60 Matching Annotations
  1. Mar 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity
    1
    1. scibot 23 Mar 2024
      RRID:AB_2722521

      DOI: 10.7554/eLife.88122

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    ncbi.nlm.nih.gov/pmc/articles/PMC10945704/
  3. Dec 2023
  4. www.sciencedirect.com www.sciencedirect.com
    Aedes aegypti saliva modulates inflammasome activation and facilitates flavivirus infection in vitro
    1
    1. scibot 21 Dec 2023
      RRID:AB_2722521

      DOI: 10.1016/j.isci.2023.108620

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    sciencedirect.com/science/article/pii/S2589004223026974
  5. Nov 2023
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
    1
    1. scibot 03 Nov 2023
      RRID: AB_2722521

      DOI: 10.1158/1078-0432.CCR-23-0103

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    ncbi.nlm.nih.gov/pmc/articles/PMC10618648/
  7. Oct 2023
  8. www.sciencedirect.com www.sciencedirect.com
    Destruction of self-derived PAMP via T3SS2 effector VopY to subvert PAMP-triggered immunity mediates Vibrio parahaemolyticus pathogenicity
    1
    1. scibot 27 Oct 2023
      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2023.113261

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    sciencedirect.com/science/article/pii/S2211124723012731
  9. www.sciencedirect.com www.sciencedirect.com
    Mechanotransduction in response to ECM stiffening impairs cGAS immune signaling in tumor cells
    1
    1. scibot 13 Oct 2023
      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2023.113213

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    sciencedirect.com/science/article/pii/S2211124723012251
  10. 52.53.155.43 52.53.155.43
    ccr-23-0103-html.html
    1
    1. scibot 07 Oct 2023
      RRID: AB_2722521

      DOI: 10.1158/1078-0432.ccr-23-0103

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    52.53.155.43/05abf3a0903b8473a428373dc7a2f791e1da90bb/ccr-23-0103-html.html
  11. Sep 2023
  12. www.sciencedirect.com www.sciencedirect.com
    Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
    1
    1. scibot 30 Sep 2023
      RRID:AB_2722521

      DOI: 10.1016/j.chom.2023.08.003

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    sciencedirect.com/science/article/pii/S1931312823003281
  13. www.sciencedirect.com www.sciencedirect.com
    Enzymolysis-based RNA pull-down identifies YTHDC2 as an inhibitor of antiviral innate response
    1
    1. scibot 30 Sep 2023
      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2023.113192

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    sciencedirect.com/science/article/pii/S2211124723012044
  14. www.sciencedirect.com www.sciencedirect.com
    SARS-CoV-2 Nsp15 suppresses type I interferon production by inhibiting IRF3 phosphorylation and nuclear translocation
    1
    1. scibot 07 Sep 2023
      RRID:AB_2722521

      DOI: 10.1016/j.isci.2023.107705

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    sciencedirect.com/science/article/pii/S2589004223017820
  15. Aug 2023
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility
    1
    1. scibot 26 Aug 2023
      RRID:AB_2722521

      DOI: 10.1126/sciadv.adg5211

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      Curator: @evieth

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    ncbi.nlm.nih.gov/pmc/articles/PMC10438455/
  17. www.science.org www.science.org
    XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility
    2
    1. scibot 25 Aug 2023
      RRID:AB_2722521

      DOI: 10.1126/sciadv.adg5211

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    2. scibot 25 Aug 2023
      RRID:AB_2722521

      DOI: 10.1126/sciadv.adg5211

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    science.org/doi/10.1126/sciadv.adg5211
  18. 52.53.155.43 52.53.155.43
    Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis
    2
    1. scibot 17 Aug 2023
      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2023.112944

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    2. scibot 11 Aug 2023
      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2023.112944

