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Jun 2025
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Satb1 directs the differentiation of TH17 cells through suppression of IL-2 expression

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sciencedirect.com/science/article/pii/S2211124725006370
May 2025
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52.53.155.43/dd3c8f74e9cdc1e420d33be7f8443dfa69ebea7a/PDF-html.html
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Targeting TUBG1 in RB1-negative tumors

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  DOI: 10.1096/fj.202403180RR
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11869804/
Feb 2025
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MARIGOLD and MitoCIAO, two searchable compendia to visualize and functionalize protein complexes during mitochondrial remodeling

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The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis

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1. scibot 08 Feb 2025
  
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  DOI: 10.7554/eLife.86931
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11801798/
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GUK1 activation is a metabolic liability in lung cancer

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  DOI: 10.1016/j.cell.2025.01.024
  
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sciencedirect.com/science/article/pii/S0092867425000935
Dec 2024
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

CSF1-R inhibition attenuates posttraumatic osteoarthritis and quadriceps atrophy following ligament injury

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  DOI: 10.1113/JP286815
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/JP286815
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UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation

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  DOI: 10.1093/nar/gkae1105
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11662662/
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A microtubule stability switch alters isolated vascular smooth muscle calcium flux in response to matrix rigidity

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pmc.ncbi.nlm.nih.gov/articles/PMC11586521/
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Pressure to evade cell-autonomous innate sensing reveals interplay between mitophagy, IFN signaling, and SARS-CoV-2 evolution

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sciencedirect.com/science/article/pii/S2211124724014669
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The kinetoplastid kinetochore protein KKT23 acetyltransferase is a structural homolog of GCN5 that acetylates the histone H2A C-terminal tail

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sciencedirect.com/science/article/pii/S0969212624004866
Oct 2024
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A High-Content Screen Identifies Drugs That Restrict Tumor Cell Extravasation across the Endothelial Barrier

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1. scibot 02 Oct 2024
  
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  DOI: 10.1158/0008-5472.CAN-19-3911
  
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aacrjournals.org/cancerres/article/81/3/619/648134/A-High-Content-Screen-Identifies-Drugs-That
Sep 2024
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Protocol to process fresh human cerebral cortex biopsies for patch-clamp recording and immunostaining

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.xpro.2024.103313
  
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sciencedirect.com/science/article/pii/S2666166724004787
Aug 2024
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Exclusive Characteristics of the p.E555K Dominant-Negative Variant in Autosomal Dominant E47 Deficiency

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  DOI: 10.1007/s10875-024-01758-x
  
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link.springer.com/article/10.1007/s10875-024-01758-x
Jul 2024
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The Acute Impact of Propofol on Blood–Brain Barrier Integrity in Mice

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1. scibot 30 Jul 2024
  
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  DOI: 10.1007/s11095-024-03735-w
  
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link.springer.com/article/10.1007/s11095-024-03735-w
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Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome

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1. scibot 16 Jul 2024
  
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sciencedirect.com/science/article/pii/S2211124724007770
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Metformin ameliorates neuroinflammatory environment for neurons and astrocytes during in vitro and in vivo stroke and tobacco smoke chemical exposure: Role of Nrf2 activation

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1. scibot 11 Jul 2024
  
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  DOI: 10.1016/j.redox.2024.103266
  
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sciencedirect.com/science/article/pii/S2213231724002441
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A mammalian model reveals inorganic polyphosphate channeling into the nucleolus and induction of a hyper-condensate state

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1. scibot 11 Jul 2024
  
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  DOI: 10.1016/j.crmeth.2024.100814
  
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cell.com/cell-reports-methods/fulltext/S2667-2375(24)00179-6
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Membrane HIV-1 Envelope Glycoproteins Stabilized More Strongly in a Pretriggered Conformation than Natural Virus Envs

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May 2024
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RNA quality control factors nucleate Clr4/SUV39H and trigger constitutive heterochromatin assembly

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  DOI: 10.1016/j.cell.2024.04.042
  
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Specificity profiling of deubiquitylases against endogenously generated ubiquitin-protein conjugates

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1. scibot 30 May 2024
  
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  DOI: 10.1016/j.chembiol.2024.05.001
  
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On the covalent nature of lysine polyphosphorylation

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sciencedirect.com/science/article/pii/S1097276524002788
Apr 2024
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Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT:AP-1 signaling

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1. scibot 03 Apr 2024
  
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  DOI: 10.1126/sciadv.adk4423
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10971413/
Mar 2024
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SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis

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1. scibot 22 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113975
  
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A dynamic ubiquitination balance of cell proliferation and endoreduplication regulators determines plant organ size

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  DOI: 10.1126/sciadv.adj2570
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10936951/
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Caldendrin is a repressor of PIEZO2 channels and touch sensation in mice

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MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors

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  DOI: 10.1016/j.isci.2024.109188
  
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  DOI: 10.1016/j.isci.2024.109188
  
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SARS-CoV-2 targets ribosomal RNA biogenesis

