 18 Apr 2023
  
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  RRID:AB_2715534
  
  DOI: 10.1038/s41467-023-37494-w
  
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nature.com/articles/s41467-023-37494-w
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Neurons require glucose uptake and glycolysis in vivo

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1. scibot 07 Apr 2023
  
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  RRID:AB_2715534
  
  DOI: 10.1016/j.celrep.2023.112335
  
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sciencedirect.com/science/article/pii/S2211124723003467
Jan 2023
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Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation

1
1. scibot 28 Jan 2023
  
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  RRID:AB_2715534
  
  DOI: 10.1016/j.celrep.2022.111897
  
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sciencedirect.com/science/article/pii/S221112472201796X
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Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

1
1. scibot 12 Jan 2023
  
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  RRID:AB_2715534
  
  DOI: 10.1158/0008-5472.CAN-21-2352
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9256808/
Jul 2022
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Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis

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1. scibot 27 Jul 2022
  
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  RRID:AB_2715534
  
  DOI: 10.1016/j.chembiol.2022.06.011
  
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sciencedirect.com/science/article/pii/S2451945622002434
Jun 2022
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Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis

1
1. scibot 25 Jun 2022
  
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  DOI: 10.1016/j.molcel.2022.06.005
  
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sciencedirect.com/science/article/pii/S109727652200541X
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Identification of metabolic pathways underlying FGF1 and CHIR99021-mediated cardioprotection

1
1. scibot 09 Jun 2022
  
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  RRID:AB_2715534
  
  DOI: 10.1016/j.isci.2022.104447
  
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sciencedirect.com/science/article/pii/S2589004222007180
Mar 2022
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Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease

1
1. scibot 27 Mar 2022
  
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  RRID:AB_2715534
  
  DOI: 10.1016/j.cmet.2022.02.013
  
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sciencedirect.com/science/article/pii/S1550413122000857
Feb 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Targeting Pyruvate Kinase M2 phosphorylation reverses aggressive cancer phenotypes

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1. scibot 16 Feb 2022
  
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  RRID:AB_2715534
  
  DOI: 10.1158/0008-5472.CAN-20-4190
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8373815/
Oct 2021
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Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy

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1. scibot 26 Oct 2021
  
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  RRID:AB_2715534
  
  DOI: 10.1016/j.molcel.2021.10.001
  
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sciencedirect.com/science/article/pii/S1097276521008005
Jun 2021
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Oncogene-regulated release of extracellular vesicles

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1. scibot 12 Jun 2021
  
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  RRID:AB_2715534
  
  DOI: 10.1016/j.devcel.2021.05.014
  
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sciencedirect.com/science/article/pii/S1534580721004433
Feb 2021
academic.oup.com academic.oup.com

LncRNA-Malat1 is involved in lipotoxicity-induced β-cell dysfunction and the therapeutic effect of exendin-4 via Ptbp1

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1. scibot 25 Feb 2021
  
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  RRID:AB_2715534
  
  DOI: 10.1210/endocr/bqaa065
  
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academic.oup.com/endo/article/161/7/bqaa065/5824261
Oct 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PKM2 Determines Myofiber Hypertrophy In Vitro and Increases in Response to Resistance Exercise in Human Skeletal Muscle

1
1. scibot 31 Oct 2020
  
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  RRID:AB_2715534
  
  DOI: 10.3390/ijms21197062
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7583908/
Sep 2020
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Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway

1
1. scibot 23 Sep 2020
  
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  RRID:AB_2715534
  
  DOI: 10.1016/j.celrep.2020.01.037
  
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sciencedirect.com/science/article/pii/S2211124720300528
Jan 2020
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Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA

1
1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.chembiol.2019.11.010
  
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sciencedirect.com/science/article/pii/S2451945619303927
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Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2715534
  
  DOI: 10.1016/j.cmet.2019.10.015
  
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sciencedirect.com/science/article/pii/S1550413119306060
Nov 2018
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Genetic Modulation of RNA Splicing with a CRISPR-Guided Cytidine Deaminase

1
1. scibot 05 Nov 2018
  
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  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S109727651830741X
Nov 2017
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MYC Controls Human Pluripotent Stem Cell Fate Decisions through Regulation of Metabolic Flux

1
1. scibot 08 Nov 2017
  
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  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S1934590917303363