109 Matching Annotations
  1. Last 7 days
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapeutic expression of RAS Degrader RRSP in Pancreatic Cancer via Nanocarrier-mediated mRNA delivery
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    1. scibot 03 Jul 2024
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      DOI: 10.1101/2024.06.11.598439

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    ncbi.nlm.nih.gov/pmc/articles/PMC11212117/
  3. Jun 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    De novo TLK1 and MDM1 mutations in a patient with a neurodevelopmental disorder and immunodeficiency
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    ncbi.nlm.nih.gov/pmc/articles/PMC11166698/
  5. 52.53.155.43 52.53.155.43
    Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency
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    De novo and salvage purine synthesis pathways across tissues and tumors
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    1. scibot 04 Jun 2024
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    sciencedirect.com/science/article/pii/S0092867424005208
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    Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
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    sciencedirect.com/science/article/pii/S1534580724003277
  8. May 2024
  9. 52.53.155.43 52.53.155.43
    2024.02.09.579580v1.full-html.html
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      DOI: 10.1038/nature05972

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  10. www.biorxiv.org www.biorxiv.org
    Targeting glioblastoma tumor hyaluronan to enhance therapeutic interventions that regulate metabolic cell properties
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    N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation
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      DOI: 10.1016/j.immuni.2024.04.004

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    sciencedirect.com/science/article/pii/S1074761324002097
  12. Apr 2024
  13. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      DOI: 10.1111/bph.16374

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16374
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    Genetic interactions reveal distinct biological and therapeutic implications in breast cancer
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    1. scibot 09 Apr 2024
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    sciencedirect.com/science/article/pii/S1535610824000916
  15. Mar 2024
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
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    1. scibot 27 Mar 2024
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      DOI: 10.1080/15384047.2024.2332000

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    ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
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    PRMT1 promotes pancreatic cancer development and resistance to chemotherapy
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    sciencedirect.com/science/article/pii/S2666379124001058
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    Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology
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    sciencedirect.com/science/article/pii/S1097276524000959
  19. Feb 2024
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sorl1 knockout inhibits expression of brain-derived neurotrophic factor: involvement in the development of late-onset Alzheimer's disease
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    1. scibot 28 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10883503/
  21. Jan 2024
  22. www.sciencedirect.com www.sciencedirect.com
    Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB
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    sciencedirect.com/science/article/pii/S1550413124000019
  23. link.springer.com link.springer.com
    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
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      DOI: 10.1038/s41388-024-02947-z

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    link.springer.com/article/10.1038/s41388-024-02947-z
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    Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer
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    sciencedirect.com/science/article/pii/S2211124724000123
  25. Nov 2023
  26. www.biorxiv.org www.biorxiv.org
    Recruitment of FBXO22 for Targeted Degradation of NSD2
    1
    1. scibot 10 Nov 2023
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      DOI: 10.1101/2023.11.01.564830

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    biorxiv.org/content/10.1101/2023.11.01.564830v1
  27. www.sciencedirect.com www.sciencedirect.com
    Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria
    1
    1. scibot 10 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113389

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    sciencedirect.com/science/article/pii/S2211124723014018
  28. www.sciencedirect.com www.sciencedirect.com
    Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice
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      DOI: 10.1016/j.isci.2023.108196

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    sciencedirect.com/science/article/pii/S2589004223022733
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts
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    ncbi.nlm.nih.gov/pmc/articles/PMC10618743/
  30. www.science.org www.science.org
    Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity
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      DOI: 10.1126/sciadv.adj1010

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    science.org/doi/10.1126/sciadv.adj1010
  31. Oct 2023
  32. 52.53.155.43 52.53.155.43
    bqad159-html.html
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      DOI: 10.1210/endocr/bqad159

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  33. www.sciencedirect.com www.sciencedirect.com
    High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma
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    sciencedirect.com/science/article/pii/S2666379123004214
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity
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    ncbi.nlm.nih.gov/pmc/articles/PMC10599629/
  35. www.embopress.org www.embopress.org
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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      DOI: 10.15252/embr.202356815

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    embopress.org/doi/10.15252/embr.202356815
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatic safety profile of pancreatic cancer‑bearing mice fed a ketogenic diet in combination with gemcitabine
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      DOI: 10.3892/ol.2023.14067

