67 Matching Annotations
  1. Aug 2024
  2. www.jtcvs.org www.jtcvs.org
    The growth of xenotransplanted hearts can be reduced with growth hormone receptor knockout pig donors
    1
    1. scibot 02 Aug 2024
      anti-CD40 (clone 2C10R4; NHP Reagent Resource

      DOI: 10.1016/j.jtcvs.2021.07.051

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

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    jtcvs.org/article/S0022-5223(21)01261-7/fulltext
  3. May 2024
  4. www.jtcvs.org www.jtcvs.org
    The growth of xenotransplanted hearts can be reduced with growth hormone receptor knockout pig donors
    1
    1. scibot 15 May 2024
      anti-CD40 (clone 2C10R4; NHP Reagent Resource

      DOI: 10.1016/j.jtcvs.2021.07.051

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @evieth

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      RRID:AB_2716325 DOI:10.1016/j.jtcvs.2021.07.051
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    jtcvs.org/article/S0022-5223(21)01261-7/fulltext
  5. Nov 2023
  6. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Initial evidence that blockade of the CD40/CD154 costimulation pathway alone is sufficient as maintenance therapy in xenotransplantation
    1
    1. scibot 03 Nov 2023
      Anti-CD40 monoclonal antibody (mAb) (2C10R4

      DOI: 10.1111/xen.12721

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

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    onlinelibrary.wiley.com/doi/10.1111/xen.12721
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Erratum: Increase in Anti-Gal IgM Level is Associated With Early Graft Failure in Intraportal Porcine Islet Xenotransplantation
    1
    1. scibot 03 Nov 2023
      anti-CD40

      DOI: 10.3343/alm.2016.36.5.504

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

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    ncbi.nlm.nih.gov/pmc/articles/PMC4940499/
  8. Oct 2023
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    T and B lymphocyte dynamics after genetically-modified pig-to-baboon kidney xenotransplantation with an anti-CD40mAb-based immunosuppressive regimen
    1
    1. scibot 25 Oct 2023
      Anti-CD40mAb (2C10R4

      DOI: 10.1016/j.trim.2022.101545

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

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    ncbi.nlm.nih.gov/pmc/articles/PMC9395207/
  10. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Bullous pemphigoid-like skin blistering disease in a rhesus macaque (Macaca mulatta)
    1
    1. scibot 25 Oct 2023
      2C10R4

      DOI: 10.1111/jmp.12225

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

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    onlinelibrary.wiley.com/doi/10.1111/jmp.12225
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Old World Monkeys are less than ideal transplantation models for testing pig organs lacking three carbohydrate antigens (Triple-Knockout)
    1
    1. scibot 25 Oct 2023
      Anti-CD40mAb (2C10R4)

      DOI: 10.1038/s41598-020-66311-3

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

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    ncbi.nlm.nih.gov/pmc/articles/PMC7300119/
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stable expression of the human thrombomodulin transgene in pig endothelial cells is associated with a reduction in the inflammatory response
    1
    1. scibot 25 Oct 2023
      Anti-CD40 2C10R4

      DOI: 10.1016/j.cyto.2021.155580

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

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    ncbi.nlm.nih.gov/pmc/articles/PMC8511266/
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    One-Year Heterotopic Cardiac Xenograft Survival In A Pig To Baboon Model
    1
    1. scibot 25 Oct 2023
      anti CD40 antibody (clone 2C10R4

      DOI: 10.1111/ajt.12562

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

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    ncbi.nlm.nih.gov/pmc/articles/PMC4184155/
  14. www.sciencedirect.com www.sciencedirect.com
    Comparative efficacy of anti-CD40 antibody–mediated costimulation blockade on long-term survival of full-thickness porcine corneal grafts in nonhuman primates
    1
    1. scibot 25 Oct 2023
      anti-CD40 Ab (2C10R4

      DOI: 10.1111/ajt.14913

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

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    sciencedirect.com/science/article/pii/S1600613522097052
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histopathology of pig kidney grafts with/without expression of the carbohydrate Neu5Gc in immunosuppressed baboons
    1
    1. scibot 25 Oct 2023
      anti-CD40 2C10R4

