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SETD2 Deficiency Drives Mitochondrial DNA Leakage and Creates a Druggable Dependency on BCL-xL in Clear Cell Renal Cell Carcinoma

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1. scibot 10 Jun 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-3195
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13244386/
May 2026
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FOXA1-mediated CEPT1 deficiency in airway epithelium drives asthma via an ER stress-mitochondrial dysfunction axis

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  DOI: 10.1016/j.celrep.2026.117368
  
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mRNA lipid-nanoparticle-mediated mitochondrial apoptosis augments adoptive T cell immunotherapy

1
1. scibot 06 May 2026
  
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  DOI: 10.1016/j.xcrm.2026.102706
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13130659/
Apr 2026
54.241.53.176 54.241.53.176

2026.04.20.719456.full-html.html

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1. scibot 30 Apr 2026
  
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  DOI: 10.64898/2026.04.20.719456
  
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54.241.53.176/6790efd246ed84de929dd028ff8d6465bfa7b2e6/2026.04.20.719456.full-html.html
Dec 2025
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Stc1-expressing myofibroblasts are a developmentally distinct lineage cleared through apoptosis in the neonatal lung

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1. scibot 23 Dec 2025
  
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sciencedirect.com:5037/science/article/pii/S2211124725015220
Jun 2025
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PRPS activity tunes redox homeostasis in Myc-driven lymphoma

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.redox.2025.103649
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12166406/
May 2025
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1-s2.0-S2589004225008454-main-html.html

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52.53.155.43/2f59eea255f6dfa2798e1e0fcb3d7e10d3ba6bc8/1-s2.0-S2589004225008454-main-html.html
Apr 2025
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BCL-XL Protects ASS1-Deficient Cancers from Arginine Starvation–Induced Apoptosis

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  DOI: 10.1158/1078-0432.CCR-24-2548
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11964295/
Feb 2025
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The Effects of Cathepsin B Inhibition in the Face of Diffuse Traumatic Brain Injury and Secondary Intracranial Pressure Elevation

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1. scibot 27 Feb 2025
  
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  DOI: 10.20944/preprints202405.1740.v1
  
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52.53.155.43 52.53.155.43

PDF-html.html

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52.53.155.43/f141eddf8d6ed9d4f64a9be0f6055059836b8d11/PDF-html.html
Oct 2024
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Neuregulin 1 signaling attenuates tumor necrosis factor-α induced female rat luteal cell death

1
1. scibot 09 Oct 2024
  
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  DOI: 10.1210/endocr/bqae129
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11456883/
Sep 2024
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A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib

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  DOI: 10.1016/j.xcrm.2024.101703
  
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sciencedirect.com/science/article/pii/S2666379124004245
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The Effects of Cathepsin B Inhibition in the Face of Diffuse Traumatic Brain Injury and Secondary Intracranial Pressure Elevation

1
1. scibot 31 Jul 2024
  
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  DOI: 10.3390/biomedicines12071612
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11274534/
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Targeting type I DED interactions at the DED filament serves as a sensitive switch for cell fate decisions

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1. scibot 25 Jul 2024
  
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  DOI: 10.1016/j.chembiol.2024.06.014
  
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sciencedirect.com/science/article/pii/S2451945624002745
Apr 2024
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Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy

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1. scibot 09 Apr 2024
  
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  DOI: 10.1016/j.bcp.2024.116198
  
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sciencedirect.com/science/article/pii/S0006295224001813
Mar 2024
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Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1

2
1. scibot 19 Mar 2024
  
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  DOI: 10.1016/j.molcel.2024.02.035
  
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  DOI: 10.1016/j.molcel.2024.02.035
  
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sciencedirect.com/science/article/pii/S109727652400176X
Oct 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX

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1. scibot 20 Oct 2023
  
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  DOI: 10.1158/0008-5472.CAN-22-1337
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10570680/
Sep 2023
www.embopress.org www.embopress.org

CCDC50 promotes tumor growth through regulation of lysosome homeostasis

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1. scibot 12 Sep 2023
  
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  DOI: 10.15252/embr.202356948
  
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embopress.org/doi/full/10.15252/embr.202356948
Aug 2023
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γ-radiation-induced damage on normal hepatocytes and its protection by ethyl cinnamate

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1. scibot 16 Aug 2023
  
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  DOI: 10.1007/s10967-023-09067-0
  
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link.springer.com/article/10.1007/s10967-023-09067-0
52.53.155.43 52.53.155.43

PIIS2211124723009543-html.html

1
1. scibot 12 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112943
  
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52.53.155.43/7a7cd2b37d518c0daab3f29f5b28b810c1030ef5/PIIS2211124723009543-html.html
Apr 2023
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USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities

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  DOI: 10.1016/j.xcrm.2023.101007
  
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sciencedirect.com/science/article/pii/S2666379123001179
Feb 2023
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IFNγ signaling sensitizes melanoma cells to BH3 Mimetics

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  DOI: 10.1016/j.jid.2023.01.017
  
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sciencedirect.com/science/article/pii/S0022202X23000726
Jan 2023
onlinelibrary.wiley.com onlinelibrary.wiley.com

Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage

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1. scibot 10 Jan 2023
  
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  DOI: 10.1111/jnc.15751
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15751
Nov 2022
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Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression

1
1. scibot 19 Nov 2022
  
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  DOI: 10.1158/2767-9764.crc-22-0024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9648413/
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Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

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1. scibot 18 Nov 2022
  
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  DOI: 10.1016/j.isci.2022.105458
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9663903/
Oct 2022
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MCL-1 is a master regulator of cancer dependency on fatty acid oxidation

