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  1. Last 7 days
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    Pericancerous cross-presentation to cytotoxic T lymphocytes impairs immunotherapeutic efficacy in hepatocellular carcinoma
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  3. Nov 2024
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Kaempferol attenuates hyperuricemia combined with gouty arthritis via urate transporters and NLRP3/NF-κB pathway modulation
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    Insulin Mediates Lipopolysaccharide-Induced Inflammatory Responses and Oxidative Stress in BV2 Microglia
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    Mitochondrial transplantation confers protection against the effects of ischemic stroke by repressing microglial pyroptosis and promoting neurogenesis
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  7. Oct 2024
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    Type I IFN drives unconventional IL-1β secretion in lupus monocytes
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    sciencedirect.com/science/article/pii/S1074761324004485
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    Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation
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    aacrjournals.org/cancerimmunolres/article/9/9/1008/666146/Overproduction-of-Gastrointestinal-5-HT-Promotes
  10. Jul 2024
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    Inhibition of SIRT1 relieves hepatocarcinogenesis via alleviating autophagy and inflammation
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    sciencedirect.com/science/article/pii/S0141813024049250
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    Small molecule inhibitor binds to NOD-like receptor family pyrin domain containing 3 and prevents inflammasome activation
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  13. May 2024
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    TUDCA alleviates atherosclerosis by inhibiting AIM2 inflammasome and enhancing cholesterol efflux capacity in macrophage
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  15. Apr 2024
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    Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia
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    sciencedirect.com/science/article/pii/S2211124724004807
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    Chang-Kang-Fang alleviates diarrhea predominant irritable bowel syndrome (IBS-D) through inhibiting TLR4/NF-κB/NLRP3 pathway
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    Semaphorin3C identified as mediator of neuroinflammation and microglia polarization after spinal cord injury
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  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation
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    AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis
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  21. Mar 2024
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    Subventricular zone stem cell niche injury is associated with intestinal perforation in preterm infants and predicts future motor impairment
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    Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway
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    The NADase CD38 is a central regulator in gouty inflammation and a novel druggable therapeutic target
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    Edaravone dexborneol promotes M2 microglia polarization against lipopolysaccharide-induced inflammation via suppressing TLR4/MyD88/NF-κB pathway
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    Age-associated accumulation of B cells promotes macrophage inflammation and inhibits lipolysis in adipose tissue during sepsis
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  27. Feb 2024
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    Lumbricus Extract Prevents LPS-Induced Inflammatory Activation of BV2 Microglia and Glutamate-Induced Hippocampal HT22 Cell Death by Suppressing MAPK/NF-κB/NLRP3 Signaling and Oxidative Stress
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    SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination
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  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effects of polyphenolic maqui (Aristotelia chilensis) extract on the inhibition of NLRP3 inflammasome and activation of mast cells in a mouse model of Crohn’s disease-like colitis
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  32. Dec 2023
  33. www.sciencedirect.com www.sciencedirect.com
    ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation
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  34. Nov 2023
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    CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline
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  36. Oct 2023
  37. www.sciencedirect.com www.sciencedirect.com
    HDL inhibits pancreatic acinar cell NLRP3 inflammasome activation and protect against acinar cell pyroptosis in acute pancreatitis
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    sciencedirect.com/science/article/pii/S1567576923012754
  38. Jul 2023
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bexarotene improves motor function after spinal cord injury in mice
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    Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing
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    sciencedirect.com/science/article/pii/S2666379123002574
  41. Jun 2023
  42. www.mdpi.com www.mdpi.com
    Effects of Dietary Oleacein Treatment on Endothelial Dysfunction and Lupus Nephritis in Balb/C Pristane-Induced Mice
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      DOI: 10.3390/antiox12061303

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    mdpi.com/2076-3921/12/6/1303
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    Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in severe patients with COVID-19
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    sciencedirect.com/science/article/pii/S2589004223010064
  44. May 2023
  45. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A novel sorbicillinoid compound as a potent anti-inflammation agent through inducing NLRP3 protein degradation
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      DOI: 10.1111/bph.16058

