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Nilotinib induces immunogenic cuproptosis to potentiate cancer immunotherapy

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1. scibot 23 Jul 2026
  
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  DOI: 10.1016/j.xcrm.2026.102928
  
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sciencedirect.com/science/article/pii/S2666379126003459
Jul 2026
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Regulation of neutrophil homeostasis by the TNFAIP8 family of polarity proteins

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1. scibot 16 Jul 2026
  
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  DOI: 10.1016/j.celrep.2026.117694
  
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sciencedirect.com/science/article/pii/S2211124726007722
Jun 2026
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STAT3 interference-driven nanomodulators reverse lipid metabolism-associated chemoresistance and potentiate metalloimmunotherapy in breast cancer

1
1. scibot 05 Jun 2026
  
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  DOI: 10.1016/j.xcrm.2026.102844
  
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sciencedirect.com/science/article/pii/S2666379126002612
Feb 2026
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Luteolin mitigates inflammatory organ injury by targeting XIAP to block PANoptosis and mitochondrial dysfunction

1
1. scibot 05 Feb 2026
  
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  DOI: 10.1016/j.intimp.2026.116271
  
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sciencedirect.com/science/article/pii/S1567576926001141
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Gut microbiota-derived isovaleric acid alleviates atrial fibrillation by suppressing GSDME-dependent pyroptosis

1
1. scibot 05 Feb 2026
  
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  DOI: 10.1016/j.cmet.2025.12.017
  
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sciencedirect.com/science/article/pii/S1550413125005480
Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Pyroptosis modulates multiple immune cell populations in targeted therapy–treated melanoma

1
1. scibot 30 Jan 2026
  
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  DOI: 10.1158/2326-6066.CIR-25-0444
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12851756/
Oct 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Inflammasome-independent IL-1β activation via staphopain A protease of Staphylococcus aureus[image]

1
1. scibot 21 Oct 2025
  
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  DOI: 10.1016/j.jbc.2025.110574
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12528902/
Sep 2025
rupress.org rupress.org

RIPK1 autophosphorylation at S161 mediates cell death and inflammation

2
1. scibot 30 Sep 2025
  
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  DOI: 10.1084/jem.20250279
  
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2. scibot 27 Sep 2025
  
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  RRID:AB_2737000
  
  DOI: 10.1084/jem.20250279
  
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rupress.org/jem/article/222/12/e20250279/278339/RIPK1-autophosphorylation-at-S161-mediates-cell
52.53.155.43 52.53.155.43

2025.08.28.672784v1.full-html.html

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1. scibot 06 Sep 2025
  
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  DOI: 10.1101/2025.08.28.672784
  
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52.53.155.43/ac7f1767c23c6666ccfc705d09859fa9a6162a49/2025.08.28.672784v1.full-html.html
Aug 2025
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High-dose ascorbic acid selectively induces pyroptosis in LKB1-deficient lung cancer and sensitizes immunotherapy

1
1. scibot 19 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102291
  
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sciencedirect.com/science/article/pii/S2666379125003647
Jul 2025
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Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity

1
1. scibot 23 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.018
  
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sciencedirect.com/science/article/pii/S1074761325002870
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IFNγ augments TKI efficacy by alleviating protein unfolding stress to promote GSDME-mediated pyroptosis in hepatocellular carcinoma

1
1. scibot 15 Jul 2025
  
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  DOI: 10.1038/s41419-025-07839-y
  
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nature.com/articles/s41419-025-07839-y
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Identification of the pyroptosis, apoptosis, and necroptosis (PANoptosis) involved in osteogenic differentiation inhibition impaired by tumor necrosis factor-α

1
1. scibot 02 Jul 2025
  
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  RRID:AB_2737000
  
  DOI: 10.1186/s40001-025-02702-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12211273/
May 2025
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Machine-learning-assisted universal protein activation in living mice

1
1. scibot 29 May 2025
  
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  DOI: 10.1016/j.cell.2025.05.006
  
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sciencedirect.com/science/article/pii/S0092867425005173
Apr 2025
52.53.155.43 52.53.155.43

PDF-html.html

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1. scibot 04 Apr 2025
  
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  DOI: 10.1158/2326-6066.cir-24-0834
  
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52.53.155.43/b8eb1cd1446295bdd52d11650093cdf439d34361/PDF-html.html
Dec 2024
52.53.155.43 52.53.155.43

1-s2.0-S2589004224028086-main-html.html

1
1. scibot 19 Dec 2024
  
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  RRID:AB_2737000
  
  DOI: 10.1016/j.isci.2024.111581
  
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52.53.155.43/9f2a0ef4271b61fdfbdda27575922c2ba8834710/1-s2.0-S2589004224028086-main-html.html
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GEFT inhibits the GSDM-mediated proptosis signalling pathway, promoting the progression and drug resistance of rhabdomyosarcoma

1
1. scibot 03 Dec 2024
  
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  DOI: 10.1038/s41419-024-07243-y
  
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nature.com/articles/s41419-024-07243-y
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Zinc promotes microbial p-coumaric acid production that protects against cholestatic liver injury

1
1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.chom.2024.11.002
  
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sciencedirect.com/science/article/pii/S1931312824004086
Nov 2024
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Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair

