118 Matching Annotations
  1. Nov 2024
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses
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    1. scibot 08 Nov 2024
      RRID:AB_2728768

      DOI: 10.1038/s44318-024-00238-7

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    pmc.ncbi.nlm.nih.gov/articles/PMC11535224/
  3. Oct 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pharmacologic inhibition of eIF4A blocks NRF2 synthesis to prevent osteosarcoma metastasis
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    1. scibot 04 Oct 2024
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      DOI: 10.1158/1078-0432.CCR-24-1317

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    ncbi.nlm.nih.gov/pmc/articles/PMC11443218/
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NAPRT silencing in FH-deficient renal cell carcinoma confers therapeutic vulnerabilities via NAD+ depletion
    1
    1. scibot 04 Oct 2024
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      DOI: 10.1158/1541-7786.MCR-23-1003

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    ncbi.nlm.nih.gov/pmc/articles/PMC11445649/
  6. Sep 2024
  7. www.sciencedirect.com www.sciencedirect.com
    Development of an adipose-tropic AAV capsid ablating liver tropism
    1
    1. scibot 27 Sep 2024
      AB_2728768

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    sciencedirect.com/science/article/pii/S2589004224021552
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    Profound cellular defects attribute to muscular pathogenesis in the rhesus monkey model of Duchenne muscular dystrophy
    1
    1. scibot 26 Sep 2024
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      DOI: 10.1016/j.cell.2024.08.041

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    sciencedirect.com/science/article/pii/S009286742400970X
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    GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant
    1
    1. scibot 04 Sep 2024
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      DOI: 10.1016/j.ccell.2024.08.006

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    sciencedirect.com/science/article/pii/S1535610824003052
  10. Aug 2024
  11. www.sciencedirect.com www.sciencedirect.com
    FRA1 controls acinar cell plasticity during murine KrasG12D-induced pancreatic acinar to ductal metaplasia
    1
    1. scibot 23 Aug 2024
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      DOI: 10.1016/j.devcel.2024.07.021

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    sciencedirect.com/science/article/pii/S1534580724004830
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    Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies
    1
    1. scibot 20 Aug 2024
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      DOI: 10.1016/j.chembiol.2024.07.005

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    sciencedirect.com/science/article/pii/S2451945624003076
  13. Jul 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
    1
    1. scibot 31 Jul 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11284272/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapeutic expression of RAS Degrader RRSP in Pancreatic Cancer via Nanocarrier-mediated mRNA delivery
    1
    1. scibot 03 Jul 2024
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      DOI: 10.1101/2024.06.11.598439

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    ncbi.nlm.nih.gov/pmc/articles/PMC11212117/
  16. Jun 2024
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    De novo TLK1 and MDM1 mutations in a patient with a neurodevelopmental disorder and immunodeficiency
    1
    1. scibot 14 Jun 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11166698/
  18. 52.53.155.43 52.53.155.43
    Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency
    2
    1. scibot 06 Jun 2024
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      DOI: 10.1101/2024.02.09.579580

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      DOI: 10.1101/2024.02.09.579580

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    52.53.155.43/be49547c4f9e1293474726024249294abe2db848/2024.02.09.579580v1.full-html.html
  19. www.sciencedirect.com www.sciencedirect.com
    De novo and salvage purine synthesis pathways across tissues and tumors
    1
    1. scibot 04 Jun 2024
      Cell Signaling TechnologyCat# 13901S

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    sciencedirect.com/science/article/pii/S0092867424005208
  20. www.sciencedirect.com www.sciencedirect.com
    Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
    1
    1. scibot 04 Jun 2024
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      DOI: 10.1016/j.devcel.2024.05.010

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    sciencedirect.com/science/article/pii/S1534580724003277
  21. May 2024
  22. 52.53.155.43 52.53.155.43
    2024.02.09.579580v1.full-html.html
    2
    1. scibot 10 May 2024
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      DOI: 10.1038/nature05972

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    52.53.155.43/32c668e9e171a0d93bacd7fd25061d69f59c1b8d/2024.02.09.579580v1.full-html.html
  23. www.biorxiv.org www.biorxiv.org
    Targeting glioblastoma tumor hyaluronan to enhance therapeutic interventions that regulate metabolic cell properties
    1
    1. scibot 02 May 2024
      13901

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    biorxiv.org/content/10.1101/2024.01.05.574065v1
  24. www.sciencedirect.com www.sciencedirect.com
    N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation
    1
    1. scibot 02 May 2024
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      DOI: 10.1016/j.immuni.2024.04.004