      DOI: 10.1111/xen.12715

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

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    ncbi.nlm.nih.gov/pmc/articles/PMC9157534/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SERUM AMYLOID A AS AN INDICATOR OF IMPENDING XENOGRAFT FAILURE: EXPERIMENTAL STUDIES
    1
    1. scibot 25 Oct 2023
      anti-CD40mAb (2C10R4

      DOI: 10.1016/j.ijsu.2018.11.027

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

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    ncbi.nlm.nih.gov/pmc/articles/PMC6310230/
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes
    1
    1. scibot 25 Oct 2023
      anti-CD40 mAb 2C10R4

      DOI: 10.1038/s41467-019-11338-y

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

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    ncbi.nlm.nih.gov/pmc/articles/PMC6677762/
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kidney transplantation from triple‐knockout pigs expressing multiple human proteins in cynomolgus macaques
    1
    1. scibot 25 Oct 2023
      anti‐CD40 (2C10R4

      DOI: 10.1111/ajt.16780

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

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      RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC9291868/
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Predictive biomarkers for graft rejection in pig-to-non-human primate corneal xenotransplantation
    1
    1. scibot 25 Oct 2023
      anti-CD40 Ab (2C10R4

      DOI: 10.1111/xen.12515

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

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    ncbi.nlm.nih.gov/pmc/articles/PMC6717035/
  20. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Failure of transplantation tolerance induction by autologous regulatory T cells in the pig-to-non-human primate islet xenotransplantation model
    1
    1. scibot 25 Oct 2023
      anti-CD40 mAb (20 mg/kg, i.v. 2C10 R4 clone

      DOI: 10.1111/xen.12246

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

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    onlinelibrary.wiley.com/doi/10.1111/xen.12246
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long-term safety outcome of systemic immunosuppression in pig-to-nonhuman primate corneal xenotransplantation
    1
    1. scibot 25 Oct 2023
      anti-CD40 Abs (2C10R4

      DOI: 10.1111/xen.12442

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

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    ncbi.nlm.nih.gov/pmc/articles/PMC6166667/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LMP1-deficient Epstein-Barr virus mutant requires T cells for lymphomagenesis
    2
    1. scibot 25 Oct 2023
      anti-CD40 Ab 2C10R4

      DOI: 10.1172/JCI76357

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

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      RRID:AB_2716325
    2. scibot 25 Oct 2023
      anti-CD40 Ab 2C10R4

      DOI: 10.1172/JCI76357

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

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      RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC4382240/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Addition of Anti-CD40 Monoclonal Antibody to Nonmyeloablative Conditioning with Belatacept Abrogated Allograft Tolerance Despite Induction of Mixed Chimerism
    1
    1. scibot 25 Oct 2023
      RRID:AB_2716325

      DOI: 10.1097/TP.0000000000002417

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @scibot

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    ncbi.nlm.nih.gov/pmc/articles/PMC6309923/
  24. Jun 2023
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts
    2
    1. scibot 16 Jun 2023
      Anti-CD40mAb (2C10R4

      DOI: 10.1111/xen.12293

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

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      RRIDCUR:Missing RRID:AB_2716325
    2. scibot 16 Jun 2023
      Anti-CD40mAb (2C10R4, a chimeric rhesus IgG4) was provided by the NIH NHP Reagent Resource

      DOI: 10.1111/xen.12293

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

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      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC5397334/
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FURTHER EVIDENCE FOR SUSTAINED SYSTEMIC INFLAMMATION IN XENOGRAFT RECIPIENTS (SIXR)
    1
    1. scibot 16 Jun 2023
      2C10R4

      DOI: 10.1111/xen.12182

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

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      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC4575631/
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Myroides Infection in a Baboon After Prolonged Pig Kidney Graft Survival
    1
    1. scibot 16 Jun 2023
      anti-CD40mAb from the NHP Reagent Resource

      DOI: 10.1097/TXD.0000000000000523

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

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      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC4486305/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    “You cannot stay in the laboratory forever”*: Taking pig kidney xenotransplantation from the laboratory to the clinic
    1
    1. scibot 15 Jun 2023
      Anti-CD40 monoclonal antibody (mAb) (2C10R4, a chimeric rhesus IgG4