1
1. scibot 16 Nov 2024
  
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  DOI: 10.1016/j.cell.2024.10.010
  
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sciencedirect.com/science/article/pii/S0092867424011589
Oct 2024
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Leucine restriction ameliorates Fusobacterium nucleatum-driven malignant progression and radioresistance in nasopharyngeal carcinoma

1
1. scibot 02 Oct 2024
  
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  DOI: 10.1016/j.xcrm.2024.101753
  
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sciencedirect.com/science/article/pii/S266637912400483X
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Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application

1
1. scibot 02 Oct 2024
  
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  DOI: 10.1038/s41467-024-52110-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11427689/
Sep 2024
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Activation of the NLRP1B inflammasome by caspase-8

1
1. scibot 25 Sep 2024
  
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  RRID:AB_2737000
  
  DOI: 10.1038/s42003-024-06882-3
  
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nature.com/articles/s42003-024-06882-3
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Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis

1
1. scibot 11 Sep 2024
  
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  AB_2737000
  
  DOI: 10.1016/j.celrep.2024.114728
  
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sciencedirect.com/science/article/pii/S2211124724010799
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Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity

1
1. scibot 10 Sep 2024
  
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  DOI: 10.1016/j.cell.2024.08.007
  
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sciencedirect.com/science/article/pii/S0092867424008985
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation

1
1. scibot 21 Jun 2024
  
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  RRID:AB_2737000
  
  DOI: 10.1016/j.cell.2024.05.034
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11283362/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Pyroptotic T cell-derived active IL-16 has a driving function in ovarian endometriosis development

1
1. scibot 03 Apr 2024
  
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  DOI: 10.1016/j.xcrm.2024.101476
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10983113/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma

2
1. scibot 06 Mar 2024
  
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  DOI: 10.1158/1535-7163.MCT-23-0025
  
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2. scibot 06 Mar 2024
  
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  DOI: 10.1158/1535-7163.MCT-23-0025
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10527992/
Feb 2024
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 16 Feb 2024
  
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  RRID:AB_2737000
  
  DOI: 10.1111/bph.16299
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16299
Dec 2023
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Emulsion and liposome-based adjuvanted R21 vaccine formulations mediate protection against malaria through distinct immune mechanisms

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1. scibot 02 Dec 2023
  
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  DOI: 10.1016/j.xcrm.2023.101245
  
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sciencedirect.com/science/article/pii/S2666379123004226
www.nature.com www.nature.com

Pyroptosis inhibiting nanobodies block Gasdermin D pore formation

1
1. scibot 02 Dec 2023
  
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  DOI: 10.1038/s41467-023-43707-z
  
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nature.com/articles/s41467-023-43707-z
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores

1
1. scibot 08 Sep 2023
  
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  DOI: 10.1016/j.isci.2023.107698
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10480325/
Aug 2023
52.53.155.43 52.53.155.43

mct-23-0025 (1)-html.html

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1. scibot 11 Aug 2023
  
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  DOI: 10.1158/1535-7163.mct-23-0025
  
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52.53.155.43/1629e82c15a2ef751662f24158b1c1b52e5a2112/mct-23-0025 (1)-html.html
Jun 2023
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Whole-genome CRISPR screen identifies RAVER1 regulates RIPK1-mediated inflammatory cell death, PANoptosis

1
1. scibot 09 Jun 2023
  
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  DOI: 10.1016/j.isci.2023.106938
  
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sciencedirect.com/science/article/pii/S2589004223010155
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NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs

1
1. scibot 02 Jun 2023
  
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  RRID:AB_2737000
  
  DOI: 10.1016/j.cell.2023.05.005
  
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Mar 2023
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Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration

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  DOI: 10.1016/j.neuron.2023.02.019
  
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Jan 2023
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A Genome-wide screen identifies PDPK1 as a target to enhance the efficacy of MEK1/2 inhibitors in NRAS mutant melanoma

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Bile acids target mitofusin 2 to differentially regulate innate immunity in physiological versus cholestatic conditions

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Gasdermins and pannexin-1 mediate pathways of chemotherapy-induced cell lysis in hematopoietic malignancies

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Raptinal induces Gasdermin E-dependent pyroptosis in naive and therapy-resistant melanoma

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Nov 2022
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Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins

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Oct 2022
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mcr-22-0040-html.html

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LANCE: a Label-Free Live Apoptotic and Necrotic Cell Explorer Using Convolutional Neural Network Image Analysis

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  DOI: 10.1021/acs.analchem.2c00878
  
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Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation

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Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma

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May 2022
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Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells

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Mar 2022
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Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases

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The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer

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ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

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Dihydroartemisinin mediating PKM2-caspase-8/3-GSDME axis for pyroptosis in esophageal squamous cell carcinoma

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Shigella OspC3 suppresses murine cytosolic LPS sensing

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Untitled document

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Gasdermin-E-mediated pyroptosis participates in the pathogenesis of Crohn’s disease by promoting intestinal inflammation

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May 2021
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Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells

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Apr 2021
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Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition

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Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases

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Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

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Sep 2020
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A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling

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Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

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Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All-trans Retinal

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  DOI: 10.1167/iovs.18-26360
  
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Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure

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