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Circulating FABP5 released by dying macrophages function as a DAMP to exacerbate septic inflammation

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Sep 2025
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Peach Gum Polysaccharide Prevents Chemotherapy-Induced Intestinal Injury and Degenerative Behavior

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Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease

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Aug 2025
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Peach Gum Polysaccharide Prevents Chemotherapy-Induced Intestinal Injury and Degenerative Behavior

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Jul 2025
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BPS Publications

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Phosphoglycerate kinase 1 contributes to diabetic kidney disease through enzyme-dependent and independent manners

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Identification of the pyroptosis, apoptosis, and necroptosis (PANoptosis) involved in osteogenic differentiation inhibition impaired by tumor necrosis factor-α

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Jun 2025
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Itaconate promotes inflammatory responses in tissue-resident alveolar macrophages and exacerbates acute lung injury

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Piezo1 senses hyphae and initiates host defense against pathogenic fungi

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Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection

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May 2025
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ATP-release pannexin channels are gated by lysophospholipids

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  DOI: 10.7554/eLife.107067
  
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Inflammasome signaling in astrocytes modulates hippocampal plasticity

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  DOI: 10.1016/j.immuni.2025.04.007
  
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Apr 2025
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The glycolytic metabolite methylglyoxal covalently inactivates the NLRP3 inflammasome

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Red blood cells undergo lytic programmed cell death involving NLRP3

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  DOI: 10.1016/j.cell.2025.03.039
  
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Coronin1A regulates the trafficking of alpha synuclein in microglia

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  DOI: 10.1523/JNEUROSCI.1337-24.2025
  
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Mar 2025
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Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

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Feb 2025
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Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP

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Lipid droplet efferocytosis attenuates proinflammatory signaling in macrophages via TREM2- and MS4A7-dependent mechanisms

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BPS Publications

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  DOI: 10.1111/bph.17344
  
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Dec 2024
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1-s2.0-S2589004224028086-main-html.html

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GEFT inhibits the GSDM-mediated proptosis signalling pathway, promoting the progression and drug resistance of rhabdomyosarcoma

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Nov 2024
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Pericancerous cross-presentation to cytotoxic T lymphocytes impairs immunotherapeutic efficacy in hepatocellular carcinoma

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Kaempferol attenuates hyperuricemia combined with gouty arthritis via urate transporters and NLRP3/NF-κB pathway modulation

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Insulin Mediates Lipopolysaccharide-Induced Inflammatory Responses and Oxidative Stress in BV2 Microglia

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Mitochondrial transplantation confers protection against the effects of ischemic stroke by repressing microglial pyroptosis and promoting neurogenesis

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Oct 2024
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Type I IFN drives unconventional IL-1β secretion in lupus monocytes

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Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation

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  DOI: 10.1158/2326-6066.CIR-20-1043
  
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Jul 2024
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Inhibition of SIRT1 relieves hepatocarcinogenesis via alleviating autophagy and inflammation

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Small molecule inhibitor binds to NOD-like receptor family pyrin domain containing 3 and prevents inflammasome activation

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May 2024
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TUDCA alleviates atherosclerosis by inhibiting AIM2 inflammasome and enhancing cholesterol efflux capacity in macrophage

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Apr 2024
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Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia

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Chang-Kang-Fang alleviates diarrhea predominant irritable bowel syndrome (IBS-D) through inhibiting TLR4/NF-κB/NLRP3 pathway

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Semaphorin3C identified as mediator of neuroinflammation and microglia polarization after spinal cord injury

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  DOI: 10.1016/j.isci.2024.109649
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11025009/
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NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation

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AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis

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Subventricular zone stem cell niche injury is associated with intestinal perforation in preterm infants and predicts future motor impairment

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Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway

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The NADase CD38 is a central regulator in gouty inflammation and a novel druggable therapeutic target

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Edaravone dexborneol promotes M2 microglia polarization against lipopolysaccharide-induced inflammation via suppressing TLR4/MyD88/NF-κB pathway

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Age-associated accumulation of B cells promotes macrophage inflammation and inhibits lipolysis in adipose tissue during sepsis

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Lumbricus Extract Prevents LPS-Induced Inflammatory Activation of BV2 Microglia and Glutamate-Induced Hippocampal HT22 Cell Death by Suppressing MAPK/NF-κB/NLRP3 Signaling and Oxidative Stress