      DOI: 10.1016/j.ebiom.2021.103562

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

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      RRID:AB_2716325 RRIDCUR:Missing
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    ncbi.nlm.nih.gov/pmc/articles/PMC8441149/
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Role of Interleukin-6 (IL-6) in the Systemic Inflammatory Response in Xenograft Recipients and in Pig Kidney Xenograft Failure
    1
    1. scibot 14 Jun 2023
      Anti-CD40mAb (2C10R4, a chimeric rhesus IgG4

      DOI: 10.3389/fimmu.2021.788949

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

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      RRID:AB_2716325 RRIDCUR:Missing
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    ncbi.nlm.nih.gov/pmc/articles/PMC8692283/
  30. www.nature.com www.nature.com
    Consistent success in life-supporting porcine cardiac xenotransplantation
    1
    1. scibot 14 Jun 2023
      anti-CD40

      DOI: 10.1038/s41586-018-0765-z

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

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    nature.com/articles/s41586-018-0765-z
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pilot Study of Delayed ICOS/ICOS-L Blockade With αCD40 to Modulate Pathogenic Alloimmunity in a Primate Cardiac Allograft Model
    1
    1. scibot 14 Jun 2023
      2C10R4

      DOI: 10.1097/TXD.0000000000000761

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

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      RRID:AB_2716325 RRIDCUR:Missing
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    ncbi.nlm.nih.gov/pmc/articles/PMC5811273/
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Delayed revascularization of islet after transplantation by IL-6 blockade in pig to nonhuman primate islet xenotransplantation model
    1
    1. scibot 14 Jun 2023
      anti-CD40 mAb (2C10R4

      DOI: 10.1111/xen.12374

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

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    ncbi.nlm.nih.gov/pmc/articles/PMC5903442/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pre-clinical results in pig-to-nonhuman primate islet xenotransplantation using anti-CD40 antibody (2C10R4)-based immunosuppression
    1
    1. scibot 14 Jun 2023
      anti-CD40 mAb (2C10R4

      DOI: 10.1111/xen.12356

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

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      RRID:AB_2716325 RRIDCUR:Missing
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    ncbi.nlm.nih.gov/pmc/articles/PMC5809197/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AN INVESTIGATION OF EXTRACELLULAR HISTONES IN PIG-TO-BABOON ORGAN XENOTRANSPLANTATION
    1
    1. scibot 14 Jun 2023
      anti-CD40mAb (2C10R4

      DOI: 10.1097/TP.0000000000001676

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

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    ncbi.nlm.nih.gov/pmc/articles/PMC5856196/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comparative Evaluation of αCD40 (2C10R4) and αCD154 (5C8H1 and IDEC-131) in a Nonhuman Primate Cardiac Allotransplant Model
    1
    1. scibot 14 Jun 2023
      2C10R4

      DOI: 10.1097/TP.0000000000001836

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

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    ncbi.nlm.nih.gov/pmc/articles/PMC5568940/
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prolonged Survival Following Pig-to-Primate Liver Xenotransplantation Utilizing Exogenous Coagulation Factors and Co-Stimulation Blockade
    1
    1. scibot 14 Jun 2023
      anti-CD40 monoclonal antibody

      DOI: 10.1111/ajt.14341

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

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    ncbi.nlm.nih.gov/pmc/articles/PMC5519420/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-CD40 antibody mediated-costimulation blockade promotes long-term survival of deep-lamellar porcine corneal grafts in non-human primates
    1
    1. scibot 14 Jun 2023
      anti-CD40 (2C10R4

      DOI: 10.1111/xen.12298

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

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    ncbi.nlm.nih.gov/pmc/articles/PMC5464973/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Immunosuppression with CD40 Costimulatory Blockade plus Rapamycin for Simultaneous Islet and Kidney Transplantation in Nonhuman Primates
    1
    1. scibot 14 Jun 2023
      anti-CD40 mAb