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    sciencedirect.com/science/article/pii/S1074761324002097
  25. Apr 2024
  26. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
    1
    1. scibot 12 Apr 2024
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      DOI: 10.1111/bph.16374

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16374
  27. www.sciencedirect.com www.sciencedirect.com
    Genetic interactions reveal distinct biological and therapeutic implications in breast cancer
    1
    1. scibot 09 Apr 2024
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      DOI: 10.1016/j.ccell.2024.03.006

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    sciencedirect.com/science/article/pii/S1535610824000916
  28. Mar 2024
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
    1
    1. scibot 27 Mar 2024
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      DOI: 10.1080/15384047.2024.2332000

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    ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
  30. www.sciencedirect.com www.sciencedirect.com
    PRMT1 promotes pancreatic cancer development and resistance to chemotherapy
    2
    1. scibot 12 Mar 2024
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      DOI: 10.1016/j.xcrm.2024.101461

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      DOI: 10.1016/j.xcrm.2024.101461

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    sciencedirect.com/science/article/pii/S2666379124001058
  31. www.sciencedirect.com www.sciencedirect.com
    Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology
    1
    1. scibot 01 Mar 2024
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      DOI: 10.1016/j.molcel.2024.01.028

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    sciencedirect.com/science/article/pii/S1097276524000959
  32. Feb 2024
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sorl1 knockout inhibits expression of brain-derived neurotrophic factor: involvement in the development of late-onset Alzheimer's disease
    1
    1. scibot 28 Feb 2024
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      DOI: 10.4103/1673-5374.387975

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    ncbi.nlm.nih.gov/pmc/articles/PMC10883503/
  34. Jan 2024
  35. www.sciencedirect.com www.sciencedirect.com
    Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB
    1
    1. scibot 25 Jan 2024
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      DOI: 10.1016/j.cmet.2024.01.001

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    sciencedirect.com/science/article/pii/S1550413124000019
  36. www.nature.com www.nature.com
    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
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    1. scibot 25 Jan 2024
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      DOI: 10.1038/s41388-024-02947-z

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    nature.com/articles/s41388-024-02947-z
  37. www.sciencedirect.com www.sciencedirect.com
    Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer
    1
    1. scibot 23 Jan 2024
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      DOI: 10.1016/j.celrep.2024.113684

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    sciencedirect.com/science/article/pii/S2211124724000123
  38. Nov 2023
  39. www.biorxiv.org www.biorxiv.org
    Recruitment of FBXO22 for Targeted Degradation of NSD2
    1
    1. scibot 10 Nov 2023
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      DOI: 10.1101/2023.11.01.564830

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    biorxiv.org/content/10.1101/2023.11.01.564830v1
  40. www.sciencedirect.com www.sciencedirect.com
    Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria
    1
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      DOI: 10.1016/j.celrep.2023.113389

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    sciencedirect.com/science/article/pii/S2211124723014018
  41. www.sciencedirect.com www.sciencedirect.com
    Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice
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      DOI: 10.1016/j.isci.2023.108196

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    sciencedirect.com/science/article/pii/S2589004223022733
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts
    1
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      DOI: 10.1158/2159-8290.CD-23-0396

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    ncbi.nlm.nih.gov/pmc/articles/PMC10618743/
  43. www.science.org www.science.org
    Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity
    1
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      DOI: 10.1126/sciadv.adj1010

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    science.org/doi/10.1126/sciadv.adj1010
  44. Oct 2023
  45. 52.53.155.43 52.53.155.43
    bqad159-html.html
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      DOI: 10.1210/endocr/bqad159

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    52.53.155.43/fadb698104ccd541263e8069783171593188288f/bqad159-html.html
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    High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma
    1
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      DOI: 10.1016/j.xcrm.2023.101244

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    sciencedirect.com/science/article/pii/S2666379123004214
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity
    1
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      DOI: 10.1126/sciadv.adj1010

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    ncbi.nlm.nih.gov/pmc/articles/PMC10599629/
  48. www.embopress.org www.embopress.org
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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      DOI: 10.15252/embr.202356815

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    embopress.org/doi/10.15252/embr.202356815
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatic safety profile of pancreatic cancer‑bearing mice fed a ketogenic diet in combination with gemcitabine
    1
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      DOI: 10.3892/ol.2023.14067

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    ncbi.nlm.nih.gov/pmc/articles/PMC10561147/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer
    1
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      DOI: 10.1158/2767-9764.CRC-22-0521

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    ncbi.nlm.nih.gov/pmc/articles/PMC10549224/
  51. Sep 2023
  52. www.sciencedirect.com www.sciencedirect.com
    Base editing corrects the common Salla disease SLC17A5 c.115C>T variant
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      DOI: 10.1016/j.omtn.2023.08.024