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SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination

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Effects of polyphenolic maqui (Aristotelia chilensis) extract on the inhibition of NLRP3 inflammasome and activation of mast cells in a mouse model of Crohn’s disease-like colitis

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ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation

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CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline

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HDL inhibits pancreatic acinar cell NLRP3 inflammasome activation and protect against acinar cell pyroptosis in acute pancreatitis

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Bexarotene improves motor function after spinal cord injury in mice

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Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing

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Effects of Dietary Oleacein Treatment on Endothelial Dysfunction and Lupus Nephritis in Balb/C Pristane-Induced Mice

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Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in severe patients with COVID-19

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A novel sorbicillinoid compound as a potent anti-inflammation agent through inducing NLRP3 protein degradation

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The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome

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Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity

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CARD-only proteins regulate in vivo inflammasome responses and ameliorate gout

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Colchicine exerts anti-atherosclerotic and ‑plaque-stabilizing effects targeting foam cell formation

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Transmission of NLRP3-IL-1β Signals in Cerebral Ischemia and Reperfusion Injury: from Microglia to Adjacent Neuron and Endothelial Cells via IL-1β/IL-1R1/TRAF6

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Commensal cow Roseburia reduces gut-dysbiosis-induced mastitis through inhibiting bacterial translocation by producing butyrate in mice

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POP1 inhibits MSU-induced inflammasome activation and ameliorates gout

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The Alzheimer’s disease-associated gene TREML2 modulates inflammation by regulating microglia polarization and NLRP3 inflammasome activation

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Histone deacetylase-2 controls IL-1β production through the regulation of NLRP3 expression and activation in tuberculosis infection

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Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity

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Investigating the NLRP3 Inflammasome and its Regulator miR-223-3p in Multiple Sclerosis and Experimental Demyelination

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A TLR4-independent critical role for CD14 in intracellular LPS sensing

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Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control

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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15758
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miR-155 activates the NLRP3 inflammasome by regulating the MEK/ERK/NF-κB pathway in carotid atherosclerotic plaques in ApoE−/− mice

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  RRID:AB_2722591
  
  DOI: 10.1007/s13105-022-00871-y
  
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Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells

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  DOI: 10.1016/j.devcel.2021.12.020
  
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Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis

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  DOI: 10.1016/j.devcel.2021.12.015
  
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1. scibot 21 Dec 2021
  
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  RRID:AB_2722591
  
  DOI: 10.1111/bph.15702
  
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Nov 2021
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Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages

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  DOI: 10.1038/s41420-021-00716-5
  
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nature.com/articles/s41420-021-00716-5
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Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins

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  DOI: 10.7554/eLife.44452
  
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Adenosine synthase A contributes to recurrent Staphylococcus aureus infection by dampening protective immunity

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  DOI: 10.1016/j.ebiom.2021.103505
  
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Gasdermin-E-mediated pyroptosis participates in the pathogenesis of Crohn’s disease by promoting intestinal inflammation

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  DOI: 10.1016/j.celrep.2021.109265
  
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Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection

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  DOI: 10.1016/j.xcrm.2021.100277
  
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Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis

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  DOI: 10.1016/j.immuni.2020.04.010
  
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Distinct effects of complement and of NLRP3- and non-NLRP3 inflammasomes for choroidal neovascularization

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1. scibot 16 Dec 2020
  
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  DOI: 10.7554/eLife.60194
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7732340/
Sep 2020
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  DOI: 10.1111/bph.15182
  
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The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

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  RRID:AB_2722591
  
  DOI: 10.1016/j.cmet.2020.07.016
  
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  RRID:AB_2722591
  
  DOI: 10.1111/bph.15083
  
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1. scibot 08 Sep 2020
  
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  RRID:AB_2722591
  
  DOI: 10.1111/bph.14998
  
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  DOI: 10.1111/bph.14938
  
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1. scibot 05 Sep 2020
  
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  AB_2722591
  
  DOI: 10.1111/bph.14806
  
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1. scibot 04 Sep 2020
  
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  RRID:AB_2722591
  
  DOI: 10.1111/bph.15026
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15026
Nov 2018
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PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism

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sciencedirect.com/science/article/pii/S1534580718305975

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