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Selective degradation of TBK1 uncovers mechanistic insights into blocking ccRCC progression

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1. scibot 09 Apr 2026
  
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  DOI: 10.1016/j.chembiol.2026.03.013
  
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sciencedirect.com/science/article/pii/S2451945626001054
Dec 2025
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Mitochondrial VHL rewires cell metabolism in hypoxia

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1. scibot 23 Dec 2025
  
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  DOI: 10.1016/j.cmet.2025.11.013
  
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sciencedirect.com:5037/science/article/pii/S1550413125005273
Nov 2025
54.241.53.176 54.241.53.176

gotthardt-et-al-2025-cysteine-reactive-covalent-chloro-n-acetamide-ligands-induce-ferroptosis-mediated-cell-death-html.html

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1. scibot 23 Nov 2025
  
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  DOI: 10.1038/s44319-025-00593-4
  
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54.241.53.176/63994eedfd6c98b86dee1f70deb73962649e18d0/gotthardt-et-al-2025-cysteine-reactive-covalent-chloro-n-acetamide-ligands-induce-ferroptosis-mediated-cell-death-html.html
Oct 2025
54.241.53.176 54.241.53.176

gotthardt-et-al-2025-cysteine-reactive-covalent-chloro-n-acetamide-ligands-induce-ferroptosis-mediated-cell-death-html.html

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1. scibot 21 Oct 2025
  
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  AB_2716279
  
  DOI: 10.1038/s44319-025-00593-4
  
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54.241.53.176/63994eedfd6c98b86dee1f70deb73962649e18d0/gotthardt-et-al-2025-cysteine-reactive-covalent-chloro-n-acetamide-ligands-induce-ferroptosis-mediated-cell-death-html.html
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells

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1. scibot 21 May 2025
  
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  DOI: 10.7554/eLife.101299
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12055005/
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Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.chembiol.2025.04.008
  
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sciencedirect.com/science/article/pii/S245194562500131X
Mar 2025
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HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy

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1. scibot 04 Mar 2025
  
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  DOI: 10.1016/j.cell.2025.01.046
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11988688/
Jan 2025
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Conserved patterns of transcriptional dysregulation, heterogeneity, and cell states in clear cell kidney cancer

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1. scibot 14 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115169
  
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sciencedirect.com/science/article/pii/S2211124724015201
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TFE3 fusions direct an oncogenic transcriptional program that drives OXPHOS and unveils vulnerabilities in translocation renal cell carcinoma

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1. scibot 26 Aug 2024
  
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  DOI: 10.1101/2024.08.09.607311
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11326252/
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The BET PROTAC inhibitor GNE-987 displays anti-tumor effects by targeting super-enhancers regulated gene in osteosarcoma

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1. scibot 18 Aug 2024
  
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  RRID:AB_2716279
  
  DOI: 10.1186/s12885-024-12691-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11292958/
Feb 2024
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The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation

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1. scibot 16 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113792
  
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sciencedirect.com/science/article/pii/S2211124724001207
Jan 2024
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Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma

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1. scibot 11 Jan 2024
  
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  RRID:AB_2716279
  
  DOI: 10.1016/j.molcel.2023.12.010
  
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sciencedirect.com/science/article/pii/S1097276523010298
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma

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1. scibot 04 Aug 2023
  
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  RRID:AB_2716279
  
  DOI: 10.1016/j.isci.2023.107369
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10393801/
Jul 2023
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Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics

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1. scibot 01 Jul 2023
  
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  RRID:AB_2716279
  
  DOI: 10.1016/j.chom.2023.05.030
  
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sciencedirect.com/science/article/pii/S1931312823002238
Nov 2022
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Pan-cancer analysis of tissue and single-cell HIF-pathway activation using a conserved gene signature

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1. scibot 16 Nov 2022
  
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  RRID:AB_2716279
  
  DOI: 10.1016/j.celrep.2022.111652
  
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sciencedirect.com/science/article/pii/S2211124722015236
Sep 2022
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Target protein localization and its impact on PROTAC-mediated degradation

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1. scibot 08 Sep 2022
  
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  RRID:AB_2716279
  
  DOI: 10.1016/j.chembiol.2022.08.004
  
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sciencedirect.com/science/article/pii/S2451945622003129
Jun 2022
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An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma

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1. scibot 29 Jun 2022
  
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  RRID:AB_2716279
  
  DOI: 10.1016/j.molcel.2022.06.003
  
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sciencedirect.com/science/article/pii/S1097276522005391
May 2022
www.cell.com www.cell.com

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer

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1. scibot 05 May 2022
  
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  RRID:AB_2716279
  
  DOI: 10.1016/j.cell.2022.04.014
  
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cell.com/cell/fulltext/S0092-8674(22)00461-5
Mar 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Profiling of diverse tumor types establishes the broad utility of VHL-based ProTaCs and triages candidate ubiquitin ligases

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1. scibot 18 Mar 2022
  
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  DOI: 10.1016/j.isci.2022.103985
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8919295/
Feb 2022
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Histone chaperone FACT complex coordinates with HIF to mediate an expeditious transcription program to adapt to poorly oxygenated cancers

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1. scibot 02 Feb 2022
  
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  DOI: 10.1016/j.celrep.2022.110304
  
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sciencedirect.com/science/article/pii/S221112472200016X
Sep 2021
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A strategy to assess the cellular activity of E3 ligase components against neo-substrates using electrophilic probes

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1. scibot 09 Sep 2021
  
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  DOI: 10.1016/j.chembiol.2021.08.007
  
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sciencedirect.com/science/article/pii/S2451945621003962
Sep 2020
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Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss

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1. scibot 15 Sep 2020
  
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  RRID:AB_2716279
  
  DOI: 10.1016/j.molcel.2020.01.009
  
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sciencedirect.com/science/article/pii/S1097276520300095
Jan 2020
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EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.chembiol.2019.11.004
  
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sciencedirect.com/science/article/pii/S2451945619303629