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  DOI: 10.1016/j.celrep.2024.113891
  
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JNEUROSCI.1402-23.2023.full-html.html

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52.53.155.43/7f223cea940290f3204f1037d8b12b16a7f6df0f/JNEUROSCI.1402-23.2023.full-html.html
Feb 2024
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Aberrant cortex contractions impact mammalian oocyte quality

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  DOI: 10.1016/j.devcel.2024.01.027
  
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sciencedirect.com/science/article/pii/S1534580724000479
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UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation

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1. scibot 22 Feb 2024
  
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  DOI: 10.1101/2024.02.13.580169
  
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JNEUROSCI.1402-23.2023.full-html.html

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BPS Publications

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1. scibot 16 Feb 2024
  
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  DOI: 10.1111/bph.16294
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16294
Jan 2024
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JNEUROSCI.1402-23.2023.full-html.html

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FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner

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Sep 2023
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Impact of in-utero electronic cigarette exposure on neonatal neuroinflammation, oxidative stress and mitochondrial function

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Jun 2023
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Sublethal necroptosis signaling promotes inflammation and liver cancer

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May 2023
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Generation of a genetically-modified induced pluripotent stem cell line harboring a Noonan syndrome-associated gene variant MRAS p.G23V

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Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis

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Apr 2023
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Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling

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Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p.G12V

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A proinsulin-dependent interaction between ENPL-1 and ASNA-1 in neurons is required to maintain insulin secretion in C. elegans

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Mar 2023
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Maternal e-cigarette use can disrupt postnatal blood-brain barrier (BBB) integrity and deteriorates motor, learning and memory function: influence of sex and age

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Feb 2023
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A complete allosteric map of a GTPase switch in its native cellular network

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Oct 2022
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Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1

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Sep 2022
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Protocol to use RNaseH1-based CRISPR to modulate locus-associated R-loops

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CTCF DNA-binding domain undergoes dynamic and selective protein–protein interactions

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RIPOR2-mediated autophagy dysfunction is critical for aminoglycoside-induced hearing loss

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A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice

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Short-term exposure to JUUL electronic cigarettes can worsen ischemic stroke outcome

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Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A

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Functional properties of the spike glycoprotein of the emerging SARS-CoV-2 variant B.1.1.529

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Coenzyme A precursors flow from mother to zygote and from microbiome to host

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Impact of Raptor and Rictor Deletion on Hippocampal Pathology Following Status Epilepticus

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Aβ-induced synaptic impairments require CaMKII activity that is stimulated by indirect signaling events

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Mar 2022
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Protein tyrosine phosphatase receptor δ serves as the orexigenic asprosin receptor

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Dec 2021
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Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts

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Nov 2021
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Functional differences among the spike glycoproteins of multiple emerging severe acute respiratory syndrome coronavirus 2 variants of concern

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TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change

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Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c

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Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors

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Sep 2021
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Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice

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Aug 2021
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CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance

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Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis

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May 2021
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The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

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Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation

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Apr 2021
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Proteomics of broad deubiquitylase inhibition unmasks redundant enzyme function to reveal substrates and assess enzyme specificity

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Opening of cohesin’s SMC ring is essential for timely DNA replication and DNA loop formation

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Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

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An HPF1/PARP1-Based Chemical Biology Strategy for Exploring ADP-Ribosylation

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Functional impact of a congenital stationary night blindness type 2 mutation depends on subunit composition of Cav1.4 Ca2+ channels

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A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking

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Prenatal Electronic Cigarette Exposure Decreases Brain Glucose Utilization & Worsens Outcome in Offspring Hypoxic‐ischemic Brain Injury

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Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype

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Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51

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chTOG is a conserved mitotic error correction factor

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An RNA Repair Operon Regulated by Damaged tRNAs

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CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion

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Poly(A)-Binding Protein Regulates the Efficiency of Translation Termination

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Metabolic profiling during malaria reveals the role of the aryl hydrocarbon receptor in regulating kidney injury

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OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis

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FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster

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UBP12 and UBP13 negatively regulate the activity of the ubiquitin-dependent peptidases DA1, DAR1 and DAR2

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The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection

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Loss of Piccolo function in rats induces cerebellar network dysfunction and Pontocerebellar Hypoplasia type 3-like phenotypes

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Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination

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Calcifediol decreases interleukin-6 secretion by cultured human trophoblasts from GDM pregnancies

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Removal of the potassium chloride co-transporter from the somatodendritic membrane of axotomized motoneurons is independent of BDNF/TrkB signaling but is controlled by neuromuscular innervation

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Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21

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Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets

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Complement C4 Prevents Viral Infection through Capsid Inactivation

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A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis

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IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration

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GRXCR2 Regulates Taperin Localization Critical for Stereocilia Morphology and Hearing

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A Hippo-like Signaling Pathway Controls Tracheal Morphogenesis in Drosophila melanogaster

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Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import

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The Balance of PI3K and ERK Signaling Is Dysregulated in Prolactinoma and Modulated by Dopamine

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