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    ncbi.nlm.nih.gov/pmc/articles/PMC10561147/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer
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      DOI: 10.1158/2767-9764.CRC-22-0521

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    ncbi.nlm.nih.gov/pmc/articles/PMC10549224/
  38. Sep 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Base editing corrects the common Salla disease SLC17A5 c.115C>T variant
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      DOI: 10.1016/j.omtn.2023.08.024

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    sciencedirect.com/science/article/pii/S2162253123002354
  40. Aug 2023
  41. www.biorxiv.org www.biorxiv.org
    Unraveling Vulnerabilities in Endocrine Therapy-Resistant HER2+/ER+ Breast Cancer
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      DOI: 10.1101/2023.08.21.554116

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    biorxiv.org/content/10.1101/2023.08.21.554116v1
  42. Jul 2023
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
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      DOI: 10.1101/2023.06.27.546707

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    ncbi.nlm.nih.gov/pmc/articles/PMC10327161/
  44. www.nature.com www.nature.com
    MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice
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      DOI: 10.1038/s41536-023-00310-6

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    nature.com/articles/s41536-023-00310-6
  45. 52.53.155.43 52.53.155.43
    cd-23-0475-html.html
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  46. www.sciencedirect.com www.sciencedirect.com
    Oncogenic K-Ras suppresses global miRNA function
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    sciencedirect.com/science/article/pii/S109727652300429X
  47. 52.53.155.43 52.53.155.43
    mcr-22-1031-html.html
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      DOI: 10.1158/1541-7786.MCR-22-1031

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  48. Jun 2023
  49. www.sciencedirect.com www.sciencedirect.com
    Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
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      DOI: 10.1016/j.celrep.2023.112696

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    sciencedirect.com/science/article/pii/S2211124723007076
  50. www.nature.com www.nature.com
    Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution
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      DOI: 10.1038/s41467-023-39326-3

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    nature.com/articles/s41467-023-39326-3
  51. www.sciencedirect.com www.sciencedirect.com
    Acetate controls endothelial-to-mesenchymal transition
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      DOI: 10.1016/j.cmet.2023.05.010

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    NAADP-Evoked Ca2+ Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes
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    IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment
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    A Novel NF2 Splicing Mutant Causes Neurofibromatosis Type 2 via Liquid-liquid Phase Separation with LATS and Hippo Pathway.
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    Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor
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    Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers
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  84. Apr 2022
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    Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis
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  110. Jul 2021
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    Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
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  115. Jun 2021
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    Intracellular H2S production is an autophagy-dependent adaptive response to DNA damage
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    Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling
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  118. May 2021
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    CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress
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  121. Apr 2021
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    NAD+ Regeneration Rescues Lifespan, but Not Ataxia, in a Mouse Model of Brain Mitochondrial Complex I Dysfunction
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    Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia
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  124. Mar 2021
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    Embryonic Stem-Cell-Derived Extracellular Vesicles Maintain ESC Stemness by Activating FAK
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  126. Feb 2021
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  129. Oct 2020
  130. www.cell.com www.cell.com
    Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity
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  131. Sep 2020
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    Challenges and Reinterpretation of Antibody-Based Research on Phosphorylation of Tyr307 on PP2Ac
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      RRID:AB_2728768

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    Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy
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      vinculin

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    A Toxic RNA Catalyzes the Cellular Synthesis of Its Own Inhibitor, Shunting It to Endogenous Decay Pathways
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    Islet O-GlcNAcylation Is Required for Lipid Potentiation of Insulin Secretion through SERCA2
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  136. Jan 2020
  137. www.sciencedirect.com www.sciencedirect.com
    Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
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      RRID:AB_2728768

      DOI: 10.1016/j.chembiol.2019.11.014

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    p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
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      RRID:AB_2728768

      DOI: 10.1016/j.ccell.2019.01.006

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    The Hippo Pathway Blocks Mammalian Retinal Müller Glial Cell Reprogramming
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      RRID:AB_2728768

      DOI: 10.1016/j.celrep.2019.04.047

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    Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM
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      RRID:AB_2728768

      DOI: 10.1016/j.neuron.2019.02.009

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    PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression
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      RRID:AB_2728768

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    sciencedirect.com/science/article/pii/S2211124719302979
  143. Nov 2018
  144. www.sciencedirect.com www.sciencedirect.com
    Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
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    LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling
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      13901

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