Hypothesis

53 Matching Annotations

Jan 2026
insight.jci.org insight.jci.org

CD4+ and CD8+ T cells are not the main driver of Lassa fever pathogenesis in macaques

1
1. scibot 09 Jan 2026
  
  in Public
  
  simianized anti-CD4 antibody (clone CD4R1; NHP reagent resource)
  
  DOI: 10.1172/jci.insight.199235
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @giovanni.decastro
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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insight.jci.org/articles/view/199235
Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CD4+ T Cells Are Key to Shaping a Protective Humoral Immunity in Primary Dengue 2 Virus Infection: Implications for Rational Vaccine Design

1
1. scibot 18 Dec 2025
  
  in Public
  
  anti-CD4 monoclonal antibody [clone CD4R1]
  
  DOI: 10.3390/vaccines13111103
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @giovanni.decastro
  
  SciCrunch record: RRID:AB_2716322
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12656844/
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The pentameric complex is not required for congenital CMV transmission in seronegative rhesus macaques

1
1. scibot 26 Jul 2025
  
  in Public
  
  recombinant RM CD4–depleting antibody (CD4R1 clone; NIH Nonhuman Primate Reagent Resource)
  
  DOI: 10.1126/scitranslmed.adm8961
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @giovanni.decastro
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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pmc.ncbi.nlm.nih.gov/articles/PMC12208562/
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Desensitization With Proteasome Inhibition and Costimulation Blockade Modulates the Xenoreactive Humoral Response in Nonhuman Primate Xenotransplantation

1
1. scibot 13 Jun 2025
  
  in Public
  
  anti‐CD4mAb (clone CD4R1; NHPRR)
  
  DOI: 10.1111/xen.70045
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @giovanni.decastro
  
  SciCrunch record: RRID:AB_2716322
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12012413/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Prolonged xenokidney graft survival in sensitized NHP recipients by expression of multiple human transgenes in a triple knockout pig

1
1. scibot 19 Mar 2025
  
  in Public
  
  AB_2716322
  
  DOI: 10.1126/scitranslmed.adk6152
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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pmc.ncbi.nlm.nih.gov/articles/PMC11328991/
www.mdpi.com www.mdpi.com

Making a Monkey out of Human Immunodeficiency Virus/Simian Immunodeficiency Virus Pathogenesis: Immune Cell Depletion Experiments as a Tool to Understand the Immune Correlates of Protection and Pathogenicity in HIV Infection

1
1. scibot 08 Mar 2025
  
  in Public
  
  CD4R1
  
  DOI: 10.3390/v16060972
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @giovanni.decastro
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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mdpi.com/1999-4915/16/6/972
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity

1
1. scibot 01 Mar 2025
  
  in Public
  
  Cat#PR-0407
  
  DOI: 10.1038/s41467-025-56419-3
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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pmc.ncbi.nlm.nih.gov/articles/PMC11782611/
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Intravenous BCG-mediated protection against tuberculosis requires CD4+ T cells and CD8α+ lymphocytes

1
1. scibot 08 Feb 2025
  
  in Public
  
  RRID:AB_2716322
  
  DOI: 10.1084/jem.20241571
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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pmc.ncbi.nlm.nih.gov/articles/PMC11801270/
Aug 2024
www.researchsquare.com www.researchsquare.com

Home

1
1. scibot 02 Aug 2024
  
  in Public
  
  anti-CD4 Ab CD4R1 (NHP Reagent Resource; https://www.nhpreagents.org
  
  DOI: 10.21203/rs.3.rs-1220220/v1
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322 RRIDCUR:Missing
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RRID:AB_2716322

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URL

researchsquare.com/article/rs-7216019/'https://www.researchsquare.com/article/rs-7216019/v1
May 2024
www.biorxiv.org www.biorxiv.org

CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques

1
1. scibot 23 May 2024
  
  in Public
  
  RRID:AB_2716322
  
  DOI: 10.1101/2024.05.14.594183
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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biorxiv.org/content/10.1101/2024.05.14.594183v1
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Antibody-mediated depletion of select leukocyte subsets in blood and tissue of nonhuman primates

1
1. scibot 27 Mar 2024
  
  in Public
  
  AB_2716322
  
  DOI: 10.3389/fimmu.2024.1359679
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC10961357/
Feb 2024
www.biorxiv.org www.biorxiv.org

Antibody-mediated depletion of select T cell subsets in blood and tissue of nonhuman primates

2
1. scibot 15 Feb 2024
  
  in Public
  
  RRID:AB_2716322
  
  DOI: 10.1101/2023.12.22.572898
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
2. scibot 15 Feb 2024
  
  in Public
  
  RRID:AB_2716322
  
  DOI: 10.1101/2023.12.22.572898
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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biorxiv.org/content/10.1101/2023.12.22.572898v1
Nov 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CD4+ levels control the odds of induction of humoral immune responses to tracer doses of therapeutic antibodies