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  DOI: 10.1016/j.celrep.2022.111445
  
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sciencedirect.com/science/article/pii/S2211124722012864
Aug 2022
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Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach

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1. scibot 23 Aug 2022
  
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  RRID:AB_2716685
  
  DOI: 10.1016/j.crmeth.2022.100271
  
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sciencedirect.com/science/article/pii/S2667237522001485
Jul 2022
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Bcl-xL Inhibition Radiosensitizes PIK3CA/PTEN Wild-type Triple-negative Breast Cancers with Low Mcl-1 Expression

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1. scibot 29 Jul 2022
  
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  DOI: 10.1158/2767-9764.CRC-22-0024
  
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aacrjournals.org/cancerrescommun/article/2/7/679/707059/Bcl-xL-Inhibition-Radiosensitizes-PIK3CA-PTEN-Wild
May 2022
journals.sagepub.com journals.sagepub.com

Cathepsin B Relocalization in Late Membrane Disrupted Neurons Following Diffuse Brain Injury in Rats - Martina L. Hernandez, Michael Marone, Karen M. Gorse, Audrey D. Lafrenaye, 2022

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  DOI: 10.1177/17590914221099112
  
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journals.sagepub.com/doi/full/10.1177/17590914221099112
Apr 2022
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Energetic metabolic reprogramming in Jurkat DFF40-deficient cancer cells

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1. scibot 26 Apr 2022
  
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  DOI: 10.1007/s11010-022-04433-0
  
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link.springer.com/article/10.1007/s11010-022-04433-0
Mar 2022
elifesciences.org elifesciences.org

Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness

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1. scibot 11 Mar 2022
  
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  DOI: 10.7554/eLife.73150
  
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elifesciences.org/articles/73150
Nov 2021
mct.aacrjournals.org mct.aacrjournals.org

SLFN11 is Widely Expressed in Pediatric Sarcoma and Induces Variable Sensitization to Replicative Stress Caused By DNA-Damaging Agents

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1. scibot 24 Nov 2021
  
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  DOI: 10.1158/1535-7163.MCT-21-0089
  
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mct.aacrjournals.org/content/20/11/2151
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TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change

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1. scibot 10 Nov 2021
  
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  DOI: 10.1016/j.celrep.2021.109979
  
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sciencedirect.com/science/article/pii/S2211124721014583
Aug 2021
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Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis

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1. scibot 16 Aug 2021
  
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  RRID:AB_2716685
  
  DOI: 10.1016/j.ccell.2021.07.006
  
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sciencedirect.com/science/article/pii/S1535610821003834
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HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways

1
1. scibot 15 Aug 2021
  
  in Public
  
  RRID:AB_2716685
  
  DOI: 10.7554/eLife.64148
  
  Resource: (Cell Signaling Technology Cat# 12105, RRID:AB_2716685)
  
  Curator: @scibot
  
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  RRID:AB_2716685
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elifesciences.org/articles/64148
Apr 2021
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Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia

1
1. scibot 22 Apr 2021
  
  in Public
  
  RRID:AB_271685
  
  DOI: 10.1016/j.ccell.2020.10.010
  
  Resource: (Cell Signaling Technology Cat# 12105, RRID:AB_2716685)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2716685
  
  Curator comments: Bak (D4E4) Rabbit mAb antibody Cell Signaling Technology Cat# 12105
  
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  RRID:AB_2716685 RRIDCUR:Incorrect RRIDCUR:Unresolved
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RRID:AB_2716685

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sciencedirect.com/science/article/pii/S1535610820305419
Sep 2020
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Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

1
1. scibot 23 Sep 2020
  
  in Public
  
  RRID:AB_2716685
  
  DOI: 10.1016/j.immuni.2020.01.014
  
  Resource: (Cell Signaling Technology Cat# 12105, RRID:AB_2716685)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2716685
  
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  RRID:AB_2716685 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S107476132030042X
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Microarray assay of circular RNAs reveals cicRNA.7079 as a new anti-apoptotic molecule in spinal cord injury in mice

1
1. scibot 05 Sep 2020
  
  in Public
  
  RRID:AB_2716685
  
  DOI: 10.1016/j.brainresbull.2020.08.004
  
  Resource: (Cell Signaling Technology Cat# 12105, RRID:AB_2716685)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2716685
  
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  RRIDCUR:Validated RRID:AB_2716685
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sciencedirect.com/science/article/pii/S0361923020305852
Jan 2020
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The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2716685
  
  DOI: 10.1016/j.cell.2019.05.035
  
  Resource: (Cell Signaling Technology Cat# 12105, RRID:AB_2716685)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2716685
  
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  RRID:AB_2716685 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S009286741930563X
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BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2716685
  
  DOI: 10.1016/j.ccell.2019.04.005
  
  Resource: (Cell Signaling Technology Cat# 12105, RRID:AB_2716685)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2716685
  
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  RRID:AB_2716685 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610819302004
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Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2716685
  
  DOI: 10.1016/j.cmet.2019.01.011
  
  Resource: (Cell Signaling Technology Cat# 12105, RRID:AB_2716685)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2716685
  
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  RRID:AB_2716685 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1550413119300117
Nov 2018
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Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_2716685
  
  Resource used:
  
  (Cell Signaling Technology Cat# 12105, RRID:AB_2716685)
  
  SciCrunch record: RRID:AB_2716685
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_2716685
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sciencedirect.com/science/article/pii/S1535610817305020