69 Matching Annotations
  1. Jul 2024
  2. aacrjournals.org aacrjournals.org
    Molecular and Clinical Determinants of Acquired Resistance and Treatment Duration for Targeted Therapies in Colorectal Cancer
    1
    1. scibot 09 Jul 2024
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      DOI: 10.1158/1078-0432.CCR-23-4005

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    aacrjournals.org/clincancerres/article/30/12/2672/745797/Molecular-and-Clinical-Determinants-of-Acquired
  3. Jun 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Setdb1 protects genome integrity in murine muscle stem cells to allow for regenerative myogenesis and inflammation
    1
    1. scibot 07 Jun 2024
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      DOI: 10.1016/j.devcel.2024.05.012

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    sciencedirect.com/science/article/pii/S1534580724003290
  5. May 2024
  6. 52.53.155.43 52.53.155.43
    ccr-23-4005-html.html
    3
    1. scibot 23 May 2024
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    2. scibot 23 May 2024
      AB_2732795

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    3. scibot 23 May 2024
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    52.53.155.43/182d0fc47d4b0787ed5f14ae9d99c52af646547f/ccr-23-4005 (1)-html.html
  7. aacrjournals.org aacrjournals.org
    TREX1 inactivation unleashes cancer cell STING-interferon signaling and promotes anti-tumor immunity
    2
    1. scibot 23 May 2024
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      DOI: 10.1158/2159-8290.CD-23-0700

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    2. scibot 23 May 2024
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      DOI: 10.1158/2159-8290.CD-23-0700

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    aacrjournals.org/cancerdiscovery/article/14/5/752/745044/TREX1-Inactivation-Unleashes-Cancer-Cell-STING
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    Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING
    1
    1. scibot 21 May 2024
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      DOI: 10.1016/j.molcel.2024.04.017

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    sciencedirect.com/science/article/pii/S109727652400354X
  9. Apr 2024
  10. www.sciencedirect.com www.sciencedirect.com
    Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
    1
    1. scibot 30 Apr 2024
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      DOI: 10.1016/j.xcrm.2024.101528

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    sciencedirect.com/science/article/pii/S2666379124001976
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SETD2 loss and ATR inhibition synergize to promote cGAS signaling and immunotherapy response in renal cell carcinoma
    1
    1. scibot 03 Apr 2024
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      DOI: 10.1158/1078-0432.CCR-23-1003

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    ncbi.nlm.nih.gov/pmc/articles/PMC10592192/
  12. Feb 2024
  13. www.sciencedirect.com www.sciencedirect.com
    The proteomic landscape of genotoxic stress-induced micronuclei
    2
    1. scibot 29 Feb 2024
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    2. scibot 29 Feb 2024
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    sciencedirect.com/science/article/pii/S1097276524000972
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    SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion
    1
    1. scibot 02 Feb 2024
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      DOI: 10.1016/j.cell.2024.01.008

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    sciencedirect.com/science/article/pii/S0092867424000102
  15. Nov 2023
  16. www.embopress.org www.embopress.org
    SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1
    1
    1. scibot 03 Nov 2023
      AB_2732795

      DOI: 10.15252/embr.202357500

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    embopress.org/doi/10.15252/embr.202357500
  17. Oct 2023
  18. www.sciencedirect.com www.sciencedirect.com
    Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.molcel.2023.09.007

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    sciencedirect.com/science/article/pii/S1097276523007025
  19. Jul 2023
  20. www.sciencedirect.com www.sciencedirect.com
    Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy
    1
    1. scibot 27 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112852

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    sciencedirect.com/science/article/pii/S221112472300863X
  21. Jun 2023
  22. www.sciencedirect.com www.sciencedirect.com
    Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity
    1
    1. scibot 23 Jun 2023
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      DOI: 10.1016/j.cell.2023.05.039

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    sciencedirect.com/science/article/pii/S0092867423005913
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    Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity
    1
    1. scibot 02 Jun 2023
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      DOI: 10.1016/j.ccell.2023.05.005

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    sciencedirect.com/science/article/pii/S1535610823001733
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    Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging
    1
    1. scibot 01 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112593

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    sciencedirect.com/science/article/pii/S2211124723006046
  25. May 2023
  26. www.sciencedirect.com www.sciencedirect.com
    Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer
    1
    1. scibot 03 May 2023
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      DOI: 10.1016/j.chom.2023.04.010

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    sciencedirect.com/science/article/abs/pii/S1931312823001610
  27. Apr 2023
  28. www.sciencedirect.com www.sciencedirect.com
    Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING
    1
    1. scibot 26 Apr 2023
      RRID:AB_2732795

      DOI: 10.1016/j.celrep.2023.112442

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    sciencedirect.com/science/article/pii/S2211124723004539
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    The mechanism of STING autoinhibition and activation
    1
    1. scibot 22 Apr 2023
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      DOI: 10.1016/j.molcel.2023.03.029

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    sciencedirect.com/science/article/pii/S1097276523002435
  30. Mar 2023
  31. www.sciencedirect.com www.sciencedirect.com
    Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS
    1
    1. scibot 28 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112309

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    sciencedirect.com/science/article/pii/S2211124723003200
  32. europepmc.org europepmc.org
    Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunity
    1
    1. scibot 23 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112275

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    europepmc.org/article/med/36943864
  33. Feb 2023
  34. www.sciencedirect.com www.sciencedirect.com
    Spermine enhances antiviral and anticancer responses by stabilizing DNA binding with the DNA sensor cGAS
    1
    1. scibot 02 Feb 2023
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      DOI: 10.1016/j.immuni.2023.01.001