1
1. scibot 08 Nov 2023
  
  in Public
  
  anti-CD4 (CD4R1)
  
  DOI: 10.1371/journal.pone.0187912
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC5679608/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients

1
1. scibot 08 Nov 2023
  
  in Public
  
  anti-CD4 mAb (CD4R1
  
  DOI: 10.1111/ajt.15067
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC7185755/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Daratumumab in Sensitized Kidney Transplantation: Potentials and Limitations of Experimental and Clinical Use

1
1. scibot 08 Nov 2023
  
  in Public
  
  anti-CD4 mAb (CD4R1)
  
  DOI: 10.1681/ASN.2018121254
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC6622431/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients

1
1. scibot 08 Nov 2023
  
  in Public
  
  anti-CD4 mAb (CD4R1
  
  DOI: 10.1681/ASN.2019030304
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC6900797/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Prolonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeys

1
1. scibot 08 Nov 2023
  
  in Public
  
  anti-CD4 antibody (CD4R1
  
  DOI: 10.1038/s41467-023-36379-2
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC9946951/
Oct 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

LMP1-deficient Epstein-Barr virus mutant requires T cells for lymphomagenesis

1
1. scibot 25 Oct 2023
  
  in Public
  
  CD4R1
  
  DOI: 10.1172/JCI76357
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC4382240/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Xenoantigen Deletion and Chemical Immunosuppression Can Prolong Renal Xenograft Survival.

1
1. scibot 25 Oct 2023
  
  in Public
  
  cloneCD4R1
  
  DOI: 10.1097/SLA.0000000000002977
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC6382078/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys

1
1. scibot 25 Oct 2023
  
  in Public
  
  CD4R1
  
  DOI: 10.1172/jci.insight.94002
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC5499366/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

An HIV gp120-CD4 Immunogen Does Not Elicit Autoimmune Antibody Responses in Cynomolgus Macaques

1
1. scibot 25 Oct 2023
  
  in Public
  
  CD4R1
  
  DOI: 10.1128/CVI.00115-16
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC4933776/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Maternal CD4+ T cells protect against severe congenital cytomegalovirus disease in a novel nonhuman primate model of placental cytomegalovirus transmission

1
1. scibot 25 Oct 2023
  
  in Public
  
  CD4R1
  
  DOI: 10.1073/pnas.1511526112
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC4640765/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Inhibitory Effect of Individual or Combinations of Broadly Neutralizing Antibodies and Antiviral Reagents against Cell-Free and Cell-to-Cell HIV-1 Transmission

1
1. scibot 25 Oct 2023
  
  in Public
  
  CD4-directed antibodies huOKT4A and hu5A8
  
  DOI: 10.1128/JVI.00783-15
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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URL

ncbi.nlm.nih.gov/pmc/articles/PMC4505680/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Mechanisms of reactivation of latent tuberculosis infection due to SIV coinfection

1
1. scibot 25 Oct 2023
  
  in Public
  
  CD4R1
  
  DOI: 10.1172/JCI125810
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC6877319/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys

1
1. scibot 25 Oct 2023
  
  in Public
  
  Cdr-OKT4A-huIgG1; clone 12F11
  
  DOI: 10.1172/JCI33814
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC2391063/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Intestinal proteomic analysis of a novel non-human primate model of experimental colitis reveals signatures of mitochondrial and metabolic dysfunction

1
1. scibot 25 Oct 2023
  
  in Public
  
  anti-CD4R1
  
  DOI: 10.1038/s41385-019-0200-2
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC7673647/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection

1
1. scibot 07 Oct 2023
  
  in Public
  
  RRID:AB_2716322
  
  DOI: 10.1371/journal.ppat.1011646
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC10553354/
Jun 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CD4+ levels control the odds of induction of humoral immune responses to tracer doses of therapeutic antibodies

1
1. scibot 16 Jun 2023
  
  in Public
  
  NIH Nonhuman Primate Reagent Resource (R24 OD010976, and NIAID contract HHSN 272201300031C) for providing humanized and rhesus recombinant anti-CD4 antibodies
  
  DOI: 10.1371/journal.pone.0187912
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4000, RRID:AB_2819255)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2819255
  
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  RRIDCUR:Missing RRID:AB_2819255 RRID:AB_2716322
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RRID:AB_2819255

RRIDCUR:Missing

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC5679608/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Quantitative PET imaging of the CD4 pool in nonhuman primates