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    52.53.155.43/f1aa479ee50c1426738d478d555cd8c52a91c49e/PIIS2211124723009555-html.html
  19. Jul 2023
  20. www.sciencedirect.com www.sciencedirect.com
    MEF2A suppresses stress responses that trigger DDX41-dependent IFN production
    1
    1. scibot 21 Jul 2023
      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2023.112805

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    sciencedirect.com/science/article/pii/S2211124723008161
  21. 52.53.155.43 52.53.155.43
    ccr-23-0103-html.html
    1
    1. scibot 08 Jul 2023
      RRID: AB_2722521

      DOI: 10.1158/1078-0432.ccr-23-0103

      Resource: (Cell Signaling Technology Cat# 11904, RRID:AB_2722521)

      Curator: @olekpark

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    52.53.155.43/05abf3a0903b8473a428373dc7a2f791e1da90bb/ccr-23-0103-html.html
  22. Jun 2023
  23. www.sciencedirect.com www.sciencedirect.com
    Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity
    1
    1. scibot 02 Jun 2023
      RRID:AB_2722521

      DOI: 10.1016/j.ccell.2023.05.005

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    sciencedirect.com/science/article/pii/S1535610823001733
  24. www.sciencedirect.com www.sciencedirect.com
    Cancer cell-autonomous cGAS-STING response confers drug resistance
    1
    1. scibot 01 Jun 2023
      RRID:AB_2722521

      DOI: 10.1016/j.chembiol.2023.05.005

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    sciencedirect.com/science/article/pii/S2451945623001411
  25. May 2023
  26. www.mdpi.com www.mdpi.com
    Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral Responses
    1
    1. scibot 06 May 2023
      RRID: AB_2722521

      DOI: 10.3390/cells10102600

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    mdpi.com/2073-4409/10/10/2600/htm
  27. Apr 2023
  28. www.sciencedirect.com www.sciencedirect.com
    Innate immune pathway modulator screen identifies STING pathway activation as a strategy to inhibit multiple families of arbo and respiratory viruses
    1
    1. scibot 29 Apr 2023
      RRID:AB_2722521

      DOI: 10.1016/j.xcrm.2023.101024

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    sciencedirect.com/science/article/pii/S2666379123001349
  29. Mar 2023
  30. www.sciencedirect.com www.sciencedirect.com
    Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS
    1
    1. scibot 28 Mar 2023
      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2023.112309

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    sciencedirect.com/science/article/pii/S2211124723003200
  31. europepmc.org europepmc.org
    UBL7 enhances antiviral innate immunity by promoting Lys27-linked polyubiquitination of MAVS
    1
    1. scibot 23 Mar 2023
      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2023.112272

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    europepmc.org/article/med/36943869
  32. Dec 2022
  33. www.embopress.org www.embopress.org
    DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma
    2
    1. scibot 31 Dec 2022
      RRID:AB_2722521

      DOI: 10.15252/embj.2022111961

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    2. scibot 31 Dec 2022
      RRID:AB_2722521

      DOI: 10.15252/embj.2022111961

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    embopress.org/doi/10.15252/embj.2022111961
  34. www.sciencedirect.com www.sciencedirect.com
    Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling
    1
    1. scibot 18 Dec 2022
      RRID:AB_2722521

      DOI: 10.1016/j.chembiol.2022.11.012

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    sciencedirect.com/science/article/pii/S2451945622004184
  35. www.sciencedirect.com www.sciencedirect.com
    Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer
    1
    1. scibot 02 Dec 2022
      RRID:AB_2722521

      DOI: 10.1016/j.ccell.2022.11.005

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    sciencedirect.com/science/article/pii/S1535610822005529
  36. Nov 2022
  37. www.sciencedirect.com www.sciencedirect.com
    LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation
    1
    1. scibot 24 Nov 2022
      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2022.111661

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    sciencedirect.com/science/article/pii/S2211124722015327
  38. Jul 2022
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS
    1
    1. scibot 27 Jul 2022
      RRID:AB_2722521

