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CDK12/13 inhibition overcomes platinum resistance by impairing RNA metabolism

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1. scibot 10 Sep 2026
  
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  DOI: 10.1038/s41392-026-02932-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13538385/
Jul 2026
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RNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunity

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1. scibot 21 Jul 2026
  
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  DOI: 10.1016/j.molcel.2026.06.036
  
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sciencedirect.com/science/article/pii/S1097276526004259
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αKG-mediated carnitine synthesis drives DNA repair via histone acetylation

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1. scibot 18 Jul 2026
  
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  DOI: 10.1038/s41586-026-10584-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13307467/
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KRAS-mediated CCDC6 degradation drives xCT upregulation and ferroptosis evasion

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1. scibot 18 Jul 2026
  
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  DOI: 10.1007/s10495-026-02400-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13369686/
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ABL kinase inactivation induces transcription-replication conflicts and impairs replication fork progression in metastatic small cell lung cancer

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1. scibot 16 Jul 2026
  
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  DOI: 10.1016/j.celrep.2026.117699
  
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sciencedirect.com/science/article/pii/S2211124726007771
Jun 2026
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C1QBP-STAT1 interaction promotes activation of the c-Myc-CHK1/CHK2 signalling axis and radioresistance in lung cancer

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1. scibot 24 Jun 2026
  
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  DOI: 10.1158/1541-7786.MCR-25-0818
  
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aacrjournals.org/mcr/article/24/5/315/784167/C1QBP-STAT1-Interaction-Promotes-Activation-of-the
May 2026
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Transcriptome profiling of bovine preantral follicles during early folliculogenesis

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1. scibot 19 May 2026
  
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  DOI: 10.1186/s40104-026-01407-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13173735/
Apr 2026
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Pathogenesis of Noonan Syndrome is Modulated by NOC2L, a Novel Interactor of LZTR1 Leading to Impaired P53 Signalling

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1. scibot 23 Apr 2026
  
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  DOI: 10.1210/clinem/dgaf602
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13099202/
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Multiomics profiling and experiments in preclinical models revealed RAD51-IN-1 as a synergistic potentiator of anlotinib sensitivity

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1. scibot 23 Apr 2026
  
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  DOI: 10.1126/sciadv.aeb0855
  
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  DOI: 10.1126/sciadv.aeb0855
  
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science.org/doi/10.1126/sciadv.aeb0855
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RAD51-based homologous recombination deficiency is associated with treatment response and survival in early breast cancer

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1. scibot 17 Apr 2026
  
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  DOI: 10.1038/s41523-026-00920-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13079792/
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CBX2 phase-separation contributes to homologous recombination repair and drug resistance in ovarian cancer

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1. scibot 03 Apr 2026
  
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  DOI: 10.1038/s41419-026-08605-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13039389/
Mar 2026
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Prenatal and postnatal atrazine-induced endocrine and ovarian chemical biotransformation protein disruption in offspring

1
1. scibot 03 Mar 2026
  
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  DOI: 10.1210/jendso/bvag027
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12946850/
Feb 2026
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Delactylation of the tumor suppressor ARHGDIB drives metastasis and chemoresistance in bladder cancer

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1. scibot 05 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.116941
  
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sciencedirect.com/science/article/pii/S2211124726000197
Jan 2026
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CCDC6 Immunostaining in Conjunction with the Rad51 HRD Assay May Expand PARPi Treatment Eligibility in Patients with HGSOC

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1. scibot 28 Jan 2026
  
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  DOI: 10.1158/2767-9764.CRC-25-0455
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12833555/
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A Phase II Multi-Center Trial of Trabectedin in Combination with Olaparib in Patients with Advanced Unresectable or Metastatic Sarcoma

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1. scibot 22 Jan 2026
  
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  DOI: 10.1158/1078-0432.CCR-25-0298
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12365955/
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Assessing PARP trapping dynamics in ovarian cancer using a CRISPR-engineered FRET biosensor

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1. scibot 06 Jan 2026
  
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  DOI: 10.1016/j.crmeth.2025.101270
  
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sciencedirect.com/science/article/pii/S2667237525003066
Nov 2025
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MYC inhibition by Omomyc causes DNA damage and overcomes PARPi resistance in breast cancer

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116604
  
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2025.11.06.687028v2.full-html.html

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1. scibot 13 Nov 2025
  
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  DOI: 10.1101/2025.11.06.687028
  
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54.241.53.176/c5747531de041288b038c2a31e89061fc2d84331/2025.11.06.687028v2.full-html.html
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WDFY2 promotes MRN complex formation required for homologous recombination-mediated DNA repair

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  DOI: 10.1016/j.celrep.2025.116520
  
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sciencedirect.com/science/article/pii/S2211124725012914
Oct 2025
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PCAF-mediated acetylation regulates RAD51 dynamic localization on chromatin during HR repair | EMBO reports

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  DOI: 10.1038/s44319-025-00513-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12373954/
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PCAF-mediated acetylation regulates RAD51 dynamic localization on chromatin during HR repair

