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Targeted lactate depletion via gluconeogenesis by engineered hepatocyte-based micronanorobots for radiosensitization and immune activation

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1. scibot 24 Oct 2026
  
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  DOI: 10.1016/j.xcrm.2026.103123
  
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H3K18 lactylation promotes Treg/Th17 imbalance via PTPRM-STAT3 axis in hepatocellular carcinoma

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1. scibot 22 Oct 2026
  
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  DOI: 10.1016/j.isci.2026.117896
  
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sciencedirect.com/science/article/pii/S2589004226032797
Oct 2026
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Sulfonylurea receptor 1 deficiency alleviates acute lung injury by activating PARP1 in epithelial cells

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1. scibot 08 Oct 2026
  
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  DOI: 10.1016/j.isci.2026.117627
  
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Cancer competition for vitamin B2 creates metabolic checkpoint for T cell ferroptosis

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1. scibot 08 Oct 2026
  
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  DOI: 10.1016/j.cell.2026.09.020
  
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sciencedirect.com/science/article/pii/S0092867426011220
Sep 2026
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PPM1L-dependent PD-L1 dephosphorylation orchestrates tumor-type-specific ubiquitin ligase recognition to govern its degradation

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RAD51AP1-MYC-Sam68 positive transcriptional feedback loop maintains lung cancer stemness

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  DOI: 10.1016/j.isci.2026.117397
  
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Aug 2026
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SPINK1-COL18A1 crosstalk shapes epigenome and drives cancer stemness in pancreatic ductal adenocarcinoma

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SOX12 and DELTA mediate ecdysone-driven adult neural cell proliferation during metamorphosis

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1. scibot 10 Aug 2026
  
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BPS Publications

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1. scibot 08 Aug 2026
  
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  DOI: 10.1111/bph.16268
  
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Repurposing simeprevir uncovers a druggable KPNB1-p65-BCL2 survival axis in cancer

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sciencedirect.com/science/article/pii/S2451945626002783
Jul 2026
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MZT2A drives epithelial-mesenchymal transition in lung adenocarcinoma via the LGALS3BP/ITGB1/TGF-β/smad2 axis

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1. scibot 20 Jul 2026
  
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  DOI: 10.1016/j.isci.2026.116856
  
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TTYH3 regulates a lysosomal chloride conductance and controls lysosomal fusion, autophagy and senescence

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1. scibot 20 Jul 2026
  
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  DOI: 10.1016/j.celrep.2026.117703
  
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BRAF Inhibition–Associated Nuclear Remodeling is Linked to Cancer-Associated Fibroblast Activation

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1. scibot 18 Jul 2026
  
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  DOI: 10.1158/2767-9764.CRC-25-0682
  
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HDAC5 depletion promotes hyper-acetylation of FOXA1 and potentiates HIF1α transcriptional activation in pancreatic cancer

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1. scibot 10 Jul 2026
  
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KIF26B promotes bladder cancer progression through activating the NF-κB signaling pathway

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1. scibot 04 Jul 2026
  
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  DOI: 10.1016/j.isci.2026.116577
  
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Troxerutin suppresses the stemness of hepatocellular carcinoma via the Syk/FOXO3 feedback loop

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1. scibot 03 Jul 2026
  
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  DOI: 10.1007/s10565-026-10194-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13319154/
Jun 2026
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Centrosome linker protein CEP68 modulates cellular stress responses via nuclear condensate formation and HSP27 interaction

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1. scibot 24 Jun 2026
  
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  DOI: 10.1016/j.isci.2026.116491
  
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STRAP promotes hepatocellular carcinoma progression through activation of an STRAP/Wnt-β-catenin/STRAP positive feedback loop

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1. scibot 17 Jun 2026
  
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  DOI: 10.1016/j.isci.2026.116377
  
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Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathogenesis

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1. scibot 11 Jun 2026
  
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  DOI: 10.1016/j.neuron.2026.05.015
  
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Deacetylated PCBP1 licenses PARP1 activity for DNA damage repair

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May 2026
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Calcium influx drives m6A-dependent RUNX1T1 splicing to promote adipogenic commitment

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Adaptive Regulation of dNTP Homeostasis Confers Osimertinib Resistance in EGFR-Mutant Non–Small Cell Lung Carcinoma

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1. scibot 27 May 2026
  
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Gasdermin C reprograms metabolism through the CAMKK2-AMPK axis to promote lung adenocarcinoma progression and radioresistance

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1. scibot 27 May 2026
  
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2026.05.11.724407.full-html.html

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S-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis

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1. scibot 13 May 2026
  
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A ketogenesis-ferroptosis axis maintains leukemic stem cell survival and leukemia progression

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Apr 2026
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Engineered CAR-monocytes coordinate fibrosis clearance and cardiac regeneration following myocardial infarction

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Mar 2026
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Enalaprilat reverses neutrophil polarization imbalance via targeting taurine-STING axis for treatment of diabetic wounds

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LENG8 mediates RNA nuclear retention and degradation in eukaryotes

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1-s2.0-S2589004226007479-main-html.html

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Dexmedetomidine inhibits fear memory consolidation via the astrocyte-specific Srebf1-Phgdh pathway in the prelimbic prefrontal cortex

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Pharmaco-genomic characterization of pancreatic and biliary tract cancer tumoroids for drug response

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Feb 2026
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RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer

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1. scibot 12 Feb 2026
  
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HMGA2 promotes hepatocellular carcinoma progression by regulating tumor-associated macrophage via Notch1/CCL2 signaling

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1. scibot 10 Feb 2026
  
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  DOI: 10.1007/s11010-026-05491-4
  
