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Aug 2025
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A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma

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C19orf12 inhibits mitochondrial function and enhances the antitumor effects of metformin in non-small cell lung cancer

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  DOI: 10.1016/j.celrep.2025.116163
  
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sciencedirect.com/science/article/pii/S2211124725009349
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Extrachromosomal DNA biogenesis is dependent on DNA looping and religation by YY1-Lig3-PARylation complex

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1. scibot 06 Aug 2025
  
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  RRID:AB_00089079
  
  DOI: 10.1016/j.molcel.2025.07.007
  
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sciencedirect.com/science/article/pii/S1097276525006082
Jul 2025
rupress.org rupress.org

A biotin-HaloTag ligand enables efficient affinity capture of protein variants from live cells

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  DOI: 10.1083/jcb.202410025
  
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rupress.org/jcb/article/224/8/e202410025/278122/A-biotin-HaloTag-ligand-enables-efficient-affinity
Jun 2025
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Altered cofactor recruitment and nucleosome dynamics underlie bisphenol A’s impact on ERα-mediated transcriptional bursting

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  DOI: 10.1016/j.isci.2025.112864
  
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sciencedirect.com/science/article/pii/S2589004225011253
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Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation

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  DOI: 10.1016/j.cmet.2025.05.013
  
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sciencedirect.com/science/article/pii/S1550413125002694
Apr 2025
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ZBP1 senses splicing aberration through Z-RNA to promote cell death

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  DOI: 10.1016/j.molcel.2025.03.023
  
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O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extracellular vesicles

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  DOI: 10.1016/j.cmet.2025.03.006
  
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sciencedirect.com/science/article/pii/S1550413125001093
Feb 2025
aacrjournals.org aacrjournals.org

Serotonin receptor HTR2B facilitates colorectal cancer metastasis via CREB1-ZEB1 axis mediated epithelial-mesenchymal transition

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1. scibot 14 Feb 2025
  
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  DOI: 10.1158/1541-7786.MCR-23-0513
  
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aacrjournals.org/mcr/article/22/6/538/745428/Serotonin-Receptor-HTR2B-Facilitates-Colorectal
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Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3

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  DOI: 10.1016/j.celrep.2025.115250
  
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sciencedirect.com/science/article/pii/S221112472500021X
Dec 2024
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The steroid hormone 20-hydroxyecdysone inhibits RAPTOR expression by repressing Hox gene transcription to induce autophagy

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1. scibot 19 Dec 2024
  
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  DOI: 10.1016/j.jbc.2024.108093
  
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sciencedirect.com/science/article/pii/S002192582402595X
Sep 2024
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Cecal necroptosis triggers lethal cardiac dysfunction in TNF-induced severe SIRS

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1. scibot 27 Sep 2024
  
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  AB_2716755
  
  DOI: 10.1016/j.celrep.2024.114778
  
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sciencedirect.com/science/article/pii/S221112472401129X
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Transient splicing inhibition causes persistent DNA damage and chemotherapy vulnerability in triple-negative breast cancer

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1. scibot 17 Sep 2024
  
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  AB_2716755
  
  DOI: 10.1016/j.celrep.2024.114751
  
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sciencedirect.com/science/article/pii/S2211124724011021
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PICKLE-mediated nucleosome condensing drives H3K27me3 spreading for the inheritance of Polycomb memory during differentiation

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1. scibot 04 Sep 2024
  
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  AB_2716755
  
  DOI: 10.1016/j.molcel.2024.08.018
  
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sciencedirect.com/science/article/pii/S1097276524006920
Aug 2024
www.embopress.org www.embopress.org

Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans

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1. scibot 02 Aug 2024
  
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  Anti‐Histone 3
  
  DOI: 10.15252/embj.2020106864
  
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embopress.org/doi/full/10.15252/embj.2020106864
Jul 2024
52.53.155.43 52.53.155.43

Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage

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1. scibot 26 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110507
  
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52.53.155.43/e9c57a9d42b1c2a342f0d34ee7a75c66e8f5b9d0/1-s2.0-S2589004224017322-main-html.html
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The extracellular matrix integrates mitochondrial homeostasis

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1. scibot 19 Jul 2024
  
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  AB_2716755
  
  DOI: 10.1016/j.cell.2024.05.057
  
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METTL1-Modulated LSM14A Facilitates Proliferation and Migration in Glioblastoma via the Stabilization of DDX5

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1. scibot 10 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110225
  
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sciencedirect.com/science/article/pii/S2589004224014500
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Depletion of Mettl3 in cholinergic neurons causes adult-onset neuromuscular degeneration

1
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  DOI: 10.1016/j.celrep.2024.113999
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11216409/
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YZL-51N functions as a selective inhibitor of SIRT7 by NAD+ competition to impede DNA damage repair

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  DOI: 10.1016/j.isci.2024.110014
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11214487/
Jun 2024
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Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer

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  DOI: 10.1016/j.cmet.2024.05.013
  
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sciencedirect.com/science/article/pii/S155041312400189X
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Mycobacterial CpsA activates type I IFN signaling in macrophages via cGAS-mediated pathway

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  DOI: 10.1016/j.isci.2024.109807
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11099328/
52.53.155.43 52.53.155.43

TERC promotes non-small cell lung cancer progression by facilitating the nuclear localization of TERT

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  DOI: 10.1016/j.isci.2024.109869
  
