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SETD2 Deficiency Drives Mitochondrial DNA Leakage and Creates a Druggable Dependency on BCL-xL in Clear Cell Renal Cell Carcinoma

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1. scibot 10 Jun 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-3195
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13244386/
Dec 2025
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Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex

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1. scibot 06 Dec 2025
  
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  DOI: 10.1158/2159-8290.CD-25-0271
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12670082/
Jul 2025
www.biorxiv.org www.biorxiv.org

Paclitaxel-induced mitotic arrest results in a convergence of apoptotic dependencies that can be safely exploited by BCL-XL degradation to overcome cancer chemoresistance

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1. scibot 11 Jul 2025
  
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  DOI: 10.1101/2025.06.24.661170
  
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biorxiv.org/content/10.1101/2025.06.24.661170v1
Apr 2025
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Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways

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1. scibot 04 Apr 2025
  
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  DOI: 10.1038/s41598-025-95766-5
  
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nature.com/articles/s41598-025-95766-5
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Identification of a TNIK-CDK9 Axis as a Targetable Strategy for Platinum-Resistant Ovarian Cancer

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1. scibot 04 Apr 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0785
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11962390/
Feb 2025
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Deubiquitinase USP9X controls Wnt signaling for CNS vascular formation and barrier maintenance

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1. scibot 06 Feb 2025
  
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  DOI: 10.1016/j.devcel.2025.01.009
  
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sciencedirect.com/science/article/pii/S1534580725000292
Dec 2024
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Castrate-resistant prostate cancer response to taxane is determined by an HNF1-dependent apoptosis resistance circuit

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1. scibot 10 Dec 2024
  
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  DOI: 10.1016/j.xcrm.2024.101868
  
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sciencedirect.com/science/article/pii/S2666379124006396
Sep 2024
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A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib

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1. scibot 04 Sep 2024
  
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  DOI: 10.1016/j.xcrm.2024.101703
  
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sciencedirect.com/science/article/pii/S2666379124004245
Aug 2024
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The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes

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1. scibot 19 Aug 2024
  
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  DOI: 10.1016/j.isci.2024.110499
  
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sciencedirect.com/science/article/pii/S2589004224017243
Mar 2024
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Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1

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1. scibot 19 Mar 2024
  
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  DOI: 10.1016/j.molcel.2024.02.035
  
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2. scibot 19 Mar 2024
  
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  DOI: 10.1016/j.molcel.2024.02.035
  
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sciencedirect.com/science/article/pii/S109727652400176X
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Therapy-induced normal tissue damage promotes breast cancer metastasis

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1. scibot 05 Jan 2024
  
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  DOI: 10.1016/j.isci.2023.108503
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10755366/
Nov 2023
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HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B

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1. scibot 17 Nov 2023
  
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  DOI: 10.1016/j.xcrm.2023.101285
  
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sciencedirect.com/science/article/pii/S2666379123004792
Sep 2023
www.embopress.org www.embopress.org

CCDC50 promotes tumor growth through regulation of lysosome homeostasis

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1. scibot 12 Sep 2023
  
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  RRID:AB_2722740
  
  DOI: 10.15252/embr.202356948
  
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embopress.org/doi/full/10.15252/embr.202356948
Apr 2023
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USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities

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1. scibot 08 Apr 2023
  
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  DOI: 10.1016/j.xcrm.2023.101007
  
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sciencedirect.com/science/article/pii/S2666379123001179
Nov 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression

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1. scibot 19 Nov 2022
  
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  DOI: 10.1158/2767-9764.crc-22-0024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9648413/
Jul 2022
aacrjournals.org aacrjournals.org

Bcl-xL Inhibition Radiosensitizes PIK3CA/PTEN Wild-type Triple-negative Breast Cancers with Low Mcl-1 Expression

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1. scibot 29 Jul 2022
  
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  DOI: 10.1158/2767-9764.CRC-22-0024
  
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aacrjournals.org/cancerrescommun/article/2/7/679/707059/Bcl-xL-Inhibition-Radiosensitizes-PIK3CA-PTEN-Wild
May 2022
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Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate

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1. scibot 25 May 2022
  
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  DOI: 10.1016/j.molcel.2022.04.016
  
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sciencedirect.com/science/article/pii/S1097276522003276
Nov 2021
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Interplay between protein acetylation and ubiquitination controls MCL1 protein stability

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1. scibot 10 Nov 2021
  
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  DOI: 10.1016/j.celrep.2021.109988
  
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sciencedirect.com/science/article/pii/S2211124721014674
Oct 2021
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Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome

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1. scibot 14 Oct 2021
  
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  DOI: 10.1016/j.celrep.2021.109806
  
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sciencedirect.com/science/article/pii/S2211124721012663
Apr 2021
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Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia

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1. scibot 22 Apr 2021
  
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  DOI: 10.1016/j.ccell.2020.10.010
  
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sciencedirect.com/science/article/pii/S1535610820305419
Jan 2021
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Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

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1. scibot 20 Jan 2021
  
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  DOI: 10.1016/j.xcrm.2020.100188
  
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sciencedirect.com/science/article/pii/S2666379120302433
Sep 2020
www.mdpi.com www.mdpi.com

Structure–Activity Relationships and Molecular Docking Analysis of Mcl-1 Targeting Renieramycin T Analogues in Patient-derived Lung Cancer Cells

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1. scibot 17 Sep 2020
  
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  DOI: 10.3390/cancers12040875
  
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mdpi.com/2072-6694/12/4/875
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Kinetic Heterogeneity of Cancer Cell Fractional Killing

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1. scibot 08 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107845
  
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sciencedirect.com/science/article/pii/S2211124720308263
clincancerres.aacrjournals.org clincancerres.aacrjournals.org

5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-mediated Apoptosis.

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1. scibot 06 Sep 2020
  
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  DOI: 10.1158/1078-0432.CCR-19-1900
  
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  RRID:AB_2722740 RRIDCUR:Validated
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clincancerres.aacrjournals.org/content/26/13/3371
Jan 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 13 Jan 2020
  
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  DOI: 10.7554/eLife.40167
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6307859/