      DOI: 10.15252/embj.2021109217

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    ncbi.nlm.nih.gov/pmc/articles/PMC9289529/
  40. www.sciencedirect.com www.sciencedirect.com
    Irradiation combined with PD-L1-/- and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING mediated T cell activation
    1
    1. scibot 13 Jul 2022
      RRID:AB_2722521

      DOI: 10.1016/j.isci.2022.104690

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    sciencedirect.com/science/article/pii/S2589004222009622
  41. Jun 2022
  42. www.sciencedirect.com www.sciencedirect.com
    Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses
    1
    1. scibot 22 Jun 2022
      RRID:AB_2722521

      DOI: 10.1016/j.chembiol.2022.05.009

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    sciencedirect.com/science/article/pii/S245194562200201X
  43. May 2022
  44. www.sciencedirect.com www.sciencedirect.com
    DDX41 is required for cGAS-STING activation against DNA virus infection
    1
    1. scibot 26 May 2022
      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2022.110856

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    sciencedirect.com/science/article/pii/S2211124722006295
  45. www.sciencedirect.com www.sciencedirect.com
    WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC
    1
    1. scibot 19 May 2022
      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2022.110814

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    sciencedirect.com/science/article/pii/S221112472200585X
  46. Feb 2022
  47. www.sciencedirect.com www.sciencedirect.com
    FEZ1 phosphorylation regulates HSPA8 localization and interferon-stimulated gene expression
    1
    1. scibot 16 Feb 2022
      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2022.110396

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    sciencedirect.com/science/article/pii/S2211124722001176
  48. Jan 2022
  49. www.sciencedirect.com www.sciencedirect.com
    STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses
    1
    1. scibot 05 Jan 2022
      RRID:AB_2722521

      DOI: 10.1016/j.cmet.2021.12.007

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    sciencedirect.com/science/article/pii/S1550413121006264
  50. Dec 2021
  51. www.sciencedirect.com www.sciencedirect.com
    IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer
    1
    1. scibot 22 Dec 2021
      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2021.110138

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    sciencedirect.com/science/article/pii/S221112472101634X
  52. Nov 2021
  53. www.sciencedirect.com www.sciencedirect.com
    APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis
    1
    1. scibot 09 Nov 2021
      AB_2722521

      DOI: 10.1016/j.immuni.2021.10.004

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    sciencedirect.com/science/article/pii/S1074761321004106
  54. Oct 2021
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CX-5461 Treatment Leads to Cytosolic DNA-Mediated STING Activation in Ovarian Cancer
    1
    1. scibot 28 Oct 2021
      RRID:AB_2722521

      DOI: 10.3390/cancers13205056

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    ncbi.nlm.nih.gov/pmc/articles/PMC8533980/
  56. Sep 2021
  57. www.sciencedirect.com www.sciencedirect.com
    A photoaffinity labeling strategy identified EF1A1 as a binding protein of cyclic dinucleotide 2′3′-cGAMP
    1
    1. scibot 03 Sep 2021
      RRID:AB_2722521

      DOI: 10.1016/j.chembiol.2021.08.006

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    sciencedirect.com/science/article/pii/S2451945621003950
  58. Aug 2021
  59. www.sciencedirect.com www.sciencedirect.com
    Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death
    1
    1. scibot 15 Aug 2021
      RRID:AB_2722521

      DOI: 10.1016/j.cell.2021.07.026

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    sciencedirect.com/science/article/pii/S0092867421008850
  60. www.sciencedirect.com www.sciencedirect.com
    FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection
    1
    1. scibot 09 Aug 2021
      RRID:AB_2722521

      DOI: 10.1016/j.chom.2018.10.006

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    sciencedirect.com/science/article/pii/S1931312818305444
  61. www.ncbi.nlm.nih.govhttp: www.ncbi.nlm.nih.govhttp:
    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
    1
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      RRID:AB_2722521