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    sciencedirect.com/science/article/pii/S1074761323000110
  35. Jan 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks
    1
    1. scibot 26 Jan 2023
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      DOI: 10.1016/j.molcel.2022.12.034

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    sciencedirect.com/science/article/pii/S1097276522012175
  37. www.sciencedirect.com www.sciencedirect.com
    Resurrection of endogenous retroviruses during aging reinforces senescence
    1
    1. scibot 07 Jan 2023
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      DOI: 10.1016/j.cell.2022.12.017

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    sciencedirect.com/science/article/pii/S0092867422015306
  38. Dec 2022
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Low-dose ganciclovir ameliorates dextran sulfate sodium-induced ulcerative colitis through inhibiting macrophage STING activation in mice
    1
    1. scibot 03 Dec 2022
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      DOI: 10.3389/fphar.2022.1020670

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    ncbi.nlm.nih.gov/pmc/articles/PMC9714675/
  40. Nov 2022
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1
    1
    1. scibot 04 Nov 2022
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      DOI: 10.1016/j.isci.2022.105352

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    ncbi.nlm.nih.gov/pmc/articles/PMC9619380/
  42. Oct 2022
  43. www.sciencedirect.com www.sciencedirect.com
    Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas
    1
    1. scibot 07 Oct 2022
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      DOI: 10.1016/j.molcel.2022.09.007

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    sciencedirect.com/science/article/pii/S1097276522008966
  44. Sep 2022
  45. www.sciencedirect.com www.sciencedirect.com
    SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA
    1
    1. scibot 24 Sep 2022
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      DOI: 10.1016/j.molcel.2022.08.031

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    sciencedirect.com/science/article/pii/S1097276522008516
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    MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer
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      DOI: 10.1016/j.ccell.2022.08.015

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    sciencedirect.com/science/article/pii/S1535610822003798
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    Ku proteins promote DNA binding and condensation of cyclic GMP-AMP synthase
    1
    1. scibot 08 Sep 2022
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      DOI: 10.1016/j.celrep.2022.111310

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    sciencedirect.com/science/article/pii/S2211124722011342
  48. May 2022
  49. www.sciencedirect.com www.sciencedirect.com
    DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
    1
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      DOI: 10.1016/j.molcel.2022.04.030

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    sciencedirect.com/science/article/pii/S1097276522003938
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    WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC
    1
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      DOI: 10.1016/j.celrep.2022.110814

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    sciencedirect.com/science/article/pii/S221112472200585X
  51. Apr 2022
  52. www.sciencedirect.com www.sciencedirect.com
    Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS
    1
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      DOI: 10.1016/j.molcel.2022.03.034

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    sciencedirect.com/science/article/pii/S1097276522002908
  53. Sep 2021
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STING nuclear partners contribute to innate immune signaling responses
    1
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      DOI: 10.1016/j.isci.2021.103055

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    ncbi.nlm.nih.gov/pmc/articles/PMC8436130/
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    Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion
    1
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      DOI: 10.1016/j.cell.2021.08.035

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    sciencedirect.com/science/article/pii/S0092867421010461
  56. Aug 2021
  57. cancerres.aacrjournals.org cancerres.aacrjournals.org
    SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer
    1
    1. scibot 16 Aug 2021
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      DOI: 10.1158/0008-5472.CAN-20-3738

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    cancerres.aacrjournals.org/content/81/12/3215
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    Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE
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      DOI: 10.1016/j.cell.2021.07.021

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    sciencedirect.com/science/article/pii/S0092867421008801
  59. Jul 2021
  60. www.sciencedirect.com www.sciencedirect.com
    LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade
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      DOI: 10.1016/j.cell.2018.05.052

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    sciencedirect.com/science/article/pii/S0092867418307153
  61. www.sciencedirect.com www.sciencedirect.com
    PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity
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  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity
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    Protocol for nuclear export signal characterization of cGAS in mammalian cells
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  64. Jun 2021
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    Translation stress and collided ribosomes are co-activators of cGAS
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  66. May 2021
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    Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion
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  68. Apr 2021
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    cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing
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  70. Mar 2021
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    Purification of micronuclei from cultured cells by flow cytometry
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    ER-directed TREX1 limits cGAS activation at micronuclei
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  73. Feb 2021
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    FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells
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  75. Jan 2021
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    A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA
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  77. Sep 2020
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    Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres
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  79. elifesciences.org elifesciences.org
    PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response
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  80. www.cell.com www.cell.com
    The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
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    cell.com/cell-reports/fulltext/S2211-1247(18)31888-6
  81. Jan 2020
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    The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death
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    RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres
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      DOI: 10.1016/j.molcel.2019.06.043

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    Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity
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      DOI: 10.1016/j.celrep.2019.09.065

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  85. www.cell.com www.cell.com
    Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury
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    Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA
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      RRID:AB_2732795

      DOI: 10.1016/j.cell.2019.01.049

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    SLC19A1 Is an Importer of the Immunotransmitter cGAMP
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      RRID:AB_2732795

      DOI: 10.1016/j.molcel.2019.05.006

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    sciencedirect.com/science/article/pii/S1097276519303594
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      DOI: 10.1016/j.cell.2019.01.016

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      DOI: 10.1016/j.celrep.2019.01.105

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    Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production
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      RRID:AB_2732795

      DOI: 10.1016/j.immuni.2018.12.013

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    Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING
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      RRID:AB_2732795

      DOI: 10.1016/j.molcel.2019.02.038

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  93. Nov 2018
  94. www.sciencedirect.com www.sciencedirect.com
    Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages
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    NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation
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    Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication
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    sciencedirect.com/science/article/pii/S1931312818303743
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