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Fc‐Dependent Targeting of the GAS6–MERTK Axis With Monoclonal and Bispecific Antibodies Overcomes Drug Resistance Across EGFR Mutations in Exons 19, 20, and 21

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1. scibot 22 Oct 2026
  
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  DOI: 10.1002/advs.78290
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13669479/
Sep 2026
www.biorxiv.org www.biorxiv.org

Membrane PI(4,5)P2 and ErbB2 abundance regulate ErbB receptor oligomerization and kinase activation

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1. scibot 03 Sep 2026
  
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  DOI: 10.64898/2026.08.24.746611
  
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biorxiv.org/content/10.64898/2026.08.24.746611v3
Aug 2026
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Gut microbiota and uric acid excretion signaling in pathogenesis of hyperuricemia and acute gouty arthritis

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1. scibot 27 Aug 2026
  
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  DOI: 10.1016/j.isci.2026.117072
  
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sciencedirect.com/science/article/pii/S2589004226024508
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Enhanced HER2 internalization by clathrin-dependent endocytosis in non-small cell lung cancer positive for HER2 mutations

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1. scibot 01 Aug 2026
  
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  DOI: 10.1038/s41416-025-03126-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12479963/
Jul 2026
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EZH2 Inhibitors Sensitize Breast Cancer to HER2 Kinase Inhibitors through Cooperative Effects on YAP and Pro-apoptotic Regulators

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1. scibot 11 Jul 2026
  
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  DOI: 10.1158/0008-5472.CAN-24-3113
  
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aacrjournals.org/cancerres/article/86/6/1467/775076/EZH2-Inhibitors-Sensitize-Breast-Cancer-to-HER2
Jun 2026
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Structures of the PI3Kα/KRas complex on lipid bilayers reveal molecular mechanisms of PI3Kα activation

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1. scibot 26 Jun 2026
  
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  DOI: 10.1016/j.molcel.2026.06.010
  
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sciencedirect.com/science/article/pii/S1097276526003813
May 2026
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Therapeutic reactivation of hippocampal progenitors reverse cognition decline in mice with progressive brain demyelination

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1. scibot 01 May 2026
  
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  DOI: 10.1016/j.stemcr.2026.102896
  
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sciencedirect.com/science/article/pii/S2213671126001074
Apr 2026
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Anticancer activity of RAS-GTP inhibition in cholangiocarcinoma

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1. scibot 24 Apr 2026
  
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  DOI: 10.1016/j.ccell.2026.03.020
  
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sciencedirect.com/science/article/pii/S1535610826001741
Jan 2026
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A combined strategy of EGFR-MET bispecific antibody and HER3 ADC to overcome osimertinib resistance in NSCLC

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1. scibot 30 Jan 2026
  
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  DOI: 10.1007/s13402-025-01152-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12847129/
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Sevabertinib, a Reversible HER2 Inhibitor with Activity in Lung Cancer

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1. scibot 14 Jan 2026
  
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  AB_2721919
  
  DOI: 10.1158/2159-8290.CD-25-0605
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12793832/
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Integrative proteogenomic analysis provides molecular insights and clinical significance in gallbladder cancer

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.ccell.2025.12.014
  
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sciencedirect.com/science/article/pii/S1535610825005483
Sep 2025
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Eradicating Drug Tolerant Persister Cells in EGFR-Mutated Non-Small Cell Lung Cancer by Targeting TROP2 with CAR-T cellular therapy

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1. scibot 07 Sep 2025
  
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  DOI: 10.1158/2159-8290.CD-24-1515
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12374242/
Aug 2025
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AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer

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1. scibot 19 Aug 2025
  
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  DOI: 10.1158/0008-5472.CAN-25-0073
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12355176/
Jun 2025
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PDF-html.html

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1. scibot 17 Jun 2025
  
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  DOI: 10.1158/1535-7163.mct-24-0972
  
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52.53.155.43/5788f38b4bbfefdb72cde14acc900869637691f1/PDF-html.html
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Expression of SSTR2a, FAP, HER2 and HER3 as potential radionuclide therapy targets in higher-grade meningioma