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52.53.155.43/761c70660e3a03a822484173742c13c4c44cc6bf/PIIS2589004224010915-html.html
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NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors

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  DOI: 10.1016/j.xgen.2024.100550
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11099347/
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PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer

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  DOI: 10.1016/j.celrep.2024.114176
  
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Apr 2024
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hnRNPU is required for spermatogonial stem cell pool establishment in mice

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  Proteintech17168-1-AP
  
  DOI: 10.1016/j.celrep.2024.114113
  
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pubs.acs.org pubs.acs.org

Covalent Peptide LSD1 Inhibitor Specifically Recognizes Cys360 in the Enzyme-Active Region

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1. scibot 18 Apr 2024
  
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  DOI: 10.1021/acs.jmedchem.3c01549
  
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  DOI: 10.1021/acs.jmedchem.3c01549
  
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pubs.acs.org/doi/10.1021/acs.jmedchem.3c01549
Mar 2024
pubs.acs.org pubs.acs.org

Covalent Peptide LSD1 Inhibitor Specifically Recognizes Cys360 in the Enzyme-Active Region

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  DOI: 10.1021/acs.jmedchem.3c01549
  
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  DOI: 10.1021/acs.jmedchem.3c01549
  
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Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia

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  DOI: 10.1016/j.chom.2024.02.001
  
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sciencedirect.com/science/article/pii/S1931312824000362
Feb 2024
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Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia

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  DOI: 10.1016/j.chom.2024.02.001
  
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  DOI: 10.1016/j.chom.2024.02.001
  
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KAT8 is upregulated and recruited to the promoter of Atg8 by FOXO to induce H4 acetylation for autophagy under 20-hydroxyecdysone regulation

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  DOI: 10.1016/j.jbc.2024.105704
  
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sciencedirect.com/science/article/pii/S0021925824000802
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YTHDF2-mediated circYAP1 drives immune escape and cancer progression through activating YAP1/TCF4-PD-L1 axis

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1. scibot 01 Feb 2024
  
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  RRID:AB_2716755
  
  DOI: 10.1016/j.isci.2023.108779
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10825049/
Dec 2023
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Metabolic regulation of homologous recombination repair by MRE11 lactylation

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1. scibot 22 Dec 2023
  
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  RRID:AB_2716755
  
  DOI: 10.1016/j.cell.2023.11.022
  
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E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC

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LncRNA DGCR5-encoded polypeptide RIP aggravates SONFH by repressing nuclear localization of β-catenin in BMSCs

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ATF7IP2, a meiosis-specific partner of SETDB1, is required for proper chromosome remodeling and crossover formation during spermatogenesis

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Bexarotene improves motor function after spinal cord injury in mice

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Glycolytic enzyme HK2 promotes PD-L1 expression and breast cancer cell immune evasion

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Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

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20-hydroxyecdysone reprograms amino acid metabolism to support the metamorphic development of Helicoverpa armigera

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(A) Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis

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RNA Pol II preferentially regulates ribosomal protein expression by trapping disassociated subunits

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Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis

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YTHDF1 phase separation triggers the fate transition of spermatogonial stem cells by activating the IκB-NF-κB-CCND1 axis

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Asparagine starvation suppresses histone demethylation through iron depletion

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Nuclear translocation of cGAS orchestrates VEGF-A-mediated angiogenesis

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Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis

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Neofunctionalisation of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes

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Global phosphoproteomic analysis identified key kinases regulating male meiosis in mouse

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The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice

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NRF2 Serves A Critical Role In Regulation Of Immune Checkpoint Proteins (ICPs) During Trophoblast Differentiation

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Linkage of methionine addiction, histone lysine hypermethylation, and malignancy

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Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex

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Recruitment of DNA to tumor-derived microvesicles

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Dysregulated lipid metabolism blunts the sensitivity of cancer cells to EZH2 inhibitor

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Liquidambaric acid inhibits Wnt/β-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2

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Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer

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BPS Publications

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Interferon functional analog activates antiviral Jak/Stat signaling through integrin in an arthropod

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PPARγ participates in the acquisition of brain ischemic tolerance induced by ischemic preconditioning via GLT‐1 in vivo and in vitro

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Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory

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Protective effect of hydrogen sulfide on endothelial cells through Sirt1-FoxO1-mediated autophagy

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Oct 2020
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Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation

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Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay

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Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

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sciencedirect.com/science/article/pii/S2211124719307922
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia

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1. scibot 13 Jan 2020
  
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  RRID:AB_2716755
  
  DOI: 10.1016/j.ccell.2019.03.006
  
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  Curator: @evieth
  
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  RRID:AB_2716755 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC6812656/
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Untitled document

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1. scibot 12 Jan 2020
  
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  DOI: 10.1016/j.ccell.2019.03.006
  
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  RRID:AB_2716755 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610819301515
pubs.acs.org pubs.acs.org

Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway

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1. scibot 12 Jan 2020
  
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  DOI: 10.1021/acschemneuro.8b00605
  
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  Curator: @Naa003
  
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pubs.acs.org/doi/full/10.1021/acschemneuro.8b00605
Nov 2018
www.cell.com www.cell.com

Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors

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1. scibot 05 Nov 2018
  
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  Curator: @Jmenke
  
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cell.com/cell/fulltext/S0092-8674(18)31119-X

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