      DOI: 10.1111/ajt.13999

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

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    ncbi.nlm.nih.gov/pmc/articles/PMC5298941/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRANSPLANTATION OF HEPATOCYTES FROM GENETICALLY-ENGINEERED PIGS IN BABOONS
    1
    1. scibot 14 Jun 2023
      anti-CD40mAb

      DOI: 10.1111/xen.12289

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

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    ncbi.nlm.nih.gov/pmc/articles/PMC5397320/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Thyroid hormone: relevance to xenotransplantation
    1
    1. scibot 14 Jun 2023
      Anti-CD40 (2C10R4

      DOI: 10.1111/xen.12243

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

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    ncbi.nlm.nih.gov/pmc/articles/PMC4988877/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft
    1
    1. scibot 14 Jun 2023
      αCD40 (clone 2C10R4

      DOI: 10.1038/ncomms11138

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRID:AB_2716325 RRIDCUR:Missing
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    ncbi.nlm.nih.gov/pmc/articles/PMC4822024/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IN VITRO TESTING OF AN ANTI-CD40 MONOCLONAL ANTIBODY, CLONE 2C10, IN PRIMATES AND PIGS
    1
    1. scibot 14 Jun 2023
      Anti-CD40mAb (clone 2C10R4

      DOI: 10.1016/j.trim.2015.09.007

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRID:AB_2716325 RRIDCUR:Missing
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    ncbi.nlm.nih.gov/pmc/articles/PMC4648655/
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PIG KIDNEY GRAFT SURVIVAL IN A BABOON FOR 136 DAYS: LONGEST LIFE-SUPPORTING ORGAN GRAFT SURVIVAL TO DATE
    1
    1. scibot 14 Jun 2023
      anti-CD40mAb

      DOI: 10.1111/xen.12174

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRID:AB_2716325 RRIDCUR:Missing
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    ncbi.nlm.nih.gov/pmc/articles/PMC4519393/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PIG-TO-BABOON HETEROTOPIC HEART TRANSPLANTATION – EXPLORATORY PRELIMINARY EXPERIENCE WITH PIGS TRANSGENIC FOR HUMAN THROMBOMODULIN AND COMPARISON OF THREE COSTIMULATION BLOCKADE-BASED REGIMENS
    1
    1. scibot 14 Jun 2023
      Anti-CD40mAb (2C10R4

      DOI: 10.1111/xen.12167

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRID:AB_2716325 RRIDCUR:Missing
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    ncbi.nlm.nih.gov/pmc/articles/PMC4464944/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    INITIAL IN VIVO EXPERIENCE OF PIG ARTERY PATCH TRANSPLANTATION IN BABOONS USING MUTANT MHC (CIITA-DN) PIGS
    1
    1. scibot 14 Jun 2023
      Anti-CD40mAb

      DOI: 10.1016/j.trim.2015.02.003

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRID:AB_2716325 RRIDCUR:Missing
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    ncbi.nlm.nih.gov/pmc/articles/PMC4368496/
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long-term safety from transmission of porcine endogenous retrovirus after pig-to-nonhuman primate corneal transplantation
    1
    1. scibot 14 Jun 2023
      anti-CD40 antibodies (2C10R4

      DOI: 10.1111/xen.12314

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRID:AB_2716325 RRIDCUR:Missing
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    ncbi.nlm.nih.gov/pmc/articles/PMC5546926/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD4+/CD8+ T cell ratio correlates with the graft fate in pig-to-nonhuman primate islet xenotransplantation
    1
    1. scibot 07 Jun 2023
      anti-CD40 mAb (2C10R4; National Institutes of Health NHP Reagent Resource

      DOI: 10.1111/xen.12562

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC7162713/
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients
    1
    1. scibot 07 Jun 2023
      anti-CD40 mAb 20 mg/kg IV (2C10R4; NIH Nonhuman Primate Reagent Resource

      DOI: 10.1111/ajt.15067

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC7185755/
  49. Apr 2023
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection
    1
    1. scibot 20 Apr 2023
      mouse-rhesus IgG4 anti-CD40, 2C10R4 (REF) (Nonhuman Primate Reagent Resource