1
1. scibot 15 Jun 2023
  
  in Public
  
  CD4R1-OKT4A/rhIgG1(CD4R1)
  
  DOI: 10.1007/s00259-022-05940-4
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322 RRIDCUR:Missing
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RRID:AB_2716322

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ncbi.nlm.nih.gov/pmc/articles/PMC9668939/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Antibody-mediated depletion of viral reservoirs is limited in SIV-infected macaques treated early with antiretroviral therapy

1
1. scibot 15 Jun 2023
  
  in Public
  
  anti-CD4 Ab (CD4R1
  
  DOI: 10.1172/JCI142421
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322 RRIDCUR:Missing
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RRID:AB_2716322

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ncbi.nlm.nih.gov/pmc/articles/PMC7954603/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Reactivation of Simian Varicella Virus in Rhesus Macaques after CD4 T Cell Depletion

1
1. scibot 14 Jun 2023
  
  in Public
  
  anti-CD4
  
  DOI: 10.1128/JVI.01375-18
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322 RRIDCUR:Missing
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RRID:AB_2716322

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ncbi.nlm.nih.gov/pmc/articles/PMC6340024/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Hybrid nanocarriers incorporating mechanistically distinct drugs for lymphatic CD4+ T cell activation and HIV-1 latency reversal

1
1. scibot 14 Jun 2023
  
  in Public
  
  anti-CD4
  
  DOI: 10.1126/sciadv.aav6322
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322 RRIDCUR:Missing
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RRID:AB_2716322

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC6436934/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells

1
1. scibot 14 Jun 2023
  
  in Public
  
  CDR-grafted anti-CD4
  
  DOI: 10.1038/s41467-018-05528-3
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322 RRIDCUR:Missing
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ncbi.nlm.nih.gov/pmc/articles/PMC6160474/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model

1
1. scibot 14 Jun 2023
  
  in Public
  
  anti-CD4 50 mg/kg IV (clone CD4R1
  
  DOI: 10.1111/xen.12166
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322 RRIDCUR:Missing
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ncbi.nlm.nih.gov/pmc/articles/PMC4930152/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CD4 Depletion in SIV-Infected Macaques Results in Macrophage and Microglia Infection with Rapid Turnover of Infected Cells

1
1. scibot 14 Jun 2023
  
  in Public
  
  CD4R1
  
  DOI: 10.1371/journal.ppat.1004467
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322 RRIDCUR:Missing
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ncbi.nlm.nih.gov/pmc/articles/PMC4214815/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Expression of the Memory Marker CD45RO on Helper T Cells in Macaques

1
1. scibot 14 Jun 2023
  
  in Public
  
  anti-CD4 mAb CD4R1
  
  DOI: 10.1371/journal.pone.0073969
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322 RRIDCUR:Missing
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ncbi.nlm.nih.gov/pmc/articles/PMC3762710/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Prolonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeys

1
1. scibot 07 Jun 2023
  
  in Public
  
  anti-CD4 antibody (CD4R1)
  
  DOI: 10.1038/s41467-023-36379-2
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322 RRIDCUR:Missing
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ncbi.nlm.nih.gov/pmc/articles/PMC9946951/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Long-Term Survival of Pig-to-Rhesus Macaque Renal Xenografts is Dependent on CD4 T cell Depletion

1
1. scibot 07 Jun 2023
  
  in Public
  
  CD4R1
  
  DOI: 10.1111/ajt.15329
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322 RRIDCUR:Missing
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ncbi.nlm.nih.gov/pmc/articles/PMC6658347/
Apr 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Antibody-mediated depletion of viral reservoirs is limited in SIV-infected macaques treated early with antiretroviral therapy

1
1. scibot 22 Apr 2023
  
  in Public
  
  anti-CD4 Ab (CD4R1, NIH Nonhuman Primate Reagent Resource
  
  DOI: 10.1172/JCI142421
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322 RRIDCUR:Missing
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ncbi.nlm.nih.gov/pmc/articles/PMC7954603/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Expression of the Memory Marker CD45RO on Helper T Cells in Macaques

1
1. scibot 20 Apr 2023
  
  in Public
  
  anti-CD4 mAb CD4R1 (NIH Nonhuman Primate Reagent Resource
  
  DOI: 10.1371/journal.pone.0073969
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRIDCUR:Missing RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC3762710/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CD4 Depletion in SIV-Infected Macaques Results in Macrophage and Microglia Infection with Rapid Turnover of Infected Cells

1
1. scibot 20 Apr 2023
  
  in Public
  
  NIH nonhuman primate reagent resource) for providing CD4R1
  
  DOI: 10.1371/journal.ppat.1004467
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRIDCUR:Missing RRID:AB_2716322
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RRIDCUR:Missing