      DOI: 10.1016/j.molcel.2018.07.034

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    ncbi.nlm.nih.govhttp://europepmc.org/articles/PMC6127031/
  62. Jul 2021
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    1. scibot 28 Jul 2021
      RRID:AB_2722521

      DOI: 10.1016/j.molcel.2018.07.034

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  64. May 2021
  65. www.sciencedirect.com www.sciencedirect.com
    Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion
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      RRID:AB_2722521

      DOI: 10.1016/j.molcel.2021.05.002

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    sciencedirect.com/science/article/pii/S1097276521003592
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    METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection
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    1. scibot 11 May 2021
      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2021.109091

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    sciencedirect.com/science/article/pii/S2211124721004253
  67. Apr 2021
  68. www.sciencedirect.com www.sciencedirect.com
    Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly
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      RRID:AB_2722521

      DOI: 10.1016/j.stem.2021.03.004

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    sciencedirect.com/science/article/pii/S1934590921001107
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    A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology
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    1. scibot 07 Apr 2021
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      DOI: 10.1016/j.ebiom.2021.103314

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    sciencedirect.com/science/article/pii/S2352396421001079
  70. Mar 2021
  71. www.sciencedirect.com www.sciencedirect.com
    IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility
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    1. scibot 24 Mar 2021
      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2021.108891

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    sciencedirect.com/science/article/pii/S2211124721002059
  72. Jan 2021
  73. www.sciencedirect.com www.sciencedirect.com
    MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells
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    1. scibot 22 Jan 2021
      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2020.108628

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    sciencedirect.com/science/article/pii/S221112472031617X
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    The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling
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      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2020.108631

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    Critical role of Syk-dependent STAT1 activation in innate antiviral immunity
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    1. scibot 20 Jan 2021
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      DOI: 10.1016/j.celrep.2020.108627

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    sciencedirect.com/science/article/pii/S2211124720316168
  76. Sep 2020
  77. www.sciencedirect.com www.sciencedirect.com
    Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity
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    1. scibot 25 Sep 2020
      RRID:AB_2722521

      DOI: 10.1016/j.molcel.2020.06.020

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    TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages
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      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2020.03.008

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    sciencedirect.com/science/article/pii/S2211124720303065
  79. Jan 2020
  80. www.sciencedirect.com www.sciencedirect.com
    The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers
    1
    1. scibot 13 Jan 2020
      RRID:AB_2722521

      DOI: 10.1016/j.chom.2019.08.010

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    sciencedirect.com/science/article/pii/S1931312819304196
  81. www.sciencedirect.com www.sciencedirect.com
    Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS
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    1. scibot 13 Jan 2020
      RRID:AB_2722521

      DOI: 10.1016/j.cell.2019.05.003

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    sciencedirect.com/science/article/pii/S009286741930501X
  82. www.sciencedirect.com www.sciencedirect.com
    Attenuation of the Innate Immune Response against Viral Infection Due to ZNF598-Promoted Binding of FAT10 to RIG-I
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    1. scibot 13 Jan 2020
      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2019.07.081

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    sciencedirect.com/science/article/pii/S2211124719309854
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      RRID:AB_2722521

      DOI: 10.7554/eLife.41159

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    ncbi.nlm.nih.gov/pmc/articles/PMC6389286/
  84. www.sciencedirect.com www.sciencedirect.com
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      RRID:AB_2722521

      DOI: 10.1016/j.celrep.2019.01.030

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    sciencedirect.com/science/article/pii/S2211124719300397
  85. www.sciencedirect.com www.sciencedirect.com
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      RRID:AB_2722521

      DOI: 10.1016/j.chom.2019.02.015

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    sciencedirect.com/science/article/pii/S1931312819301118
  86. Nov 2018
  87. www.ncbi.nlm.nih.govhttp: www.ncbi.nlm.nih.govhttp:
    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
    1
    1. scibot 05 Nov 2018
      RRID:AB_2722521

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  88. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S0092867418308560