      DOI: 10.1111/ajt.12526

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC3985346/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long-term safety from transmission of porcine endogenous retrovirus after pig-to-nonhuman primate corneal transplantation
    1
    1. scibot 20 Apr 2023
      anti-CD40 antibodies (2C10R4, NIH Nonhuman Primate Reagent Resource)

      DOI: 10.1111/xen.12314

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC5546926/
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetically Engineered Pigs And Target Specific Immunomodulation Provide Significant Graft Survival And Hope For Clinical Cardiac Xenotransplantation
    1
    1. scibot 20 Apr 2023
      Keith Reimann, PhD for providing the anti CD40 mAb

      DOI: 10.1016/j.jtcvs.2014.06.002

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC4135017/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    INITIAL IN VIVO EXPERIENCE OF PIG ARTERY PATCH TRANSPLANTATION IN BABOONS USING MUTANT MHC (CIITA-DN) PIGS
    1
    1. scibot 20 Apr 2023
      Anti-CD40mAb (NIH NHP Resource Center, Boston, MA

      DOI: 10.1016/j.trim.2015.02.003

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC4368496/
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PIG-TO-BABOON HETEROTOPIC HEART TRANSPLANTATION – EXPLORATORY PRELIMINARY EXPERIENCE WITH PIGS TRANSGENIC FOR HUMAN THROMBOMODULIN AND COMPARISON OF THREE COSTIMULATION BLOCKADE-BASED REGIMENS
    1
    1. scibot 20 Apr 2023
      Anti-CD40mAb (2C10R4; NIH NHP Reagent Resource

      DOI: 10.1111/xen.12167

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC4464944/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PIG KIDNEY GRAFT SURVIVAL IN A BABOON FOR 136 DAYS: LONGEST LIFE-SUPPORTING ORGAN GRAFT SURVIVAL TO DATE
    1
    1. scibot 20 Apr 2023
      We thank Dr. Keith Reimann for providing anti-CD40mAb from the NHP Reagent Resource

      DOI: 10.1111/xen.12174

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC4519393/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IN VITRO TESTING OF AN ANTI-CD40 MONOCLONAL ANTIBODY, CLONE 2C10, IN PRIMATES AND PIGS
    1
    1. scibot 20 Apr 2023
      Anti-CD40mAb (clone 2C10R4) was kindly provided by Keith Reimann through the NIH NHP Reagent Resource facility

      DOI: 10.1016/j.trim.2015.09.007

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC4648655/
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft
    1
    1. scibot 20 Apr 2023
      αCD40 (clone 2C10R4)15 (NHP Reagent Resource

      DOI: 10.1038/ncomms11138

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC4822024/
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRANSPLANTATION OF HEPATOCYTES FROM GENETICALLY-ENGINEERED PIGS IN BABOONS
    1
    1. scibot 20 Apr 2023
      anti-CD40mAb from the NHP Reagent Resource

      DOI: 10.1111/xen.12289

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC5397320/
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    THERAPEUTIC REGULATION OF SYSTEMIC INFLAMMATION IN XENOGRAFT RECIPIENTS
    1
    1. scibot 20 Apr 2023
      2C10R4 was kindly provided by Keith Reimann of the NIH NHP Resource Center

      DOI: 10.1111/xen.12296

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC5397335/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Immunosuppression with CD40 Costimulatory Blockade plus Rapamycin for Simultaneous Islet and Kidney Transplantation in Nonhuman Primates
    1
    1. scibot 20 Apr 2023
      anti-CD40 mAb (Nonhuman Primate Reagent Resource

      DOI: 10.1111/ajt.13999

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC5298941/
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-CD40 antibody mediated-costimulation blockade promotes long-term survival of deep-lamellar porcine corneal grafts in non-human primates
    1
    1. scibot 20 Apr 2023
      anti-CD40 (2C10R4, NIH Nonhuman Primate Reagent Resource

      DOI: 10.1111/xen.12298

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC5464973/
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prolonged Survival Following Pig-to-Primate Liver Xenotransplantation Utilizing Exogenous Coagulation Factors and Co-Stimulation Blockade
    1
    1. scibot 20 Apr 2023
      anti-CD40 monoclonal antibody (mAb) (n = 1) (20 mg/kg on Days 0 and 5 and 10 mg/kg on Day 7 and weekly thereafter, NHP Reagent Resource