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  53. Aug 2023
  54. www.biorxiv.org www.biorxiv.org
    Unraveling Vulnerabilities in Endocrine Therapy-Resistant HER2+/ER+ Breast Cancer
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  55. Jul 2023
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
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  57. www.nature.com www.nature.com
    MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice
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  58. 52.53.155.43 52.53.155.43
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    Oncogenic K-Ras suppresses global miRNA function
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  61. Jun 2023
  62. www.sciencedirect.com www.sciencedirect.com
    Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
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    Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution
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    Acetate controls endothelial-to-mesenchymal transition
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    Cancer cell-autonomous cGAS-STING response confers drug resistance
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  66. May 2023
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    Human nuclear hormone receptor activity contributes to malaria parasite liver stage development
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    A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Anti-apoptotic Protein in Kidney Cancer
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  69. Apr 2023
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    Proteomic discovery of chemical probes that perturb protein complexes in human cells
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  71. Mar 2023
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    NAADP-Evoked Ca2+ Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes
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  74. Feb 2023
  75. www.cell.com www.cell.com
    Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma
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    IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment
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  77. Jan 2023
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    Neoadjuvant chemotherapy is associated with an altered metabolic profile and increased cancer stemness in patients with pancreatic ductal adenocarcinoma
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    In utero intracerebroventricular delivery of adeno-associated viral vectors to target mouse choroid plexus and cerebrospinal fluid
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  80. Dec 2022
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    The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation
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  82. Nov 2022
  83. academic.oup.com academic.oup.com
    Laminin-α4 negatively regulates adipocyte beiging through the suppression of AMPKα in male mice
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    Estrogen-related receptor alpha drives mitochondrial biogenesis and resistance to neoadjuvant chemoradiation in esophageal cancer
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    Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling
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    Cloning BRD4 long isoform into overexpression vectors for stable overexpression of BRD4-L in mammalian cells
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  87. Oct 2022
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    A Novel NF2 Splicing Mutant Causes Neurofibromatosis Type 2 via Liquid-liquid Phase Separation with LATS and Hippo Pathway.
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    Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy
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  90. Sep 2022
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    Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor
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    Choroid plexus-CSF-targeted antioxidant therapy protects the brain from toxicity of cancer chemotherapy
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  93. Aug 2022
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    Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers
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  95. May 2022
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    Proteolytic pan-RAS cleavage leads to tumor regression in patient-derived pancreatic cancer xenografts
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  97. Apr 2022
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    WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy
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    MIRO2 regulates prostate cancer cell growth via GCN1-dependent stress signaling
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  100. Mar 2022
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    A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis
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    PTPN2 elicits cell autonomous and non–cell autonomous effects on antitumor immunity in triple-negative breast cancer
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    Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML
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    Regulation of GTPase function by autophosphorylation
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    MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape
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  108. elifesciences.org elifesciences.org
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  109. Jan 2022
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    Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells
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  112. Nov 2021
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    Genomic alterations in PIK3CA-mutated breast cancer result in mTORC1 activation and limit the sensitivity to PI3Kα inhibitors
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  114. Oct 2021
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  117. Sep 2021
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    Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia
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  119. Aug 2021
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    Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis
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  123. Jul 2021
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    Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
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  128. Jun 2021
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    Intracellular H2S production is an autophagy-dependent adaptive response to DNA damage
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    Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling
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  131. May 2021
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    CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress
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  134. Apr 2021
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    NAD+ Regeneration Rescues Lifespan, but Not Ataxia, in a Mouse Model of Brain Mitochondrial Complex I Dysfunction
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    Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia
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  137. Mar 2021
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    Embryonic Stem-Cell-Derived Extracellular Vesicles Maintain ESC Stemness by Activating FAK
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  139. Feb 2021
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    Tyrosine kinase inhibitors protect the salivary gland from radiation damage by increasing DNA double strand break repair
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  142. Oct 2020
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    Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity
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  144. Sep 2020
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    Challenges and Reinterpretation of Antibody-Based Research on Phosphorylation of Tyr307 on PP2Ac
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    Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy
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    Islet O-GlcNAcylation Is Required for Lipid Potentiation of Insulin Secretion through SERCA2
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  149. Jan 2020
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    Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
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      RRID:AB_2728768

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    p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
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      RRID:AB_2728768

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    The Hippo Pathway Blocks Mammalian Retinal Müller Glial Cell Reprogramming
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    Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM
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    PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression
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  156. Nov 2018
  157. www.sciencedirect.com www.sciencedirect.com
    Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
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    LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling
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