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ncbi.nlm.nih.gov/pmc/articles/PMC4214815/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model

1
1. scibot 20 Apr 2023
  
  in Public
  
  anti-CD4 50 mg/kg IV (clone CD4R1; NIH Nonhuman Primate Reagent Resource
  
  DOI: 10.1111/xen.12166
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRIDCUR:Missing RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC4930152/
www.biorxiv.org www.biorxiv.org

Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection

1
1. scibot 20 Apr 2023
  
  in Public
  
  RRID:AB_2716322
  
  DOI: 10.1101/2023.04.10.536057
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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biorxiv.org/content/10.1101/2023.04.10.536057v1
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells

1
1. scibot 19 Apr 2023
  
  in Public
  
  anti-CD4 antibody (denoted as cohort 2) or control rhesus IgG1 (50 mg/kg SQ; NIH Nonhuman Primate Reagent Resource
  
  DOI: 10.1038/s41467-018-05528-3
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRIDCUR:Missing RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC6160474/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Antibody-Mediated CD4 Depletion Induces Homeostatic CD4+ T Cell Proliferation without Detectable Virus Reactivation in Antiretroviral Therapy-Treated Simian Immunodeficiency Virus-Infected Macaques

1
1. scibot 19 Apr 2023
  
  in Public
  
  CD4R1 (clone OKT4 with RM IgG1 heavy chain) CD4+ depletion antibody (NIH NHP Reagent Resource Program
  
  DOI: 10.1128/JVI.01235-18
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRIDCUR:Missing RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC6206490/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Hybrid nanocarriers incorporating mechanistically distinct drugs for lymphatic CD4+ T cell activation and HIV-1 latency reversal

1
1. scibot 19 Apr 2023
  
  in Public
  
  Rhesus recombinant anti-CD4 antibody and rhesus recombinant immunoglobulin G1 (IgG1) isotype control antibody were purchased from the National Institutes of Health (NIH) Nonhuman Primate Reagent Resource
  
  DOI: 10.1126/sciadv.aav6322
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRIDCUR:Missing RRID:AB_2716322
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RRIDCUR:Missing

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URL

ncbi.nlm.nih.gov/pmc/articles/PMC6436934/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Reactivation of Simian Varicella Virus in Rhesus Macaques after CD4 T Cell Depletion

1
1. scibot 19 Apr 2023
  
  in Public
  
  anti-CD4 antibody used in these studies which was provided by the NIH Nonhuman Primate Reagent Resource
  
  DOI: 10.1128/JVI.01375-18
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRIDCUR:Missing RRID:AB_2716322
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RRIDCUR:Missing

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URL

ncbi.nlm.nih.gov/pmc/articles/PMC6340024/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients

1
1. scibot 18 Apr 2023
  
  in Public
  
  CD4R1; NIH NHP Reagent Resource
  
  DOI: 10.1681/ASN.2019030304
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322 RRIDCUR:Missing
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URL

ncbi.nlm.nih.gov/pmc/articles/PMC6900797/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Quantitative PET imaging of the CD4 pool in nonhuman primates

1
1. scibot 15 Apr 2023
  
  in Public
  
  CD4R1-OKT4A/rhIgG1(CD4R1), was obtained from NIH Nonhuman Primate Reagent Resource
  
  DOI: 10.1007/s00259-022-05940-4
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322 RRIDCUR:Missing
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URL

ncbi.nlm.nih.gov/pmc/articles/PMC9668939/
Jan 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Belatacept-Based Maintenance Immunosuppression Controls the Post-Transplant Humoral Immune Response in Highly Sensitized Nonhuman Primates

1
1. scibot 06 Jan 2023
  
  in Public
  
  RRID:AB_2716322
  
  DOI: 10.34067/KID.0001732022
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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ncbi.nlm.nih.gov/pmc/articles/PMC9802566/
Aug 2022
www.sciencedirect.com www.sciencedirect.com

Infection order outweighs the role of CD4+ T cells in tertiary flavivirus exposure

1
1. scibot 10 Aug 2022
  
  in Public
  
  AB_2716322
  
  DOI: 10.1016/j.isci.2022.104764
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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sciencedirect.com/science/article/pii/S2589004222010367
Nov 2021
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

CD4+ T Cells Are Dispensable for Induction of Broad Heterologous HIV Neutralizing Antibodies in Rhesus Macaques

1
1. scibot 05 Nov 2021
  
  in Public
  
  RRID:AB_2716322
  
  DOI: 10.3389/fimmu.2021.757811
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-0407, RRID:AB_2716322)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2716322
  
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  RRID:AB_2716322
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pubmed.ncbi.nlm.nih.gov/34745131/