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16058
  46. Apr 2023
  47. www.sciencedirect.com www.sciencedirect.com
    The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome
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    sciencedirect.com/science/article/pii/S1074761323001231
  48. Mar 2023
  49. www.sciencedirect.com www.sciencedirect.com
    Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity
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    sciencedirect.com/science/article/pii/S1074761323000882
  50. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    CARD-only proteins regulate in vivo inflammasome responses and ameliorate gout
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      DOI: 10.1016/j.celrep.2023.112265

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  51. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Colchicine exerts anti-atherosclerotic and ‑plaque-stabilizing effects targeting foam cell formation
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      DOI: 10.1096/fj.202201469R

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202201469R
  52. Feb 2023
  53. link.springer.com link.springer.com
    Transmission of NLRP3-IL-1β Signals in Cerebral Ischemia and Reperfusion Injury: from Microglia to Adjacent Neuron and Endothelial Cells via IL-1β/IL-1R1/TRAF6
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      DOI: 10.1007/s12035-023-03232-y

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    link.springer.com/article/10.1007/s12035-023-03232-y
  54. Nov 2022
  55. www.sciencedirect.com www.sciencedirect.com
    Commensal cow Roseburia reduces gut-dysbiosis-induced mastitis through inhibiting bacterial translocation by producing butyrate in mice
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  57. Oct 2022
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    POP1 inhibits MSU-induced inflammasome activation and ameliorates gout
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  59. Aug 2022
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Alzheimer’s disease-associated gene TREML2 modulates inflammation by regulating microglia polarization and NLRP3 inflammasome activation
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  61. www.sciencedirect.com www.sciencedirect.com
    Histone deacetylase-2 controls IL-1β production through the regulation of NLRP3 expression and activation in tuberculosis infection
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  62. www.sciencedirect.com www.sciencedirect.com
    Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity
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  63. Jun 2022
  64. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Investigating the NLRP3 Inflammasome and its Regulator miR-223-3p in Multiple Sclerosis and Experimental Demyelination
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  65. May 2022
  66. www.sciencedirect.com www.sciencedirect.com
    A TLR4-independent critical role for CD14 in intracellular LPS sensing
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  67. Apr 2022
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control
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  69. Mar 2022
  70. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  71. Jan 2022
  72. link.springer.com link.springer.com
    miR-155 activates the NLRP3 inflammasome by regulating the MEK/ERK/NF-κB pathway in carotid atherosclerotic plaques in ApoE−/− mice
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  73. www.sciencedirect.com www.sciencedirect.com
    Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells
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    Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis
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  75. Dec 2021
  76. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  77. Nov 2021
  78. www.nature.com www.nature.com
    Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages
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  79. Aug 2021
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins
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  81. www.sciencedirect.com www.sciencedirect.com
    Adenosine synthase A contributes to recurrent Staphylococcus aureus infection by dampening protective immunity
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  82. Jun 2021
  83. www.sciencedirect.com www.sciencedirect.com
    Gasdermin-E-mediated pyroptosis participates in the pathogenesis of Crohn’s disease by promoting intestinal inflammation
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  84. May 2021
  85. www.sciencedirect.com www.sciencedirect.com
    Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection
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    Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis
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    sciencedirect.com/science/article/pii/S1074761320301680
  87. Dec 2020
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct effects of complement and of NLRP3- and non-NLRP3 inflammasomes for choroidal neovascularization
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      DOI: 10.7554/eLife.60194

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  89. Sep 2020
  90. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation
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      DOI: 10.1016/j.cmet.2020.07.016

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      RRID:AB_2722591

      DOI: 10.1111/bph.15083

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      RRID:AB_2722591

      DOI: 10.1111/bph.14998

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  94. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      DOI: 10.1111/bph.14938

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  95. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      DOI: 10.1111/bph.14806

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  96. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      RRID:AB_2722591

      DOI: 10.1111/bph.15026

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  97. Nov 2018
  98. www.sciencedirect.com www.sciencedirect.com
    PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism
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