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1. scibot 17 Jun 2025
  
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  DOI: 10.1007/s00259-025-07075-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12162718/
Apr 2025
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The Co-Expression and Cellular Location of HER Family Members, EGFRvIII, Putative Cancer Stem Cell Biomarkers CD44 and CD109 in Patients with Glioblastoma, and Their Impacts on Prognosis

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1. scibot 16 Apr 2025
  
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  DOI: 10.3390/cancers17071221
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11987930/
Mar 2025
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Comparative Single-Cell Transcriptomics of Human Neuroblastoma and Preclinical Models Reveals Conservation of an Adrenergic Cell State

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1. scibot 20 Mar 2025
  
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  RRID:AB_2721919
  
  DOI: 10.1158/0008-5472.CAN-24-1507
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11907193/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ERBB3 overexpression is enriched in diverse patient populations with castration-sensitive prostate cancer and is associated with a unique AR activity signature

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1. scibot 18 Apr 2024
  
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  DOI: 10.1158/1078-0432.CCR-23-2161
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11016893/
Oct 2023
52.53.155.43 52.53.155.43

bqad159-html.html

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1. scibot 31 Oct 2023
  
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  RRID:AB_2721919
  
  DOI: 10.1210/endocr/bqad159
  
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52.53.155.43/fadb698104ccd541263e8069783171593188288f/bqad159-html.html
Aug 2023
www.biorxiv.org www.biorxiv.org

Unraveling Vulnerabilities in Endocrine Therapy-Resistant HER2+/ER+ Breast Cancer

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1. scibot 27 Aug 2023
  
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  RRID:AB_2721919
  
  DOI: 10.1101/2023.08.21.554116
  
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biorxiv.org/content/10.1101/2023.08.21.554116v1
52.53.155.43 52.53.155.43

L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab

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1. scibot 18 Aug 2023
  
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  DOI: 10.1016/j.xcrm.2023.101142
  
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2. scibot 10 Aug 2023
  
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  RRID:AB_2721919
  
  DOI: 10.1016/j.xcrm.2023.101142
  
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52.53.155.43/bb31ad2b14838f5cede2aca897c595e2febf2f88/PIIS2666379123002951-html.html
Jun 2023
aacrjournals.org aacrjournals.org

Olig1/2-expressing intermediate lineage progenitors are predisposed to PTEN/p53-loss-induced gliomagenesis and harbor specific therapeutic vulnerabilities

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1. scibot 03 Jun 2023
  
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  DOI: 10.1158/0008-5472.CAN-22-1577
  
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aacrjournals.org/cancerres/article/83/6/890/718574/Olig1-2-Expressing-Intermediate-Lineage
Dec 2022
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BPS Publications

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1. scibot 23 Dec 2022
  
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  RRID:AB_2721919
  
  DOI: 10.1111/bph.15988
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15988
Nov 2022
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Neuronal-epithelial cross-talk drives acinar specification via NRG1-ERBB3-mTORC2 signaling

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1. scibot 22 Nov 2022
  
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  DOI: 10.1016/j.devcel.2022.10.011
  
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sciencedirect.com/science/article/pii/S1534580722007638
Jun 2022
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Liver Endothelium Promotes HER3-mediated Cell Survival in Colorectal Cancer with Wild-type and Mutant KRAS

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1. scibot 14 Jun 2022
  
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  DOI: 10.1158/1541-7786.MCR-21-0633
  
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aacrjournals.org/mcr/article/20/6/996/699064/Liver-Endothelium-Promotes-HER3-Mediated-Cell
May 2022
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EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma

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1. scibot 13 May 2022
  
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  DOI: 10.1158/2159-8290.CD-21-1168
  
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aacrjournals.org/cancerdiscovery/article/12/5/1378/694560/EGFR-Inhibition-Potentiates-FGFR-Inhibitor-Therapy
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Systematic discovery of mutation-directed neo-protein-protein interactions in cancer

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1. scibot 05 May 2022
  
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  DOI: 10.1016/j.cell.2022.04.014
  