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  DOI: 10.1038/s44319-025-00513-6
  
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embopress.org/doi/10.1038/s44319-025-00513-6
Aug 2025
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Assessing Determinants of Response to PARP Inhibition in Germline ATM Mutant Melanoma

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1. scibot 05 Aug 2025
  
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  DOI: 10.3390/ijms26157420
  
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mdpi.com/1422-0067/26/15/7420
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Using CCDC6 immunostaining in conjunction with the RAD51 HRD assay as a novel approach to expand PARPi treatment eligibility in HGSOC patients

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1. scibot 05 Aug 2025
  
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  DOI: 10.1101/2025.07.29.667411
  
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biorxiv.org/content/10.1101/2025.07.29.667411v1
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PALB2 and 53BP1 govern post-resection homologous recombination DNA repair

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  DOI: 10.1016/j.molcel.2025.07.003
  
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sciencedirect.com/science/article/pii/S1097276525006045
Jul 2025
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Cancer-associated fibroblast-derived fibulin-5 promotes radioresistance in non-small-cell lung cancer

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  DOI: 10.1016/j.celrep.2025.116018
  
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sciencedirect.com/science/article/pii/S2211124725007892
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Protocol for induction and study of DNA double-strand breaks in mammalian cells using PALM microdissection and expansion microscopy

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  DOI: 10.1016/j.xpro.2025.103938
  
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sciencedirect.com/science/article/pii/S2666166725003442
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KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.ccell.2025.06.011
  
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sciencedirect.com/science/article/pii/S1535610825002612
Jun 2025
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1-s2.0-S2589004225011216-main-html.html

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  DOI: 10.1016/j.isci.2025.112860
  
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52.53.155.43/2abcfe5fe766e4300373f461f78d375160fe8922/1-s2.0-S2589004225011216-main-html.html
May 2025
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BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability

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  DOI: 10.1016/j.molcel.2025.05.010
  
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sciencedirect.com/science/article/pii/S1097276525004150
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MePCE promotes homologous recombination through coordinating R-loop resolution at DNA double-stranded breaks

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  DOI: 10.1016/j.celrep.2025.115740
  
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sciencedirect.com/science/article/pii/S221112472500511X
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Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target

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  DOI: 10.1016/j.ccell.2025.04.014
  
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sciencedirect.com/science/article/pii/S1535610825001734
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Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors

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  DOI: 10.1016/j.cell.2025.04.012
  
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sciencedirect.com/science/article/pii/S0092867425004143
Feb 2025
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Homologous recombination repair status in metastatic prostate cancer by next-generation sequencing and functional immunofluorescence

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  DOI: 10.1016/j.xcrm.2025.101937
  
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sciencedirect.com/science/article/pii/S2666379125000102
Dec 2024
www.cell.com www.cell.com

UBA1 inhibition sensitizes cancer cells to PARP inhibitors

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1. scibot 05 Dec 2024
  
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  DOI: 10.1016/j.xcrm.2024.101834
  
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cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00605-0
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Two-ended recombination at a Flp-nickase-broken replication fork

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1. scibot 05 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.006
  
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sciencedirect.com/science/article/pii/S1097276524009110
Feb 2024
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A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers

1
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  RRID:AB_2722613
  
  DOI: 10.1016/j.xcrm.2024.101434
  
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sciencedirect.com/science/article/pii/S2666379124000570
Nov 2023
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Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA-binding proteins

1
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  RRID:AB_2722613
  
  DOI: 10.1016/j.xcrm.2023.101255
  
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sciencedirect.com/science/article/pii/S2666379123004329
Oct 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms

1
1. scibot 06 Oct 2023
  
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  RRID:AB_2722613
  
  DOI: 10.1016/j.celrep.2023.112792
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10529362/
Sep 2023
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KMT2C expression and DNA homologous recombination repair factors in lung cancers with a high-grade fetal adenocarcinoma component

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  DOI: 10.21037/tlcr-23-137
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10483084/
Aug 2023
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Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes

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  RRID:AB_2722613
  
  DOI: 10.1158/1078-0432.CCR-22-3156
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10425726/
Jul 2023
52.53.155.43 52.53.155.43

GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1-dependent manner

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  RRID:AB_2722613
  
  DOI: 10.15252/embr.202256437
  
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52.53.155.43/82562d81b2014f2e2d5c134f5e9ab42cec01f29a/embr.202256437-html.html
May 2023
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MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

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  RRID:AB_2722613
  
  DOI: 10.1016/j.celrep.2023.112484
  
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sciencedirect.com/science/article/pii/S2211124723004953
Apr 2023
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A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression

1
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  RRID:AB_2722613
  
  DOI: 10.1016/j.ccell.2023.04.002
  
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sciencedirect.com/science/article/pii/S1535610823001289
Feb 2023
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Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma

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  RRID:AB_2722613
  
  DOI: 10.15252/emmm.202216863
  
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embopress.org/doi/10.15252/emmm.202216863
Jan 2023
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Elevated PAF1-RAD52 axis confers chemoresistance to human cancers

1
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  RRID:AB_2722613
  
  DOI: 10.1016/j.celrep.2023.112043
  
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Human metastatic cholangiocarcinoma patient-derived xenografts and tumoroids for preclinical drug evaluation

1
1. scibot 28 Jan 2023
  
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  RRID:AB_2722613
  
  DOI: 10.1158/1078-0432.CCR-22-2551
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9873249/
Oct 2022
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RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA

1
1. scibot 20 Oct 2022
  
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  RRID:AB_272261
  
  DOI: 10.1016/j.molcel.2022.09.025
  
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Jun 2022
52.53.155.43 52.53.155.43

mct-21-0798-html.html

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1. scibot 30 Jun 2022
  
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  RRID:AB_2722613
  
  DOI: 10.1158/1535-7163.mct-21-0798
  
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  RRID:AB_2722613
  
  DOI: 10.1158/1535-7163.MCT-21-0798
  
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52.53.155.43/9002f710d59c7dcb5dd8d70237b19dc81be5139d/mct-21-0798 (1)-html.html
May 2022
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A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination

1
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  RRID:AB_2722613
  
  DOI: 10.1016/j.molcel.2022.04.031
  
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sciencedirect.com/science/article/pii/S109727652200394X
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SRSF3-mediated regulation of N6-methyladenosine modification-related lncRNA ANRIL splicing promotes resistance of pancreatic cancer to gemcitabine

1
1. scibot 12 May 2022
  
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  RRID:AB_2722613
  
  DOI: 10.1016/j.celrep.2022.110813
  
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sciencedirect.com/science/article/pii/S2211124722005848
Apr 2022
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Genetic instability from a single S phase after whole-genome duplication

1
1. scibot 08 Apr 2022
  
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  RRID:AB_2722613
  
  DOI: 10.1038/s41586-022-04578-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8986533/
Mar 2022
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Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation

1
1. scibot 02 Mar 2022
  
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  RRID:AB_2722613
  
  DOI: 10.1016/j.molcel.2022.01.020
  
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sciencedirect.com/science/article/pii/S1097276522000855
Dec 2021
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Inhibition of ATM induces hypersensitivity to proton irradiation by upregulating toxic end joining

1
1. scibot 17 Dec 2021
  
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  RRID:AB_2722613
  
  DOI: 10.1158/0008-5472.CAN-20-2960
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8260463/
Sep 2021
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Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps

1
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  RRID:AB_2722613
  
  DOI: 10.1016/j.molcel.2021.09.005
  
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sciencedirect.com/science/article/pii/S1097276521007395
Jul 2021
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MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer

1
1. scibot 31 Jul 2021
  
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  RRID:AB_2722613
  
  DOI: 10.1016/j.ebiom.2019.03.027
  
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sciencedirect.com/science/article/pii/S2352396419301677
Mar 2021
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A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death

1
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  RRID:AB_2722613
  
  DOI: 10.1016/j.chembiol.2021.02.006
  
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sciencedirect.com/science/article/pii/S2451945621000581
Jan 2021
jeccr.biomedcentral.com jeccr.biomedcentral.com

Vulnerability to low-dose combination of irinotecan and niraparib in ATM-mutated colorectal cancer

1
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  RRID:AB_2722613
  
  DOI: 10.1186/s13046-020-01811-8
  
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jeccr.biomedcentral.com/articles/10.1186/s13046-020-01811-8
Nov 2020
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PRDX1 Counteracts Catastrophic Telomeric Cleavage Events That Are Triggered by DNA Repair Activities Post Oxidative Damage

1
1. scibot 07 Nov 2020
  
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  RRID:AB_2722613
  
  DOI: 10.1016/j.celrep.2020.108347
  
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sciencedirect.com/science/article/pii/S221112472031336X
Oct 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B

1
1. scibot 24 Oct 2020
  
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  RRID:AB_2722613
  
  DOI: 10.7554/eLife.61287
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7553775/
Sep 2020
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METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation

1
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  RRID:AB_2722613
  
  DOI: 10.1016/j.molcel.2020.06.017
  
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sciencedirect.com/science/article/pii/S1097276520304020
Jan 2020
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C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2722613
  
  DOI: 10.1016/j.molcel.2019.06.023
  
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sciencedirect.com/science/article/pii/S1097276519304794
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Untitled document

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2722613
  
  DOI: 10.1016/j.celrep.2019.01.083
  
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sciencedirect.com/science/article/pii/S2211124719301123
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MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer

1
1. scibot 12 Jan 2020
  
  in Public
  
  RRID:AB_2722613
  
  DOI: 10.1016/j.ebiom.2019.03.027
  
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sciencedirect.com/science/article/pii/S2352396419301677
Nov 2018
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Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair

1
1. scibot 05 Nov 2018
  
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  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S0092867418311176

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