      DOI: 10.1111/ajt.14341

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC5519420/
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comparative Evaluation of αCD40 (2C10R4) and αCD154 (5C8H1 and IDEC-131) in a Nonhuman Primate Cardiac Allotransplant Model
    1
    1. scibot 20 Apr 2023
      5C8H1 is a mouse-human IgG1κ chimeric anti-CD154 antibody, and 2C10R4 is a mouse-rhesus IgG4κ anti-CD40 antibody.21 Both were obtained from the NIH Nonhuman Primate Reagent Resource

      DOI: 10.1097/TP.0000000000001836

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1547, RRID:AB_2716324)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716324

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      RRIDCUR:Missing RRID:AB_2716324 RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC5568940/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates
    1
    1. scibot 20 Apr 2023
      Anti-CD40mAb (2C10) used in this study was produced and provided by the Non-human Primate Reagent Resource

      DOI: 10.1182/bloodadvances.2017010991

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

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      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC5737135/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AN INVESTIGATION OF EXTRACELLULAR HISTONES IN PIG-TO-BABOON ORGAN XENOTRANSPLANTATION
    1
    1. scibot 20 Apr 2023
      nti-CD40mAb (2C10R4; NIH NHP Reagent Resource

      DOI: 10.1097/TP.0000000000001676

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC5856196/
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pre-clinical results in pig-to-nonhuman primate islet xenotransplantation using anti-CD40 antibody (2C10R4)-based immunosuppression
    1
    1. scibot 20 Apr 2023
      anti-CD40 mAb (2C10R4, NIH NHP Reagent Resource

      DOI: 10.1111/xen.12356

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC5809197/
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Delayed revascularization of islet after transplantation by IL-6 blockade in pig to nonhuman primate islet xenotransplantation model
    1
    1. scibot 20 Apr 2023
      anti-CD40 mAb (2C10R4, NIH NHP Reagent Resource

      DOI: 10.1111/xen.12374

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC5903442/
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pilot Study of Delayed ICOS/ICOS-L Blockade With αCD40 to Modulate Pathogenic Alloimmunity in a Primate Cardiac Allograft Model
    1
    1. scibot 20 Apr 2023
      Both 2C10R4 and ICOS-Ig were obtained from NIH Nonhuman Primate Reagent Resource

      DOI: 10.1097/TXD.0000000000000761

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

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      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC5811273/
  69. www.nature.com www.nature.com
    Consistent success in life-supporting porcine cardiac xenotransplantation
    1
    1. scibot 19 Apr 2023
      anti-CD40 monoclonal antibody (mouse/rhesus chimeric IgG4 clone 2C10R4, NIH Non-human Primate Reagent Resource

      DOI: 10.1038/s41586-018-0765-z

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

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      RRIDCUR:Missing RRID:AB_2716325
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    nature.com/articles/s41586-018-0765-z
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Role of Interleukin-6 (IL-6) in the Systemic Inflammatory Response in Xenograft Recipients and in Pig Kidney Xenograft Failure
    1
    1. scibot 18 Apr 2023
      Anti-CD40mAb (2C10R4, a chimeric rhesus IgG4) was provided by the NIH NHP Reagent Resource

      DOI: 10.3389/fimmu.2021.788949

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

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      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC8692283/
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    “You cannot stay in the laboratory forever”*: Taking pig kidney xenotransplantation from the laboratory to the clinic
    1
    1. scibot 18 Apr 2023
      Anti-CD40 monoclonal antibody (mAb) (2C10R4, a chimeric rhesus IgG4) (NIH NHP Resource Center, Boston, MA)

      DOI: 10.1016/j.ebiom.2021.103562

      Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-4047, RRID:AB_2716325)

      Curator: @Apiekniewska

      SciCrunch record: RRID:AB_2716325

      What is this?
      RRIDCUR:Missing RRID:AB_2716325
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    ncbi.nlm.nih.gov/pmc/articles/PMC8441149/