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cell.com/cell/fulltext/S0092-8674(22)00461-5
Apr 2022
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Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis

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1. scibot 26 Apr 2022
  
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  DOI: 10.1016/j.isci.2022.104211
  
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sciencedirect.com/science/article/pii/S2589004222004813
Jun 2021
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Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity

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1. scibot 25 Jun 2021
  
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  DOI: 10.1016/j.ccell.2021.06.001
  
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sciencedirect.com/science/article/pii/S1535610821002841
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Dysregulation of the NRG1/ERBB pathway causes a developmental disorder with gastrointestinal dysmotility in humans

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1. scibot 17 Jun 2021
  
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  DOI: 10.1172/JCI145837
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7954599/
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Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling

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1. scibot 15 Jun 2021
  
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  DOI: 10.1016/j.crmeth.2021.100015
  
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sciencedirect.com/science/article/pii/S2667237521000151
May 2021
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Stem-like cells drive NF1-associated MPNST functional heterogeneity and tumor progression

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1. scibot 19 May 2021
  
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  DOI: 10.1016/j.stem.2021.04.029
  
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sciencedirect.com/science/article/pii/S1934590921001879
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BPS Publications

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1. scibot 10 May 2021
  
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  RRID:AB_2721919
  
  DOI: 10.1111/bph.15372
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15372
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Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium

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1. scibot 09 May 2021
  
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  RRID:AB_2721919
  
  DOI: 10.1016/j.stem.2020.06.021
  
  Resource: (Cell Signaling Technology Cat# 12708, RRID:AB_2721919)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2721919
  
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  RRID:AB_2721919
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sciencedirect.com/science/article/pii/S1934590920302885
Apr 2021
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Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer

1
1. scibot 29 Apr 2021
  
  in Public
  
  RRID:AB_2721919
  
  DOI: 10.1016/j.cmet.2020.10.018
  
  Resource: (Cell Signaling Technology Cat# 12708, RRID:AB_2721919)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2721919
  
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  RRID:AB_2721919
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sciencedirect.com/science/article/pii/S1550413120305519
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Cell Lineage-Based Stratification for Glioblastoma

1
1. scibot 20 Apr 2021
  
  in Public
  
  RRID:AB_2721919
  
  DOI: 10.1016/j.ccell.2020.06.003
  
  Resource: (Cell Signaling Technology Cat# 12708, RRID:AB_2721919)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2721919
  
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  RRID:AB_2721919 RRIDCUR:Validated
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scibot

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sciencedirect.com/science/article/pii/S153561082030307X
Jan 2020
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TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2721919
  
  DOI: 10.1016/j.celrep.2019.07.086
  
  Resource: (Cell Signaling Technology Cat# 12708, RRID:AB_2721919)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2721919
  
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  RRID:AB_2721919 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124719310022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2721919
  
  DOI: 10.7554/eLife.46551
  
  Resource: (Cell Signaling Technology Cat# 12708, RRID:AB_2721919)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2721919
  
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  RRID:AB_2721919 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC6606022/
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Untitled document

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2721919
  
  DOI: 10.1016/j.celrep.2018.12.013
  
  Resource: (Cell Signaling Technology Cat# 12708, RRID:AB_2721919)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2721919
  
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  RRID:AB_2721919 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124718319247
Nov 2018
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EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics

1
1. scibot 05 Nov 2018
  
  in Public
  
  12708
  
  Curator: @Jmenke
  
  Resource used:
  
  (Cell Signaling Technology Cat# 12708, RRID:AB_2721919)
  
  SciCrunch record: RRID:AB_2721919
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_2721919 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S0092867417310668
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Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes

1
1. scibot 05 Nov 2018
  
  in Public
  
  HER3 (clone D22C5)Cell SignalingCat#12708S
  
  Curator: @evieth
  
  Curator note: HER3/ErbB3 (D22C5) XP® Rabbit mAb antibody
  
  Resource used:
  
  (Cell Signaling Technology Cat# 12708, RRID:AB_2721919)
  
  SciCrunch record: RRID:AB_2721919
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_2721919 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S2405471218300541