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Jan 2026
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Targeting ZDHHC12-mediated PARP1 palmitoylation potentiates PARP inhibitor cytotoxicity

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1. scibot 27 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116910
  
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1-s2.0-S2589004226000933-main-html.html

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Nov 2025
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Dexmedetomidine alleviates ferroptosis caused by traumatic brain injury via the NRF2/HO-1/GPX4 pathway

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A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma

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C19orf12 inhibits mitochondrial function and enhances the antitumor effects of metformin in non-small cell lung cancer

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Extrachromosomal DNA biogenesis is dependent on DNA looping and religation by YY1-Lig3-PARylation complex

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A biotin-HaloTag ligand enables efficient affinity capture of protein variants from live cells

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Altered cofactor recruitment and nucleosome dynamics underlie bisphenol A’s impact on ERα-mediated transcriptional bursting

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Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation

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ZBP1 senses splicing aberration through Z-RNA to promote cell death

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O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extracellular vesicles

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Serotonin receptor HTR2B facilitates colorectal cancer metastasis via CREB1-ZEB1 axis mediated epithelial-mesenchymal transition

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Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3

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The steroid hormone 20-hydroxyecdysone inhibits RAPTOR expression by repressing Hox gene transcription to induce autophagy

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Cecal necroptosis triggers lethal cardiac dysfunction in TNF-induced severe SIRS

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Transient splicing inhibition causes persistent DNA damage and chemotherapy vulnerability in triple-negative breast cancer

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PICKLE-mediated nucleosome condensing drives H3K27me3 spreading for the inheritance of Polycomb memory during differentiation

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Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans

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Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage

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The extracellular matrix integrates mitochondrial homeostasis

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METTL1-Modulated LSM14A Facilitates Proliferation and Migration in Glioblastoma via the Stabilization of DDX5

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Depletion of Mettl3 in cholinergic neurons causes adult-onset neuromuscular degeneration

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YZL-51N functions as a selective inhibitor of SIRT7 by NAD+ competition to impede DNA damage repair

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Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer

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Mycobacterial CpsA activates type I IFN signaling in macrophages via cGAS-mediated pathway

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TERC promotes non-small cell lung cancer progression by facilitating the nuclear localization of TERT

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NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors

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PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer

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hnRNPU is required for spermatogonial stem cell pool establishment in mice

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Covalent Peptide LSD1 Inhibitor Specifically Recognizes Cys360 in the Enzyme-Active Region

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Covalent Peptide LSD1 Inhibitor Specifically Recognizes Cys360 in the Enzyme-Active Region

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Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia

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Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia

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KAT8 is upregulated and recruited to the promoter of Atg8 by FOXO to induce H4 acetylation for autophagy under 20-hydroxyecdysone regulation

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YTHDF2-mediated circYAP1 drives immune escape and cancer progression through activating YAP1/TCF4-PD-L1 axis

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Metabolic regulation of homologous recombination repair by MRE11 lactylation

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E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC

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LncRNA DGCR5-encoded polypeptide RIP aggravates SONFH by repressing nuclear localization of β-catenin in BMSCs

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ATF7IP2, a meiosis-specific partner of SETDB1, is required for proper chromosome remodeling and crossover formation during spermatogenesis

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Bexarotene improves motor function after spinal cord injury in mice

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Glycolytic enzyme HK2 promotes PD-L1 expression and breast cancer cell immune evasion

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Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

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20-hydroxyecdysone reprograms amino acid metabolism to support the metamorphic development of Helicoverpa armigera

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(A) Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis

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RNA Pol II preferentially regulates ribosomal protein expression by trapping disassociated subunits

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Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis

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YTHDF1 phase separation triggers the fate transition of spermatogonial stem cells by activating the IκB-NF-κB-CCND1 axis

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Asparagine starvation suppresses histone demethylation through iron depletion

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Nuclear translocation of cGAS orchestrates VEGF-A-mediated angiogenesis

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Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis

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Neofunctionalisation of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes

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Global phosphoproteomic analysis identified key kinases regulating male meiosis in mouse

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The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice

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NRF2 Serves A Critical Role In Regulation Of Immune Checkpoint Proteins (ICPs) During Trophoblast Differentiation

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Linkage of methionine addiction, histone lysine hypermethylation, and malignancy

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Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex

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Recruitment of DNA to tumor-derived microvesicles

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Dysregulated lipid metabolism blunts the sensitivity of cancer cells to EZH2 inhibitor

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Liquidambaric acid inhibits Wnt/β-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2

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Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer

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BPS Publications

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Interferon functional analog activates antiviral Jak/Stat signaling through integrin in an arthropod

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PPARγ participates in the acquisition of brain ischemic tolerance induced by ischemic preconditioning via GLT‐1 in vivo and in vitro

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Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory

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Protective effect of hydrogen sulfide on endothelial cells through Sirt1-FoxO1-mediated autophagy

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Oct 2020
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Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation

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  DOI: 10.1016/j.celrep.2020.108327
  
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sciencedirect.com/science/article/pii/S2211124720313164
Jan 2020
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Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.molcel.2019.06.001
  
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sciencedirect.com/science/article/pii/S1097276519304344
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Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.06.026
  
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Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.ccell.2019.03.006
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6812656/
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Untitled document

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1. scibot 12 Jan 2020
  
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  DOI: 10.1016/j.ccell.2019.03.006
  
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sciencedirect.com/science/article/pii/S1535610819301515
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Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway

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1. scibot 12 Jan 2020
  
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  DOI: 10.1021/acschemneuro.8b00605
  
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pubs.acs.org/doi/full/10.1021/acschemneuro.8b00605
Nov 2018
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Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors

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1. scibot 05 Nov 2018
  
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cell.com/cell/fulltext/S0092-8674(18)31119-X

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